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P37288 (V1AR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin V1a receptor

Short name=V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene names
Name:AVPR1A
Synonyms:AVPR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein.

Miscellaneous

Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 10858434. Source: ProtInc

activation of phospholipase C activity

Traceable author statement Ref.1. Source: ProtInc

blood circulation

Traceable author statement Ref.1. Source: ProtInc

calcium-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cellular response to water deprivation

Inferred from electronic annotation. Source: Ensembl

generation of precursor metabolites and energy

Traceable author statement Ref.1. Source: ProtInc

grooming behavior

Inferred from electronic annotation. Source: Ensembl

maternal aggressive behavior

Inferred from electronic annotation. Source: Ensembl

maternal behavior

Inferred from electronic annotation. Source: Ensembl

myotube differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of female receptivity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transmission of nerve impulse

Inferred from electronic annotation. Source: Ensembl

penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cellular pH reduction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Traceable author statement Ref.1. Source: ProtInc

positive regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by vasopressin

Inferred from electronic annotation. Source: Ensembl

response to corticosterone

Inferred from electronic annotation. Source: Ensembl

social behavior

Inferred from electronic annotation. Source: Ensembl

sperm ejaculation

Inferred from electronic annotation. Source: Ensembl

telencephalon development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

endosome

Traceable author statement PubMed 10858434. Source: ProtInc

integral component of plasma membrane

Traceable author statement PubMed 8838314. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide hormone binding

Inferred from electronic annotation. Source: Ensembl

protein kinase C binding

Traceable author statement PubMed 10858434. Source: ProtInc

vasopressin receptor activity

Traceable author statement PubMed 10858434. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Vasopressin V1a receptor
PRO_0000070197

Regions

Topological domain1 – 5252Extracellular Potential
Transmembrane53 – 7624Helical; Name=1; Potential
Topological domain77 – 8812Cytoplasmic Potential
Transmembrane89 – 11022Helical; Name=2; Potential
Topological domain111 – 12515Extracellular Potential
Transmembrane126 – 14722Helical; Name=3; Potential
Topological domain148 – 16821Cytoplasmic Potential
Transmembrane169 – 19022Helical; Name=4; Potential
Topological domain191 – 21828Extracellular Potential
Transmembrane219 – 23921Helical; Name=5; Potential
Topological domain240 – 29354Cytoplasmic Potential
Transmembrane294 – 31320Helical; Name=6; Potential
Topological domain314 – 33118Extracellular Potential
Transmembrane332 – 35120Helical; Name=7; Potential
Topological domain352 – 41867Cytoplasmic Potential

Amino acid modifications

Modified residue4041Phosphoserine By similarity
Lipidation3651S-palmitoyl cysteine By similarity
Lipidation3661S-palmitoyl cysteine By similarity
Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Potential
Disulfide bond124 ↔ 203 By similarity

Natural variations

Natural variant61G → S.
Corresponds to variant rs2228154 [ dbSNP | Ensembl ].
VAR_022065

Sequences

Sequence LengthMass (Da)Tools
P37288 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 477D4260EC826561

FASTA41846,800
        10         20         30         40         50         60 
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL AKLEIAVLAV 

        70         80         90        100        110        120 
TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQMC WDITYRFRGP 

       130        140        150        160        170        180 
DWLCRVVKHL QVFGMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAAAWVLSFV 

       190        200        210        220        230        240 
LSTPQYFVFS MIEVNNVTKA RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC 

       250        260        270        280        290        300 
YNIWCNVRGK TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY 

       310        320        330        340        350        360 
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF FSGHLLQDCV 

       370        380        390        400        410 
QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM WKDSPKSSKS IKFIPVST 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor."
Thibonnier M., Auzan C., Madhun Z., Wilkins P., Berti-Mattera L., Clauser E.
J. Biol. Chem. 269:3304-3310(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor."
Hirasawa A., Shibata K., Kotosai K., Tsujimoto G.
Biochem. Biophys. Res. Commun. 203:72-79(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma."
North W.G., Fay M.J., Longo K.A., Du J.
Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[4]"Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
North W.G., Fay M.J., Longo K.A., Du J.
Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[7]"Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism."
Kim S.J., Young L.J., Gonen D., Veenstra-VanderWeele J., Courchesne R., Courchesne E., Lord C., Leventhal B.L., Cook E.H. Jr., Insel T.R.
Mol. Psychiatry 7:503-507(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ROLE IN SOCIAL BEHAVIOR.
[8]"A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein."
Adikesavan N.V., Mahmood S.S., Stanley N., Xu Z., Wu N., Thibonnier M., Shoham M.
Acta Crystallogr. F 61:341-345(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 362-418.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L25615 mRNA. Translation: AAA62271.1.
U19906 Genomic DNA. Translation: AAB19232.1.
S73899 mRNA. Translation: AAC60638.1.
AF030625 mRNA. Translation: AAC51861.1.
AF101725 mRNA. Translation: AAD17891.1.
AY322550 mRNA. Translation: AAP84363.1.
BC074803 mRNA. Translation: AAH74803.1.
BC074804 mRNA. Translation: AAH74804.1.
PIRA53046.
RefSeqNP_000697.1. NM_000706.4.
UniGeneHs.2131.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YTVX-ray1.80M/N362-418[»]
ProteinModelPortalP37288.
SMRP37288. Positions 43-367.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107033. 2 interactions.
IntActP37288. 2 interactions.
STRING9606.ENSP00000299178.

Chemistry

BindingDBP37288.
ChEMBLCHEMBL1889.
DrugBankDB00872. Conivaptan.
DB00035. Desmopressin.
DB00093. Felypressin.
DB02638. Terlipressin.
DB00067. Vasopressin.
GuidetoPHARMACOLOGY366.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP37288.

Polymorphism databases

DMDM586197.

Proteomic databases

PaxDbP37288.
PRIDEP37288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299178; ENSP00000299178; ENSG00000166148.
GeneID552.
KEGGhsa:552.
UCSCuc001sro.2. human.

Organism-specific databases

CTD552.
GeneCardsGC12M063540.
H-InvDBHIX0171663.
HGNCHGNC:895. AVPR1A.
MIM600821. gene.
neXtProtNX_P37288.
PharmGKBPA25187.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299951.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidP37288.
KOK04226.
OMAQLCWDIT.
PhylomeDBP37288.
TreeFamTF106499.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP37288.
BgeeP37288.
CleanExHS_AVPR1A.
GenevestigatorP37288.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP37288.
GeneWikiArginine_vasopressin_receptor_1A.
GenomeRNAi552.
NextBio2281.
PROP37288.
SOURCESearch...

Entry information

Entry nameV1AR_HUMAN
AccessionPrimary (citable) accession number: P37288
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries