Skip Header

Contribute Send feedback
Read comments (?) or add your own

P37359 (MT3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-3
Short name=MT-3
Alternative name(s):
Growth inhibitory factor
Short name=GIF
Metallothionein-III
Short name=MT-III
Gene names
Name:MT3
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium.

Tissue specificity

Brain.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6868Metallothionein-3
PRO_0000197248

Regions

Region1 – 3030Beta
Region31 – 6838Alpha

Sites

Metal binding61Divalent metal cation; cluster B By similarity
Metal binding81Divalent metal cation; cluster B By similarity
Metal binding141Divalent metal cation; cluster B By similarity
Metal binding161Divalent metal cation; cluster B By similarity
Metal binding201Divalent metal cation; cluster B By similarity
Metal binding221Divalent metal cation; cluster B By similarity
Metal binding251Divalent metal cation; cluster B By similarity
Metal binding271Divalent metal cation; cluster B By similarity
Metal binding341Divalent metal cation; cluster A By similarity
Metal binding351Divalent metal cation; cluster A By similarity
Metal binding371Divalent metal cation; cluster A By similarity
Metal binding381Divalent metal cation; cluster A By similarity
Metal binding421Divalent metal cation; cluster A By similarity
Metal binding451Divalent metal cation; cluster A By similarity
Metal binding491Divalent metal cation; cluster A By similarity
Metal binding511Divalent metal cation; cluster A By similarity
Metal binding641Divalent metal cation; cluster A By similarity
Metal binding661Divalent metal cation; cluster A By similarity
Metal binding671Divalent metal cation; cluster A By similarity

Amino acid modifications

Modified residue11N-acetylmethionine

Experimental info

Sequence conflict301S → C AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
P37359 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: 1DD24B83AA52AE71

FASTA686,937
        10         20         30         40         50         60 
MDPETCPCPT GGSCTCSDPC KCEGCTCASS KKSCCSCCPA ECEKCAKDCV CKGGEGAEAE 


EKKCSCCQ

« Hide

References

« Hide 'large scale' references
[1]"Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain."
Pountney D.L., Fundel S.M., Faller P., Birchler N.E., Hunziker P., Vasak M.
FEBS Lett. 345:193-197(1994) [PubMed: 8200454] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Brain.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC126773 mRNA. Translation: AAI26774.1.
IPIIPI00697902.
PIRS44391.
RefSeqNP_001106775.1. NM_001113304.1.
UniGeneBt.16213.

3D structure databases

ProteinModelPortalP37359.
SMRP37359. Positions 32-68.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000022460; ENSBTAP00000022460; ENSBTAG00000016886.
GeneID613320.
KEGGbta:613320.

Organism-specific databases

CTD4504.

Phylogenomic databases

GeneTreeENSGT00390000010461.
HOVERGENHBG095156.
InParanoidP37359.
OMAETCPCPT.

Family and domain databases

InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
KOK14740.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. Metallothionein_sfam. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT3_BOVIN
AccessionPrimary (citable) accession number: P37359
Secondary accession number(s): A0JNL9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 17, 2007
Last modified: November 16, 2011
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents