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P37360

- MT3_HORSE

UniProt

P37360 - MT3_HORSE

Protein

Metallothionein-3

Gene

MT3

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
    Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
    Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
    Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
    Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
    Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
    Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
    Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
    Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
    Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
    Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
    Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
    Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
    Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
    Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
    Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
    Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
    Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity
    Metal bindingi66 – 661Divalent metal cation; cluster ABy similarity
    Metal bindingi67 – 671Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. cadmium ion binding Source: UniProtKB
    2. copper ion binding Source: UniProtKB
    3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    4. drug binding Source: UniProtKB
    5. protein kinase activator activity Source: UniProtKB
    6. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase B activity Source: UniProtKB
    2. astrocyte development Source: UniProtKB
    3. cadmium ion homeostasis Source: UniProtKB
    4. cellular lipid catabolic process Source: UniProtKB
    5. cellular response to cadmium ion Source: UniProtKB
    6. cellular response to drug Source: UniProtKB
    7. cellular response to nitric oxide Source: UniProtKB
    8. cellular response to oxidative stress Source: UniProtKB
    9. cellular zinc ion homeostasis Source: UniProtKB
    10. cholesterol catabolic process Source: UniProtKB
    11. energy reserve metabolic process Source: UniProtKB
    12. ERK1 and ERK2 cascade Source: UniProtKB
    13. histone modification Source: UniProtKB
    14. leptin-mediated signaling pathway Source: UniProtKB
    15. negative regulation of apoptotic process Source: UniProtKB
    16. negative regulation of autophagy Source: UniProtKB
    17. negative regulation of axon extension Source: UniProtKB
    18. negative regulation of cell growth Source: UniProtKB
    19. negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
    20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    21. negative regulation of necrotic cell death Source: UniProtKB
    22. negative regulation of neuron apoptotic process Source: UniProtKB
    23. negative regulation of oxidoreductase activity Source: UniProtKB
    24. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
    25. negative regulation of transcription, DNA-templated Source: UniProtKB
    26. positive regulation of catalytic activity Source: UniProtKB
    27. positive regulation of cell death Source: UniProtKB
    28. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    29. positive regulation of gene expression Source: UniProtKB
    30. positive regulation of lysosomal membrane permeability Source: UniProtKB
    31. positive regulation of necrotic cell death Source: UniProtKB
    32. positive regulation of oxygen metabolic process Source: UniProtKB
    33. positive regulation of protein phosphorylation Source: UniProtKB
    34. positive regulation of transcription, DNA-templated Source: UniProtKB
    35. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
    36. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
    37. protein import into nucleus, translocation Source: UniProtKB
    38. protein kinase B signaling Source: UniProtKB
    39. protein stabilization Source: UniProtKB
    40. regulation of protein glycosylation Source: UniProtKB
    41. regulation of response to food Source: UniProtKB
    42. removal of superoxide radicals Source: UniProtKB
    43. response to hypoxia Source: UniProtKB
    44. zinc ion homeostasis Source: UniProtKB
    45. zinc ion transport Source: UniProtKB

    Keywords - Ligandi

    Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-3
    Short name:
    MT-3
    Alternative name(s):
    Growth inhibitory factor
    Short name:
    GIF
    Metallothionein-III
    Short name:
    MT-III
    Gene namesi
    Name:MT3
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. inclusion body Source: UniProtKB
    2. intracellular Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB
    5. synaptic vesicle Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6868Metallothionein-3PRO_0000197249Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine

    Keywords - PTMi

    Acetylation

    Expressioni

    Tissue specificityi

    Brain.

    Structurei

    3D structure databases

    ProteinModelPortaliP37360.
    SMRiP37360. Positions 32-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3030BetaAdd
    BLAST
    Regioni31 – 6838AlphaAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000236262.
    InParanoidiP37360.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37360-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPETCPCPT GGSCTCSGEC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV   50
    CKGGEGAEAE AEKCSCCQ 68
    Length:68
    Mass (Da):6,927
    Last modified:October 1, 1994 - v1
    Checksum:i5998E0F17FC52CE6
    GO

    Sequence databases

    PIRiS44392.

    Cross-referencesi

    Sequence databases

    PIRi S44392.

    3D structure databases

    ProteinModelPortali P37360.
    SMRi P37360. Positions 32-68.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000236262.
    InParanoidi P37360.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain."
      Pountney D.L., Fundel S.M., Faller P., Birchler N.E., Hunziker P., Vasak M.
      FEBS Lett. 345:193-197(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Brain.

    Entry informationi

    Entry nameiMT3_HORSE
    AccessioniPrimary (citable) accession number: P37360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3