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P37362

- PYRRH_PYRAP

UniProt

P37362 - PYRRH_PYRAP

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Protein

Pyrrhocoricin

Gene
N/A
Organism
Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrhocoricin
OrganismiPyrrhocoris apterus (Sap sucking bug) (Cimex apterus)
Taxonomic identifieri37000 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraPentatomomorphaPyrrhocoroideaPyrrhocoridaePyrrhocoris

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2020PyrrhocoricinPRO_0000043590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111O-linked (GalNAc...)1 Publication

Post-translational modificationi

O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity.1 Publication

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DPOX-ray2.10C/D7-11[»]
3DPPX-ray2.50C/D7-20[»]
3DPQX-ray2.60C/D/G/H7-20[»]
4EZNX-ray1.80C/D1-20[»]
4EZQX-ray2.00B12-20[»]
4HY9X-ray1.55C/D1-11[»]
4HYBX-ray1.70C/D1-10[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37362.

Family & Domainsi

Sequence similaritiesi

Belongs to the drosocin family.Curated

Sequencei

Sequence statusi: Complete.

P37362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
VDKGSYLPRP TPPRPIYNRN
Length:20
Mass (Da):2,341
Last modified:October 1, 1994 - v1
Checksum:iF4320EC2FF29462C
GO

Sequence databases

PIRiS44465.

Cross-referencesi

Sequence databases

PIRi S44465.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DPO X-ray 2.10 C/D 7-11 [» ]
3DPP X-ray 2.50 C/D 7-20 [» ]
3DPQ X-ray 2.60 C/D/G/H 7-20 [» ]
4EZN X-ray 1.80 C/D 1-20 [» ]
4EZQ X-ray 2.00 B 12-20 [» ]
4HY9 X-ray 1.55 C/D 1-11 [» ]
4HYB X-ray 1.70 C/D 1-10 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P37362.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus."
    Cociancich S., Dupont A., Hegy G., Lanot R., Holder F., Hetru C., Hoffmann J.A., Bulet P.
    Biochem. J. 300:567-575(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Hemolymph.
  2. "Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects."
    Hoffmann R., Bulet P., Urge L., Otvoes L. Jr.
    Biochim. Biophys. Acta 1426:459-467(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-11.

Entry informationi

Entry nameiPYRRH_PYRAP
AccessioniPrimary (citable) accession number: P37362
Secondary accession number(s): P80307
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3