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P37362

- PYRRH_PYRAP

UniProt

P37362 - PYRRH_PYRAP

Protein

Pyrrhocoricin

Gene
N/A
Organism
Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis.

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrhocoricin
    OrganismiPyrrhocoris apterus (Sap sucking bug) (Cimex apterus)
    Taxonomic identifieri37000 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraEuhemipteraHeteropteraPanheteropteraPentatomomorphaPyrrhocoroideaPyrrhocoridaePyrrhocoris

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2020PyrrhocoricinPRO_0000043590Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111O-linked (GalNAc...)1 Publication

    Post-translational modificationi

    O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity.1 Publication

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DPOX-ray2.10C/D7-11[»]
    3DPPX-ray2.50C/D7-20[»]
    3DPQX-ray2.60C/D/G/H7-20[»]
    4EZNX-ray1.80C/D1-20[»]
    4EZQX-ray2.00B12-20[»]
    4HY9X-ray1.55C/D1-11[»]
    4HYBX-ray1.70C/D1-10[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP37362.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the drosocin family.Curated

    Sequencei

    Sequence statusi: Complete.

    P37362-1 [UniParc]FASTAAdd to Basket

    « Hide

    VDKGSYLPRP TPPRPIYNRN                                    20
    Length:20
    Mass (Da):2,341
    Last modified:October 1, 1994 - v1
    Checksum:iF4320EC2FF29462C
    GO

    Sequence databases

    PIRiS44465.

    Cross-referencesi

    Sequence databases

    PIRi S44465.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DPO X-ray 2.10 C/D 7-11 [» ]
    3DPP X-ray 2.50 C/D 7-20 [» ]
    3DPQ X-ray 2.60 C/D/G/H 7-20 [» ]
    4EZN X-ray 1.80 C/D 1-20 [» ]
    4EZQ X-ray 2.00 B 12-20 [» ]
    4HY9 X-ray 1.55 C/D 1-11 [» ]
    4HYB X-ray 1.70 C/D 1-10 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P37362.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus."
      Cociancich S., Dupont A., Hegy G., Lanot R., Holder F., Hetru C., Hoffmann J.A., Bulet P.
      Biochem. J. 300:567-575(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Hemolymph.
    2. "Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects."
      Hoffmann R., Bulet P., Urge L., Otvoes L. Jr.
      Biochim. Biophys. Acta 1426:459-467(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT THR-11.

    Entry informationi

    Entry nameiPYRRH_PYRAP
    AccessioniPrimary (citable) accession number: P37362
    Secondary accession number(s): P80307
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3