Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynein heavy chain, cytoplasmic

Gene

Dhc64C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1895 – 19028ATPSequence analysis
Nucleotide bindingi2210 – 22178ATPSequence analysis
Nucleotide bindingi2580 – 25878ATPSequence analysis
Nucleotide bindingi2922 – 29298ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • axo-dendritic transport Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • cellularization Source: FlyBase
  • centrosome cycle Source: FlyBase
  • centrosome localization Source: FlyBase
  • chitin-based cuticle development Source: FlyBase
  • cystoblast division Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • establishment of epithelial cell apical/basal polarity Source: FlyBase
  • establishment of Golgi localization Source: FlyBase
  • establishment of mitotic spindle localization Source: FlyBase
  • establishment or maintenance of epithelial cell apical/basal polarity Source: FlyBase
  • female germline ring canal formation Source: FlyBase
  • fusome organization Source: FlyBase
  • germarium-derived oocyte fate determination Source: FlyBase
  • germ-line cyst formation Source: FlyBase
  • intracellular mRNA localization Source: FlyBase
  • intracellular protein transport Source: FlyBase
  • maintenance of RNA location Source: FlyBase
  • melanotic encapsulation of foreign target Source: FlyBase
  • microtubule-based movement Source: FlyBase
  • mitochondrion distribution Source: FlyBase
  • mitochondrion transport along microtubule Source: FlyBase
  • mitotic nuclear division Source: FlyBase
  • mitotic spindle organization Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuroblast proliferation Source: FlyBase
  • oocyte nucleus migration involved in oocyte dorsal/ventral axis specification Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian fusome organization Source: FlyBase
  • pole cell formation Source: FlyBase
  • positive regulation of mitotic centrosome separation Source: FlyBase
  • positive regulation of neuron remodeling Source: FlyBase
  • protein localization to kinetochore Source: FlyBase
  • regulation of mitotic metaphase/anaphase transition Source: FlyBase
  • retrograde axonal transport Source: FlyBase
  • RNA transport Source: FlyBase
  • spindle organization Source: FlyBase
  • stress granule assembly Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain, cytoplasmic
Alternative name(s):
Dynein heavy chain, cytosolic
Short name:
DYHC
Gene namesi
Name:Dhc64C
Synonyms:cDhc
ORF Names:CG7507
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261797. Dhc64C.

Subcellular locationi

GO - Cellular componenti

  • axon cytoplasm Source: GOC
  • cell cortex Source: FlyBase
  • cytoplasm Source: FlyBase
  • cytoplasmic dynein complex Source: FlyBase
  • dynein complex Source: FlyBase
  • fusome Source: FlyBase
  • germline ring canal Source: FlyBase
  • Golgi apparatus Source: FlyBase
  • intracellular ribonucleoprotein complex Source: FlyBase
  • kinetochore Source: FlyBase
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 46394639Dynein heavy chain, cytoplasmicPRO_0000114636Add
BLAST

Proteomic databases

PaxDbiP37276.
PRIDEiP37276.

Expressioni

Gene expression databases

BgeeiP37276.
ExpressionAtlasiP37276. differential.
GenevisibleiP37276. DM.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi64049. 4 interactions.
DIPiDIP-59317N.
IntActiP37276. 4 interactions.
STRINGi7227.FBpp0304991.

Structurei

3D structure databases

ProteinModelPortaliP37276.
SMRiP37276. Positions 184-435, 1444-2382, 2917-2945, 3196-3826, 4034-4257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 18561856StemBy similarityAdd
BLAST
Regioni1857 – 2084228AAA 1By similarityAdd
BLAST
Regioni2166 – 2437272AAA 2By similarityAdd
BLAST
Regioni2541 – 2790250AAA 3By similarityAdd
BLAST
Regioni2884 – 3153270AAA 4By similarityAdd
BLAST
Regioni3189 – 3478290StalkBy similarityAdd
BLAST
Regioni3539 – 3768230AAA 5By similarityAdd
BLAST
Regioni3989 – 4205217AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili530 – 56536Sequence analysisAdd
BLAST
Coiled coili774 – 79421Sequence analysisAdd
BLAST
Coiled coili1264 – 1368105Sequence analysisAdd
BLAST
Coiled coili3189 – 326173Sequence analysisAdd
BLAST
Coiled coili3382 – 347897Sequence analysisAdd
BLAST
Coiled coili3723 – 378260Sequence analysisAdd
BLAST

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00760000118964.
InParanoidiP37276.
KOiK10413.
OrthoDBiEOG76471R.
PhylomeDBiP37276.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 3 hits.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 4 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P37276-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDSLENPDT SVDPIVNLSI ANYDAFANYL RKAVTILLPE DDVVPASLND
60 70 80 90 100
ALDDPVNQDT IRKFLSDPQV QALYVQRNCI KEDDSEQPAE GEDEKEQVTY
110 120 130 140 150
QISNDVHFTN SRMASLACIK RGLVVEADKS IHSQLRLINF SDGSPYETLH
160 170 180 190 200
AFISKSLAPY FKSYVKESGR ADRDGDKMAP SVEKKLAELE MGLLHLQQNI
210 220 230 240 250
DIPEITLTAH QTVNNVIRKC AEENRKAKVA DFGDKVEDSS FLNLLQNGVN
260 270 280 290 300
RWIAEIKKVT KLNRDPGSGT ALQEISFWLN LERALYRIQE KRESPEVALT
310 320 330 340 350
LDILKHGKRF HATVSFDTDT GLKQALATVA DYNPLMKDFP INDLLSATEL
360 370 380 390 400
EKIRPAVQQI FAHLRKVRNT KYPIQRCLKL IEAISRDLSQ QLLKVLGTRR
410 420 430 440 450
LMHIPFDEFE RVMNQCFEIF SCWDDEYDKL QGLLRDIVKK KRDEHLKMVW
460 470 480 490 500
RVSPAHKKLQ TRMEHMRKFR RQHEQLRTVI LRVLRPTKPA VGDDGNVVET
510 520 530 540 550
KQPYSLDAAD ANAIEEVNLA YENVKEVDCL DITKEGSEAW EAAVKRYEEK
560 570 580 590 600
IDRVETRITA HLRDQLGTAK NANEMFRIFS RFNALFVRPH IRGAIREYQT
610 620 630 640 650
QLIQRVKDDI EALHEKFKVQ YPQSKSCRLS SVRDLPPVAG SIIWARQIDN
660 670 680 690 700
QLTMYLKRVE DVLGKGWETH IEGQKLKADG DSFRAKLSIS DVFHEWARKV
710 720 730 740 750
QERNFGSTGR IFTIESTRSR IGRGNVLRLR VNFLPEIITL AKEVRNIKNL
760 770 780 790 800
GFRVPLTIVN KAHQANQIYP YAISLIESVR TYERTLEKIE DRASIVPLVA
810 820 830 840 850
GLRKDVLNLV SEGIGLIWES YKLDPYVIRL SECVTQFQEK VDDLLVVEEQ
860 870 880 890 900
LDVDVRSLET CPYSAATFVE ILSKIQHAVD DLSLRQYSNL SVWVTRLDEE
910 920 930 940 950
VEKKLALRLQ AGIQAWTEAL TGNKKEVDTS MDTDAPAQPT HKLGGDPQIQ
960 970 980 990 1000
NAVHEIRITN QQMYLYPSIE EARFQIMQQF FAWQAIVTSQ VRLQSTRYQV
1010 1020 1030 1040 1050
GLEKHVSQTY RNLLTKLPEG KILENAYGAI EQKVSEVRNY VDEWLRYQSL
1060 1070 1080 1090 1100
WDLQADMLYG RLGEDVNLWI KCLNDIKQSR TTFDTSDTRR AYGPIIIDYA
