P37457 (WECG_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable UDP-N-acetyl-D-mannosaminuronic acid transferase
Short name=UDP-ManNAcA transferase
EC=2.4.1.-

Gene names

Name:	wecG
Synonyms:	rffM
Ordered Locus Names:	STM3929
ORF Names:	STMD1.61

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis By similarity. HAMAP MF_01001
Catalytic activity	UDP-ManNAcA + Und-PP-GlcNAc = UDP + Und-PP-GlcNAc-ManNAcA. HAMAP MF_01001
Pathway	Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. HAMAP MF_01001
Sequence similarities	Belongs to the glycosyltransferase 26 family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	transferase activity, transferring hexosyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Probable UDP-N-acetyl-D-mannosaminuronic acid transferase HAMAP MF_01001		PRO_0000208434

Sequences

	Sequence		Length	Mass (Da)
	P37457 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 847009586988CF0D	FASTA	246	27,599
	10 20 30 40 50 60 MTNNAAAPLY SLRGLPLIGW RDMSHALNYL FADGQLKQGT LVAINAEKLL TAEDNPEVRA 70 80 90 100 110 120 LIAAAEFKYA DGISVVRSIR KKFPQAQVSR VAGADLWEAL MARAGKEGTP VFLVGGKPEV 130 140 150 160 170 180 LAQTEAKLRT QWNVNIVGSQ DGYFTPEQRQ ALFARIHASG AKIVTVAMGS PKQELLMRDC 190 200 210 220 230 240 REVHPHALYM GVGGTYDVFT GHVKRAPKIW QNLGLEWLYR LLSQPRRITR QMRLLRYLRW HYTGDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Salmonella typhimurium uracil-sensitive mutation use is in argU and encodes a minor arginine tRNA." Lu C.D., Abdelal A.T. J. Bacteriol. 175:3897-3899(1993) [PubMed: 8509342] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M95047 Genomic DNA. Translation: AAA92025.1. AF233324 Genomic DNA. Translation: AAF33458.1. AE006468 Genomic DNA. Translation: AAL22778.1.
PIR	S27727.
RefSeq	NP_462819.1. NC_003197.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT26. Glycosyltransferase Family 26.
Proteomic databases
PRIDE	P37457.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1255455.
GenomeReviews	Gene locus STM3929 in contig AE006468_GR.
KEGG	stm:STM3929.
PATRIC	32386721. VBISalEnt20916_4150.
Phylogenomic databases
HOGENOM	HBG685240.
OMA	MLAIRKE.
ProtClustDB	PRK03692.
Enzyme and pathway databases
BioCyc	STYP99287:STM3929-MONOMER.
Family and domain databases
HAMAP	MF_01001. WecG_RffM. [Tree]
InterPro	IPR023085. UDP-ManNAcA_Trfase_WecG. IPR004629. WecB_TagA_CpsF. [Graphical view]
KO	K02852.
Pfam	PF03808. Glyco_tran_WecB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00696. WecB_tagA_cpsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

WECG_SALTY

Accession

Primary (citable) accession number: P37457

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program