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Protein

Protein HokA

Gene

hokA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration (PubMed:10361310, PubMed:20105222). Its toxic effect is probably neutralized by antisense antitoxin RNA SokA (PubMed:10361310).1 Publication2 Publications

Miscellaneous

Interrupted by an IS150 element, which silences the locus in strain K12 MG1655.1 Publication

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1605

Protein family/group databases

TCDBi1.E.53.1.2 the toxic hok/gef protein (hok/gef) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HokA
Gene namesi
Name:hokA1 Publication
Synonyms:yiaZ
Ordered Locus Names:b4455, JW3526
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12346 hokA

Subcellular locationi

  • Cell inner membrane By similarityCurated; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 24HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990291 – 50Protein HokAAdd BLAST50

Proteomic databases

PaxDbiP37305
PRIDEiP37305

Expressioni

Inductioni

May be repressed by MqsA.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259713, 12 interactors
IntActiP37305, 1 interactor
STRINGi316385.ECDH10B_3736

Structurei

3D structure databases

ProteinModelPortaliP37305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Hok/Gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41060TC Bacteria
ENOG41129RB LUCA
HOGENOMiHOG000041219
KOiK18920
OMAiFLACDIK
PhylomeDBiP37305

Family and domain databases

InterProiView protein in InterPro
IPR000021 Hok/gef_toxin
IPR018084 Hok/gef_toxin_CS
PfamiView protein in Pfam
PF01848 HOK_GEF, 1 hit
PRINTSiPR00281 HOKGEFTOXIC
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005979 Hok/gef_toxin, 1 hit
PROSITEiView protein in PROSITE
PS00556 HOK_GEF, 1 hit

Sequencei

Sequence statusi: Complete.

P37305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQKYRLLSL IVICFTLLFF TWMIRDSLCE LHIKQESYEL AAFLACKLKE
Length:50
Mass (Da):5,998
Last modified:October 1, 1994 - v1
Checksum:iA7E0BD75F45781AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 2MP → NA in M30139 (PubMed:8041620).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30139 Genomic DNA No translation available.
U00039 Genomic DNA No translation available.
U00096 Genomic DNA Translation: AAT48191.1
AP009048 Genomic DNA Translation: BAE77738.1
RefSeqiWP_001135732.1, NZ_LN832404.1
YP_026229.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48191; AAT48191; b4455
BAE77738; BAE77738; BAE77738
GeneIDi2847732
KEGGiecj:JW3526
eco:b4455
PATRICifig|83333.103.peg.4475

Similar proteinsi

Entry informationi

Entry nameiHOKA_ECOLI
AccessioniPrimary (citable) accession number: P37305
Secondary accession number(s): Q2M7L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health