P37451 (PDUF_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Propanediol diffusion facilitator

Gene names

Name:	pduF
Ordered Locus Names:	STM2037

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May facilitate the diffusion of propanediol.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Induction	By propanediol.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Propanediol diffusion facilitator		PRO_0000064095
Regions
	Transmembrane	10 – 30	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Transmembrane	228 – 248	21	Helical; Potential
	Motif	66 – 68	3	NPA 1
	Motif	201 – 203	3	NPA 2
Experimental info
	Sequence conflict	121	1	R → A Ref.1
	Sequence conflict	121	1	R → A Ref.2
	Sequence conflict	177 – 181	5	APLLI → RLCLL Ref.1
	Sequence conflict	177 – 181	5	APLLI → RLCLL Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P37451 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: CBFB5E729061A26C	FASTA	264	27,744
	10 20 30 40 50 60 MNDSLKAQCG AEFLGTGLFL FFGIGCLSAL KVAGASLGLW EICIIWGLGI SLAVYLTAGI 70 80 90 100 110 120 SGGHLNPAVT IALWLFACFP KQKVLPYIIA QFAGAFGGAL LAYVLYSSLF TEFETAHHMV 130 140 150 160 170 180 RGSVESLQLA SIFSTYPAAA LNVWQAALVE VVITSILMGM IMALTDDGNG IPKGPLAPLL 190 200 210 220 230 240 IGILVAVIGA STGPLTGFAM NPARDFGPKL FTWLAGWGNM AMSGGREIPY FIVPIVAPVI 250 260 GACAGAAIYR YFIGKNLPCN RCEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The control region of the pdu/cob regulon in Salmonella typhimurium." Chen P., Anderson D.I., Roth J.R. J. Bacteriol. 176:5474-5482(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Propanediol utilization genes (pdu) of Salmonella typhimurium: three genes for the propanediol dehydratase." Bobik T.A., Xu Y., Jeter R.M., Otto K.E., Roth J.R. J. Bacteriol. 179:6633-6639(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[3]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF026270 Genomic DNA. Translation: AAB84108.1. AE006468 Genomic DNA. Translation: AAL20941.1.
RefSeq	NP_460982.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P37451.
SMR	P37451. Positions 4-257.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM2037.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL20941; AAL20941; STM2037.
GeneID	1253558.
KEGG	stm:STM2037.
PATRIC	32382657. VBISalEnt20916_2159.
Phylogenomic databases
eggNOG	COG0580.
HOGENOM	HOG000288287.
OMA	EVVITSM.
ProtClustDB	CLSK2393520.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
InterPro	IPR023271. Aquaporin-like. IPR000425. MIP. IPR022357. MIP_CS. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
TIGRFAMs	TIGR00861. MIP. 1 hit.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDUF_SALTY

Accession

Primary (citable) accession number: P37451

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	January 23, 2002
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program