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P37299

- QCR10_YEAST

UniProt

P37299 - QCR10_YEAST

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Protein
Cytochrome b-c1 complex subunit 10
Gene
QCR10, YHR001W-A, YHR001BW
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR10 is required for stable association of the iron-sulfur protein with the complex.

GO - Biological processi

  1. aerobic respiration Source: SGD
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciMetaCyc:G3O-31243-MONOMER.
YEAST:G3O-31243-MONOMER.
YEAST:YHR001W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 8.5 kDa protein
Gene namesi
Name:QCR10
Ordered Locus Names:YHR001W-A
ORF Names:YHR001BW
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

SGDiS000003529. QCR10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. mitochondrial respiratory chain complex III Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 7776Cytochrome b-c1 complex subunit 10
PRO_0000193563Add
BLAST

Proteomic databases

MaxQBiP37299.
PaxDbiP37299.
PeptideAtlasiP37299.

Expressioni

Gene expression databases

GenevestigatoriP37299.

Interactioni

Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridi36426. 56 interactions.
IntActiP37299. 2 interactions.
MINTiMINT-4488383.
STRINGi4932.YHR001W-A.

Structurei

3D structure databases

ProteinModelPortaliP37299.
SMRiP37299. Positions 16-64.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR11/QCR10 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71733.
HOGENOMiHOG000163401.
KOiK00420.
OMAiVFTEGWP.
OrthoDBiEOG7G7M2R.

Family and domain databases

InterProiIPR019182. Cytochrome_b-c1_su10_fun.
[Graphical view]
PfamiPF09796. QCR10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37299-1 [UniParc]FASTAAdd to Basket

« Hide

MAYTSHLSSK TGLHFGRLSL RSLTAYAPNL MLWGGASMLG LFVFTEGWPK   50
FQDTLYKKIP LLGPTLEDHT PPEDKPN 77
Length:77
Mass (Da):8,593
Last modified:January 23, 2007 - v2
Checksum:iB9212B4FD194BB3E
GO

Sequence cautioni

The sequence AAB68434.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07275 Unassigned DNA. Translation: AAA19322.1.
U10555 Genomic DNA. Translation: AAB68434.1. Sequence problems.
BK006934 Genomic DNA. Translation: DAA06688.1.
PIRiA53768.
RefSeqiNP_011864.1. NM_001181426.1.

Genome annotation databases

EnsemblFungiiYHR001W-A; YHR001W-A; YHR001W-A.
GeneIDi856390.
KEGGisce:YHR001W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07275 Unassigned DNA. Translation: AAA19322.1 .
U10555 Genomic DNA. Translation: AAB68434.1 . Sequence problems.
BK006934 Genomic DNA. Translation: DAA06688.1 .
PIRi A53768.
RefSeqi NP_011864.1. NM_001181426.1.

3D structure databases

ProteinModelPortali P37299.
SMRi P37299. Positions 16-64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36426. 56 interactions.
IntActi P37299. 2 interactions.
MINTi MINT-4488383.
STRINGi 4932.YHR001W-A.

Proteomic databases

MaxQBi P37299.
PaxDbi P37299.
PeptideAtlasi P37299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR001W-A ; YHR001W-A ; YHR001W-A .
GeneIDi 856390.
KEGGi sce:YHR001W-A.

Organism-specific databases

SGDi S000003529. QCR10.

Phylogenomic databases

eggNOGi NOG71733.
HOGENOMi HOG000163401.
KOi K00420.
OMAi VFTEGWP.
OrthoDBi EOG7G7M2R.

Enzyme and pathway databases

BioCyci MetaCyc:G3O-31243-MONOMER.
YEAST:G3O-31243-MONOMER.
YEAST:YHR001W-MONOMER.

Miscellaneous databases

NextBioi 981902.

Gene expression databases

Genevestigatori P37299.

Family and domain databases

InterProi IPR019182. Cytochrome_b-c1_su10_fun.
[Graphical view ]
Pfami PF09796. QCR10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex."
    Brandt U., Uribe S., Schaegger H., Trumpower B.L.
    J. Biol. Chem. 269:12947-12953(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome-c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron-sulfur subunit."
    Geier B.M., Schaegger H., Brandt U., Colson A.-M., von Jagow G.
    Eur. J. Biochem. 208:375-380(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-29 AND 38-59.
    Strain: GM50-3C.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQCR10_YEAST
AccessioniPrimary (citable) accession number: P37299
Secondary accession number(s): D3DKR8, O13538, Q9T2W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5590 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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