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Protein

Metallothionein-3

Gene

MT3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi64Divalent metal cation; cluster ABy similarity1
Metal bindingi66Divalent metal cation; cluster ABy similarity1
Metal bindingi67Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-5661231. Metallothioneins bind metals.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:MT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972481 – 68Metallothionein-3Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP37359.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSBTAG00000016886.

Structurei

3D structure databases

ProteinModelPortaliP37359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 30BetaAdd BLAST30
Regioni31 – 68AlphaAdd BLAST38

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111484.
HOGENOMiHOG000236262.
HOVERGENiHBG095156.
InParanoidiP37359.
KOiK14740.
OMAiTCPCPTG.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

P37359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPETCPCPT GGSCTCSDPC KCEGCTCASS KKSCCSCCPA ECEKCAKDCV
60
CKGGEGAEAE EKKCSCCQ
Length:68
Mass (Da):6,937
Last modified:April 17, 2007 - v2
Checksum:i1DD24B83AA52AE71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30S → C AA sequence (PubMed:8200454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126773 mRNA. Translation: AAI26774.1.
PIRiS44391.
RefSeqiNP_001106775.1. NM_001113304.2.
UniGeneiBt.16213.

Genome annotation databases

EnsembliENSBTAT00000022460; ENSBTAP00000022460; ENSBTAG00000016886.
GeneIDi613320.
KEGGibta:613320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126773 mRNA. Translation: AAI26774.1.
PIRiS44391.
RefSeqiNP_001106775.1. NM_001113304.2.
UniGeneiBt.16213.

3D structure databases

ProteinModelPortaliP37359.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP37359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022460; ENSBTAP00000022460; ENSBTAG00000016886.
GeneIDi613320.
KEGGibta:613320.

Organism-specific databases

CTDi4504.

Phylogenomic databases

GeneTreeiENSGT00730000111484.
HOGENOMiHOG000236262.
HOVERGENiHBG095156.
InParanoidiP37359.
KOiK14740.
OMAiTCPCPTG.

Enzyme and pathway databases

ReactomeiR-BTA-5661231. Metallothioneins bind metals.

Gene expression databases

BgeeiENSBTAG00000016886.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMT3_BOVIN
AccessioniPrimary (citable) accession number: P37359
Secondary accession number(s): A0JNL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.