Vasopressin V1a receptor - Homo sapiens (Human)

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P37288 (V1AR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 125. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Vasopressin V1a receptor
Short name=V1aR

Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor

Gene names

Name:	AVPR1A
Synonyms:	AVPR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Ref.7
Subcellular location	Cell membrane; Multi-pass membrane protein.
Miscellaneous	Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Traceable author statement Ref.1. Source: ProtInc blood circulation Traceable author statement Ref.1. Source: ProtInc calcium-mediated signaling Inferred from electronic annotation. Source: Compara cellular response to water deprivation Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Traceable author statement Ref.1. Source: ProtInc generation of precursor metabolites and energy Traceable author statement Ref.1. Source: ProtInc grooming behavior Inferred from electronic annotation. Source: Compara maternal aggressive behavior Inferred from electronic annotation. Source: Compara maternal behavior Inferred from electronic annotation. Source: Compara myotube differentiation Inferred from electronic annotation. Source: Compara negative regulation of female receptivity Inferred from electronic annotation. Source: Compara negative regulation of transmission of nerve impulse Inferred from electronic annotation. Source: Compara penile erection Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cellular pH reduction Inferred from electronic annotation. Source: Compara positive regulation of glutamate secretion Inferred from electronic annotation. Source: Compara positive regulation of heart rate Inferred from electronic annotation. Source: Compara positive regulation of prostaglandin biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara positive regulation of vasoconstriction Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by vasopressin Inferred from electronic annotation. Source: Compara response to corticosterone stimulus Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara sperm ejaculation Inferred from electronic annotation. Source: Compara telencephalon development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasmic vesicle Inferred from electronic annotation. Source: Compara endosome Traceable author statement PubMed 10858434. Source: ProtInc integral to plasma membrane Traceable author statement PubMed 8838314. Source: ProtInc
Molecular_function	peptide hormone binding Inferred from electronic annotation. Source: Compara protein kinase C binding Traceable author statement PubMed 10858434. Source: ProtInc vasopressin receptor activity Traceable author statement PubMed 10858434. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 418

418

Vasopressin V1a receptor

PRO_0000070197

Regions

Topological domain

1 – 52

Extracellular Potential

Transmembrane

53 – 76

Helical; Name=1; Potential

Topological domain

77 – 88

Cytoplasmic Potential

Transmembrane

89 – 110

Helical; Name=2; Potential

Topological domain

111 – 125

Extracellular Potential

Transmembrane

126 – 147

Helical; Name=3; Potential

Topological domain

148 – 168

Cytoplasmic Potential

Transmembrane

169 – 190

Helical; Name=4; Potential

Topological domain

191 – 218

Extracellular Potential

Transmembrane

219 – 239

Helical; Name=5; Potential

Topological domain

240 – 293

Cytoplasmic Potential

Transmembrane

294 – 313

Helical; Name=6; Potential

Topological domain

314 – 331

Extracellular Potential

Transmembrane

332 – 351

Helical; Name=7; Potential

Topological domain

352 – 418

Cytoplasmic Potential

Amino acid modifications

Modified residue

404

Phosphoserine By similarity

Lipidation

365

S-palmitoyl cysteine By similarity

Lipidation

366

S-palmitoyl cysteine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

196

N-linked (GlcNAc...) Potential

Disulfide bond

124 ↔ 203

By similarity

Natural variations

Natural variant

G → S.
Corresponds to variant rs2228154 [ dbSNP | Ensembl ].

VAR_022065

Sequences

Sequence

Length

Mass (Da)

Tools

P37288 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 477D4260EC826561
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FASTA

418

46,800

        10         20         30         40         50         60 
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL AKLEIAVLAV 

        70         80         90        100        110        120 
TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQMC WDITYRFRGP 

       130        140        150        160        170        180 
DWLCRVVKHL QVFGMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAAAWVLSFV 

       190        200        210        220        230        240 
LSTPQYFVFS MIEVNNVTKA RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC 

       250        260        270        280        290        300 
YNIWCNVRGK TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY 

       310        320        330        340        350        360 
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF FSGHLLQDCV 

       370        380        390        400        410 
QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM WKDSPKSSKS IKFIPVST

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor." Thibonnier M., Auzan C., Madhun Z., Wilkins P., Berti-Mattera L., Clauser E. J. Biol. Chem. 269:3304-3310(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor." Hirasawa A., Shibata K., Kotosai K., Tsujimoto G. Biochem. Biophys. Res. Commun. 203:72-79(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma." North W.G., Fay M.J., Longo K.A., Du J. Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[4]	"Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide." North W.G., Fay M.J., Longo K.A., Du J. Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[7]	"Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism." Kim S.J., Young L.J., Gonen D., Veenstra-VanderWeele J., Courchesne R., Courchesne E., Lord C., Leventhal B.L., Cook E.H. Jr., Insel T.R. Mol. Psychiatry 7:503-507(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ROLE IN SOCIAL BEHAVIOR.
[8]	"A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein." Adikesavan N.V., Mahmood S.S., Stanley N., Xu Z., Wu N., Thibonnier M., Shoham M. Acta Crystallogr. F 61:341-345(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 362-418.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L25615 mRNA. Translation: AAA62271.1.
U19906 Genomic DNA. Translation: AAB19232.1.
S73899 mRNA. Translation: AAC60638.1.
AF030625 mRNA. Translation: AAC51861.1.
AF101725 mRNA. Translation: AAD17891.1.
AY322550 mRNA. Translation: AAP84363.1.
BC074803 mRNA. Translation: AAH74803.1.
BC074804 mRNA. Translation: AAH74804.1.

IPI

IPI00020968.

PIR

A53046.

RefSeq

NP_000697.1. NM_000706.4.

UniGene

Hs.2131.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YTV	X-ray	1.80	M/N	362-418	[»]

ProteinModelPortal

P37288.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000299178.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P37288.

Polymorphism databases

DMDM

586197.

Proteomic databases

PaxDb

P37288.

PRIDE

P37288.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000299178; ENSP00000299178; ENSG00000166148.

GeneID

552.

KEGG

hsa:552.

UCSC

uc001sro.1. human.

Organism-specific databases

CTD

552.

GeneCards

GC12M063540.

H-InvDB

HIX0171663.

HGNC

HGNC:895. AVPR1A.

MIM

600821. gene.

neXtProt

NX_P37288.

PharmGKB

PA25187.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG299951.

HOGENOM

HOG000237331.

HOVERGEN

HBG105710.

InParanoid

P37288.

K04226.

OMA

QLCWDIT.

OrthoDB

EOG4KSPJT.

PhylomeDB

P37288.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P37288.

Bgee

P37288.

CleanEx

HS_AVPR1A.

Genevestigator

P37288.

GermOnline

ENSG00000166148. Homo sapiens.

Family and domain databases

InterPro

IPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P37288.

ChEMBL

CHEMBL1889.

DrugBank

DB00872. Conivaptan.
DB00035. Desmopressin.
DB00093. Felypressin.
DB02638. Terlipressin.
DB00067. Vasopressin.

EvolutionaryTrace

P37288.

GenomeRNAi

552.

NextBio

2281.

SOURCE

Search...

Entry information

Entry name

V1AR_HUMAN

Accession

Primary (citable) accession number: P37288

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 1, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.