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Protein

HTH-type transcriptional repressor CsiR

Gene

csiR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Modulates expression of csiD and lhgO in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi29 – 48H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12386-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor CsiR
Alternative name(s):
Carbon starvation induced regulator
Gene namesi
Name:csiR
Synonyms:gabC, ygaE
Ordered Locus Names:b2664, JW2639
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12386 csiR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506801 – 220HTH-type transcriptional repressor CsiRAdd BLAST220

Proteomic databases

PaxDbiP37338
PRIDEiP37338

Interactioni

Protein-protein interaction databases

BioGridi4262265, 4 interactors
DIPiDIP-12095N
IntActiP37338, 4 interactors
STRINGi316385.ECDH10B_2831

Structurei

3D structure databases

ProteinModelPortaliP37338
SMRiP37338
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG4108PVQ Bacteria
COG1802 LUCA
HOGENOMiHOG000273992
InParanoidiP37338
KOiK15735
OMAiGNENWEL
PhylomeDBiP37338

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.20.120.530, 1 hit
InterProiView protein in InterPro
IPR011711 GntR_C
IPR008920 TF_FadR/GntR_C
IPR000524 Tscrpt_reg_HTH_GntR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF07729 FCD, 1 hit
PF00392 GntR, 1 hit
SMARTiView protein in SMART
SM00895 FCD, 1 hit
SM00345 HTH_GNTR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48008 SSF48008, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P37338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITSLDGYR WLKNDIIRGN FQPDEKLRMS LLTSRYALGV GPLREALSQL
60 70 80 90 100
VAERLVTVVN QKGYRVASMS EQELLDIFDA RANMEAMLVS LAIARGGDEW
110 120 130 140 150
EADVLAKAHL LSKLEACDAS EKMLDEWDLR HQAFHTAIVA GCGSHYLLQM
160 170 180 190 200
RERLFDLAAR YRFIWLRRTV LSVEMLEDKH DQHQTLTAAV LARDTARASE
210 220
LMRQHLLTPI PIIQQAMAGN
Length:220
Mass (Da):24,991
Last modified:November 1, 1997 - v2
Checksum:iC86A1AE9F767D092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75711.2
AP009048 Genomic DNA Translation: BAA16527.1
M88334 Genomic DNA No translation available.
RefSeqiNP_417150.4, NC_000913.3
WP_000156811.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75711; AAC75711; b2664
BAA16527; BAA16527; BAA16527
GeneIDi948055
KEGGiecj:JW2639
eco:b2664
PATRICifig|1411691.4.peg.4077

Similar proteinsi

Entry informationi

Entry nameiCSIR_ECOLI
AccessioniPrimary (citable) accession number: P37338
Secondary accession number(s): P76623, P77021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health