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P37288

- V1AR_HUMAN

UniProt

P37288 - V1AR_HUMAN

Protein

Vasopressin V1a receptor

Gene

AVPR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.1 Publication

    GO - Molecular functioni

    1. peptide hormone binding Source: Ensembl
    2. protein binding Source: UniProtKB
    3. protein kinase C binding Source: ProtInc
    4. vasopressin receptor activity Source: ProtInc

    GO - Biological processi

    1. activation of phospholipase C activity Source: ProtInc
    2. blood circulation Source: ProtInc
    3. calcium-mediated signaling Source: Ensembl
    4. cellular response to water deprivation Source: Ensembl
    5. generation of precursor metabolites and energy Source: ProtInc
    6. G-protein coupled receptor signaling pathway Source: ProtInc
    7. grooming behavior Source: Ensembl
    8. maternal aggressive behavior Source: Ensembl
    9. maternal behavior Source: Ensembl
    10. myotube differentiation Source: Ensembl
    11. negative regulation of female receptivity Source: Ensembl
    12. negative regulation of transmission of nerve impulse Source: Ensembl
    13. penile erection Source: Ensembl
    14. positive regulation of cell growth Source: Ensembl
    15. positive regulation of cell proliferation Source: Ensembl
    16. positive regulation of cellular pH reduction Source: Ensembl
    17. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    18. positive regulation of glutamate secretion Source: Ensembl
    19. positive regulation of heart rate Source: Ensembl
    20. positive regulation of prostaglandin biosynthetic process Source: Ensembl
    21. positive regulation of renal sodium excretion Source: Ensembl
    22. positive regulation of systemic arterial blood pressure Source: Ensembl
    23. positive regulation of vasoconstriction Source: Ensembl
    24. regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
    25. response to corticosterone Source: Ensembl
    26. social behavior Source: Ensembl
    27. sperm ejaculation Source: Ensembl
    28. telencephalon development Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V1a receptor
    Short name:
    V1aR
    Alternative name(s):
    AVPR V1a
    Antidiuretic hormone receptor 1a
    Vascular/hepatic-type arginine vasopressin receptor
    Gene namesi
    Name:AVPR1A
    Synonyms:AVPR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:895. AVPR1A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. endosome Source: ProtInc
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25187.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Vasopressin V1a receptorPRO_0000070197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 203PROSITE-ProRule annotation
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Lipidationi365 – 3651S-palmitoyl cysteineBy similarity
    Lipidationi366 – 3661S-palmitoyl cysteineBy similarity
    Modified residuei404 – 4041PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP37288.
    PRIDEiP37288.

    PTM databases

    PhosphoSiteiP37288.

    Expressioni

    Gene expression databases

    ArrayExpressiP37288.
    BgeeiP37288.
    CleanExiHS_AVPR1A.
    GenevestigatoriP37288.

    Interactioni

    Protein-protein interaction databases

    BioGridi107033. 2 interactions.
    IntActiP37288. 2 interactions.
    STRINGi9606.ENSP00000299178.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YTVX-ray1.80M/N362-418[»]
    ProteinModelPortaliP37288.
    SMRiP37288. Positions 43-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP37288.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 8812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 16821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 21828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 29354CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini314 – 33118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini352 – 41867CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7624Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 11022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 19022Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei294 – 31320Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiP37288.
    KOiK04226.
    OMAiQLCWDIT.
    PhylomeDBiP37288.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR001224. Vprs_V1A_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00752. VASOPRSNV1AR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37288-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL    50
    AKLEIAVLAV TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV 100
    AFFQVLPQMC WDITYRFRGP DWLCRVVKHL QVFGMFASAY MLVVMTADRY 150
    IAVCHPLKTL QQPARRSRLM IAAAWVLSFV LSTPQYFVFS MIEVNNVTKA 200
    RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC YNIWCNVRGK 250
    TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY 300
    IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF 350
    FSGHLLQDCV QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM 400
    WKDSPKSSKS IKFIPVST 418
    Length:418
    Mass (Da):46,800
    Last modified:October 1, 1994 - v1
    Checksum:i477D4260EC826561
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61G → S.
    Corresponds to variant rs2228154 [ dbSNP | Ensembl ].
    VAR_022065

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25615 mRNA. Translation: AAA62271.1.
    U19906 Genomic DNA. Translation: AAB19232.1.
    S73899 mRNA. Translation: AAC60638.1.
    AF030625 mRNA. Translation: AAC51861.1.
    AF101725 mRNA. Translation: AAD17891.1.
    AY322550 mRNA. Translation: AAP84363.1.
    BC074803 mRNA. Translation: AAH74803.1.
    BC074804 mRNA. Translation: AAH74804.1.
    CCDSiCCDS8965.1.
    PIRiA53046.
    RefSeqiNP_000697.1. NM_000706.4.
    UniGeneiHs.2131.

