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Protein

Vasopressin V1a receptor

Gene

AVPR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.1 Publication

GO - Molecular functioni

  • peptide binding Source: GO_Central
  • peptide hormone binding Source: Ensembl
  • protein kinase C binding Source: ProtInc
  • vasopressin receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166148-MONOMER.
ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:AVPR1A
Synonyms:AVPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:895. AVPR1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 76Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini77 – 88CytoplasmicSequence analysisAdd BLAST12
Transmembranei89 – 110Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini111 – 125ExtracellularSequence analysisAdd BLAST15
Transmembranei126 – 147Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini148 – 168CytoplasmicSequence analysisAdd BLAST21
Transmembranei169 – 190Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini191 – 218ExtracellularSequence analysisAdd BLAST28
Transmembranei219 – 239Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini240 – 293CytoplasmicSequence analysisAdd BLAST54
Transmembranei294 – 313Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini314 – 331ExtracellularSequence analysisAdd BLAST18
Transmembranei332 – 351Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini352 – 418CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

  • cytoplasmic vesicle Source: Ensembl
  • endosome Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi552.
OpenTargetsiENSG00000166148.
PharmGKBiPA25187.

Chemistry databases

ChEMBLiCHEMBL1889.
DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB00093. Felypressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi366.

Polymorphism and mutation databases

BioMutaiAVPR1A.
DMDMi586197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701971 – 418Vasopressin V1a receptorAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 203PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Lipidationi365S-palmitoyl cysteineBy similarity1
Lipidationi366S-palmitoyl cysteineBy similarity1
Modified residuei404PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP37288.
PRIDEiP37288.

PTM databases

iPTMnetiP37288.
PhosphoSitePlusiP37288.

Expressioni

Gene expression databases

BgeeiENSG00000166148.
CleanExiHS_AVPR1A.
ExpressionAtlasiP37288. baseline and differential.
GenevisibleiP37288. HS.

Interactioni

GO - Molecular functioni

  • protein kinase C binding Source: ProtInc

Protein-protein interaction databases

BioGridi107033. 2 interactors.
IntActiP37288. 2 interactors.
STRINGi9606.ENSP00000299178.

Chemistry databases

BindingDBiP37288.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YTVX-ray1.80M/N362-418[»]
ProteinModelPortaliP37288.
SMRiP37288.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37288.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP37288.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.
PhylomeDBiP37288.
TreeFamiTF106499.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL
60 70 80 90 100
AKLEIAVLAV TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQMC WDITYRFRGP DWLCRVVKHL QVFGMFASAY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAAAWVLSFV LSTPQYFVFS MIEVNNVTKA
210 220 230 240 250
RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC YNIWCNVRGK
260 270 280 290 300
TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY
310 320 330 340 350
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF
360 370 380 390 400
FSGHLLQDCV QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM
410
WKDSPKSSKS IKFIPVST
Length:418
Mass (Da):46,800
Last modified:October 1, 1994 - v1
Checksum:i477D4260EC826561
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0220656G → S.Corresponds to variant rs2228154dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25615 mRNA. Translation: AAA62271.1.
U19906 Genomic DNA. Translation: AAB19232.1.
S73899 mRNA. Translation: AAC60638.1.
AF030625 mRNA. Translation: AAC51861.1.
AF101725 mRNA. Translation: AAD17891.1.
AY322550 mRNA. Translation: AAP84363.1.
BC074803 mRNA. Translation: AAH74803.1.
BC074804 mRNA. Translation: AAH74804.1.
CCDSiCCDS8965.1.
PIRiA53046.
RefSeqiNP_000697.1. NM_000706.4.
UniGeneiHs.2131.

Genome annotation databases

EnsembliENST00000299178; ENSP00000299178; ENSG00000166148.
GeneIDi552.
KEGGihsa:552.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25615 mRNA. Translation: AAA62271.1.
U19906 Genomic DNA. Translation: AAB19232.1.
S73899 mRNA. Translation: AAC60638.1.
AF030625 mRNA. Translation: AAC51861.1.
AF101725 mRNA. Translation: AAD17891.1.
AY322550 mRNA. Translation: AAP84363.1.
BC074803 mRNA. Translation: AAH74803.1.
BC074804 mRNA. Translation: AAH74804.1.
CCDSiCCDS8965.1.
PIRiA53046.
RefSeqiNP_000697.1. NM_000706.4.
UniGeneiHs.2131.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YTVX-ray1.80M/N362-418[»]
ProteinModelPortaliP37288.
SMRiP37288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107033. 2 interactors.
IntActiP37288. 2 interactors.
STRINGi9606.ENSP00000299178.

Chemistry databases

BindingDBiP37288.
ChEMBLiCHEMBL1889.
DrugBankiDB00872. Conivaptan.
DB00035. Desmopressin.
DB00093. Felypressin.
DB02638. Terlipressin.
DB06212. Tolvaptan.
DB00067. Vasopressin.
GuidetoPHARMACOLOGYi366.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP37288.
PhosphoSitePlusiP37288.

Polymorphism and mutation databases

BioMutaiAVPR1A.
DMDMi586197.

Proteomic databases

PaxDbiP37288.
PRIDEiP37288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299178; ENSP00000299178; ENSG00000166148.
GeneIDi552.
KEGGihsa:552.

Organism-specific databases

CTDi552.
DisGeNETi552.
GeneCardsiAVPR1A.
H-InvDBHIX0171663.
HGNCiHGNC:895. AVPR1A.
MIMi600821. gene.
neXtProtiNX_P37288.
OpenTargetsiENSG00000166148.
PharmGKBiPA25187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP37288.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.
PhylomeDBiP37288.
TreeFamiTF106499.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166148-MONOMER.
ReactomeiR-HSA-388479. Vasopressin-like receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).

Miscellaneous databases

EvolutionaryTraceiP37288.
GeneWikiiArginine_vasopressin_receptor_1A.
GenomeRNAii552.
PROiP37288.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166148.
CleanExiHS_AVPR1A.
ExpressionAtlasiP37288. baseline and differential.
GenevisibleiP37288. HS.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1AR_HUMAN
AccessioniPrimary (citable) accession number: P37288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.