Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA repair protein RAD51 homolog 1

Gene

RAD51A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi127 – 1348ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-265976. Homologous DNA pairing and strand exchange.
R-GGA-351433. ATM mediated phosphorylation of repair proteins.
R-GGA-5685938. HDR through Single Strand Annealing (SSA).
R-GGA-5685942. HDR through Homologous Recombination (HRR).
R-GGA-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-GGA-5693579. Homologous DNA Pairing and Strand Exchange.
R-GGA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homolog 1
Gene namesi
Name:RAD51A
Synonyms:RAD51
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339DNA repair protein RAD51 homolog 1PRO_0000122935Add
BLAST

Proteomic databases

PaxDbiP37383.

Expressioni

Tissue specificityi

Expressed at high levels in lymphoid and reproductive organs.

Gene expression databases

BgeeiENSGALG00000004516.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032107.

Structurei

3D structure databases

ProteinModelPortaliP37383.
SMRiP37383. Positions 24-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 7730HhHAdd
BLAST

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated
Contains 1 HhH domain.Curated

Phylogenomic databases

eggNOGiKOG1433. Eukaryota.
COG0468. LUCA.
GeneTreeiENSGT00770000120539.
HOGENOMiHOG000227426.
HOVERGENiHBG001504.
InParanoidiP37383.
KOiK04482.
OMAiCQLPIDQ.
OrthoDBiEOG091G09QY.
PhylomeDBiP37383.
TreeFamiTF101218.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011941. DNA_recomb/repair_Rad51.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02239. recomb_RAD51. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMQVQFEAS TDTSAEEESF GPEPISRLEQ CGINANDVKK LEEAGYHTVE
60 70 80 90 100
SVAHAPKKEL LNIKGISEAK ADKILAEAAK LVPMGFTTAT EFHQRRSEII
110 120 130 140 150
QITTGSKELD KLLQGGIETG SITELFGEFR TGKTQLCHTL AVTCQLPIDR
160 170 180 190 200
GGGEGKAMYI DTEGTFRPER LLAVAERYGL SGSDVLDNVA YARGFNTDHQ
210 220 230 240 250
TQLLYQASAM MAESRYALLI VDSATALYRT DYSGRGELSA RQMHLARFLR
260 270 280 290 300
MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL
310 320 330
YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKE
Length:339
Mass (Da):36,904
Last modified:October 1, 1994 - v1
Checksum:i549C59DBD3529DA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09655 mRNA. No translation available.
S59426 mRNA. Translation: AAB26354.1.
PIRiS35642.
RefSeqiNP_990504.1. NM_205173.1.
XP_015141632.1. XM_015286146.1.
XP_015141633.1. XM_015286147.1.
UniGeneiGga.2303.

Genome annotation databases

EnsembliENSGALT00000032744; ENSGALP00000032107; ENSGALG00000004516.
GeneIDi396086.
KEGGigga:396086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09655 mRNA. No translation available.
S59426 mRNA. Translation: AAB26354.1.
PIRiS35642.
RefSeqiNP_990504.1. NM_205173.1.
XP_015141632.1. XM_015286146.1.
XP_015141633.1. XM_015286147.1.
UniGeneiGga.2303.

3D structure databases

ProteinModelPortaliP37383.
SMRiP37383. Positions 24-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032107.

Proteomic databases

PaxDbiP37383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000032744; ENSGALP00000032107; ENSGALG00000004516.
GeneIDi396086.
KEGGigga:396086.

Organism-specific databases

CTDi5888.

Phylogenomic databases

eggNOGiKOG1433. Eukaryota.
COG0468. LUCA.
GeneTreeiENSGT00770000120539.
HOGENOMiHOG000227426.
HOVERGENiHBG001504.
InParanoidiP37383.
KOiK04482.
OMAiCQLPIDQ.
OrthoDBiEOG091G09QY.
PhylomeDBiP37383.
TreeFamiTF101218.

Enzyme and pathway databases

ReactomeiR-GGA-265976. Homologous DNA pairing and strand exchange.
R-GGA-351433. ATM mediated phosphorylation of repair proteins.
R-GGA-5685938. HDR through Single Strand Annealing (SSA).
R-GGA-5685942. HDR through Homologous Recombination (HRR).
R-GGA-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-GGA-5693579. Homologous DNA Pairing and Strand Exchange.
R-GGA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.

Miscellaneous databases

PROiP37383.

Gene expression databases

BgeeiENSGALG00000004516.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011941. DNA_recomb/repair_Rad51.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02239. recomb_RAD51. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAD51_CHICK
AccessioniPrimary (citable) accession number: P37383
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.