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P37362 (PYRRH_PYRAP) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length20 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis.

Subcellular location

Secreted.

Post-translational modification

O-linked glycan consists of a Gal-GalNAc disaccharide, O-glycosylation is essential for full biological activity.

Sequence similarities

Belongs to the drosocin family.

Ontologies

Keywords
   Biological processImmunity
Innate immunity
   Cellular componentSecreted
   Molecular functionAntibiotic
Antimicrobial
   PTMGlycoprotein
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 2020Pyrrhocoricin
PRO_0000043590

Amino acid modifications

Glycosylation111O-linked (GalNAc...) Ref.2

Sequences

Sequence LengthMass (Da)Tools
P37362 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: F4320EC2FF29462C

FASTA202,341
        10         20 
VDKGSYLPRP TPPRPIYNRN 

« Hide

References

[1]"Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus."
Cociancich S., Dupont A., Hegy G., Lanot R., Holder F., Hetru C., Hoffmann J.A., Bulet P.
Biochem. J. 300:567-575(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Hemolymph.
[2]"Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects."
Hoffmann R., Bulet P., Urge L., Otvoes L. Jr.
Biochim. Biophys. Acta 1426:459-467(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT THR-11.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRS44465.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DPOX-ray2.10C/D7-11[»]
3DPPX-ray2.50C/D7-20[»]
3DPQX-ray2.60C/D/G/H7-20[»]
4EZNX-ray1.80C/D1-20[»]
4EZQX-ray2.00B12-20[»]
4HY9X-ray1.55C/D1-11[»]
4HYBX-ray1.70C/D1-10[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Other

EvolutionaryTraceP37362.

Entry information

Entry namePYRRH_PYRAP
AccessionPrimary (citable) accession number: P37362
Secondary accession number(s): P80307
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references