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Protein

Carbamate kinase

Gene

arcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + NH3 + CO2 = ADP + carbamoyl phosphate.

Pathwayi: carbamoyl phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Carbamate kinase (arcC)
This subpathway is part of the pathway carbamoyl phosphate degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate, the pathway carbamoyl phosphate degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processArginine metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12384-MONOMER
SABIO-RKP37306
UniPathwayiUPA00996; UER00366

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamate kinase (EC:2.7.2.2)
Gene namesi
Name:arcC
Synonyms:ybcF
Ordered Locus Names:b0521, JW0510
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12384 ybcF

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851191 – 297Carbamate kinaseAdd BLAST297

Proteomic databases

PaxDbiP37306
PRIDEiP37306

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi4262013, 3 interactors
IntActiP37306, 3 interactors
STRINGi316385.ECDH10B_0477

Structurei

3D structure databases

ProteinModelPortaliP37306
SMRiP37306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbamate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105C5B Bacteria
COG0549 LUCA
HOGENOMiHOG000277403
InParanoidiP37306
KOiK00926
OMAiESQGFIG
PhylomeDBiP37306

Family and domain databases

CDDicd04235 AAK_CK, 1 hit
Gene3Di3.40.1160.10, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR003964 Carb_kinase
PANTHERiPTHR30409 PTHR30409, 1 hit
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF000723 Carbamate_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR00746 arcC, 1 hit

Sequencei

Sequence statusi: Complete.

P37306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLVVALGG NALLQRGEAL TAENQYRNIA SAVPALARLA RSYRLAIVHG
60 70 80 90 100
NGPQVGLLAL QNLAWKEVEP YPLDVLVAES QGMIGYMLAQ SLSAQPQMPP
110 120 130 140 150
VTTVLTRIEV SPDDPAFLQP EKFIGPVYQP EEQEALEAAY GWQMKRDGKY
160 170 180 190 200
LRRVVASPQP RKILDSEAIE LLLKEGHVVI CSGGGGVPVT DDGAGSEAVI
210 220 230 240 250
DKDLAAALLA EQINADGLVI LTDADAVYEN WGTPQQRAIR HATPDELAPF
260 270 280 290
AKADGSMGPN VTAVSGYVRS RGKPAWIGAL SRIEETLAGE AGTCISL
Length:297
Mass (Da):31,644
Last modified:November 1, 1997 - v2
Checksum:i0169371E119AE832
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279 – 297ALSRI…TCISL → RYRELKRRWRAKRGPVFRCS RRH in X12982 (PubMed:2464576).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA Translation: AAB40273.1
U00096 Genomic DNA Translation: AAC73623.1
AP009048 Genomic DNA Translation: BAE76298.1
M19657 Genomic DNA No translation available.
X12982 Genomic DNA No translation available.
PIRiH64783
RefSeqiNP_415054.1, NC_000913.3
WP_000855379.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73623; AAC73623; b0521
BAE76298; BAE76298; BAE76298
GeneIDi944972
KEGGiecj:JW0510
eco:b0521
PATRICifig|1411691.4.peg.1757

Similar proteinsi

Entry informationi

Entry nameiARCC_ECOLI
AccessioniPrimary (citable) accession number: P37306
Secondary accession number(s): P77419, Q2MBQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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