Reviewed,
UniProtKB/Swiss-Prot P37454 (EXOA_BACSU)
Last modified
November 3, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Exodeoxyribonuclease EC=3.1.11.2 | ||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 252 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. |
| Subcellular location | |
| Sequence similarities | Belongs to the DNA repair enzymes AP/exoA family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Exonuclease Hydrolase Nuclease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activityInferred from electronic annotation. Source: InterPro exodeoxyribonuclease III activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin." Ogasawara N., Nakai S., Yoshikawa H. DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Characterization of Bacillus subtilis ExoA protein: a multifunctional DNA-repair enzyme similar to the Escherichia coli exonuclease III." Shida T., Ogawa T., Ogasawara N., Sekiguchi J. Biosci. Biotechnol. Biochem. 63:1528-1534(1999) [PubMed: 10540738] [Abstract] Cited for: CHARACTERIZATION. |
Cross-references
Sequence databases | |
|---|---|
| D26185 Genomic DNA. Translation: BAA05218.1. AL009126 Genomic DNA. Translation: CAB16125.1. | |
| PIR | S66012. |
| RefSeq | NP_391968.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HD7 based on UniProtKB P27695. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 937918. |
| GenomeReviews | Gene locus BSU40880 in contig AL009126_GR. |
| KEGG | bsu:BSU40880. |
| NMPDR | fig|224308.1.peg.4094. |
Organism-specific databases | |
| SubtiList | BG10046. exoA. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P37454. |
| OMA | YTWWSYM. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU4085-MON. |
| BRENDA | 3.1.11.2. 150. |
Family and domain databases | |
| InterPro | IPR000097. AP_endonuclease_F1. IPR005135. Endo/exonuclease/phosphatase. IPR004808. exoDNase_III. [Graphical view] |
| PANTHER | PTHR22748. ExoIII_xth. 1 hit. |
| Pfam | PF03372. Exo_endo_phos. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00195. exoDNase_III. 1 hit. TIGR00633. xth. 1 hit. |
| PROSITE | PS00726. AP_NUCLEASE_F1_1. 1 hit. PS00727. AP_NUCLEASE_F1_2. 1 hit. PS00728. AP_NUCLEASE_F1_3. 1 hit. PS51435. AP_NUCLEASE_F1_4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | EXOA_BACSU | ||||||||
| Accession | Primary (citable) accession number: P37454 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |

Clusters with


