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P37288

- V1AR_HUMAN

UniProt

P37288 - V1AR_HUMAN

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Protein
Vasopressin V1a receptor
Gene
AVPR1A, AVPR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.1 Publication

GO - Molecular functioni

  1. peptide hormone binding Source: Ensembl
  2. protein binding Source: UniProtKB
  3. protein kinase C binding Source: ProtInc
  4. vasopressin receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. activation of phospholipase C activity Source: ProtInc
  3. blood circulation Source: ProtInc
  4. calcium-mediated signaling Source: Ensembl
  5. cellular response to water deprivation Source: Ensembl
  6. generation of precursor metabolites and energy Source: ProtInc
  7. grooming behavior Source: Ensembl
  8. maternal aggressive behavior Source: Ensembl
  9. maternal behavior Source: Ensembl
  10. myotube differentiation Source: Ensembl
  11. negative regulation of female receptivity Source: Ensembl
  12. negative regulation of transmission of nerve impulse Source: Ensembl
  13. penile erection Source: Ensembl
  14. positive regulation of cell growth Source: Ensembl
  15. positive regulation of cell proliferation Source: Ensembl
  16. positive regulation of cellular pH reduction Source: Ensembl
  17. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  18. positive regulation of glutamate secretion Source: Ensembl
  19. positive regulation of heart rate Source: Ensembl
  20. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  21. positive regulation of renal sodium excretion Source: Ensembl
  22. positive regulation of systemic arterial blood pressure Source: Ensembl
  23. positive regulation of vasoconstriction Source: Ensembl
  24. regulation of systemic arterial blood pressure by vasopressin Source: Ensembl
  25. response to corticosterone Source: Ensembl
  26. social behavior Source: Ensembl
  27. sperm ejaculation Source: Ensembl
  28. telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:AVPR1A
Synonyms:AVPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:895. AVPR1A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252Extracellular Reviewed prediction
Add
BLAST
Transmembranei53 – 7624Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini77 – 8812Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei89 – 11022Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini111 – 12515Extracellular Reviewed prediction
Add
BLAST
Transmembranei126 – 14722Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini148 – 16821Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei169 – 19022Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini191 – 21828Extracellular Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini240 – 29354Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei294 – 31320Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini314 – 33118Extracellular Reviewed prediction
Add
BLAST
Transmembranei332 – 35120Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini352 – 41867Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. endosome Source: ProtInc
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Vasopressin V1a receptor
PRO_0000070197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi124 ↔ 203 By similarity
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Lipidationi365 – 3651S-palmitoyl cysteine By similarity
Lipidationi366 – 3661S-palmitoyl cysteine By similarity
Modified residuei404 – 4041Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP37288.
PRIDEiP37288.

PTM databases

PhosphoSiteiP37288.

Expressioni

Gene expression databases

ArrayExpressiP37288.
BgeeiP37288.
CleanExiHS_AVPR1A.
GenevestigatoriP37288.

Interactioni

Protein-protein interaction databases

BioGridi107033. 2 interactions.
IntActiP37288. 2 interactions.
STRINGi9606.ENSP00000299178.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YTVX-ray1.80M/N362-418[»]
ProteinModelPortaliP37288.
SMRiP37288. Positions 43-348.

Miscellaneous databases

EvolutionaryTraceiP37288.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP37288.
KOiK04226.
OMAiQLCWDIT.
PhylomeDBiP37288.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37288-1 [UniParc]FASTAAdd to Basket

« Hide

MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL    50
AKLEIAVLAV TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV 100
AFFQVLPQMC WDITYRFRGP DWLCRVVKHL QVFGMFASAY MLVVMTADRY 150
IAVCHPLKTL QQPARRSRLM IAAAWVLSFV LSTPQYFVFS MIEVNNVTKA 200
RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC YNIWCNVRGK 250
TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY 300
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF 350
FSGHLLQDCV QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM 400
WKDSPKSSKS IKFIPVST 418
Length:418
Mass (Da):46,800
Last modified:October 1, 1994 - v1
Checksum:i477D4260EC826561
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61G → S.
Corresponds to variant rs2228154 [ dbSNP | Ensembl ].
VAR_022065

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25615 mRNA. Translation: AAA62271.1.
U19906 Genomic DNA. Translation: AAB19232.1.
S73899 mRNA. Translation: AAC60638.1.
AF030625 mRNA. Translation: AAC51861.1.
AF101725 mRNA. Translation: AAD17891.1.
AY322550 mRNA. Translation: AAP84363.1.
BC074803 mRNA. Translation: AAH74803.1.
BC074804 mRNA. Translation: AAH74804.1.
CCDSiCCDS8965.1.
PIRiA53046.
RefSeqiNP_000697.1. NM_000706.4.
UniGeneiHs.2131.

