Reviewed, UniProtKB/Swiss-Prot P37385 (ATSY_SYNE7)

Names and origin

Protein names

Recommended name:
    Probable copper-transporting ATPase synA
    EC=3.6.3.4

Gene names

Name:	synA
Ordered Locus Names:	Synpcc7942_2317

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	790 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in copper transport.
Catalytic activity	ATP + H(2)O + Cu(2+)(In) = ADP + phosphate + Cu(2+)(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IB subfamily. Contains 1 HMA domain.

Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	copper ion transport Inferred from electronic annotation. Source: InterPro metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 790	790	Probable copper-transporting ATPase synA		PRO_0000046158
Regions
	Topological domain	1 – 105	105	Cytoplasmic Potential
	Transmembrane	106 – 127	22	Potential
	Topological domain	128 – 136	9	Extracellular Potential
	Transmembrane	137 – 156	20	Potential
	Topological domain	157 – 163	7	Cytoplasmic Potential
	Transmembrane	164 – 184	21	Potential
	Topological domain	185 – 198	14	Extracellular Potential
	Transmembrane	199 – 219	21	Potential
	Topological domain	220 – 358	139	Cytoplasmic Potential
	Transmembrane	359 – 381	23	Potential
	Topological domain	382 – 420	39	Extracellular Potential
	Transmembrane	421 – 438	18	Potential
	Topological domain	439 – 723	285	Cytoplasmic Potential
	Transmembrane	724 – 743	20	Potential
	Topological domain	744 – 755	12	Extracellular Potential
	Transmembrane	756 – 774	19	Potential
	Topological domain	775 – 790	16	Cytoplasmic Potential
	Domain	15 – 82	68	HMA
Sites
	Active site	476	1	4-aspartylphosphate intermediate By similarity
	Metal binding	25	1	Copper Potential
	Metal binding	28	1	Copper Potential
	Metal binding	669	1	Magnesium By similarity
	Metal binding	673	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37385-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: FA5B7BFEDF4C3793	FASTA	790	83,695
	10 20 30 40 50 60 MPAAIVHSAD PSSTSILVEV EGMKCAGCVA AVERRLQQTA GVEAVSVNLI TRLAKVDYDA 70 80 90 100 110 120 ALIEDPTVLT TEITGLGFRA QLRQDDNPLT LPIAEIPPLQ QQRLQLAIAA FLLIVSSWGH 130 140 150 160 170 180 LGHWLDHPLP GTDQLWFHAL LATWALLGPG RSILQAGWQG LRCGAPNMNS LVLLGTGSAY 190 200 210 220 230 240 LASLVALLWP QLGWVCFFDE PVMLLGFILL GRTLEEQARF RSQAALQNLL ALQPETTQLL 250 260 270 280 290 300 TAPSSIAPQD LLEAPAQIWP VAQLRAGDYV QVLPGDRIPV DGCIVAGQST LDTAMLTGEP 310 320 330 340 350 360 LPQPCQVGDR VCAGTLNLSH RLVIRAEQTG SQTRLAAIVR CVAEAQQRKA PVQRFADAIA 370 380 390 400 410 420 GRFVYGVCAI AALTFGFWAT LGSRWWPQVL QQPLPGLLIH APHHGMEMAH PHSHSPLLLA 430 440 450 460 470 480 LTLAISVLVV ACPCALGLAT PTAILVATGL AAEQGILVRG GDVLEQLARI KHFVFDKTGT 490 500 510 520 530 540 LTQGQFELIE IQPLADVDPD RLLQWAAALE ADSRHPLATA LQTAAQAANL APIAASDRQQ 550 560 570 580 590 600 VPGLGVSGTC DGRSLRLGNP TWVQVATAKL PTGSAAATSI WLADDQQLLA CFWLQDQPRP 610 620 630 640 650 660 EAAEVVQALR SRGATVQILS GDRQTTAVAL AQQLGLESET VVAEVLPEDK AAAIAALQSQ 670 680 690 700 710 720 GDAVAMIGDG INDAPALATA AVGISLAAGS DIAQDSAGLL LSRDRLDSVL VAWNLSQMGL 730 740 750 760 770 780 RTIRQNLTWA LGYNVVMLPL AAGAFLPAYG LALTPAIAGA CMAVSSLAVV SNSLLLRYWF 790 RRSLNHSVSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"P-type ATPase from the cyanobacterium Synechococcus 7942 related to the human Menkes and Wilson disease gene products." Phung L.T., Ajlani G., Haselkorn R. Proc. Natl. Acad. Sci. U.S.A. 91:9651-9654(1994) [PubMed: 7937823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U04356 Genomic DNA. Translation: AAB82020.1. CP000100 Genomic DNA. Translation: ABB58347.1.
RefSeq	YP_401334.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0V based on UniProtKB O32221.
ModBase	Search...
Genome annotation databases
GeneID	3774600.
GenomeReviews	Gene locus Synpcc7942_2317 in contig CP000100_GR.
KEGG	syf:Synpcc7942_2317.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P37385.
Enzyme and pathway databases
BioCyc	SELO1140:SYNPCC7942_2317-MON.
Family and domain databases
InterPro	IPR006416. ATPase-IB_hvy. IPR001757. ATPase_P. IPR006403. ATPase_P_cat/Cu. IPR001877. Cu_ATPase1. IPR005834. Dehalogen-like_hydro. IPR008250. E1-E2_ATPase_reg. IPR006121. HeavyMe_transpt. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00942. CUATPASEI.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATSY_SYNE7

Accession

Primary (citable) accession number: P37385
Secondary accession number(s): Q31KS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)