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Protein

Calponin-3

Gene

Cnn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

GO - Molecular functioni

  • microtubule binding Source: RGD
  • protein binding, bridging Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-3
Alternative name(s):
Calponin, acidic isoform
Calponin, non-muscle isoform
Gene namesi
Name:Cnn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi71044. Cnn3.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: RGD
  • cytoplasm Source: Ensembl
  • dendrite Source: RGD
  • dendritic spine Source: RGD
  • focal adhesion Source: Ensembl
  • microtubule Source: RGD
  • neuronal cell body Source: RGD
  • postsynaptic density Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Calponin-3PRO_0000204778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP37397.
PRIDEiP37397.

PTM databases

iPTMnetiP37397.
PhosphoSiteiP37397.

Expressioni

Gene expression databases

GenevisibleiP37397. RN.

Interactioni

GO - Molecular functioni

  • microtubule binding Source: RGD
  • protein binding, bridging Source: RGD

Protein-protein interaction databases

BioGridi248537. 3 interactions.
IntActiP37397. 1 interaction.
STRINGi10116.ENSRNOP00000015579.

Structurei

3D structure databases

ProteinModelPortaliP37397.
SMRiP37397. Positions 11-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 129104CHPROSITE-ProRule annotationAdd
BLAST
Repeati164 – 18926Calponin-like 1Add
BLAST
Repeati204 – 22926Calponin-like 2Add
BLAST
Repeati243 – 26826Calponin-like 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 33041Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 3 calponin-like repeats.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37397.
OMAiDDYPREY.
OrthoDBiEOG71P2B3.
PhylomeDBiP37397.
TreeFamiTF313921.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHFNKGPSY GLSAEVKNKI ASKYDQQAEE DLRNWIEEVT GMGIGTNFQL
60 70 80 90 100
GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP
110 120 130 140 150
HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDI GVKYAEKQTR
160 170 180 190 200
RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD
210 220 230 240 250
QTTISLQMGT NKGASQAGMS APGTRRDIYD QKLTLQPVDN STISLQMGTN
260 270 280 290 300
KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
310 320 330
QAEYPDEYHG EYPDEYPREY QYGDDQGIDY
Length:330
Mass (Da):36,435
Last modified:October 1, 1994 - v1
Checksum:i428226594E10BA05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06755 mRNA. Translation: AAA18590.1.
BC062020 mRNA. Translation: AAH62020.1.
PIRiA53742.
RefSeqiNP_062232.1. NM_019359.1.
UniGeneiRn.57635.

Genome annotation databases

EnsembliENSRNOT00000015579; ENSRNOP00000015579; ENSRNOG00000011559.
GeneIDi54321.
KEGGirno:54321.
UCSCiRGD:71044. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06755 mRNA. Translation: AAA18590.1.
BC062020 mRNA. Translation: AAH62020.1.
PIRiA53742.
RefSeqiNP_062232.1. NM_019359.1.
UniGeneiRn.57635.

3D structure databases

ProteinModelPortaliP37397.
SMRiP37397. Positions 11-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248537. 3 interactions.
IntActiP37397. 1 interaction.
STRINGi10116.ENSRNOP00000015579.

PTM databases

iPTMnetiP37397.
PhosphoSiteiP37397.

Proteomic databases

PaxDbiP37397.
PRIDEiP37397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015579; ENSRNOP00000015579; ENSRNOG00000011559.
GeneIDi54321.
KEGGirno:54321.
UCSCiRGD:71044. rat.

Organism-specific databases

CTDi1266.
RGDi71044. Cnn3.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP37397.
OMAiDDYPREY.
OrthoDBiEOG71P2B3.
PhylomeDBiP37397.
TreeFamiTF313921.

Miscellaneous databases

NextBioi611010.
PROiP37397.

Gene expression databases

GenevisibleiP37397. RN.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle."
    Applegate D.E., Feng W., Green R.S., Taubman M.B.
    J. Biol. Chem. 269:10683-10690(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Vascular smooth muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 54-64, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiCNN3_RAT
AccessioniPrimary (citable) accession number: P37397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 20, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.