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Protein

Prostaglandin F2-alpha receptor

Gene

PTGFR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin F2-alpha receptor
Short name:
PGF receptor
Short name:
PGF2-alpha receptor
Alternative name(s):
Prostanoid FP receptor
Gene namesi
Name:PTGFR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence analysisAdd
BLAST
Transmembranei32 – 5423Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 6915CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10919ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 13122Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini132 – 15221CytoplasmicSequence analysisAdd
BLAST
Transmembranei153 – 17523Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 19823ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 22426Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini225 – 25026CytoplasmicSequence analysisAdd
BLAST
Transmembranei251 – 26717Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini268 – 28518ExtracellularSequence analysisAdd
BLAST
Transmembranei286 – 30722Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini308 – 36255CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Prostaglandin F2-alpha receptorPRO_0000070069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP37289.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041321.

Chemistry

BindingDBiP37289.

Structurei

3D structure databases

ProteinModelPortaliP37289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP37289.
KOiK04262.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000141. PglndnF_rcpt.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF4. PTHR11866:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00855. PRSTNOIDFPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNSSIQPV SPESELLSNT TCQLEEDLSI SFSIIFMTVG ILSNSLAIAI
60 70 80 90 100
LMKAYQRFRQ KYKSSFLLLA SALVITDFFG HLINGTIAVF VYASDKDWIY
110 120 130 140 150
FDKSNILCSI FGICMVFSGL CPLFLGSLMA IERCIGVTKP IFHSTKITTK
160 170 180 190 200
HVKMMLSGVC FFAVFVALLP ILGHRDYKIQ ASRTWCFYKT DEIKDWEDRF
210 220 230 240 250
YLLLFAFLGL LALGISFVCN AITGISLLKV KFRSQQHRQG RSHHFEMVIQ
260 270 280 290 300
LLGIMCVSCI CWSPFLVTMA SIGMNIQDFK DSCERTLFTL RMATWNQILD
310 320 330 340 350
PWVYILLRKA VLRNLYVCTR RCCGVHVISL HVWELSSIKD SLKVAAISDL
360
PVTEKVTQQT ST
Length:362
Mass (Da):41,032
Last modified:October 1, 1994 - v1
Checksum:i041AC4D696C3CC57
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401D → N in BAA20871 (PubMed:9197544).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17395 mRNA. Translation: BAA04218.1.
D89039 Genomic DNA. Translation: BAA20871.1.
PIRiA53058.
RefSeqiNP_851368.1. NM_181025.3.
XP_005204428.1. XM_005204371.3.
UniGeneiBt.352.

Genome annotation databases

GeneIDi282020.
KEGGibta:282020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17395 mRNA. Translation: BAA04218.1.
D89039 Genomic DNA. Translation: BAA20871.1.
PIRiA53058.
RefSeqiNP_851368.1. NM_181025.3.
XP_005204428.1. XM_005204371.3.
UniGeneiBt.352.

3D structure databases

ProteinModelPortaliP37289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041321.

Chemistry

BindingDBiP37289.
ChEMBLiCHEMBL4820.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP37289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282020.
KEGGibta:282020.

Organism-specific databases

CTDi5737.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP37289.
KOiK04262.
TreeFamiTF324982.

Miscellaneous databases

PROiP37289.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000141. PglndnF_rcpt.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF4. PTHR11866:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00855. PRSTNOIDFPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor."
    Sakamoto K., Ezashi T., Miwa K., Okuda-Ashitaka E., Houtani T., Sugimoto T., Ito S., Hayaishi O.
    J. Biol. Chem. 269:3881-3886(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Corpus luteum.
  2. "Genomic organization and characterization of the gene encoding bovine prostaglandin F2alpha receptor."
    Ezashi T., Sakamoto K., Miwa K., Okuda-Ashitaka E., Ito S., Hayaishi O.
    Gene 190:271-278(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiPF2R_BOVIN
AccessioniPrimary (citable) accession number: P37289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.