ID   V1AR_HUMAN              Reviewed;         418 AA.
AC   P37288;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   24-JAN-2024, entry version 198.
DE   RecName: Full=Vasopressin V1a receptor;
DE            Short=V1aR;
DE   AltName: Full=AVPR V1a;
DE   AltName: Full=Antidiuretic hormone receptor 1a;
DE   AltName: Full=Vascular/hepatic-type arginine vasopressin receptor;
GN   Name=AVPR1A; Synonyms=AVPR1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=8106369; DOI=10.1016/s0021-9258(17)41863-1;
RA   Thibonnier M., Auzan C., Madhun Z., Wilkins P., Berti-Mattera L.,
RA   Clauser E.;
RT   "Molecular cloning, sequencing, and functional expression of a cDNA
RT   encoding the human V1a vasopressin receptor.";
RL   J. Biol. Chem. 269:3304-3310(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=8074728; DOI=10.1006/bbrc.1994.2150;
RA   Hirasawa A., Shibata K., Kotosai K., Tsujimoto G.;
RT   "Cloning, functional expression and tissue distribution of human cDNA for
RT   the vascular-type vasopressin receptor.";
RL   Biochem. Biophys. Res. Commun. 203:72-79(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RX   PubMed=9357056; DOI=10.1016/s0196-9781(97)00072-7;
RA   North W.G., Fay M.J., Longo K.A., Du J.;
RT   "Functional vasopressin V1 type receptors are present in variant as well as
RT   classical forms of small-cell carcinoma.";
RL   Peptides 18:985-993(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9581826;
RA   North W.G., Fay M.J., Longo K.A., Du J.;
RT   "Expression of all known vasopressin receptor subtypes by small cell tumors
RT   implies a multifaceted role for this neuropeptide.";
RL   Cancer Res. 58:1866-1871(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   ROLE IN SOCIAL BEHAVIOR.
RX   PubMed=12082568; DOI=10.1038/sj.mp.4001125;
RA   Kim S.J., Young L.J., Gonen D., Veenstra-VanderWeele J., Courchesne R.,
RA   Courchesne E., Lord C., Leventhal B.L., Cook E.H. Jr., Insel T.R.;
RT   "Transmission disequilibrium testing of arginine vasopressin receptor 1A
RT   (AVPR1A) polymorphisms in autism.";
RL   Mol. Psychiatry 7:503-507(2002).
RN   [8]
RP   X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 362-418.
RX   PubMed=16511036; DOI=10.1107/s1744309105007293;
RA   Adikesavan N.V., Mahmood S.S., Stanley N., Xu Z., Wu N., Thibonnier M.,
RA   Shoham M.;
RT   "A C-terminal segment of the V1R vasopressin receptor is unstructured in
RT   the crystal structure of its chimera with the maltose-binding protein.";
RL   Acta Crystallogr. F 61:341-345(2005).
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate a phosphatidyl-
CC       inositol-calcium second messenger system. Has been involved in social
CC       behaviors, including affiliation and attachment.
CC       {ECO:0000269|PubMed:12082568}.
CC   -!- INTERACTION:
CC       P37288; P25106: ACKR3; NbExp=7; IntAct=EBI-6656842, EBI-1965291;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Differences in regional receptor expression in the brain
CC       as well as differences in social behavior may result from a highly
CC       variable repetitive sequence in the 5' flanking region of AVPR1A. One
CC       such allelic variant has been linked to autism.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
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DR   EMBL; L25615; AAA62271.1; -; mRNA.
DR   EMBL; U19906; AAB19232.1; -; Genomic_DNA.
DR   EMBL; S73899; AAC60638.1; -; mRNA.
DR   EMBL; AF030625; AAC51861.1; -; mRNA.
DR   EMBL; AF101725; AAD17891.1; -; mRNA.
DR   EMBL; AY322550; AAP84363.1; -; mRNA.
DR   EMBL; BC074803; AAH74803.1; -; mRNA.
DR   EMBL; BC074804; AAH74804.1; -; mRNA.
DR   CCDS; CCDS8965.1; -.
DR   PIR; A53046; A53046.
DR   RefSeq; NP_000697.1; NM_000706.4.
DR   PDB; 1YTV; X-ray; 1.80 A; M/N=362-418.
DR   PDBsum; 1YTV; -.
DR   AlphaFoldDB; P37288; -.
DR   SMR; P37288; -.
DR   BioGRID; 107033; 3.
DR   IntAct; P37288; 4.
DR   STRING; 9606.ENSP00000299178; -.
DR   BindingDB; P37288; -.
DR   ChEMBL; CHEMBL1889; -.
DR   DrugBank; DB09059; Atosiban.
DR   DrugBank; DB00872; Conivaptan.
DR   DrugBank; DB00035; Desmopressin.
DR   DrugBank; DB00093; Felypressin.
DR   DrugBank; DB14642; Lypressin.
DR   DrugBank; DB16279; Pecavaptan.
DR   DrugBank; DB05452; PH-284.
DR   DrugBank; DB13929; Relcovaptan.
DR   DrugBank; DB02638; Terlipressin.
DR   DrugBank; DB06212; Tolvaptan.
DR   DrugBank; DB00067; Vasopressin.
DR   DrugCentral; P37288; -.
DR   GuidetoPHARMACOLOGY; 366; -.
