Cation-transporting ATPase PacS - Synechococcus elongatus (strain PCC 7942)

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P37279 (ATCS_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cation-transporting ATPase PacS
EC=3.6.3.-

Gene names

Name:	pacS
Ordered Locus Names:	Synpcc7942_1570
ORF Names:	sed0002

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a role in the osmotic adaptation.
Catalytic activity	ATP + H₂O = ADP + phosphate.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification] Contains 1 HMA domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 747

747

Cation-transporting ATPase PacS

PRO_0000046160

Regions

Topological domain

1 – 101

101

Cytoplasmic Potential

Transmembrane

102 – 122

Helical; Potential

Topological domain

123 – 132

Extracellular Potential

Transmembrane

133 – 151

Helical; Potential

Topological domain

152 – 158

Cytoplasmic Potential

Transmembrane

159 – 179

Helical; Potential

Topological domain

180 – 199

Extracellular Potential

Transmembrane

200 – 220

Helical; Potential

Topological domain

221 – 348

128

Cytoplasmic Potential

Transmembrane

349 – 371

Helical; Potential

Topological domain

372 – 378

Extracellular Potential

Transmembrane

379 – 396

Helical; Potential

Topological domain

397 – 688

292

Cytoplasmic Potential

Transmembrane

689 – 708

Helical; Potential

Topological domain

709 – 720

Extracellular Potential

Transmembrane

721 – 739

Helical; Potential

Topological domain

740 – 747

Cytoplasmic Potential

Domain

4 – 70

HMA

Sites

Active site

434

4-aspartylphosphate intermediate By similarity

Metal binding

Potential

Metal binding

Potential

Metal binding

634

Magnesium By similarity

Metal binding

638

Magnesium By similarity

Experimental info

Sequence conflict

366

V → L in BAA03907. Ref.1

Sequence conflict

386

L → M in BAA03907. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P37279 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: 125EFF764BEF17D9
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FASTA

747

79,700

        10         20         30         40         50         60 
MVNQQTLTLR GMGCAACAGR IEALIQALPG VQECSVNFGA EQAQVCYDPA LTQVAAIQAA 

        70         80         90        100        110        120 
IEAAGYHAFP LQDPWDNEVE AQERHRRARS QRQLAQRVWV SGLIASLLVI GSLPMMLGIS 

       130        140        150        160        170        180 
IPGIPMWLHH PGLQLGLTLP VLWAGRSFFI NAWKAFRQNT ATMDTLVAVG TGAAFLYSLA 

       190        200        210        220        230        240 
VTLFPQWLTR QGLPPDVYYE AIAVIIALLL LGRSLEERAK GQTSAAIRQL IGLQAKTARV 

       250        260        270        280        290        300 
LRQGQELTLP ITEVQVEDWV RVRPGEKVPV DGEVIDGRST VDESMVTGES LPVQKQVGDE 

       310        320        330        340        350        360 
VIGATLNKTG SLTIRATRVG RETFLAQIVQ LVQQAQASKA PIQRLADQVT GWFVPAVIAI 

       370        380        390        400        410        420 
AILTFVLWFN WIGNVTLALI TAVGVLIIAC PCALGLATPT SIMVGTGKGA EYGILIKSAE 

       430        440        450        460        470        480 
SLELAQTIQT VILDKTGTLT QGQPSVTDFL AIGDRDQQQT LLGWAASLEN YSEHPLAEAI 

       490        500        510        520        530        540 
VRYGEAQGIT LSTVTDFEAI PGSGVQGQVE GIWLQIGTQR WLGELGIETS ALQNQWEDWE 

       550        560        570        580        590        600 
AAGKTVVGVA ADGHLQAILS IADQLKPSSV AVVRSLQRLG LQVVMLTGDN RRTADAIAQA 

       610        620        630        640        650        660 
VGITQVLAEV RPDQKAAQVA QLQSRGQVVA MVGDGINDAP ALAQADVGIA IGTGTDVAIA 

       670        680        690        700        710        720 
ASDITLISGD LQGIVTAIQL SRATMTNIRQ NLFFAFIYNV AGIPIAAGIL YPLLGWLLSP 

       730        740 
MLAGAAMAFS SVSVVTNALR LRQFQPR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cyanobacterium, Synechococcus sp. PCC7942, possesses two distinct genes encoding cation-transporting P-type ATPases." Kanamaru K., Kashiwagi S., Mizuno T. FEBS Lett. 330:99-104(1993) [PubMed: 8370468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Synechococcus elongatus PCC7942 cosmid 6C3." Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A., Salinas I., McMurtry S., Golden S.S., Youderian P. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7942.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16437 Genomic DNA. Translation: BAA03907.1. AY120852 Genomic DNA. Translation: AAM82673.1. CP000100 Genomic DNA. Translation: ABB57600.1.
RefSeq	YP_400587.1. NC_007604.1.
3D structure databases
ProteinModelPortal	P37279.
SMR	P37279. Positions 226-335.
ModBase	Search...
Protein-protein interaction databases
STRING	P37279.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3774994.
GenomeReviews	Gene locus Synpcc7942_1570 in contig CP000100_GR.
KEGG	syf:Synpcc7942_1570.
PATRIC	23788531. VBISynElo51371_1789.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2217.
HOGENOM	HBG507745.
PhylomeDB	P37279.
ProtClustDB	CLSK2767371.
Enzyme and pathway databases
BioCyc	SYNEL:SYNPCC7942_1570-MONOMER.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K01533.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00943. CUATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 1 hit.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATCS_SYNE7

Accession

Primary (citable) accession number: P37279
Secondary accession number(s): Q8KPV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents