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Protein

Zinc finger E-box-binding homeobox 1

Gene

ZEB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 292C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST25
DNA bindingi581 – 640Homeobox; atypicalAdd BLAST60
Zinc fingeri904 – 926C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri932 – 954C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri960 – 981C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • E-box binding Source: UniProtKB
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: BHF-UCL
  • transcription coactivator activity Source: ProtInc
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • transcription factor binding Source: Ensembl
  • zinc ion binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6785807. Interleukin-4 and 13 signaling.
SignaLinkiP37275.
SIGNORiP37275.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger E-box-binding homeobox 1
Alternative name(s):
NIL-2-A zinc finger protein
Negative regulator of IL2
Transcription factor 8
Short name:
TCF-8
Gene namesi
Name:ZEB1
Synonyms:AREB6, TCF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11642. ZEB1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • transcription factor complex Source: Ensembl

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Corneal dystrophy, posterior polymorphous, 3 (PPCD3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA subtype of posterior corneal dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic.
See also OMIM:609141
Corneal dystrophy, Fuchs endothelial, 6 (FECD6)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
See also OMIM:613270
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06375978N → T in FECD6; no effect on protein expression; no effect on nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs80194531Ensembl.1
Natural variantiVAR_072897525G → E Found in a patient with FECD6. 1 Publication1
Natural variantiVAR_072898640Q → H in FECD6; down-regulation of several collagen genes expression. 1 PublicationCorresponds to variant dbSNP:rs779148597Ensembl.1
Natural variantiVAR_063760649P → A in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs781750314Ensembl.1
Natural variantiVAR_072899696N → S in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs567252241Ensembl.1
Natural variantiVAR_063761810Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs199944415Ensembl.1
Natural variantiVAR_063762840Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs118020901Ensembl.1
Natural variantiVAR_072900905A → G in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs78449005Ensembl.1
Natural variantiVAR_063763905A → T in FECD6. 1 Publication1

Keywords - Diseasei

Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNETi6935.
MalaCardsiZEB1.
MIMi609141. phenotype.
613270. phenotype.
OpenTargetsiENSG00000148516.
Orphaneti98974. Fuchs endothelial corneal dystrophy.
98973. Posterior polymorphous corneal dystrophy.
PharmGKBiPA162409589.

Polymorphism and mutation databases

BioMutaiZEB1.
DMDMi6166575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472311 – 1124Zinc finger E-box-binding homeobox 1Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei313PhosphoserineBy similarity1
Modified residuei322PhosphoserineCombined sources1
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki493Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki504Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki515Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei642PhosphoserineCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei686PhosphoserineBy similarity1
Modified residuei693PhosphoserineBy similarity1
Modified residuei700PhosphoserineBy similarity1
Modified residuei702PhosphothreonineCombined sources1
Modified residuei704PhosphoserineBy similarity1
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP37275.
MaxQBiP37275.
PaxDbiP37275.
PeptideAtlasiP37275.
PRIDEiP37275.

PTM databases

iPTMnetiP37275.
PhosphoSitePlusiP37275.

Expressioni

Tissue specificityi

Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.1 Publication

Gene expression databases

BgeeiENSG00000148516.
CleanExiHS_ZEB1.
ExpressionAtlasiP37275. baseline and differential.
GenevisibleiP37275. HS.

Organism-specific databases

HPAiCAB058686.
HPA027524.

Interactioni

Subunit structurei

Interacts (via N-terminus) with SMARCA4/BRG1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112796. 26 interactors.
IntActiP37275. 3 interactors.
MINTiMINT-94525.
STRINGi9606.ENSP00000354487.

Structurei

Secondary structure

11124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi590 – 600Combined sources11
Helixi608 – 618Combined sources11
Helixi622 – 634Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E19NMR-A586-642[»]
ProteinModelPortaliP37275.
SMRiP37275.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37275.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi989 – 1124Glu-rich (acidic)Add BLAST136

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 292C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri904 – 926C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri932 – 954C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri960 – 981C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3623. Eukaryota.
ENOG410ZFMZ. LUCA.
GeneTreeiENSGT00630000089829.
HOGENOMiHOG000264256.
HOVERGENiHBG004697.
InParanoidiP37275.
KOiK09299.
OMAiECEKPQG.
OrthoDBiEOG091G0F7Y.
PhylomeDBiP37275.
TreeFamiTF331759.

