P37359 (MT3_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 91.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein-3 Short name=MT-3 Alternative name(s): Growth inhibitory factor Short name=GIF Metallothionein-III Short name=MT-III | ||
| Gene names |
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| Organism | Bos taurus (Bovine) [Reference proteome] | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 68 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium. |
| Tissue specificity | Brain. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 68 | 68 | Metallothionein-3 | PRO_0000197248 | |||||
Regions | |||||||||
| Region | 1 – 30 | 30 | Beta | ||||||
| Region | 31 – 68 | 38 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 37 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 38 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 45 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 51 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 64 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 66 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 67 | 1 | Divalent metal cation; cluster A By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine | ||||||
Experimental info | |||||||||
| Sequence conflict | 30 | 1 | S → C AA sequence Ref.1 | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain." Pountney D.L., Fundel S.M., Faller P., Birchler N.E., Hunziker P., Vasak M. FEBS Lett. 345:193-197(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Brain. |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal pons. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC126773 mRNA. Translation: AAI26774.1. |
| IPI | IPI00697902. |
| PIR | S44391. |
| RefSeq | NP_001106775.1. NM_001113304.2. |
| UniGene | Bt.16213. |
3D structure databases | |
| ProteinModelPortal | P37359. |
| SMR | P37359. Positions 32-68. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAT00000022460; ENSBTAP00000022460; ENSBTAG00000016886. |
| GeneID | 613320. |
| KEGG | bta:613320. |
Organism-specific databases | |
| CTD | 4504. |
Phylogenomic databases | |
| GeneTree | ENSGT00390000010461. |
| HOGENOM | HOG000236262. |
| HOVERGEN | HBG095156. |
| InParanoid | P37359. |
| KO | K14740. |
| OMA | ETCPCPT. |
Family and domain databases | |
| Gene3D | 4.10.10.10. 1 hit. |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. [Graphical view] |
| PANTHER | PTHR23299. PTHR23299. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20898520. |
Entry information
| Entry name | MT3_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P37359 Secondary accession number(s): A0JNL9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |