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P37294

- CRTB_SYNY3

UniProt

P37294 - CRTB_SYNY3

Protein

All-trans-phytoene synthase

Gene

crtB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield all-trans phytoene.1 Publication

    Catalytic activityi

    2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate.1 Publication

    Cofactori

    ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.By similarity
    Manganese or magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSSP1148:GJOT-1287-MONOMER.
    UniPathwayiUPA00799; UER00773.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    All-trans-phytoene synthase (EC:2.5.1.99)
    Short name:
    PSase
    Gene namesi
    Name:crtB
    Synonyms:pys
    Ordered Locus Names:slr1255
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337All-trans-phytoene synthasePRO_0000067438Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1148.slr1255.

    Structurei

    3D structure databases

    ProteinModelPortaliP37294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phytoene/squalene synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG1562.
    HOGENOMiHOG000220848.
    KOiK02291.
    OMAiPFRDMIA.
    OrthoDBiEOG63FW00.
    PhylomeDBiP37294.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37294-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANGQISPQR AVTKPQSWWL TSEPRPSLML QLPKPSPSAK PCASVEEAYE    50
    ICRQVTAQYA KTFYLGTLLM PPAKRRAIWA IYLWCRRTDE LVDGPQAATT 100
    TPETLDHWER RLEGIFAGQP QDDADVALVD TLETFPLDIQ PFRDMIAGQR 150
    MDLYRSRYQT FEELDLYCYR VAGTVGLMSS AVLGVDTGNG QAPWQPDAVY 200
    IPQEEAIALG VANQLTNILR DVGEDVERGR IYLPLEDLER FNYSEQDLLN 250
    GVNDDRWRSL MKFEIDRARH YFEDAERGIR ALNRDARWPV WTALMLYKGI 300
    LDVIEANNYN VFNRRAYVPT PKKLLYLPVA WLRAQVL 337
    Length:337
    Mass (Da):38,707
    Last modified:October 1, 1994 - v1
    Checksum:i860C059CFC92B7F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69172 Genomic DNA. Translation: CAA48922.1.
    BA000022 Genomic DNA. Translation: BAA17848.1.
    PIRiS45360.
    RefSeqiNP_441168.1. NC_000911.1.
    YP_007451050.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA17848; BAA17848; BAA17848.
    GeneIDi954504.
    KEGGisyn:slr1255.
    syz:MYO_112830.
    PATRICi23839649. VBISynSp132158_1387.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69172 Genomic DNA. Translation: CAA48922.1 .
    BA000022 Genomic DNA. Translation: BAA17848.1 .
    PIRi S45360.
    RefSeqi NP_441168.1. NC_000911.1.
    YP_007451050.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P37294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.slr1255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA17848 ; BAA17848 ; BAA17848 .
    GeneIDi 954504.
    KEGGi syn:slr1255.
    syz:MYO_112830.
    PATRICi 23839649. VBISynSp132158_1387.

    Phylogenomic databases

    eggNOGi COG1562.
    HOGENOMi HOG000220848.
    KOi K02291.
    OMAi PFRDMIA.
    OrthoDBi EOG63FW00.
    PhylomeDBi P37294.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    BioCyci SSP1148:GJOT-1287-MONOMER.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression in Escherichia coli of the gene coding for phytoene synthase from the cyanobacterium Synechocystis sp. PCC6803."
      Martinez-Ferez I.M., Fernandez-Gonzalez B., Sandmann G., Vioque A.
      Biochim. Biophys. Acta 1218:145-152(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiCRTB_SYNY3
    AccessioniPrimary (citable) accession number: P37294
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3