1110 1120 1130 1140 1150
KVQAKVTLKY DSWHKEALGK FGTLLGTEMT SFHSKVSKSR TDLEMQSIEA
1160 1170 1180 1190 1200
ASTSDAVSFI TYVQSLKKDM IAWDKQVEVF REAQRILERQ RFQFPNTWLH
1210 1220 1230 1240 1250
VDNIEGEWSA FNEIIKRKDT AIQTQVASLQ AKIVAEDKAV ETRTVDFLND
1260 1270 1280 1290 1300
WEKTKPTGGK IRPDDALQQL QIFESKYSRL KEERDNVVKA KEALELQESA
1310 1320 1330 1340 1350
VPNNSAERMN VALEELQDLR GVWSELSKVW TQIDETREKP WLSVQPRKLR
1360 1370 1380 1390 1400
QQLEAMMAQL KELPARLRMY ESYEYVKKLI QSYIKVNMLI VELKSDALKE
1410 1420 1430 1440 1450
RHWKQLTKQL RVNWVLSDLS LGQVWDVNLQ KNEGIVKDII LVAQGEMALE
1460 1470 1480 1490 1500
EFLKQVRESW QNYELDLINY QNKCRIIRGW DDLFNKVKEH INSVAAMKLS
1510 1520 1530 1540 1550
PYYKVFEEEA LTWEEKLNRI NALFDVWIDV QRRWVYLEGI FSGSADIKTL
1560 1570 1580 1590 1600
LPVETSRFQS ISSEFLGLMK KVTKSPKVMD VLNIPAVQRS LERLADLLGK
1610 1620 1630 1640 1650
IQKALGEYLE RERTSFPRFY FVGDEDLLEI IGNSKNIARL QKHFKKMFAG
1660 1670 1680 1690 1700
VAAILLNEEN NVILGISSRE GEEVHFMNPV STVEHPKINE WLSLVEKQMR
1710 1720 1730 1740 1750
FTLASLLAQA VQDIKQFRDG KIDPQAYMEW CDKYQAQIVV LAAQILWSED
1760 1770 1780 1790 1800
VESALQQASE NNQSKPMQRV LGNVESTLNV LADSVLQEQP PLRRRKLEHL
1810 1820 1830 1840 1850
INEFVHKRTV TRRLLNNGVT SPKSFQWLCE MRFYFDPRQT EVLQQLTIHM
1860 1870 1880 1890 1900
ANARFFYGFE YLGVQDRLVQ TPLTDRCYLT MTQALESRLG GSPFGPAGTG
1910 1920 1930 1940 1950
KTESVKALGN QLGRFVLVFN CDETFDFQAM GRIFVGLCQV GAWGCFDEFN
1960 1970 1980 1990 2000
RLEERMLSAC SQQIQTIQEA LKYEMDSNKE SITVELVGKQ VRVSPDMAIF
2010 2020 2030 2040 2050
ITMNPGYAGR SNLPDNLKKL FRSLAMTTPD RQLIAEVMLF SQGFRSAEKL
2060 2070 2080 2090 2100
ACKIVPFFKL CDEQLSNQSH YDFGLRALKS VLISAGNVKR DRIMKIKEQM
2110 2120 2130 2140 2150
KQRGDENIDE ASVAENLPEQ EILIQSVCET MVPKLVAEDI PLLFSLLSDV
2160 2170 2180 2190 2200
FPNVGYTRAE MKGLKEEIRK VCQEDYLVCG EGDEQGAAWM EKVLQLYQIS
2210 2220 2230 2240 2250
NLNHGLMMVG PSGSGKSTAW KTLLKALERF EGVEGVAHVI DPKAISKEAL
2260 2270 2280 2290 2300
YGVLDPNTRE WTDGLFTHIL RKIIDNVRGE INKRQWIIFD GDVDPEWVEN
2310 2320 2330 2340 2350