Family and domain databases

InterProiView protein in InterPro
IPR008598. Di19_Zn_binding_dom.
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF05605. zf-Di19. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P37275-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA
60 70 80 90 100
ADCEGVPEDD LPTDQTVLPG RSSEREGNAK NCWEDDRKEG QEILGPEAQA
110 120 130 140 150
DEAGCTVKDD ECESDAENEQ NHDPNVEEFL QQQDTAVIFP EAPEEDQRQG
160 170 180 190 200
TPEASGHDEN GTPDAFSQLL TCPYCDRGYK RFTSLKEHIK YRHEKNEDNF
210 220 230 240 250
SCSLCSYTFA YRTQLERHMT SHKSGRDQRH VTQSGCNRKF KCTECGKAFK
260 270 280 290 300
YKHHLKEHLR IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCISLIPVNG
310 320 330 340 350
RPRTGLKTSQ CSSPSLSASP GSPTRPQIRQ KIENKPLQEQ LSVNQIKTEP
360 370 380 390 400
VDYEFKPIVV ASGINCSTPL QNGVFTGGGP LQATSSPQGM VQAVVLPTVG
410 420 430 440 450
LVSPISINLS DIQNVLKVAV DGNVIRQVLE NNQANLASKE QETINASPIQ
460 470 480 490 500
QGGHSVISAI SLPLVDQDGT TKIIINYSLE QPSQLQVVPQ NLKKENPVAT
510 520 530 540 550
NSCKSEKLPE DLTVKSEKDK SFEGGVNDST CLLCDDCPGD INALPELKHY
560 570 580 590 600
DLKQPTQPPP LPAAEAEKPE SSVSSATGDG NLSPSQPPLK NLLSLLKAYY
610 620 630 640 650
ALNAQPSAEE LSKIADSVNL PLDVVKKWFE KMQAGQISVQ SSEPSSPEPG
660 670 680 690 700
KVNIPAKNND QPQSANANEP QDSTVNLQSP LKMTNSPVLP VGSTTNGSRS
710 720 730 740 750
STPSPSPLNL SSSRNTQGYL YTAEGAQEEP QVEPLDLSLP KQQGELLERS
760 770 780 790 800
TITSVYQNSV YSVQEEPLNL SCAKKEPQKD SCVTDSEPVV NVIPPSANPI
810 820 830 840 850
NIAIPTVTAQ LPTIVAIADQ NSVPCLRALA ANKQTILIPQ VAYTYSTTVS
860 870 880 890 900
PAVQEPPLKV IQPNGNQDER QDTSSEGVSN VEDQNDSDST PPKKKMRKTE
910 920 930 940 950
NGMYACDLCD KIFQKSSSLL RHKYEHTGKR PHECGICKKA FKHKHHLIEH
960 970 980 990 1000
MRLHSGEKPY QCDKCGKRFS HSGSYSQHMN HRYSYCKREA EERDSTEQEE
1010 1020 1030 1040 1050
AGPEILSNEH VGARASPSQG DSDERESLTR EEDEDSEKEE EEEDKEMEEL
1060 1070 1080 1090 1100
QEEKECEKPQ GDEEEEEEEE EVEEEEVEEA ENEGEEAKTE GLMKDDRAES
1110 1120
QASSLGQKVG ESSEQVSEEK TNEA
Length:1,124
Mass (Da):124,074
Last modified:July 15, 1999 - v2
Checksum:i0A2714CC37C848D1
GO
Isoform 2 (identifier: P37275-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: R → TG

Note: No experimental confirmation available.
Show »
Length:1,125
Mass (Da):124,076
Checksum:i3C327EEBBA18D19B
GO
Isoform 3 (identifier: P37275-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-87: VTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDDLPTDQTVLPGRSSEREGNAKNCWEDDR → G

Show »
Length:1,057
Mass (Da):116,593
Checksum:i7C683713C6562DC8
GO
Isoform 4 (identifier: P37275-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-107: RKEGQEILGPEAQADEAGCTV → I

Show »
Length:1,104
Mass (Da):122,003
Checksum:i3F8DAA9A05DFA6E4
GO
Isoform 5 (identifier: P37275-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MADGPRCKRRKQANPRRNN → MK
     87-87: R → TG

