P37299 (QCR10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b-c1 complex subunit 10

Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 8.5 kDa protein

Gene names

Name:	QCR10
Ordered Locus Names:	YHR001W-A
ORF Names:	YHR001BW

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	77 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR10 is required for stable association of the iron-sulfur protein with the complex.
Subunit structure	Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.
Subcellular location	Mitochondrion inner membrane.
Miscellaneous	Present with 5590 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the UQCR11/QCR10 family.
Sequence caution	The sequence AAB68434.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from genetic interaction Ref.1. Source: SGD mitochondrial electron transport, ubiquinol to cytochrome c Inferred from mutant phenotype Ref.1. Source: SGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex III Inferred from direct assay Ref.1. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 77	76	Cytochrome b-c1 complex subunit 10		PRO_0000193563
Regions
	Transmembrane	25 – 45	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P37299 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B9212B4FD194BB3E	FASTA	77	8,593
	10 20 30 40 50 60 MAYTSHLSSK TGLHFGRLSL RSLTAYAPNL MLWGGASMLG LFVFTEGWPK FQDTLYKKIP 70 LLGPTLEDHT PPEDKPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex." Brandt U., Uribe S., Schaegger H., Trumpower B.L. J. Biol. Chem. 269:12947-12953(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome-c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron-sulfur subunit." Geier B.M., Schaegger H., Brandt U., Colson A.-M., von Jagow G. Eur. J. Biochem. 208:375-380(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-29 AND 38-59. Strain: GM50-3C.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07275 Unassigned DNA. Translation: AAA19322.1. U10555 Genomic DNA. Translation: AAB68434.1. Sequence problems. BK006934 Genomic DNA. Translation: DAA06688.1.
PIR	A53768.
RefSeq	NP_011864.1. NM_001181426.1.
3D structure databases
ProteinModelPortal	P37299.
SMR	P37299. Positions 16-64.
ModBase	Search...
Protein-protein interaction databases
IntAct	P37299. 2 interactions.
MINT	MINT-4488383.
STRING	4932.YHR001W-A.
Proteomic databases
PaxDb	P37299.
PeptideAtlas	P37299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR001W-A; YHR001W-A; YHR001W-A.
GeneID	856390.
KEGG	sce:YHR001W-A.
Organism-specific databases
SGD	S000003529. QCR10.
Phylogenomic databases
eggNOG	NOG71733.
HOGENOM	HOG000163401.
KO	K00420.
OMA	WIYNPDP.
OrthoDB	EOG4W11PZ.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31243-MONOMER. YEAST:YHR001W-MONOMER.
Gene expression databases
Genevestigator	P37299.
GermOnline	YHR001W-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR019182. Cytochrome_b-c1_10. [Graphical view]
Pfam	PF09796. QCR10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981902.

Entry information

Entry name

QCR10_YEAST

Accession

Primary (citable) accession number: P37299
Secondary accession number(s): D3DKR8, O13538, Q9T2W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program