P37388 (XYLG_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose import ATP-binding protein XylG
EC=3.6.3.17

Gene names

Name:	xylG
Ordered Locus Names:	b3567, JW3539

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system Probable. The XylFGH system can also transport ribose in absence of xylose. Ref.4
Catalytic activity	ATP + H2O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
Subunit structure	The complex is composed of two ATP-binding proteins (XylG), two transmembrane proteins (XylH) and a solute-binding protein (XylF) Potential.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. [View classification] Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-ribose-importing ATPase activity Inferred from genetic interaction Ref.4. Source: EcoCyc D-xylose-importing ATPase activity Inferred from genetic interaction PubMed 8581399. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	Xylose import ATP-binding protein XylG		PRO_0000093124
Regions
	Domain	5 – 242	238	ABC transporter 1
	Domain	259 – 505	247	ABC transporter 2
	Nucleotide binding	37 – 44	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P37388 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: FAD2C65D178D50DF	FASTA	513	56,470
	10 20 30 40 50 60 MPYLLEMKNI TKTFGSVKAI DNVCLRLNAG EIVSLCGENG SGKSTLMKVL CGIYPHGSYE 70 80 90 100 110 120 GEIIFAGEEI QASHIRDTER KGIAIIHQEL ALVKELTVLE NIFLGNEITH NGIMDYDLMT 130 140 150 160 170 180 LRCQKLLAQV SLSISPDTRV GDLGLGQQQL VEIAKALNKQ VRLLILDEPT ASLTEQETSI 190 200 210 220 230 240 LLDIIRDLQQ HGIACIYISH KLNEVKAISD TICVIRDGQH IGTRDAAGMS EDDIITMMVG 250 260 270 280 290 300 RELTALYPNE PHTTGDEILR IEHLTAWHPV NRHIKRVNDV SFSLKRGEIL GIAGLVGAGR 310 320 330 340 350 360 TETIQCLFGV WPGQWEGKIY IDGKQVDIRN CQQAIAQGIA MVPEDRKRDG IVPVMAVGKN 370 380 390 400 410 420 ITLAALNKFT GGISQLDDAA EQKCILESIQ QLKVKTSSPD LAIGRLSGGN QQKAILARCL 430 440 450 460 470 480 LLNPRILILD EPTRGIDIGA KYEIYKLINQ LVQQGIAVIV ISSELPEVLG LSDRVLVMHE 490 500 510 GKLKANLINH NLTQEQVMEA ALRSEHHVEK QSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R. Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Utilization of D-ribose through D-xylose transporter." Song S., Park C. FEMS Microbiol. Lett. 163:255-261(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN XYLOSE TRANSPORT, ABILITY TO TRANSPORT RIBOSE. Strain: K12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00039 Genomic DNA. Translation: AAB18544.1. U00096 Genomic DNA. Translation: AAC76591.1. AP009048 Genomic DNA. Translation: BAE77726.1.
PIR	S47788.
RefSeq	NP_418024.1. NC_000913.2. YP_491867.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P37388.
SMR	P37388. Positions 9-502.
ModBase	Search...
Protein-protein interaction databases
IntAct	P37388. 6 interactions.
STRING	511145.b3567.
Protein family/group databases
TCDB	3.A.1.2.4. ATP-binding cassette (ABC) superfamily.
Proteomic databases
PaxDb	P37388.
PRIDE	P37388.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76591; AAC76591; b3567. BAE77726; BAE77726; BAE77726.
GeneID	12933548. 948127.
KEGG	ecj:Y75_p3608. eco:b3567.
PATRIC	32122610. VBIEscCol129921_3682.
Organism-specific databases
EchoBASE	EB2184.
EcoGene	EG12275. xylG.
Phylogenomic databases
eggNOG	COG1129.
KO	K10545.
OMA	GVMDYDA.
ProtClustDB	PRK13549.
Enzyme and pathway databases
BioCyc	EcoCyc:XYLG-MONOMER. ECOL316407:JW3539-MONOMER.
Gene expression databases
Genevestigator	P37388.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013455. ABC_transptr_xylose_ATP-bd. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF52540. SSF52540. 2 hits.
TIGRFAMs	TIGR02633. xylG. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. PS51280. XYLG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLG_ECOLI

Accession

Primary (citable) accession number: P37388
Secondary accession number(s): Q2M7N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 29, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program