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Protein

HTH-type transcriptional repressor CsiR

Gene

csiR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Modulates expression of csiD and lhgO in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi29 – 48H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12386-MONOMER.
ECOL316407:JW2639-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor CsiR
Alternative name(s):
Carbon starvation induced regulator
Gene namesi
Name:csiR
Synonyms:gabC, ygaE
Ordered Locus Names:b2664, JW2639
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12386. csiR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506801 – 220HTH-type transcriptional repressor CsiRAdd BLAST220

Proteomic databases

PaxDbiP37338.
PRIDEiP37338.

Interactioni

Protein-protein interaction databases

BioGridi4262265. 4 interactors.
DIPiDIP-12095N.
IntActiP37338. 4 interactors.
STRINGi511145.b2664.

Structurei

3D structure databases

ProteinModelPortaliP37338.
SMRiP37338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 69HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108PVQ. Bacteria.
COG1802. LUCA.
HOGENOMiHOG000273992.
InParanoidiP37338.
KOiK15735.
OMAiGNENWEL.
PhylomeDBiP37338.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITSLDGYR WLKNDIIRGN FQPDEKLRMS LLTSRYALGV GPLREALSQL
60 70 80 90 100
VAERLVTVVN QKGYRVASMS EQELLDIFDA RANMEAMLVS LAIARGGDEW
110 120 130 140 150
EADVLAKAHL LSKLEACDAS EKMLDEWDLR HQAFHTAIVA GCGSHYLLQM
160 170 180 190 200
RERLFDLAAR YRFIWLRRTV LSVEMLEDKH DQHQTLTAAV LARDTARASE
210 220
LMRQHLLTPI PIIQQAMAGN
Length:220
Mass (Da):24,991
Last modified:November 1, 1997 - v2
Checksum:iC86A1AE9F767D092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75711.2.
AP009048 Genomic DNA. Translation: BAA16527.1.
M88334 Genomic DNA. No translation available.
RefSeqiNP_417150.4. NC_000913.3.
WP_000156811.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75711; AAC75711; b2664.
BAA16527; BAA16527; BAA16527.
GeneIDi948055.
KEGGiecj:JW2639.
eco:b2664.
PATRICi32120718. VBIEscCol129921_2756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75711.2.
AP009048 Genomic DNA. Translation: BAA16527.1.
M88334 Genomic DNA. No translation available.
RefSeqiNP_417150.4. NC_000913.3.
WP_000156811.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37338.
SMRiP37338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262265. 4 interactors.
DIPiDIP-12095N.
IntActiP37338. 4 interactors.
STRINGi511145.b2664.

Proteomic databases

PaxDbiP37338.
PRIDEiP37338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75711; AAC75711; b2664.
BAA16527; BAA16527; BAA16527.
GeneIDi948055.
KEGGiecj:JW2639.
eco:b2664.
PATRICi32120718. VBIEscCol129921_2756.

Organism-specific databases

EchoBASEiEB2287.
EcoGeneiEG12386. csiR.

Phylogenomic databases

eggNOGiENOG4108PVQ. Bacteria.
COG1802. LUCA.
HOGENOMiHOG000273992.
InParanoidiP37338.
KOiK15735.
OMAiGNENWEL.
PhylomeDBiP37338.

Enzyme and pathway databases

BioCyciEcoCyc:EG12386-MONOMER.
ECOL316407:JW2639-MONOMER.

Miscellaneous databases

PROiP37338.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSIR_ECOLI
AccessioniPrimary (citable) accession number: P37338
Secondary accession number(s): P76623, P77021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.