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Protein

Extended-spectrum beta-lactamase PER-1

Gene

per1

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP37321.

Names & Taxonomyi

Protein namesi
Recommended name:
Extended-spectrum beta-lactamase PER-1 (EC:3.5.2.6)
Gene namesi
Name:per1
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Pathology & Biotechi

Chemistry databases

DrugBankiDB09060. Avibactam.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001704227 – 308Extended-spectrum beta-lactamase PER-1Add BLAST282

Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 39Combined sources11
Beta strandi42 – 51Combined sources10
Beta strandi59 – 62Combined sources4
Helixi70 – 72Combined sources3
Helixi73 – 86Combined sources14
Beta strandi95 – 99Combined sources5
Turni100 – 102Combined sources3
Helixi111 – 114Combined sources4
Beta strandi117 – 123Combined sources7
Helixi124 – 134Combined sources11
Helixi137 – 147Combined sources11
Helixi149 – 159Combined sources11
Helixi171 – 176Combined sources6
Helixi180 – 183Combined sources4
Beta strandi184 – 186Combined sources3
Helixi188 – 199Combined sources12
Helixi206 – 217Combined sources12
Turni226 – 229Combined sources4
Beta strandi236 – 242Combined sources7
Beta strandi249 – 260Combined sources12
Beta strandi266 – 276Combined sources11
Helixi280 – 304Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E25X-ray1.90A27-308[»]
ProteinModelPortaliP37321.
SMRiP37321.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37321.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni239 – 241Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18797.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVIIKAVVT ASTLLMVSFS SFETSAQSPL LKEQIESIVI GKKATVGVAV
60 70 80 90 100
WGPDDLEPLL INPFEKFPMQ SVFKLHLAML VLHQVDQGKL DLNQTVIVNR
110 120 130 140 150
AKVLQNTWAP IMKAYQGDEF SVPVQQLLQY SVSHSDNVAC DLLFELVGGP
160 170 180 190 200
AALHDYIQSM GIKETAVVAN EAQMHADDQV QYQNWTSMKG AAEILKKFEQ
210 220 230 240 250
KTQLSETSQA LLWKWMVETT TGPERLKGLL PAGTVVAHKT GTSGIKAGKT
260 270 280 290 300
AATNDLGIIL LPDGRPLLVA VFVKDSAESS RTNEAIIAQV AQTAYQFELK

KLSALSPN
Length:308
Mass (Da):33,573
Last modified:October 1, 1994 - v1
Checksum:iCED838DFC7D6E117
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21957 Genomic DNA. Translation: CAA79968.1.
PIRiS35931.
RefSeqiWP_001100753.1. NZ_LLVO01000072.1.

Genome annotation databases

KEGGiag:CAA79968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21957 Genomic DNA. Translation: CAA79968.1.
PIRiS35931.
RefSeqiWP_001100753.1. NZ_LLVO01000072.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E25X-ray1.90A27-308[»]
ProteinModelPortaliP37321.
SMRiP37321.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB09060. Avibactam.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:CAA79968.

Phylogenomic databases

KOiK18797.

Enzyme and pathway databases

SABIO-RKP37321.

Miscellaneous databases

EvolutionaryTraceiP37321.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLE1_PSEAI
AccessioniPrimary (citable) accession number: P37321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.