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P37299

- QCR10_YEAST

UniProt

P37299 - QCR10_YEAST

Protein

Cytochrome b-c1 complex subunit 10

Gene

QCR10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR10 is required for stable association of the iron-sulfur protein with the complex.

    GO - Biological processi

    1. aerobic respiration Source: SGD
    2. hydrogen ion transmembrane transport Source: GOC
    3. mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:G3O-31243-MONOMER.
    YEAST:G3O-31243-MONOMER.
    YEAST:YHR001W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 10
    Alternative name(s):
    Complex III subunit 10
    Complex III subunit XI
    Ubiquinol-cytochrome c reductase complex 8.5 kDa protein
    Gene namesi
    Name:QCR10
    Ordered Locus Names:YHR001W-A
    ORF Names:YHR001BW
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    SGDiS000003529. QCR10.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex III Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 7776Cytochrome b-c1 complex subunit 10PRO_0000193563Add
    BLAST

    Proteomic databases

    MaxQBiP37299.
    PaxDbiP37299.
    PeptideAtlasiP37299.

    Expressioni

    Gene expression databases

    GenevestigatoriP37299.

    Interactioni

    Subunit structurei

    Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

    Protein-protein interaction databases

    BioGridi36426. 56 interactions.
    IntActiP37299. 2 interactions.
    MINTiMINT-4488383.
    STRINGi4932.YHR001W-A.

    Structurei

    3D structure databases

    ProteinModelPortaliP37299.
    SMRiP37299. Positions 16-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UQCR11/QCR10 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71733.
    HOGENOMiHOG000163401.
    KOiK00420.
    OMAiVFTEGWP.
    OrthoDBiEOG7G7M2R.

    Family and domain databases

    InterProiIPR019182. Cytochrome_b-c1_su10_fun.
    [Graphical view]
    PfamiPF09796. QCR10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37299-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYTSHLSSK TGLHFGRLSL RSLTAYAPNL MLWGGASMLG LFVFTEGWPK   50
    FQDTLYKKIP LLGPTLEDHT PPEDKPN 77
    Length:77
    Mass (Da):8,593
    Last modified:January 23, 2007 - v2
    Checksum:iB9212B4FD194BB3E
    GO

    Sequence cautioni

    The sequence AAB68434.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07275 Unassigned DNA. Translation: AAA19322.1.
    U10555 Genomic DNA. Translation: AAB68434.1. Sequence problems.
    BK006934 Genomic DNA. Translation: DAA06688.1.
    PIRiA53768.
    RefSeqiNP_011864.1. NM_001181426.1.

    Genome annotation databases

    EnsemblFungiiYHR001W-A; YHR001W-A; YHR001W-A.
    GeneIDi856390.
    KEGGisce:YHR001W-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U07275 Unassigned DNA. Translation: AAA19322.1 .
    U10555 Genomic DNA. Translation: AAB68434.1 . Sequence problems.
    BK006934 Genomic DNA. Translation: DAA06688.1 .
    PIRi A53768.
    RefSeqi NP_011864.1. NM_001181426.1.

    3D structure databases

    ProteinModelPortali P37299.
    SMRi P37299. Positions 16-64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36426. 56 interactions.
    IntActi P37299. 2 interactions.
    MINTi MINT-4488383.
    STRINGi 4932.YHR001W-A.

    Proteomic databases

    MaxQBi P37299.
    PaxDbi P37299.
    PeptideAtlasi P37299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR001W-A ; YHR001W-A ; YHR001W-A .
    GeneIDi 856390.
    KEGGi sce:YHR001W-A.

    Organism-specific databases

    SGDi S000003529. QCR10.

    Phylogenomic databases

    eggNOGi NOG71733.
    HOGENOMi HOG000163401.
    KOi K00420.
    OMAi VFTEGWP.
    OrthoDBi EOG7G7M2R.

    Enzyme and pathway databases

    BioCyci MetaCyc:G3O-31243-MONOMER.
    YEAST:G3O-31243-MONOMER.
    YEAST:YHR001W-MONOMER.

    Miscellaneous databases

    NextBioi 981902.

    Gene expression databases

    Genevestigatori P37299.

    Family and domain databases

    InterProi IPR019182. Cytochrome_b-c1_su10_fun.
    [Graphical view ]
    Pfami PF09796. QCR10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex."
      Brandt U., Uribe S., Schaegger H., Trumpower B.L.
      J. Biol. Chem. 269:12947-12953(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome-c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron-sulfur subunit."
      Geier B.M., Schaegger H., Brandt U., Colson A.-M., von Jagow G.
      Eur. J. Biochem. 208:375-380(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-29 AND 38-59.
      Strain: GM50-3C.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQCR10_YEAST
    AccessioniPrimary (citable) accession number: P37299
    Secondary accession number(s): D3DKR8, O13538, Q9T2W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 5590 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3