P37367 (ATA1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cation-transporting ATPase pma1
EC=3.6.3.-

Gene names

Name:	pma1
Ordered Locus Names:	sll1614

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	905 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could mediate calcium influx.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 905	905	Cation-transporting ATPase pma1		PRO_0000046178
Regions
	Transmembrane	60 – 80	21	Helical; Potential
	Transmembrane	81 – 101	21	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential
	Transmembrane	283 – 303	21	Helical; Potential
	Transmembrane	716 – 736	21	Helical; Potential
	Transmembrane	774 – 794	21	Helical; Potential
	Transmembrane	809 – 829	21	Helical; Potential
	Transmembrane	848 – 868	21	Helical; Potential
	Transmembrane	880 – 900	21	Helical; Potential
Sites
	Active site	333	1	4-aspartylphosphate intermediate Probable
Experimental info
	Sequence conflict	1 – 34	34	MDFPT…GLTAE → MGAFPLPPNQYGFPHLKFLP PSPSTRGRHSCRFAHRSRFR SDSG in CAA50340. Ref.1
	Sequence conflict	288	1	A → G in CAA50340. Ref.1
	Sequence conflict	897	1	A → R in CAA50340. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P37367 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 0E438F17DE581D61	FASTA	905	97,590
	10 20 30 40 50 60 MDFPTLSSYL HHHRPGEDIL ADLHTDPGLG LTAEAVAQRY EQYGRNELKF KPGKPAWLRF 70 80 90 100 110 120 LLQFHQPLLY ILLIAGTVKA FLGSWTNAWV IWGVTLVNAI IGYIQEAKAE GAIASLAKAV 130 140 150 160 170 180 TTEATVLRDG QNLRIPSQDL VIGDIVSLAS GDKVPADLRL LKVRNLQVDE SALTGEAVPV 190 200 210 220 230 240 EKAVELLPEE TPLAERLNMA YAGSFVTFGQ GTGVVVATAN ATEMGQISQS MEKQVSLMTP 250 260 270 280 290 300 LTRKFAKFSH TLLYVIVTLA AFTFAVGWGR GGSPLEMFEA AVALAVSAIP EGLPAVVTVT 310 320 330 340 350 360 LAIGVNRMAK RNAIIRKLPA VEALGSATVV CSDKTGTLTE NQMTVQAVYA GGKHYEVSGG 370 380 390 400 410 420 GYSPKGEFWQ VMGEEVDNVL LDGLPPVLEE CLLTGMLCND SQLEHRGDDW AVVGDPTEGA 430 440 450 460 470 480 LLASAAKAGF SQAGLASQKP RLDSIPFESD YQYMATLHDG DGRTIYVKGS VESLLQRCES 490 500 510 520 530 540 MLLDDGQMVS IDRGEIEENV EDMAQQGLRV LAFAKKTVEP HHHAIDHGDI ETGLIFLGLQ 550 560 570 580 590 600 GMIDPPRPEA IAAVHACHDA GIEVKMITGD HISTAQAIAK RMGIAAEGDG IAFEGRQLAT 610 620 630 640 650 660 MGPAELAQAA EDSCVFARVA PAQKLQLVEA LQEKGHIVAM TGDGVNDAPA LKRADIGIAM 670 680 690 700 710 720 GKGGTEVARE SSDMLLTDDN FASIEAAVEE GRTVYQNLRK AIAFLLPVNG GESMTILISV 730 740 750 760 770 780 LLALNLPILS LQVLWLNMIN SITMTVPLAF EAKSPGIMQQ APRNPNEPLI TKKLLHRILL 790 800 810 820 830 840 VSLFNWILIF GMFEWVNRTY DDLALARTMA IQALVAARVI YLLSISQLGR SFLGYVTGKR 850 860 870 880 890 900 QTITKASILL LGIAVAIALQ IGFSQLPFMN VLFKTAPMDW QQWAICLLPM IPMVPVAILA NRLDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a P-type ATPase gene from the cyanobacterium Synechocystis sp. PCC 6803. Homology to eukaryotic Ca(2+)-ATPases." Geisler M., Richter J., Schumann J. J. Mol. Biol. 234:1284-1289(1993) [PubMed: 8263933] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71022 Genomic DNA. Translation: CAA50340.1. BA000022 Genomic DNA. Translation: BAA17897.1.
PIR	S75035.
RefSeq	NP_441217.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P37367.
ModBase	Search...
Protein-protein interaction databases
IntAct	P37367. 53 interactions.
STRING	P37367.
Protein family/group databases
TCDB	3.A.3.2.4. P-type ATPase (P-ATPase) superfamily.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	954558.
GenomeReviews	Gene locus sll1614 in contig BA000022_GR.
KEGG	syn:sll1614.
NMPDR	fig|1148.1.peg.1318.
PATRIC	23839765. VBISynSp132158_1444.
Phylogenomic databases
eggNOG	COG0474.
HOGENOM	HBG456486.
OMA	TAALQHW.
PhylomeDB	P37367.
ProtClustDB	CLSK893042.
Enzyme and pathway databases
BioCyc	SSP1148:SLL1614-MONOMER.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
KO	K01552.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATA1_SYNY3

Accession

Primary (citable) accession number: P37367
Secondary accession number(s): P73840

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program