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Protein

D-xylose-binding periplasmic protein

Gene

xylF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose.

GO - Molecular functioni

  • monosaccharide binding Source: EcoCyc

GO - Biological processi

  • D-xylose transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:XYLF-MONOMER.
ECOL316407:JW3538-MONOMER.
MetaCyc:XYLF-MONOMER.
RETL1328306-WGS:GSTH-3225-MONOMER.

Protein family/group databases

TCDBi3.A.1.2.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
D-xylose-binding periplasmic protein
Gene namesi
Name:xylF
Synonyms:xylT
Ordered Locus Names:b3566, JW3538
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20252. xylF.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23233 PublicationsAdd
BLAST
Chaini24 – 330307D-xylose-binding periplasmic proteinPRO_0000031738Add
BLAST

Proteomic databases

EPDiP37387.
PaxDbiP37387.
PRIDEiP37387.

Interactioni

Protein-protein interaction databases

BioGridi4262541. 7 interactions.
IntActiP37387. 3 interactions.
STRINGi511145.b3566.

Structurei

Secondary structure

1
330
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 337Combined sources
Beta strandi36 – 383Combined sources
Helixi41 – 5313Combined sources
Beta strandi57 – 626Combined sources
Helixi67 – 7913Combined sources
Beta strandi83 – 886Combined sources
Helixi96 – 1038Combined sources
Turni104 – 1063Combined sources
Beta strandi108 – 1147Combined sources
Beta strandi122 – 1276Combined sources
Helixi129 – 14315Combined sources
Beta strandi145 – 15410Combined sources
Helixi159 – 17719Combined sources
Beta strandi180 – 1889Combined sources
Helixi190 – 1923Combined sources
Helixi194 – 20714Combined sources
Turni208 – 2103Combined sources
Beta strandi214 – 2196Combined sources
Helixi220 – 23112Combined sources
Turni232 – 2343Combined sources
Turni236 – 2383Combined sources
Beta strandi239 – 2413Combined sources
Helixi248 – 2569Combined sources
Beta strandi262 – 2643Combined sources
Helixi267 – 28216Combined sources
Beta strandi290 – 2945Combined sources
Beta strandi296 – 30510Combined sources
Beta strandi308 – 3103Combined sources
Turni312 – 3154Combined sources
Helixi316 – 3205Combined sources
Turni321 – 3233Combined sources
Helixi327 – 3293Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M9WX-ray2.15A24-330[»]
3M9XX-ray2.20A24-330[»]
3MA0X-ray2.20A/B/C24-330[»]
ProteinModelPortaliP37387.
SMRiP37387. Positions 26-330.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37387.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DFW. Bacteria.
COG4213. LUCA.
HOGENOMiHOG000240882.
InParanoidiP37387.
KOiK10543.
OMAiQQWVPEW.
PhylomeDBiP37387.

Family and domain databases

InterProiIPR028082. Peripla_BP_I.
IPR025997. SBP_2_dom.
IPR013456. XylF.
[Graphical view]
PfamiPF13407. Peripla_BP_4. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR02634. xylF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKNILLTL CTSLLLTNVA AHAKEVKIGM AIDDLRLERW QKDRDIFVKK
60 70 80 90 100
AESLGAKVFV QSANGNEETQ MSQIENMINR GVDVLVIIPY NGQVLSNVVK
110 120 130 140 150
EAKQEGIKVL AYDRMINDAD IDFYISFDNE KVGELQAKAL VDIVPQGNYF
160 170 180 190 200
LMGGSPVDNN AKLFRAGQMK VLKPYVDSGK IKVVGDQWVD GWLPENALKI
210 220 230 240 250
MENALTANNN KIDAVVASND ATAGGAIQAL SAQGLSGKVA ISGQDADLAG
260 270 280 290 300
IKRIAAGTQT MTVYKPITLL ANTAAEIAVE LGNGQEPKAD TTLNNGLKDV
310 320 330
PSRLLTPIDV NKNNIKDTVI KDGFHKESEL
Length:330
Mass (Da):35,734
Last modified:October 1, 1994 - v1
Checksum:iE0AFC0326511B056
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18543.1.
U00096 Genomic DNA. Translation: AAC76590.1.
AP009048 Genomic DNA. Translation: BAE77727.1.
PIRiS47787.
RefSeqiNP_418023.1. NC_000913.3.
WP_000694881.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76590; AAC76590; b3566.
BAE77727; BAE77727; BAE77727.
GeneIDi948090.
KEGGiecj:JW3538.
eco:b3566.
PATRICi32122608. VBIEscCol129921_3681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18543.1.
U00096 Genomic DNA. Translation: AAC76590.1.
AP009048 Genomic DNA. Translation: BAE77727.1.
PIRiS47787.
RefSeqiNP_418023.1. NC_000913.3.
WP_000694881.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M9WX-ray2.15A24-330[»]
3M9XX-ray2.20A24-330[»]
3MA0X-ray2.20A/B/C24-330[»]
ProteinModelPortaliP37387.
SMRiP37387. Positions 26-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262541. 7 interactions.
IntActiP37387. 3 interactions.
STRINGi511145.b3566.

Protein family/group databases

TCDBi3.A.1.2.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

EPDiP37387.
PaxDbiP37387.
PRIDEiP37387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76590; AAC76590; b3566.
BAE77727; BAE77727; BAE77727.
GeneIDi948090.
KEGGiecj:JW3538.
eco:b3566.
PATRICi32122608. VBIEscCol129921_3681.

Organism-specific databases

EchoBASEiEB4153.
EcoGeneiEG20252. xylF.

Phylogenomic databases

eggNOGiENOG4105DFW. Bacteria.
COG4213. LUCA.
HOGENOMiHOG000240882.
InParanoidiP37387.
KOiK10543.
OMAiQQWVPEW.
PhylomeDBiP37387.

Enzyme and pathway databases

BioCyciEcoCyc:XYLF-MONOMER.
ECOL316407:JW3538-MONOMER.
MetaCyc:XYLF-MONOMER.
RETL1328306-WGS:GSTH-3225-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP37387.
PROiP37387.

Family and domain databases

InterProiIPR028082. Peripla_BP_I.
IPR025997. SBP_2_dom.
IPR013456. XylF.
[Graphical view]
PfamiPF13407. Peripla_BP_4. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
TIGRFAMsiTIGR02634. xylF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiXYLF_ECOLI
AccessioniPrimary (citable) accession number: P37387
Secondary accession number(s): Q2M7M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

E.coli has two D-xylose transport systems that accumulate sugar against a concentration gradient: the XylE system which utilizes the electrochemical gradient of protons and that is insensitive to cold osmotic shock and the XylF system that uses a high-energy phosphate compound and is sensitive to cold osmotic shock.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.