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Protein

Metallothionein-3

Gene

Mt3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi62Divalent metal cation; cluster ABy similarity1
Metal bindingi64Divalent metal cation; cluster ABy similarity1
Metal bindingi65Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5661231. Metallothioneins bind metals.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:Mt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621252. Mt3.

Subcellular locationi

GO - Cellular componenti

  • astrocyte end-foot Source: RGD
  • astrocyte projection Source: RGD
  • axon Source: RGD
  • dendritic spine Source: RGD
  • extracellular space Source: RGD
  • inclusion body Source: UniProtKB
  • intracellular Source: UniProtKB
  • microtubule Source: RGD
  • mitochondrial outer membrane Source: RGD
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: RGD
  • postsynaptic density Source: RGD
  • ribosome Source: RGD
  • rough endoplasmic reticulum Source: RGD
  • synaptic vesicle Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972531 – 66Metallothionein-3Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP37361.
PRIDEiP37361.

PTM databases

iPTMnetiP37361.
PhosphoSitePlusiP37361.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSRNOG00000018958.
GenevisibleiP37361. RN.

Interactioni

Protein-protein interaction databases

IntActiP37361. 2 interactors.
MINTiMINT-7905875.
STRINGi10116.ENSRNOP00000025669.

Structurei

3D structure databases

ProteinModelPortaliP37361.
SMRiP37361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 30BetaAdd BLAST30
Regioni31 – 66AlphaAdd BLAST36

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111484.
HOGENOMiHOG000236262.
InParanoidiP37361.
KOiK14740.
OMAiAGSCKCE.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiView protein in Pfam
PF00131. Metallothio. 1 hit.
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiView protein in PROSITE
PS00203. METALLOTHIONEIN_VRT. 1 hit.

Sequencei

Sequence statusi: Complete.

P37361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPETCPCPT GGSCTCSDKC KCKGCKCTNC KKSCCSCCPA GCEKCAKDCV
60
CKGEEGAKAE KCSCCQ
Length:66
Mass (Da):6,809
Last modified:October 1, 1994 - v1
Checksum:iBE7538E85664EBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65838 mRNA. Translation: AAB28366.1.
X89603 mRNA. Translation: CAA61762.1.
Y08235 Genomic DNA. Translation: CAA69404.1.
BC058453 mRNA. Translation: AAH58453.1.
PIRiS58086.
RefSeqiNP_446420.1. NM_053968.3.
UniGeneiRn.11325.

Genome annotation databases

EnsembliENSRNOT00000025669; ENSRNOP00000025669; ENSRNOG00000018958.
GeneIDi117038.
KEGGirno:117038.
UCSCiRGD:621252. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT3_RAT
AccessioniPrimary (citable) accession number: P37361
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 7, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families