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Protein

Vasopressin V1a receptor

Gene

AVPR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.1 Publication

GO - Molecular functioni

  1. peptide binding Source: GO_Central
  2. peptide hormone binding Source: Ensembl
  3. protein kinase C binding Source: ProtInc
  4. vasopressin receptor activity Source: ProtInc

GO - Biological processi

  1. activation of phospholipase C activity Source: ProtInc
  2. blood circulation Source: ProtInc
  3. calcium-mediated signaling Source: Ensembl
  4. cellular response to hormone stimulus Source: GO_Central
  5. cellular response to water deprivation Source: Ensembl
  6. generation of precursor metabolites and energy Source: ProtInc
  7. G-protein coupled receptor signaling pathway Source: ProtInc
  8. grooming behavior Source: Ensembl
  9. maternal aggressive behavior Source: Ensembl
  10. maternal behavior Source: GO_Central
  11. myotube differentiation Source: Ensembl
  12. negative regulation of female receptivity Source: Ensembl
  13. negative regulation of transmission of nerve impulse Source: Ensembl
  14. penile erection Source: Ensembl
  15. positive regulation of cell growth Source: Ensembl
  16. positive regulation of cell proliferation Source: Ensembl
  17. positive regulation of cellular pH reduction Source: Ensembl
  18. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  19. positive regulation of glutamate secretion Source: Ensembl
  20. positive regulation of heart rate Source: Ensembl
  21. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  22. positive regulation of renal sodium excretion Source: Ensembl
  23. positive regulation of systemic arterial blood pressure Source: Ensembl
  24. positive regulation of vasoconstriction Source: GO_Central
  25. regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  26. response to corticosterone Source: Ensembl
  27. response to peptide Source: GO_Central
  28. social behavior Source: Ensembl
  29. sperm ejaculation Source: Ensembl
  30. telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:AVPR1A
Synonyms:AVPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:895. AVPR1A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7624Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini77 – 8812CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei89 – 11022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini111 – 12515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14722Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini148 – 16821CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei169 – 19022Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini191 – 21828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini240 – 29354CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei294 – 31320Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini314 – 33118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei332 – 35120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini352 – 41867CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. endosome Source: ProtInc
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25187.

Chemistry

DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB00093. Felypressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.

Polymorphism and mutation databases

BioMutaiAVPR1A.
DMDMi586197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Vasopressin V1a receptorPRO_0000070197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 203PROSITE-ProRule annotation
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Lipidationi365 – 3651S-palmitoyl cysteineBy similarity
Lipidationi366 – 3661S-palmitoyl cysteineBy similarity
Modified residuei404 – 4041PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP37288.
PRIDEiP37288.

PTM databases

PhosphoSiteiP37288.

Expressioni

Gene expression databases

BgeeiP37288.
CleanExiHS_AVPR1A.
ExpressionAtlasiP37288. baseline and differential.
GenevestigatoriP37288.

Interactioni

Protein-protein interaction databases

BioGridi107033. 2 interactions.
IntActiP37288. 2 interactions.
STRINGi9606.ENSP00000299178.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YTVX-ray1.80M/N362-418[»]
ProteinModelPortaliP37288.
SMRiP37288. Positions 43-348.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37288.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP37288.
KOiK04226.
OMAiTNSTGMW.
PhylomeDBiP37288.
TreeFamiTF106499.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL
60 70 80 90 100
AKLEIAVLAV TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQMC WDITYRFRGP DWLCRVVKHL QVFGMFASAY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAAAWVLSFV LSTPQYFVFS MIEVNNVTKA
210 220 230 240 250
RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC YNIWCNVRGK
260 270 280 290 300
TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY
310 320 330 340 350
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF
360 370 380 390 400
FSGHLLQDCV QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM
410
WKDSPKSSKS IKFIPVST
Length:418
Mass (Da):46,800
Last modified:October 1, 1994 - v1
Checksum:i477D4260EC826561
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61G → S.
Corresponds to variant rs2228154 [ dbSNP | Ensembl ].
VAR_022065

