Reviewed,
UniProtKB/Swiss-Prot P37360 (MT3_HORSE)
Last modified
November 24, 2009.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Metallothionein-3 Short name=MT-3 Alternative name(s): Metallothionein-III Short name=MT-III Growth inhibitory factor Short name=GIF | ||
| Gene names |
| ||
| Organism | Equus caballus (Horse) | ||
| Taxonomic identifier | 9796 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus |
Protein attributes
| Sequence length | 68 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. |
| Tissue specificity | Brain. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Copper Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | removal of superoxide radicals Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxiaInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 68 | 68 | Metallothionein-3 | PRO_0000197249 | |||||
Regions | |||||||||
| Region | 1 – 30 | 30 | Beta | ||||||
| Region | 31 – 68 | 38 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 6 | 1 | Cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Cluster B By similarity | ||||||
| Metal binding | 30 | 1 | Cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Cluster A By similarity | ||||||
| Metal binding | 37 | 1 | Cluster A By similarity | ||||||
| Metal binding | 38 | 1 | Cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Cluster A By similarity | ||||||
| Metal binding | 45 | 1 | Cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Cluster A By similarity | ||||||
| Metal binding | 51 | 1 | Cluster A By similarity | ||||||
| Metal binding | 64 | 1 | Cluster A By similarity | ||||||
| Metal binding | 66 | 1 | Cluster A By similarity | ||||||
| Metal binding | 67 | 1 | Cluster A By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine | ||||||
Sequences
References
| [1] | "Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain." Pountney D.L., Fundel S.M., Faller P., Birchler N.E., Hunziker P., Vasak M. FEBS Lett. 345:193-197(1994) [PubMed: 8200454] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| PIR | S44392. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSECAT00000015904; ENSECAP00000012822; ENSECAG00000015212; Equus caballus. [Genome view] |
Phylogenomic databases | |
| HOVERGEN | P37360. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT3_HORSE | ||||||||
| Accession | Primary (citable) accession number: P37360 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


