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Protein

Carbamate kinase

Gene

arcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + NH3 + CO2 = ADP + carbamoyl phosphate.

Pathwayi: carbamoyl phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Carbamate kinase (arcC)
This subpathway is part of the pathway carbamoyl phosphate degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate, the pathway carbamoyl phosphate degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12384-MONOMER.
ECOL316407:JW0510-MONOMER.
SABIO-RKP37306.
UniPathwayiUPA00996; UER00366.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamate kinase (EC:2.7.2.2)
Gene namesi
Name:arcC
Synonyms:ybcF
Ordered Locus Names:b0521, JW0510
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12384. ybcF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001851191 – 297Carbamate kinaseAdd BLAST297

Proteomic databases

PaxDbiP37306.
PRIDEiP37306.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi4262013. 3 interactors.
IntActiP37306. 3 interactors.
STRINGi511145.b0521.

Structurei

3D structure databases

ProteinModelPortaliP37306.
SMRiP37306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbamate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105C5B. Bacteria.
COG0549. LUCA.
HOGENOMiHOG000277403.
InParanoidiP37306.
KOiK00926.
OMAiYQLVIVH.
PhylomeDBiP37306.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.

Sequencei

Sequence statusi: Complete.

P37306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLVVALGG NALLQRGEAL TAENQYRNIA SAVPALARLA RSYRLAIVHG
60 70 80 90 100
NGPQVGLLAL QNLAWKEVEP YPLDVLVAES QGMIGYMLAQ SLSAQPQMPP
110 120 130 140 150
VTTVLTRIEV SPDDPAFLQP EKFIGPVYQP EEQEALEAAY GWQMKRDGKY
160 170 180 190 200
LRRVVASPQP RKILDSEAIE LLLKEGHVVI CSGGGGVPVT DDGAGSEAVI
210 220 230 240 250
DKDLAAALLA EQINADGLVI LTDADAVYEN WGTPQQRAIR HATPDELAPF
260 270 280 290
AKADGSMGPN VTAVSGYVRS RGKPAWIGAL SRIEETLAGE AGTCISL
Length:297
Mass (Da):31,644
Last modified:November 1, 1997 - v2
Checksum:i0169371E119AE832
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279 – 297ALSRI…TCISL → RYRELKRRWRAKRGPVFRCS RRH in X12982 (PubMed:2464576).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40273.1.
U00096 Genomic DNA. Translation: AAC73623.1.
AP009048 Genomic DNA. Translation: BAE76298.1.
M19657 Genomic DNA. No translation available.
X12982 Genomic DNA. No translation available.
PIRiH64783.
RefSeqiNP_415054.1. NC_000913.3.
WP_000855379.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73623; AAC73623; b0521.
BAE76298; BAE76298; BAE76298.
GeneIDi944972.
KEGGiecj:JW0510.
eco:b0521.
PATRICi32116202. VBIEscCol129921_0542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40273.1.
U00096 Genomic DNA. Translation: AAC73623.1.
AP009048 Genomic DNA. Translation: BAE76298.1.
M19657 Genomic DNA. No translation available.
X12982 Genomic DNA. No translation available.
PIRiH64783.
RefSeqiNP_415054.1. NC_000913.3.
WP_000855379.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37306.
SMRiP37306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262013. 3 interactors.
IntActiP37306. 3 interactors.
STRINGi511145.b0521.

Proteomic databases

PaxDbiP37306.
PRIDEiP37306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73623; AAC73623; b0521.
BAE76298; BAE76298; BAE76298.
GeneIDi944972.
KEGGiecj:JW0510.
eco:b0521.
PATRICi32116202. VBIEscCol129921_0542.

Organism-specific databases

EchoBASEiEB2285.
EcoGeneiEG12384. ybcF.

Phylogenomic databases

eggNOGiENOG4105C5B. Bacteria.
COG0549. LUCA.
HOGENOMiHOG000277403.
InParanoidiP37306.
KOiK00926.
OMAiYQLVIVH.
PhylomeDBiP37306.

Enzyme and pathway databases

UniPathwayiUPA00996; UER00366.
BioCyciEcoCyc:EG12384-MONOMER.
ECOL316407:JW0510-MONOMER.
SABIO-RKP37306.

Miscellaneous databases

PROiP37306.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCC_ECOLI
AccessioniPrimary (citable) accession number: P37306
Secondary accession number(s): P77419, Q2MBQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.