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25615 mRNA. Translation: AAA62271.1.
U19906 Genomic DNA. Translation: AAB19232.1.
S73899 mRNA. Translation: AAC60638.1.
AF030625 mRNA. Translation: AAC51861.1.
AF101725 mRNA. Translation: AAD17891.1.
AY322550 mRNA. Translation: AAP84363.1.
BC074803 mRNA. Translation: AAH74803.1.
BC074804 mRNA. Translation: AAH74804.1.
CCDSiCCDS8965.1.
PIRiA53046.
RefSeqiNP_000697.1. NM_000706.4.
UniGeneiHs.2131.

Genome annotation databases

EnsembliENST00000299178; ENSP00000299178; ENSG00000166148.
GeneIDi552.
KEGGihsa:552.
UCSCiuc001sro.2. human.

Polymorphism and mutation databases

BioMutaiAVPR1A.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25615 mRNA. Translation: AAA62271.1.
U19906 Genomic DNA. Translation: AAB19232.1.
S73899 mRNA. Translation: AAC60638.1.
AF030625 mRNA. Translation: AAC51861.1.
AF101725 mRNA. Translation: AAD17891.1.
AY322550 mRNA. Translation: AAP84363.1.
BC074803 mRNA. Translation: AAH74803.1.
BC074804 mRNA. Translation: AAH74804.1.
CCDSiCCDS8965.1.
PIRiA53046.
RefSeqiNP_000697.1. NM_000706.4.
UniGeneiHs.2131.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YTVX-ray1.80M/N362-418[»]
ProteinModelPortaliP37288.
SMRiP37288. Positions 43-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107033. 2 interactions.
IntActiP37288. 2 interactions.
STRINGi9606.ENSP00000299178.

Chemistry

BindingDBiP37288.
ChEMBLiCHEMBL2363078.
DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB00093. Felypressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi366.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP37288.

Polymorphism and mutation databases

BioMutaiAVPR1A.
DMDMi586197.

Proteomic databases

PaxDbiP37288.
PRIDEiP37288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299178; ENSP00000299178; ENSG00000166148.
GeneIDi552.
KEGGihsa:552.
UCSCiuc001sro.2. human.

Organism-specific databases

CTDi552.
GeneCardsiGC12M063540.
H-InvDBHIX0171663.
HGNCiHGNC:895. AVPR1A.
MIMi600821. gene.
neXtProtiNX_P37288.
PharmGKBiPA25187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299951.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP37288.
KOiK04226.
OMAiTNSTGMW.
PhylomeDBiP37288.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTraceiP37288.
GeneWikiiArginine_vasopressin_receptor_1A.
GenomeRNAii552.
NextBioi2281.
PROiP37288.
SOURCEiSearch...

Gene expression databases

BgeeiP37288.
CleanExiHS_AVPR1A.
ExpressionAtlasiP37288. baseline and differential.
GenevestigatoriP37288.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor."
    Thibonnier M., Auzan C., Madhun Z., Wilkins P., Berti-Mattera L., Clauser E.
    J. Biol. Chem. 269:3304-3310(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor."
    Hirasawa A., Shibata K., Kotosai K., Tsujimoto G.
    Biochem. Biophys. Res. Commun. 203:72-79(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma."
    North W.G., Fay M.J., Longo K.A., Du J.
    Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  4. "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
    North W.G., Fay M.J., Longo K.A., Du J.
    Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism."
    Kim S.J., Young L.J., Gonen D., Veenstra-VanderWeele J., Courchesne R., Courchesne E., Lord C., Leventhal B.L., Cook E.H. Jr., Insel T.R.
    Mol. Psychiatry 7:503-507(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN SOCIAL BEHAVIOR.
  8. "A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein."
    Adikesavan N.V., Mahmood S.S., Stanley N., Xu Z., Wu N., Thibonnier M., Shoham M.
    Acta Crystallogr. F 61:341-345(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 362-418.

Entry informationi

Entry nameiV1AR_HUMAN
AccessioniPrimary (citable) accession number: P37288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 29, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.