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P37299 (QCR10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 8.5 kDa protein
Gene names
Name:QCR10
Ordered Locus Names:YHR001W-A
ORF Names:YHR001BW
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length77 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR10 is required for stable association of the iron-sulfur protein with the complex.

Subunit structure

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Subcellular location

Mitochondrion inner membrane.

Miscellaneous

Present with 5590 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the UQCR11/QCR10 family.

Sequence caution

The sequence AAB68434.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 7776Cytochrome b-c1 complex subunit 10
PRO_0000193563

Regions

Transmembrane25 – 4521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P37299 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: B9212B4FD194BB3E

FASTA778,593
        10         20         30         40         50         60 
MAYTSHLSSK TGLHFGRLSL RSLTAYAPNL MLWGGASMLG LFVFTEGWPK FQDTLYKKIP 

        70 
LLGPTLEDHT PPEDKPN 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex."
Brandt U., Uribe S., Schaegger H., Trumpower B.L.
J. Biol. Chem. 269:12947-12953(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome-c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron-sulfur subunit."
Geier B.M., Schaegger H., Brandt U., Colson A.-M., von Jagow G.
Eur. J. Biochem. 208:375-380(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-29 AND 38-59.
Strain: GM50-3C.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U07275 Unassigned DNA. Translation: AAA19322.1.
U10555 Genomic DNA. Translation: AAB68434.1. Sequence problems.
BK006934 Genomic DNA. Translation: DAA06688.1.
PIRA53768.
RefSeqNP_011864.1. NM_001181426.1.

3D structure databases

ProteinModelPortalP37299.
SMRP37299. Positions 16-64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36426. 55 interactions.
IntActP37299. 2 interactions.
MINTMINT-4488383.
STRING4932.YHR001W-A.

Proteomic databases

PaxDbP37299.
PeptideAtlasP37299.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR001W-A; YHR001W-A; YHR001W-A.
GeneID856390.
KEGGsce:YHR001W-A.

Organism-specific databases

SGDS000003529. QCR10.

Phylogenomic databases

eggNOGNOG71733.
HOGENOMHOG000163401.
KOK00420.
OMAWIYNPDP.
OrthoDBEOG7G7M2R.

Enzyme and pathway databases

BioCycMetaCyc:G3O-31243-MONOMER.
YEAST:G3O-31243-MONOMER.
YEAST:YHR001W-MONOMER.

Gene expression databases

GenevestigatorP37299.

Family and domain databases

InterProIPR019182. Cytochrome_b-c1_su10_fun.
[Graphical view]
PfamPF09796. QCR10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981902.

Entry information

Entry nameQCR10_YEAST
AccessionPrimary (citable) accession number: P37299
Secondary accession number(s): D3DKR8, O13538, Q9T2W2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families