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Protein

Metallothionein-3

Gene

Mt3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
Metal bindingi62 – 621Divalent metal cation; cluster ABy similarity
Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity
Metal bindingi65 – 651Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5661231. Metallothioneins bind metals.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:Mt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621252. Mt3.

Subcellular locationi

GO - Cellular componenti

  • astrocyte end-foot Source: RGD
  • astrocyte projection Source: RGD
  • axon Source: RGD
  • dendritic spine Source: RGD
  • extracellular space Source: RGD
  • inclusion body Source: UniProtKB
  • intracellular Source: UniProtKB
  • microtubule Source: RGD
  • mitochondrial outer membrane Source: RGD
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: RGD
  • postsynaptic density Source: RGD
  • ribosome Source: RGD
  • rough endoplasmic reticulum Source: RGD
  • synaptic vesicle Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Metallothionein-3PRO_0000197253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP37361.
PRIDEiP37361.

PTM databases

iPTMnetiP37361.
PhosphoSiteiP37361.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSRNOG00000018958.
GenevisibleiP37361. RN.

Interactioni

Protein-protein interaction databases

IntActiP37361. 2 interactions.
MINTiMINT-7905875.
STRINGi10116.ENSRNOP00000025669.

Structurei

3D structure databases

ProteinModelPortaliP37361.
SMRiP37361. Positions 32-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030BetaAdd
BLAST
Regioni31 – 6636AlphaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111484.
HOGENOMiHOG000236262.
InParanoidiP37361.
KOiK14740.
OMAiTCPCPTG.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPETCPCPT GGSCTCSDKC KCKGCKCTNC KKSCCSCCPA GCEKCAKDCV
60
CKGEEGAKAE KCSCCQ
Length:66
Mass (Da):6,809
Last modified:October 1, 1994 - v1
Checksum:iBE7538E85664EBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65838 mRNA. Translation: AAB28366.1.
X89603 mRNA. Translation: CAA61762.1.
Y08235 Genomic DNA. Translation: CAA69404.1.
BC058453 mRNA. Translation: AAH58453.1.
PIRiS58086.
RefSeqiNP_446420.1. NM_053968.3.
UniGeneiRn.11325.

Genome annotation databases

EnsembliENSRNOT00000025669; ENSRNOP00000025669; ENSRNOG00000018958.
GeneIDi117038.
KEGGirno:117038.
UCSCiRGD:621252. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65838 mRNA. Translation: AAB28366.1.
X89603 mRNA. Translation: CAA61762.1.
Y08235 Genomic DNA. Translation: CAA69404.1.
BC058453 mRNA. Translation: AAH58453.1.
PIRiS58086.
RefSeqiNP_446420.1. NM_053968.3.
UniGeneiRn.11325.

3D structure databases

ProteinModelPortaliP37361.
SMRiP37361. Positions 32-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP37361. 2 interactions.
MINTiMINT-7905875.
STRINGi10116.ENSRNOP00000025669.

PTM databases

iPTMnetiP37361.
PhosphoSiteiP37361.

Proteomic databases

PaxDbiP37361.
PRIDEiP37361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025669; ENSRNOP00000025669; ENSRNOG00000018958.
GeneIDi117038.
KEGGirno:117038.
UCSCiRGD:621252. rat.

Organism-specific databases

CTDi4504.
RGDi621252. Mt3.

Phylogenomic databases

GeneTreeiENSGT00730000111484.
HOGENOMiHOG000236262.
InParanoidiP37361.
KOiK14740.
OMAiTCPCPTG.

Enzyme and pathway databases

ReactomeiR-RNO-5661231. Metallothioneins bind metals.

Miscellaneous databases

PROiP37361.

Gene expression databases

BgeeiENSRNOG00000018958.
GenevisibleiP37361. RN.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT3_RAT
AccessioniPrimary (citable) accession number: P37361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.