LNSVLDDNKL LTLPNGERLS LPPNVRVMFE VQDLKFATLA TVSRCGMVWF
2360 2370 2380 2390 2400
SEDVLSTEMI FENYLSRLRS IPLEDGDEDF VGVIKPAKDK EEEVSPSLQV
2410 2420 2430 2440 2450
QRDIALLLLP FFSADGIVVR TLEYAMDQEH IMDFTRLRAL SSLFSMLNQA
2460 2470 2480 2490 2500
ARNVLTFNAQ HPDFPCSADQ LEHYIPKALV YSVLWSFAGD AKLKVRIDLG
2510 2520 2530 2540 2550
DFVRSVTTVP LPGAAGAPII DYEVNMSGDW VPWSNKVPVI EVETHKVASP
2560 2570 2580 2590 2600
DIVVPTLDTV RHESLLYTWL AEHKPLVLCG PPGSGKTMTL FSALRALPDM
2610 2620 2630 2640 2650
EVVGLNFSSA TTPELLLKTF DHYCEYRKTP NGVVLSPVQI GKWLVLFCDE
2660 2670 2680 2690 2700
INLPDMDSYG TQRVISFLRQ LVEHKGFYRA SDQAWVSLER IQFVGACNPP
2710 2720 2730 2740 2750
TDPGRKPLSH RFLRHVPIIY VDYPGETSLK QIYGTFSRAM LRLMPALRGY
2760 2770 2780 2790 2800
AEPLTNAMVE FYLASQDRFT QDMQPHYVYS PREMTRWVRG ICEAIRPLDS
2810 2820 2830 2840 2850
LPVEGLVRLW AHEALRLFQD RLVDDSERRW TNENIDLVGQ KHFPGINQEE
2860 2870 2880 2890 2900
ALQRPILYSN WLSKDYMPVN REELREYVHA RLKVFYEEEL DVPLVLFDEV
2910 2920 2930 2940 2950
LDHVLRIDRI FRQPQGHLLL IGVSGAGKTT LSRFVAWMNG LSIFQIKVHN
2960 2970 2980 2990 3000
KYTSEDFDED LRCVLRRSGC KDEKIAFILD ESNVLDSGFL ERMNTLLANG
3010 3020 3030 3040 3050
EVPGLFEGDE YTTLMTQCKE GAQREGLMLD SSDELYKWFT QQVMRNLHVV
3060 3070 3080 3090 3100
FTMNPSTDGL KDRAATSPAL FNRCVLNWFG DWSDSALFQV GKEFTTRVDL
3110 3120 3130 3140 3150
EKPNWHAPDF FPSVCPLVPA NPTHRDAVIN SCVYVHQTLH QANARLAKRG
3160 3170 3180 3190 3200
GRTMAVTPRH YLDFIHHFVK LYNEKRSDLE EQQLHLNVGL NKIAETVEQV
3210 3220 3230 3240 3250
EEMQKSLAVK KQELQAKNEA ANAKLKQMFQ DQQEAEKKKI QSQEIQIRLA
3260 3270 3280 3290 3300
DQTVKIEEKR KYVMADLAQV EPAVIDAQAA VKSIRKQQLV EVRTMANPPS
3310 3320 3330 3340 3350
VVKLALESIC LLLGENATDW KSIRAVIMRE NFINSIVSNF GTENITDDVR
3360 3370 3380 3390 3400
EKMKSKYLSN PDYNFEKVNR ASMACGPMVK WAIAQIEYAD MLKRVEPLRE
3410 3420 3430 3440 3450
ELRSLEEQAD VNLASAKETK DLVEQLERSI AAYKEEYAQL ISQAQAIKTD
3460 3470 3480 3490 3500
LENVQAKVDR SIALLKSLNI ERERWESTSE TFKSQMSTII GDVLLSAAFI
3510 3520 3530 3540 3550
AYGGYFDQHY RLNLFTTWSQ HLQAASIQYR ADIARTEYLS NPDERLRWQA
