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Reviewed, UniProtKB/Swiss-Prot P37321 (BLE1_PSEAE)

Last modified November 24, 2009. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Extended-spectrum beta-lactamase PER-1
    EC=3.5.2.6
Gene names
Name: per1
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

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Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

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Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbeta-lactamase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626
Chain27 – 308282Extended-spectrum beta-lactamase PER-1
PRO_0000017042

Regions

Region239 – 2413Substrate binding By similarity

Sites

Active site711Acyl-ester intermediate By similarity

Secondary structure

1 ......................................... 308
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P37321-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: CED838DFC7D6E117

FASTA30833,573
        10         20         30         40         50         60 
MNVIIKAVVT ASTLLMVSFS SFETSAQSPL LKEQIESIVI GKKATVGVAV WGPDDLEPLL 

        70         80         90        100        110        120 
INPFEKFPMQ SVFKLHLAML VLHQVDQGKL DLNQTVIVNR AKVLQNTWAP IMKAYQGDEF 

       130        140        150        160        170        180 
SVPVQQLLQY SVSHSDNVAC DLLFELVGGP AALHDYIQSM GIKETAVVAN EAQMHADDQV 

       190        200        210        220        230        240 
QYQNWTSMKG AAEILKKFEQ KTQLSETSQA LLWKWMVETT TGPERLKGLL PAGTVVAHKT 

       250        260        270        280        290        300 
GTSGIKAGKT AATNDLGIIL LPDGRPLLVA VFVKDSAESS RTNEAIIAQV AQTAYQFELK 


KLSALSPN

« Hide

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References

[1]"Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases."
Nordmann P., Naas T.
Antimicrob. Agents Chemother. 38:104-114(1994) [PubMed: 8141562] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Strain: RNL-1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z21957 Genomic DNA. Translation: CAA79968.1.
PIRS35931.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1E25X-ray1.90A27-308[»]
ModBaseSearch...

Enzyme and pathway databases

BRENDA3.5.2.6. 354.

Family and domain databases

InterProIPR012338. B-lactamase-typ_transpept_fold.
IPR001466. Beta_lactamase-related.
IPR000871. Beta_lactamase_A/D.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameBLE1_PSEAE
AccessionPrimary (citable) accession number: P37321
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 24, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents