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P37321

- BLE1_PSEAI

UniProt

P37321 - BLE1_PSEAI

Protein

Extended-spectrum beta-lactamase PER-1

Gene

per1

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    SABIO-RKP37321.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extended-spectrum beta-lactamase PER-1 (EC:3.5.2.6)
    Gene namesi
    Name:per1
    OrganismiPseudomonas aeruginosa
    Taxonomic identifieri287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Add
    BLAST
    Chaini27 – 308282Extended-spectrum beta-lactamase PER-1PRO_0000017042Add
    BLAST

    Structurei

    Secondary structure

    1
    308
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi29 – 3911
    Beta strandi42 – 5110
    Beta strandi59 – 624
    Helixi70 – 723
    Helixi73 – 8614
    Beta strandi95 – 995
    Turni100 – 1023
    Helixi111 – 1144
    Beta strandi117 – 1237
    Helixi124 – 13411
    Helixi137 – 14711
    Helixi149 – 15911
    Helixi171 – 1766
    Helixi180 – 1834
    Beta strandi184 – 1863
    Helixi188 – 19912
    Helixi206 – 21712
    Turni226 – 2294
    Beta strandi236 – 2427
    Beta strandi249 – 26012
    Beta strandi266 – 27611
    Helixi280 – 30425

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1E25X-ray1.90A27-308[»]
    ProteinModelPortaliP37321.
    SMRiP37321. Positions 28-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP37321.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni239 – 2413Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37321-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVIIKAVVT ASTLLMVSFS SFETSAQSPL LKEQIESIVI GKKATVGVAV    50
    WGPDDLEPLL INPFEKFPMQ SVFKLHLAML VLHQVDQGKL DLNQTVIVNR 100
    AKVLQNTWAP IMKAYQGDEF SVPVQQLLQY SVSHSDNVAC DLLFELVGGP 150
    AALHDYIQSM GIKETAVVAN EAQMHADDQV QYQNWTSMKG AAEILKKFEQ 200
    KTQLSETSQA LLWKWMVETT TGPERLKGLL PAGTVVAHKT GTSGIKAGKT 250
    AATNDLGIIL LPDGRPLLVA VFVKDSAESS RTNEAIIAQV AQTAYQFELK 300
    KLSALSPN 308
    Length:308
    Mass (Da):33,573
    Last modified:October 1, 1994 - v1
    Checksum:iCED838DFC7D6E117
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21957 Genomic DNA. Translation: CAA79968.1.
    PIRiS35931.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21957 Genomic DNA. Translation: CAA79968.1 .
    PIRi S35931.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1E25 X-ray 1.90 A 27-308 [» ]
    ProteinModelPortali P37321.
    SMRi P37321. Positions 28-305.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P37321.

    Miscellaneous databases

    EvolutionaryTracei P37321.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases."
      Nordmann P., Naas T.
      Antimicrob. Agents Chemother. 38:104-114(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: RNL-1.

    Entry informationi

    Entry nameiBLE1_PSEAI
    AccessioniPrimary (citable) accession number: P37321
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3