Genome annotation databases

EnsembliENST00000299178; ENSP00000299178; ENSG00000166148.
GeneIDi552.
KEGGihsa:552.
UCSCiuc001sro.2. human.

Polymorphism databases

DMDMi586197.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25615 mRNA. Translation: AAA62271.1 .
U19906 Genomic DNA. Translation: AAB19232.1 .
S73899 mRNA. Translation: AAC60638.1 .
AF030625 mRNA. Translation: AAC51861.1 .
AF101725 mRNA. Translation: AAD17891.1 .
AY322550 mRNA. Translation: AAP84363.1 .
BC074803 mRNA. Translation: AAH74803.1 .
BC074804 mRNA. Translation: AAH74804.1 .
CCDSi CCDS8965.1.
PIRi A53046.
RefSeqi NP_000697.1. NM_000706.4.
UniGenei Hs.2131.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YTV X-ray 1.80 M/N 362-418 [» ]
ProteinModelPortali P37288.
SMRi P37288. Positions 43-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107033. 2 interactions.
IntActi P37288. 2 interactions.
STRINGi 9606.ENSP00000299178.

Chemistry

BindingDBi P37288.
ChEMBLi CHEMBL2363078.
DrugBanki DB00872. Conivaptan.
DB00035. Desmopressin.
DB00093. Felypressin.
DB02638. Terlipressin.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi 366.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P37288.

Polymorphism databases

DMDMi 586197.

Proteomic databases

PaxDbi P37288.
PRIDEi P37288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299178 ; ENSP00000299178 ; ENSG00000166148 .
GeneIDi 552.
KEGGi hsa:552.
UCSCi uc001sro.2. human.

Organism-specific databases

CTDi 552.
GeneCardsi GC12M063540.
H-InvDB HIX0171663.
HGNCi HGNC:895. AVPR1A.
MIMi 600821. gene.
neXtProti NX_P37288.
PharmGKBi PA25187.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299951.
HOGENOMi HOG000237331.
HOVERGENi HBG105710.
InParanoidi P37288.
KOi K04226.
OMAi QLCWDIT.
PhylomeDBi P37288.
TreeFami TF106499.

Enzyme and pathway databases

Reactomei REACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P37288.
GeneWikii Arginine_vasopressin_receptor_1A.
GenomeRNAii 552.
NextBioi 2281.
PROi P37288.
SOURCEi Search...

Gene expression databases

ArrayExpressi P37288.
Bgeei P37288.
CleanExi HS_AVPR1A.
Genevestigatori P37288.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor."
    Thibonnier M., Auzan C., Madhun Z., Wilkins P., Berti-Mattera L., Clauser E.
    J. Biol. Chem. 269:3304-3310(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor."
    Hirasawa A., Shibata K., Kotosai K., Tsujimoto G.
    Biochem. Biophys. Res. Commun. 203:72-79(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma."
    North W.G., Fay M.J., Longo K.A., Du J.
    Peptides 18:985-993(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  4. "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide."
    North W.G., Fay M.J., Longo K.A., Du J.
    Cancer Res. 58:1866-1871(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism."
    Kim S.J., Young L.J., Gonen D., Veenstra-VanderWeele J., Courchesne R., Courchesne E., Lord C., Leventhal B.L., Cook E.H. Jr., Insel T.R.
    Mol. Psychiatry 7:503-507(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN SOCIAL BEHAVIOR.
  8. "A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein."
    Adikesavan N.V., Mahmood S.S., Stanley N., Xu Z., Wu N., Thibonnier M., Shoham M.
    Acta Crystallogr. F 61:341-345(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 362-418.

Entry informationi

Entry nameiV1AR_HUMAN
AccessioniPrimary (citable) accession number: P37288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 3, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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