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P37323

- BLA4_KLEPN

UniProt

P37323 - BLA4_KLEPN

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Protein
Beta-lactamase SHV-4
Gene
bla, shv4
Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime. SHV-4 causes particularly high levels of resistance to aztreonam and ceftazidime.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Acyl-ester intermediate By similarity
Active sitei143 – 1431Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase SHV-4 (EC:3.5.2.6)
Alternative name(s):
Ceftazidimase 5
Short name:
CAZ-5
Gene namesi
Name:bla
Synonyms:shv4
Encoded oniPlasmid pUD210 Publication
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Beta-lactamase SHV-4
PRO_0000195440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 98 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP37323.
SMRiP37323. Positions 1-265.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2113Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37323-1 [UniParc]FASTAAdd to Basket

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SPQPLEQIKL SESQLSGRVG MIEMDLASGR TLTAWRADER FPMMSTFKVV    50
LCGAVLARVD AGDEQLERKI HYRQQDLVDY SPVSEKHLAD GMTVGELCAA 100
AITMSDNSAA NLLLATVGGP AGLTAFLRQI GDNVTRLDRW ETELNEALPG 150
DARDTTTPAS MAATLRKLLT SQRLSARSQL QLLQWMVDDR VAGPLIRSVL 200
PAGWFIADKT GASKRGARGI VALLGPNNKA ERIVVIYLRD TPASMAERNQ 250
QIAGIGAALI EHWQR 265
Length:265
Mass (Da):28,860
Last modified:October 1, 1994 - v1
Checksum:iE575CF38B1ADE304
GO

Sequence databases

PIRiA60448.

Cross-referencesi

Sequence databases

PIRi A60448.

3D structure databases

ProteinModelPortali P37323.
SMRi P37323. Positions 1-265.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 beta-lactamase."
    Peduzzi J., Barthelemy M., Tiwari K., Mattioni D., Labia R.
    Antimicrob. Agents Chemother. 33:2160-2163(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: 210-2.

Entry informationi

Entry nameiBLA4_KLEPN
AccessioniPrimary (citable) accession number: P37323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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