Show »
Length:1,108
Mass (Da):122,084
Checksum:i33855F3B478635C8
GO

Sequence cautioni

The sequence BAG62481 differs from that shown. Reason: Frameshift at position 177.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12Q → R in BAC03673 (PubMed:14702039).Curated1
Sequence conflicti81N → S in BAC03673 (PubMed:14702039).Curated1
Sequence conflicti84E → K in BAC03673 (PubMed:14702039).Curated1
Sequence conflicti220T → A in BAG62481 (PubMed:14702039).Curated1
Sequence conflicti390M → T in BAG62481 (PubMed:14702039).Curated1
Sequence conflicti420V → I in AAA20602 (Ref. 2) Curated1
Sequence conflicti472K → R in BAG58962 (PubMed:14702039).Curated1
Sequence conflicti609E → Q in M81699 (PubMed:1840704).Curated1
Sequence conflicti654I → T in AAA20602 (Ref. 2) Curated1
Sequence conflicti672D → H in M81699 (PubMed:1840704).Curated1
Sequence conflicti681L → S in M81699 (PubMed:1840704).Curated1
Sequence conflicti775K → T in BAG62481 (PubMed:14702039).Curated1
Sequence conflicti793 – 794IP → KY in BAG58962 (PubMed:14702039).Curated2
Sequence conflicti797A → N in BAG58962 (PubMed:14702039).Curated1
Sequence conflicti818A → V in BAG62481 (PubMed:14702039).Curated1
Sequence conflicti838I → T in BAC03673 (PubMed:14702039).Curated1
Sequence conflicti1066E → G in BAC03673 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06375978N → T in FECD6; no effect on protein expression; no effect on nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs80194531Ensembl.1
Natural variantiVAR_05273190G → R. Corresponds to variant dbSNP:rs12217419Ensembl.1
Natural variantiVAR_072897525G → E Found in a patient with FECD6. 1 Publication1
Natural variantiVAR_031824553K → R. Corresponds to variant dbSNP:rs35753967Ensembl.1
Natural variantiVAR_072898640Q → H in FECD6; down-regulation of several collagen genes expression. 1 PublicationCorresponds to variant dbSNP:rs779148597Ensembl.1
Natural variantiVAR_063760649P → A in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs781750314Ensembl.1
Natural variantiVAR_072899696N → S in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs567252241Ensembl.1
Natural variantiVAR_063761810Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs199944415Ensembl.1
Natural variantiVAR_063762840Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs118020901Ensembl.1
Natural variantiVAR_072900905A → G in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs78449005Ensembl.1
Natural variantiVAR_063763905A → T in FECD6. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0472791 – 19MADGP…PRRNN → MK in isoform 5. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_04728020 – 87VTNYN…WEDDR → G in isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_04728187 – 107RKEGQ…AGCTV → I in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_04518487R → TG in isoform 2 and isoform 5. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15050 mRNA. Translation: BAA03646.1.
U12170 mRNA. Translation: AAA20602.1.
AK091478 mRNA. Translation: BAC03673.1.
AK296244 mRNA. Translation: BAG58962.1.
AK300830 mRNA. Translation: BAG62481.1. Frameshift.
AL158080
, AL117340, AL161935, AL355148 Genomic DNA. Translation: CAI17320.1.
AL161935
, AL117340, AL158080, AL355148 Genomic DNA. Translation: CAH74132.1.
AL117340
, AL158080, AL161935, AL355148 Genomic DNA. Translation: CAI12550.1.
AL355148
, AL117340, AL158080, AL161935 Genomic DNA. Translation: CAI15108.1.
CH471072 Genomic DNA. Translation: EAW85989.1.
BC112392 mRNA. Translation: AAI12393.1.
M81699 mRNA. No translation available.
CCDSiCCDS44370.1. [P37275-5]
CCDS53505.1. [P37275-2]
CCDS53506.1. [P37275-4]
CCDS53507.1. [P37275-3]
CCDS7169.1. [P37275-1]
PIRiJX0293.
RefSeqiNP_001121600.1. NM_001128128.2. [P37275-5]
NP_001167564.1. NM_001174093.1. [P37275-4]
NP_001167565.1. NM_001174094.1.
NP_001167566.1. NM_001174095.1. [P37275-3]
NP_001167567.1. NM_001174096.1. [P37275-2]
NP_110378.3. NM_030751.5. [P37275-1]
UniGeneiHs.124503.