3560 3570 3580 3590 3600
NALPTDDLCT ENAIMLKRFN RYPLIIDPSG QATTFLLNEY AGKKITKTSF
3610 3620 3630 3640 3650
LDDSFRKNLE SALRFGNPLL VQDVENYDPI LNPVLNRELR RTGGRVLITL
3660 3670 3680 3690 3700
GDQDIDLSPS FVIFLSTRDP TVEFPPDICS RVTFVNFTVT RSSLQSQCLN
3710 3720 3730 3740 3750
QVLKAERPDI DEKRSDLLKL QGEFRLRLRQ LEKSLLQALN DAKGKILDDD
3760 3770 3780 3790 3800
SVITTLETLK KEAYDINQKV DETDKVIAEI ETVSQQYLPL SVACSNIYFT
3810 3820 3830 3840 3850
MDSLNQVHFL YQYSLKMFLD IFSTVLYNNP KLEGRTDHSE RLGIVTRDLF
3860 3870 3880 3890 3900
QVCYERVARG MIHIDRLTFA LLMCKIHLKG TSESNLDAEF NFFLRSREGL
3910 3920 3930 3940 3950
LANPTPVEGL SAEQIESVNR LALRLPIFRK LLEKVRSIPE LGAWLQQSSP
3960 3970 3980 3990 4000
EQVVPQLWDE SKALSPIASS VHQLLLIQAF RPDRVIAAAH NVVNTVLGED
4010 4020 4030 4040 4050
FMPNAEQELD FTSVVDKQLN CNTPALLCSV PGFDASGRVD DLAAEQNKQI
4060 4070 4080 4090 4100
SSIAIGSAEG FNQAERAINM ACKTGRWVLL KNVHLAPQWL VQLEKKMHSL
4110 4120 4130 4140 4150
QPHSGFRLFL TMEINPKVPV NLLRAGRIFV FEPPPGIRAN LLRTFSTVPA
4160 4170 4180 4190 4200
ARMMKTPSER ARLYFLLAWF HAIVQERLRY VPLGWAKKYE FNESDLRVAC
4210 4220 4230 4240 4250
DTLDTWIDTT AMGRTNLPPE KVPWDALVTL LSQSIYGGKI DNDFDQRLLT
4260 4270 4280 4290 4300
SFLKKLFTAR SFEADFALVA NVDGASGGLR HITMPDGTRR DHFLKWIENL
4310 4320 4330 4340 4350
TDRQTPSWLG LPNNAEKVLL TTRGTDLVSK LLKMQQLEDD DELAYSVEDQ
4360 4370 4380 4390 4400
SEQSAVGRGE DGRPSWMKTL HNSATAWLEL LPKNLQVLKR TVENIKDPLY
4410 4420 4430 4440 4450
RYFEREVTSG SRLLQTVILD LQDVVLICQG EKKQTNHHRS MLSELVRGII
4460 4470 4480 4490 4500
PKGWKRYTVP AGCTVIQWIT DFSNRVQQLQ KVSQLVSQAG AKELQGFPVW
4510 4520 4530 4540 4550
LGGLLNPEAY ITATRQCVAQ ANSWSLEELA LDVTITDAGL KNDQKDCCFG
4560 4570 4580 4590 4600
VTGLKLQGAQ CKNNELLLAS TIMMDLPVTI LKWIKISSEP RISKLTLPVY
4610 4620 4630
LNSTRTELLF TVDLAVAAGQ ESHSFYERGV AVLTSTALN
Length:4,639
Mass (Da):530,184
Last modified:December 7, 2004 - v2
Checksum:i2A3D4F1F8BE52096
GO
Isoform C (identifier: P37276-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3282-3344: KSIRKQQLVE...SIVSNFGTEN → SSIKKKHLAE...SSIVNLETDK