    Genome annotation databases

    EnsembliENST00000299178; ENSP00000299178; ENSG00000166148.
    GeneIDi552.
    KEGGihsa:552.
    UCSCiuc001sro.2. human.

    Polymorphism databases

    DMDMi586197.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25615 mRNA. Translation: AAA62271.1 .
    U19906 Genomic DNA. Translation: AAB19232.1 .
    S73899 mRNA. Translation: AAC60638.1 .
    AF030625 mRNA. Translation: AAC51861.1 .
    AF101725 mRNA. Translation: AAD17891.1 .
    AY322550 mRNA. Translation: AAP84363.1 .
    BC074803 mRNA. Translation: AAH74803.1 .
    BC074804 mRNA. Translation: AAH74804.1 .
    CCDSi CCDS8965.1.
    PIRi A53046.
    RefSeqi NP_000697.1. NM_000706.4.
    UniGenei Hs.2131.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YTV X-ray 1.80 M/N 362-418 [» ]
    ProteinModelPortali P37288.
    SMRi P37288. Positions 43-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107033. 2 interactions.
    IntActi P37288. 2 interactions.
    STRINGi 9606.ENSP00000299178.

    Chemistry

    BindingDBi P37288.
    ChEMBLi CHEMBL2363078.
    DrugBanki DB00872. Conivaptan.
    DB00035. Desmopressin.
    DB00093. Felypressin.
    DB02638. Terlipressin.
    DB00067. Vasopressin.
    GuidetoPHARMACOLOGYi 366.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P37288.

    Polymorphism databases

    DMDMi 586197.

    Proteomic databases

    PaxDbi P37288.
    PRIDEi P37288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299178 ; ENSP00000299178 ; ENSG00000166148 .
    GeneIDi 552.
    KEGGi hsa:552.
    UCSCi uc001sro.2. human.

    Organism-specific databases

    CTDi 552.
    GeneCardsi GC12M063540.
    H-InvDB HIX0171663.
    HGNCi HGNC:895. AVPR1A.
    MIMi 600821. gene.
    neXtProti NX_P37288.
    PharmGKBi PA25187.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299951.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi P37288.
    KOi K04226.
    OMAi QLCWDIT.
    PhylomeDBi P37288.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P37288.
    GeneWikii Arginine_vasopressin_receptor_1A.
    GenomeRNAii 552.
    NextBioi 2281.
    PROi P37288.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P37288.
    Bgeei P37288.
    CleanExi HS_AVPR1A.
    Genevestigatori P37288.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR001224. Vprs_V1A_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00752. VASOPRSNV1AR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor."
      Thibonnier M., Auzan C., Madhun Z., Wilkins P., Berti-Mattera L., Clauser E.
      J. Biol. Chem. 269:3304-3310(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor."
      Hirasawa A., Shibata K., Kotosai K., Tsujimoto G.
      Biochem. Biophys. Res. Commun. 203:72-79(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma."
      North W.G., Fay M.J., Longo K.A., Du J.
      Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    4. "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
      North W.G., Fay M.J., Longo K.A., Du J.
      Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. "Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism."
      Kim S.J., Young L.J., Gonen D., Veenstra-VanderWeele J., Courchesne R., Courchesne E., Lord C., Leventhal B.L., Cook E.H. Jr., Insel T.R.
      Mol. Psychiatry 7:503-507(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE IN SOCIAL BEHAVIOR.
    8. "A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein."
      Adikesavan N.V., Mahmood S.S., Stanley N., Xu Z., Wu N., Thibonnier M., Shoham M.
      Acta Crystallogr. F 61:341-345(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 362-418.

    Entry informationi

    Entry nameiV1AR_HUMAN
    AccessioniPrimary (citable) accession number: P37288
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3