Genome annotation databases

EnsembliENST00000320985; ENSP00000319248; ENSG00000148516. [P37275-1]
ENST00000361642; ENSP00000354487; ENSG00000148516. [P37275-2]
ENST00000446923; ENSP00000391612; ENSG00000148516. [P37275-5]
ENST00000542815; ENSP00000444891; ENSG00000148516. [P37275-3]
ENST00000560721; ENSP00000452787; ENSG00000148516. [P37275-4]
GeneIDi6935.
KEGGihsa:6935.
UCSCiuc001ivs.5. human. [P37275-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15050 mRNA. Translation: BAA03646.1.
U12170 mRNA. Translation: AAA20602.1.
AK091478 mRNA. Translation: BAC03673.1.
AK296244 mRNA. Translation: BAG58962.1.
AK300830 mRNA. Translation: BAG62481.1. Frameshift.
AL158080
, AL117340, AL161935, AL355148 Genomic DNA. Translation: CAI17320.1.
AL161935
, AL117340, AL158080, AL355148 Genomic DNA. Translation: CAH74132.1.
AL117340
, AL158080, AL161935, AL355148 Genomic DNA. Translation: CAI12550.1.
AL355148
, AL117340, AL158080, AL161935 Genomic DNA. Translation: CAI15108.1.
CH471072 Genomic DNA. Translation: EAW85989.1.
BC112392 mRNA. Translation: AAI12393.1.
M81699 mRNA. No translation available.
CCDSiCCDS44370.1. [P37275-5]
CCDS53505.1. [P37275-2]
CCDS53506.1. [P37275-4]
CCDS53507.1. [P37275-3]
CCDS7169.1. [P37275-1]
PIRiJX0293.
RefSeqiNP_001121600.1. NM_001128128.2. [P37275-5]
NP_001167564.1. NM_001174093.1. [P37275-4]
NP_001167565.1. NM_001174094.1.
NP_001167566.1. NM_001174095.1. [P37275-3]
NP_001167567.1. NM_001174096.1. [P37275-2]
NP_110378.3. NM_030751.5. [P37275-1]
UniGeneiHs.124503.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E19NMR-A586-642[»]
ProteinModelPortaliP37275.
SMRiP37275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112796. 26 interactors.
IntActiP37275. 3 interactors.
MINTiMINT-94525.
STRINGi9606.ENSP00000354487.

PTM databases

iPTMnetiP37275.
PhosphoSitePlusiP37275.

Polymorphism and mutation databases

BioMutaiZEB1.
DMDMi6166575.

Proteomic databases

EPDiP37275.
MaxQBiP37275.
PaxDbiP37275.
PeptideAtlasiP37275.
PRIDEiP37275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320985; ENSP00000319248; ENSG00000148516. [P37275-1]
ENST00000361642; ENSP00000354487; ENSG00000148516. [P37275-2]
ENST00000446923; ENSP00000391612; ENSG00000148516. [P37275-5]
ENST00000542815; ENSP00000444891; ENSG00000148516. [P37275-3]
ENST00000560721; ENSP00000452787; ENSG00000148516. [P37275-4]
GeneIDi6935.
KEGGihsa:6935.
UCSCiuc001ivs.5. human. [P37275-1]

Organism-specific databases

CTDi6935.
DisGeNETi6935.
GeneCardsiZEB1.
HGNCiHGNC:11642. ZEB1.
HPAiCAB058686.
HPA027524.
MalaCardsiZEB1.
MIMi189909. gene.
609141. phenotype.
613270. phenotype.
neXtProtiNX_P37275.
OpenTargetsiENSG00000148516.
Orphaneti98974. Fuchs endothelial corneal dystrophy.
98973. Posterior polymorphous corneal dystrophy.
PharmGKBiPA162409589.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3623. Eukaryota.
ENOG410ZFMZ. LUCA.
GeneTreeiENSGT00630000089829.
HOGENOMiHOG000264256.
HOVERGENiHBG004697.
InParanoidiP37275.
KOiK09299.
OMAiECEKPQG.
OrthoDBiEOG091G0F7Y.
PhylomeDBiP37275.
TreeFamiTF331759.

Enzyme and pathway databases

ReactomeiR-HSA-6785807. Interleukin-4 and 13 signaling.
SignaLinkiP37275.
SIGNORiP37275.

Miscellaneous databases

ChiTaRSiZEB1. human.
EvolutionaryTraceiP37275.
GeneWikiiZEB1.
GenomeRNAii6935.
PROiPR:P37275.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148516.
CleanExiHS_ZEB1.
ExpressionAtlasiP37275. baseline and differential.
GenevisibleiP37275. HS.

Family and domain databases

InterProiView protein in InterPro
IPR008598. Di19_Zn_binding_dom.
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF05605. zf-Di19. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZEB1_HUMAN
AccessioniPrimary (citable) accession number: P37275
Secondary accession number(s): B4DJV0
, B4DUW9, E9PCM7, F5H4I8, Q12924, Q13800, Q2KJ05, Q5T968, Q5VZ84, Q8NB68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1999
Last modified: May 10, 2017
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.