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Protein

Cyclin CCL1

Gene

CCL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34185-MONOMER.
ReactomeiR-SCE-113418. Formation of the Early Elongation Complex.
R-SCE-5696395. Formation of Incision Complex in GG-NER.
R-SCE-674695. RNA Polymerase II Pre-transcription Events.
R-SCE-6781823. Formation of TC-NER Pre-Incision Complex.
R-SCE-6782135. Dual incision in TC-NER.
R-SCE-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SCE-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-SCE-69202. Cyclin E associated events during G1/S transition.
R-SCE-69273. Cyclin A/B1 associated events during G2/M transition.
R-SCE-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-SCE-72086. mRNA Capping.
R-SCE-73776. RNA Polymerase II Promoter Escape.
R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SCE-75953. RNA Polymerase II Transcription Initiation.
R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SCE-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin CCL1
Gene namesi
Name:CCL1
Ordered Locus Names:YPR025C
ORF Names:YP9367.05C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR025C.
SGDiS000006229. CCL1.

Subcellular locationi

GO - Cellular componenti

  • cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
  • holo TFIIH complex Source: SGD
  • TFIIK complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805041 – 393Cyclin CCL1Add BLAST393

Proteomic databases

MaxQBiP37366.
PRIDEiP37366.

PTM databases

iPTMnetiP37366.

Interactioni

Subunit structurei

CCL1 and KIN28 form the TFIIK complex, a component of TFIIH holo complex. Component of a complex consisting of KIN28, CCL1 and TFB3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KIN28P062426EBI-4385,EBI-9691
PHO85P171572EBI-4385,EBI-13327
TFB3Q032904EBI-4385,EBI-31406

Protein-protein interaction databases

BioGridi36202. 37 interactors.
DIPiDIP-2258N.
IntActiP37366. 49 interactors.
MINTiMINT-528773.

Structurei

3D structure databases

ProteinModelPortaliP37366.
SMRiP37366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008634.
HOGENOMiHOG000247914.
InParanoidiP37366.
KOiK06634.
OMAiFTLLVHH.
OrthoDBiEOG092C3VA4.

Family and domain databases

Gene3Di1.10.472.10. 4 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PANTHERiPTHR10026:SF8. PTHR10026:SF8. 3 hits.
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 4 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.

Sequencei

Sequence statusi: Complete.

P37366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIQLNGKS TLDTPSATMS AKEKEAKLKS ADENNKPPNY KRISDDDLYR
60 70 80 90 100
HSSQYRMWSY TKDQLQEKRV DTNARAIAYI EENLLKFREA HNLTEEEIKV
110 120 130 140 150
LEAKAIPLTM EEELDLVNFY AKKVQVIAQH LNLPTEVVAT AISFFRRFFL
160 170 180 190 200
ENSVMQIDPK SIVHTTIFLA CKSENYFISV DSFAQKAKST RDSVLKFEFK
210 220 230 240 250
LLESLKFSLL NHHPYKPLHG FFLDIQNVLY GKVDLNYMGQ IYDRCKKRIT
260 270 280 290 300
AALLTDVVYF YTPPQITLAT LLIEDEALVT RYLETKFPSR EGSQESVPGN
310 320 330 340 350
EKEEPQNDAS TTEKNKEKST ESEEYSIDSA KLLTIIRECK SIIEDCKPPS
360 370 380 390
TEEAKKIAAK NYYCQNPSTL IQKLKRKLNG EDTSSTVEKK QKT
Length:393
Mass (Da):45,210
Last modified:October 1, 1994 - v1
Checksum:iFE06E78FC38A8433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71902 Genomic DNA. Translation: CAA50721.1.
Z49274 Genomic DNA. Translation: CAA89279.1.
Z71255 Genomic DNA. Translation: CAA95021.1.
BK006949 Genomic DNA. Translation: DAA11451.1.
PIRiS39383.
RefSeqiNP_015350.1. NM_001184122.1.

Genome annotation databases

EnsemblFungiiYPR025C; YPR025C; YPR025C.
GeneIDi856136.
KEGGisce:YPR025C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71902 Genomic DNA. Translation: CAA50721.1.
Z49274 Genomic DNA. Translation: CAA89279.1.
Z71255 Genomic DNA. Translation: CAA95021.1.
BK006949 Genomic DNA. Translation: DAA11451.1.
PIRiS39383.
RefSeqiNP_015350.1. NM_001184122.1.

3D structure databases

ProteinModelPortaliP37366.
SMRiP37366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36202. 37 interactors.
DIPiDIP-2258N.
IntActiP37366. 49 interactors.
MINTiMINT-528773.

PTM databases

iPTMnetiP37366.

Proteomic databases

MaxQBiP37366.
PRIDEiP37366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR025C; YPR025C; YPR025C.
GeneIDi856136.
KEGGisce:YPR025C.

Organism-specific databases

EuPathDBiFungiDB:YPR025C.
SGDiS000006229. CCL1.

Phylogenomic databases

GeneTreeiENSGT00390000008634.
HOGENOMiHOG000247914.
InParanoidiP37366.
KOiK06634.
OMAiFTLLVHH.
OrthoDBiEOG092C3VA4.

Enzyme and pathway databases

BioCyciYEAST:G3O-34185-MONOMER.
ReactomeiR-SCE-113418. Formation of the Early Elongation Complex.
R-SCE-5696395. Formation of Incision Complex in GG-NER.
R-SCE-674695. RNA Polymerase II Pre-transcription Events.
R-SCE-6781823. Formation of TC-NER Pre-Incision Complex.
R-SCE-6782135. Dual incision in TC-NER.
R-SCE-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SCE-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-SCE-69202. Cyclin E associated events during G1/S transition.
R-SCE-69273. Cyclin A/B1 associated events during G2/M transition.
R-SCE-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-SCE-72086. mRNA Capping.
R-SCE-73776. RNA Polymerase II Promoter Escape.
R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SCE-75953. RNA Polymerase II Transcription Initiation.
R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SCE-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

PROiP37366.

Family and domain databases

Gene3Di1.10.472.10. 4 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PANTHERiPTHR10026:SF8. PTHR10026:SF8. 3 hits.
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 4 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCL1_YEAST
AccessioniPrimary (citable) accession number: P37366
Secondary accession number(s): D6W435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.