Reviewed, UniProtKB/Swiss-Prot P37359 (MT3_BOVIN)

Names and origin

Protein names

Recommended name:
    Metallothionein-3
      Short name=MT-3
Alternative name(s):
    Metallothionein-III
      Short name=MT-III
    Growth inhibitory factor
      Short name=GIF

Gene names

Name:

MT3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium.
Tissue specificity	Brain.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from sequence or structural similarity. Source: UniProtKB response to hypoxia Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 68	68	Metallothionein-3		PRO_0000197248
Regions
	Region	1 – 30	30	Beta
	Region	31 – 68	38	Alpha
Sites
	Metal binding	6	1	Cluster B By similarity
	Metal binding	8	1	Cluster B By similarity
	Metal binding	14	1	Cluster B By similarity
	Metal binding	16	1	Cluster B By similarity
	Metal binding	20	1	Cluster B By similarity
	Metal binding	22	1	Cluster B By similarity
	Metal binding	25	1	Cluster B By similarity
	Metal binding	27	1	Cluster B By similarity
	Metal binding	34	1	Cluster A By similarity
	Metal binding	35	1	Cluster A By similarity
	Metal binding	37	1	Cluster A By similarity
	Metal binding	38	1	Cluster A By similarity
	Metal binding	42	1	Cluster A By similarity
	Metal binding	45	1	Cluster A By similarity
	Metal binding	49	1	Cluster A By similarity
	Metal binding	51	1	Cluster A By similarity
	Metal binding	64	1	Cluster A By similarity
	Metal binding	66	1	Cluster A By similarity
	Metal binding	67	1	Cluster A By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine
Experimental info
	Sequence conflict	30	1	S → C AA sequence Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P37359-1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: 1DD24B83AA52AE71	FASTA	68	6,937
	10 20 30 40 50 60 MDPETCPCPT GGSCTCSDPC KCEGCTCASS KKSCCSCCPA ECEKCAKDCV CKGGEGAEAE EKKCSCCQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain." Pountney D.L., Fundel S.M., Faller P., Birchler N.E., Hunziker P., Vasak M. FEBS Lett. 345:193-197(1994) [PubMed: 8200454] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Brain.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC126773 mRNA. Translation: AAI26774.1.
IPI	IPI00697902.
PIR	S44391.
RefSeq	NP_001106775.1. XP_001790206.1.
UniGene	Bt.16213
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000022460; ENSBTAP00000022460; ENSBTAG00000016886; Bos taurus. [Genome view]
GeneID	613320.
KEGG	bta:613320.
Organism-specific databases
CTD	613320.
Phylogenomic databases
HOVERGEN	P37359.
InParanoid	P37359.
OMA	ETCPCPT.
Family and domain databases
InterPro	IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT3_BOVIN

Accession

Primary (citable) accession number: P37359
Secondary accession number(s): A0JNL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	April 17, 2007
Last modified:	December 15, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)