DR   GlyCosmos; P37288; 2 sites, No reported glycans.
DR   GlyGen; P37288; 3 sites.
DR   iPTMnet; P37288; -.
DR   PhosphoSitePlus; P37288; -.
DR   BioMuta; AVPR1A; -.
DR   DMDM; 586197; -.
DR   MassIVE; P37288; -.
DR   PaxDb; 9606-ENSP00000299178; -.
DR   PeptideAtlas; P37288; -.
DR   ProteomicsDB; 55276; -.
DR   Antibodypedia; 29106; 329 antibodies from 35 providers.
DR   CPTC; P37288; 1 antibody.
DR   DNASU; 552; -.
DR   Ensembl; ENST00000299178.4; ENSP00000299178.3; ENSG00000166148.4.
DR   GeneID; 552; -.
DR   KEGG; hsa:552; -.
DR   MANE-Select; ENST00000299178.4; ENSP00000299178.3; NM_000706.5; NP_000697.1.
DR   AGR; HGNC:895; -.
DR   CTD; 552; -.
DR   DisGeNET; 552; -.
DR   GeneCards; AVPR1A; -.
DR   HGNC; HGNC:895; AVPR1A.
DR   HPA; ENSG00000166148; Tissue enhanced (adrenal).
DR   MIM; 600821; gene.
DR   neXtProt; NX_P37288; -.
DR   OpenTargets; ENSG00000166148; -.
DR   PharmGKB; PA25187; -.
DR   VEuPathDB; HostDB:ENSG00000166148; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244882; -.
DR   HOGENOM; CLU_009579_15_3_1; -.
DR   InParanoid; P37288; -.
DR   OMA; FSMVEVN; -.
DR   OrthoDB; 2879183at2759; -.
DR   PhylomeDB; P37288; -.
DR   TreeFam; TF106499; -.
DR   PathwayCommons; P37288; -.
DR   Reactome; R-HSA-388479; Vasopressin-like receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   Reactome; R-HSA-5619099; Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI).
DR   SignaLink; P37288; -.
DR   SIGNOR; P37288; -.
DR   BioGRID-ORCS; 552; 53 hits in 1158 CRISPR screens.
DR   ChiTaRS; AVPR1A; human.
DR   EvolutionaryTrace; P37288; -.
DR   GeneWiki; Arginine_vasopressin_receptor_1A; -.
DR   GenomeRNAi; 552; -.
DR   Pharos; P37288; Tclin.
DR   PRO; PR:P37288; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P37288; Protein.
DR   Bgee; ENSG00000166148; Expressed in left adrenal gland and 139 other cell types or tissues.
DR   ExpressionAtlas; P37288; baseline and differential.
DR   GO; GO:0030139; C:endocytic vesicle; IDA:ARUK-UCL.
DR   GO; GO:0005768; C:endosome; IDA:ARUK-UCL.
DR   GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR   GO; GO:0005080; F:protein kinase C binding; TAS:ProtInc.
DR   GO; GO:0031894; F:V1A vasopressin receptor binding; IEA:Ensembl.
DR   GO; GO:0005000; F:vasopressin receptor activity; IDA:ARUK-UCL.
DR   GO; GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.
DR   GO; GO:0008015; P:blood circulation; TAS:ProtInc.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR   GO; GO:0042631; P:cellular response to water deprivation; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
DR   GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
DR   GO; GO:0002125; P:maternal aggressive behavior; IEA:Ensembl.
DR   GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
DR   GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR   GO; GO:0007621; P:negative regulation of female receptivity; IEA:Ensembl.
DR   GO; GO:0051970; P:negative regulation of transmission of nerve impulse; IEA:Ensembl.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:ARUK-UCL.
DR   GO; GO:0032849; P:positive regulation of cellular pH reduction; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc.
DR   GO; GO:0014049; P:positive regulation of glutamate secretion; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:Ensembl.
DR   GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Ensembl.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR   GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR   GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR   GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR   GO; GO:0042713; P:sperm ejaculation; IEA:Ensembl.
DR   GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR   GO; GO:0150104; P:transport across blood-brain barrier; NAS:ARUK-UCL.
DR   CDD; cd15385; 7tmA_V1aR; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR015076; V1R_C.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR001224; Vprs_V1A_rcpt.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF17; VASOPRESSIN V1A RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF08983; V1R_C; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00752; VASOPRSNV1AR.
DR   SMART; SM01164; DUF1856; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P37288; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..418
FT                   /note="Vasopressin V1a receptor"
FT                   /id="PRO_0000070197"
FT   TOPO_DOM        1..52
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..76
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..110
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..125
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..147
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..168
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..190
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..293
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..313
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314..331
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..351
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        352..418
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         404
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62463"
FT   LIPID           365
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           366
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        196
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        124..203
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         6
FT                   /note="G -> S (in dbSNP:rs2228154)"
FT                   /id="VAR_022065"
SQ   SEQUENCE   418 AA;  46800 MW;  477D4260EC826561 CRC64;
     MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL AKLEIAVLAV
     TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQMC WDITYRFRGP
     DWLCRVVKHL QVFGMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAAAWVLSFV
     LSTPQYFVFS MIEVNNVTKA RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC
     YNIWCNVRGK TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY
     IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF FSGHLLQDCV
     QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM WKDSPKSSKS IKFIPVST
//