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Protein

Protein HokA

Gene

hokA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Overproduction is toxic.1 Publication

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1605.
ECOL316407:JW3526-MONOMER.

Protein family/group databases

TCDBi1.E.53.1.2. the toxic hok/gef protein (hok/gef) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HokA
Gene namesi
Name:hokA
Synonyms:yiaZ
Ordered Locus Names:b4455, JW3526
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12346. hokA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 24HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990291 – 50Protein HokAAdd BLAST50

Proteomic databases

PaxDbiP37305.
PRIDEiP37305.

Expressioni

Inductioni

May be repressed by MqsA.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259713. 12 interactors.
IntActiP37305. 1 interactor.
STRINGi511145.b4455.

Structurei

3D structure databases

ProteinModelPortaliP37305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hok/gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41060TC. Bacteria.
ENOG41129RB. LUCA.
HOGENOMiHOG000041219.
KOiK18920.
OMAiICVTILC.
PhylomeDBiP37305.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQKYRLLSL IVICFTLLFF TWMIRDSLCE LHIKQESYEL AAFLACKLKE
Length:50
Mass (Da):5,998
Last modified:October 1, 1994 - v1
Checksum:iA7E0BD75F45781AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 2MP → NA in M30139 (PubMed:8041620).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30139 Genomic DNA. No translation available.
U00039 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAT48191.1.
AP009048 Genomic DNA. Translation: BAE77738.1.
RefSeqiWP_001135732.1. NZ_LN832404.1.
YP_026229.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48191; AAT48191; b4455.
BAE77738; BAE77738; BAE77738.
GeneIDi2847732.
KEGGiecj:JW3526.
eco:b4455.
PATRICi32122586. VBIEscCol129921_3670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30139 Genomic DNA. No translation available.
U00039 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAT48191.1.
AP009048 Genomic DNA. Translation: BAE77738.1.
RefSeqiWP_001135732.1. NZ_LN832404.1.
YP_026229.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP37305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259713. 12 interactors.
IntActiP37305. 1 interactor.
STRINGi511145.b4455.

Protein family/group databases

TCDBi1.E.53.1.2. the toxic hok/gef protein (hok/gef) family.

Proteomic databases

PaxDbiP37305.
PRIDEiP37305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48191; AAT48191; b4455.
BAE77738; BAE77738; BAE77738.
GeneIDi2847732.
KEGGiecj:JW3526.
eco:b4455.
PATRICi32122586. VBIEscCol129921_3670.

Organism-specific databases

EchoBASEiEB2250.
EcoGeneiEG12346. hokA.

Phylogenomic databases

eggNOGiENOG41060TC. Bacteria.
ENOG41129RB. LUCA.
HOGENOMiHOG000041219.
KOiK18920.
OMAiICVTILC.
PhylomeDBiP37305.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1605.
ECOL316407:JW3526-MONOMER.

Miscellaneous databases

PROiP37305.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOKA_ECOLI
AccessioniPrimary (citable) accession number: P37305
Secondary accession number(s): Q2M7L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.