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Protein

Arsenical resistance operon repressor

Gene

arsR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • response to arsenic-containing substance Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Arsenical resistance, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12235-MONOMER.
ECOL316407:JW3468-MONOMER.
MetaCyc:EG12235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenical resistance operon repressor
Gene namesi
Name:arsR
Synonyms:arsE
Ordered Locus Names:b3501, JW3468
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12235. arsR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606131 – 117Arsenical resistance operon repressorAdd BLAST117

Proteomic databases

PaxDbiP37309.
PRIDEiP37309.

Interactioni

Subunit structurei

Binds DNA as a homodimer.By similarity

Protein-protein interaction databases

BioGridi4261323. 8 interactors.
DIPiDIP-9163N.
IntActiP37309. 3 interactors.
MINTiMINT-1525524.
STRINGi511145.b3501.

Structurei

3D structure databases

ProteinModelPortaliP37309.
SMRiP37309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92HTH arsR-typePROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105KBH. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP37309.
KOiK03892.
OMAiWVYYELS.
PhylomeDBiP37309.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLLPIQLF KILADETRLG IVLLLSELGE LCVCDLCTAL DQSQPKISRH
60 70 80 90 100
LALLRESGLL LDRKQGKWVH YRLSPHIPAW AAKIIDEAWR CEQEKVQAIV
110
RNLARQNCSG DSKNICS
Length:117
Mass (Da):13,253
Last modified:October 1, 1994 - v1
Checksum:i35BC3F6F94BBD3DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA. Translation: CAA56361.1.
U00039 Genomic DNA. Translation: AAB18477.1.
U00096 Genomic DNA. Translation: AAC76526.1.
AP009048 Genomic DNA. Translation: BAE77793.1.
PIRiA56269.
RefSeqiNP_417958.1. NC_000913.3.
WP_000008957.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76526; AAC76526; b3501.
BAE77793; BAE77793; BAE77793.
GeneIDi948013.
KEGGiecj:JW3468.
eco:b3501.
PATRICi32122456. VBIEscCol129921_3605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA. Translation: CAA56361.1.
U00039 Genomic DNA. Translation: AAB18477.1.
U00096 Genomic DNA. Translation: AAC76526.1.
AP009048 Genomic DNA. Translation: BAE77793.1.
PIRiA56269.
RefSeqiNP_417958.1. NC_000913.3.
WP_000008957.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37309.
SMRiP37309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261323. 8 interactors.
DIPiDIP-9163N.
IntActiP37309. 3 interactors.
MINTiMINT-1525524.
STRINGi511145.b3501.

Proteomic databases

PaxDbiP37309.
PRIDEiP37309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76526; AAC76526; b3501.
BAE77793; BAE77793; BAE77793.
GeneIDi948013.
KEGGiecj:JW3468.
eco:b3501.
PATRICi32122456. VBIEscCol129921_3605.

Organism-specific databases

EchoBASEiEB2147.
EcoGeneiEG12235. arsR.

Phylogenomic databases

eggNOGiENOG4105KBH. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP37309.
KOiK03892.
OMAiWVYYELS.
PhylomeDBiP37309.

Enzyme and pathway databases

BioCyciEcoCyc:EG12235-MONOMER.
ECOL316407:JW3468-MONOMER.
MetaCyc:EG12235-MONOMER.

Miscellaneous databases

PROiP37309.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARSR_ECOLI
AccessioniPrimary (citable) accession number: P37309
Secondary accession number(s): Q2M7G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.