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Protein

Protein HokA

Gene

hokA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Overproduction is toxic.1 Publication

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1605.
ECOL316407:JW3526-MONOMER.

Protein family/group databases

TCDBi1.E.53.1.2. the toxic hok/gef protein (hok/gef) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HokA
Gene namesi
Name:hokA
Synonyms:yiaZ
Ordered Locus Names:b4455, JW3526
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12346. hokA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2418HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5050Protein HokAPRO_0000199029Add
BLAST

Proteomic databases

PaxDbiP37305.

Expressioni

Inductioni

May be repressed by MqsA.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259713. 12 interactions.
IntActiP37305. 1 interaction.
STRINGi511145.b4455.

Structurei

3D structure databases

ProteinModelPortaliP37305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hok/gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41060TC. Bacteria.
ENOG41129RB. LUCA.
HOGENOMiHOG000041219.
KOiK18920.
OMAiICVTILC.
OrthoDBiEOG6TR0M8.
PhylomeDBiP37305.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQKYRLLSL IVICFTLLFF TWMIRDSLCE LHIKQESYEL AAFLACKLKE
Length:50
Mass (Da):5,998
Last modified:October 1, 1994 - v1
Checksum:iA7E0BD75F45781AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 22MP → NA in M30139 (PubMed:8041620).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30139 Genomic DNA. No translation available.
U00039 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAT48191.1.
AP009048 Genomic DNA. Translation: BAE77738.1.
RefSeqiWP_001135732.1. NZ_LN832404.1.
YP_026229.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48191; AAT48191; b4455.
BAE77738; BAE77738; BAE77738.
GeneIDi2847732.
KEGGiecj:JW3526.
eco:b4455.
PATRICi32122586. VBIEscCol129921_3670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30139 Genomic DNA. No translation available.
U00039 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAT48191.1.
AP009048 Genomic DNA. Translation: BAE77738.1.
RefSeqiWP_001135732.1. NZ_LN832404.1.
YP_026229.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP37305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259713. 12 interactions.
IntActiP37305. 1 interaction.
STRINGi511145.b4455.

Protein family/group databases

TCDBi1.E.53.1.2. the toxic hok/gef protein (hok/gef) family.

Proteomic databases

PaxDbiP37305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48191; AAT48191; b4455.
BAE77738; BAE77738; BAE77738.
GeneIDi2847732.
KEGGiecj:JW3526.
eco:b4455.
PATRICi32122586. VBIEscCol129921_3670.

Organism-specific databases

EchoBASEiEB2250.
EcoGeneiEG12346. hokA.

Phylogenomic databases

eggNOGiENOG41060TC. Bacteria.
ENOG41129RB. LUCA.
HOGENOMiHOG000041219.
KOiK18920.
OMAiICVTILC.
OrthoDBiEOG6TR0M8.
PhylomeDBiP37305.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1605.
ECOL316407:JW3526-MONOMER.

Miscellaneous databases

PROiP37305.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "New genes in old sequence: a strategy for finding genes in the bacterial genome."
    Borodovsky M., Koonin E.V., Rudd K.E.
    Trends Biochem. Sci. 19:309-313(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome."
    Borodovsky M., Rudd K.E., Koonin E.V.
    Nucleic Acids Res. 22:4756-4767(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Multiple hok genes on the chromosome of Escherichia coli."
    Pedersen K., Gerdes K.
    Mol. Microbiol. 32:1090-1102(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  8. "Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD."
    Kim Y., Wang X., Zhang X.S., Grigoriu S., Page R., Peti W., Wood T.K.
    Environ. Microbiol. 12:1105-1121(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TOXIN, INDUCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiHOKA_ECOLI
AccessioniPrimary (citable) accession number: P37305
Secondary accession number(s): Q2M7L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 20, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.