Note: No experimental confirmation available.
Show »
Length:4,638
Mass (Da):529,905
Checksum:iBD43645B38CD2368
GO

Sequence cautioni

The sequence AAK92925.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511A → V in AAA60323 (PubMed:8089180).Curated
Sequence conflicti2010 – 20101R → H in AAA60323 (PubMed:8089180).Curated
Sequence conflicti2348 – 23481V → A in AAA60323 (PubMed:8089180).Curated
Sequence conflicti2370 – 23701S → T in AAA60323 (PubMed:8089180).Curated
Sequence conflicti2549 – 25491S → T in AAA60323 (PubMed:8089180).Curated
Sequence conflicti3864 – 38641I → N in AAA60323 (PubMed:8089180).Curated
Sequence conflicti4073 – 40731K → N in AAK92925 (PubMed:12537569).Curated
Sequence conflicti4369 – 43691T → A in AAA60323 (PubMed:8089180).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3282 – 334463KSIRK…FGTEN → SSIKKKHLAEVRSMANPPAV VKLALESVCELLNESATDWK AIRGILVKDSFISSIVNLET DK in isoform C. CuratedVSP_012085Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23195 mRNA. Translation: AAA60323.1.
AE014296 Genomic DNA. Translation: AAF47942.3.
AE014296 Genomic DNA. Translation: AAN11615.2.
L25122 mRNA. Translation: AAA28492.1.
AY051501 mRNA. Translation: AAK92925.1. Different initiation.
PIRiA54794.
RefSeqiNP_523929.2. NM_079205.4. [P37276-1]
NP_729034.2. NM_168103.3. [P37276-2]
UniGeneiDm.846.

Genome annotation databases

EnsemblMetazoaiFBtr0073359; FBpp0073215; FBgn0261797. [P37276-1]
GeneIDi38580.
KEGGidme:Dmel_CG7507.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23195 mRNA. Translation: AAA60323.1.
AE014296 Genomic DNA. Translation: AAF47942.3.
AE014296 Genomic DNA. Translation: AAN11615.2.
L25122 mRNA. Translation: AAA28492.1.
AY051501 mRNA. Translation: AAK92925.1. Different initiation.
PIRiA54794.
RefSeqiNP_523929.2. NM_079205.4. [P37276-1]
NP_729034.2. NM_168103.3. [P37276-2]
UniGeneiDm.846.

3D structure databases

ProteinModelPortaliP37276.
SMRiP37276. Positions 184-435, 1444-2382, 2917-2945, 3196-3826, 4034-4257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64049. 4 interactions.
DIPiDIP-59317N.
IntActiP37276. 4 interactions.
STRINGi7227.FBpp0304991.

Proteomic databases

PaxDbiP37276.
PRIDEiP37276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073359; FBpp0073215; FBgn0261797. [P37276-1]
GeneIDi38580.
KEGGidme:Dmel_CG7507.

Organism-specific databases

CTDi38580.
FlyBaseiFBgn0261797. Dhc64C.

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00760000118964.
InParanoidiP37276.
KOiK10413.
OrthoDBiEOG76471R.
PhylomeDBiP37276.

Enzyme and pathway databases

ReactomeiR-DME-6807878. COPI-mediated anterograde transport.
R-DME-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

GenomeRNAii38580.
PROiP37276.

Gene expression databases

BgeeiP37276.
ExpressionAtlasiP37276. differential.
GenevisibleiP37276. DM.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 3 hits.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 4 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte."
    Li M., McGrail M., Serr M., Hays T.S.
    J. Cell Biol. 126:1475-1494(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. "A family of dynein genes in Drosophila melanogaster."
    Rasmusson K., Serr M., Gepner J., Gibbons I., Hays T.S.
    Mol. Biol. Cell 5:45-55(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1877-1998.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3758-4639 (ISOFORMS A/C).
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiDYHC_DROME
AccessioniPrimary (citable) accession number: P37276
Secondary accession number(s): Q8IRA5, Q961M8, Q9VZ83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 7, 2004
Last modified: July 6, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.