P37275 (ZEB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger E-box-binding homeobox 1

Alternative name(s):
NIL-2-A zinc finger protein
Negative regulator of IL2
Transcription factor 8
Short name=TCF-8

Gene names

Name:	ZEB1
Synonyms:	AREB6, TCF8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1124 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Ref.12 Ref.14 Ref.15
Subunit structure	Interacts (via N-terminus) with SMARCA4/BRG1. Ref.15
Subcellular location	Nucleus Ref.15.
Tissue specificity	Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Ref.15
Involvement in disease	Defects in ZEB1 are the cause of posterior polymorphous corneal dystrophy type 3 (PPCD3) [MIM:609141]. PPCD is a rare disease involving metaplasia and overgrowth of corneal endothelial cells. In patients with PPCD, these cells manifest in an epithelial morphology and gene expression pattern, produce an aberrant basement membrane, and, sometimes, spread over the iris and nearby structures in a way that increases the risk for glaucoma. Ref.7 Defects in ZEB1 are the cause of corneal dystrophy Fuchs endothelial type 6 (FECD6) [MIM:613270]. It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Ref.18
Sequence similarities	Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. Contains 7 C2H2-type zinc fingers. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Homeobox Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell proliferation Traceable author statement. Source: ProtInc immune response Traceable author statement. Source: ProtInc negative regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc positive regulation of neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay Ref.15. Source: UniProtKB
Molecular function	E-box binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding Inferred from physical interaction Ref.15. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement. Source: ProtInc transcription coactivator activity Traceable author statement. Source: ProtInc transcription corepressor activity Traceable author statement. Source: ProtInc zinc ion binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1124

1124

Zinc finger E-box-binding homeobox 1

PRO_0000047231

Regions

Zinc finger

170 – 193

24

C2H2-type 1

Zinc finger

200 – 222

23

C2H2-type 2

Zinc finger

240 – 262

23

C2H2-type 3

Zinc finger

268 – 292

25

C2H2-type 4; atypical

DNA binding

581 – 640

60

Homeobox; atypical

Zinc finger

904 – 926

23

C2H2-type 5

Zinc finger

932 – 954

23

C2H2-type 6

Zinc finger

960 – 981

22

C2H2-type 7; atypical

Compositional bias

989 – 1124

136

Glu-rich (acidic)

Amino acid modifications

Modified residue

31

1

Phosphoserine Ref.9

Modified residue

33

1

Phosphoserine Ref.9

Modified residue

322

1

Phosphoserine Ref.10

Modified residue

583

1

Phosphoserine Ref.11

Modified residue

642

1

Phosphoserine Ref.13

Modified residue

646

1

Phosphoserine Ref.10 Ref.11

Modified residue

679

1

Phosphoserine Ref.6 Ref.13

Modified residue

702

1

Phosphothreonine Ref.11 Ref.13

Modified residue

704

1

Phosphoserine Ref.11

Cross-link

347

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Ref.8

Cross-link

774

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Ref.8

Natural variations

Natural variant

78

1

N → T in FECD6. Ref.18

VAR_063759

Natural variant

90

1

G → R.
Corresponds to variant rs12217419 [ dbSNP | Ensembl ].

VAR_052731

Natural variant

553

1

K → R.
Corresponds to variant rs35753967 [ dbSNP | Ensembl ].

VAR_031824

Natural variant

649

1

P → A in FECD6. Ref.18

VAR_063760

Natural variant

810

1

Q → P in FECD6. Ref.18

VAR_063761

Natural variant

840

1

Q → P in FECD6. Ref.18

VAR_063762

Natural variant

905

1

A → T in FECD6. Ref.18

VAR_063763

Experimental info

Sequence conflict

420

1

V → I in AAA20602. Ref.2

Sequence conflict

609

1

E → Q in M81699. Ref.5

Sequence conflict

654

1

I → T in AAA20602. Ref.2

Sequence conflict

672

1

D → H in M81699. Ref.5

Sequence conflict

681

1

L → S in M81699. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

1124

Helix Strand Turn

Details...

Helix

590 – 600

11

Helix

608 – 618

11

Helix

622 – 633

12

Sequences

	Sequence		Length	Mass (Da)
	P37275 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 0A2714CC37C848D1	FASTA	1,124	124,074
	10 20 30 40 50 60 MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA ADCEGVPEDD 70 80 90 100 110 120 LPTDQTVLPG RSSEREGNAK NCWEDDRKEG QEILGPEAQA DEAGCTVKDD ECESDAENEQ 130 140 150 160 170 180 NHDPNVEEFL QQQDTAVIFP EAPEEDQRQG TPEASGHDEN GTPDAFSQLL TCPYCDRGYK 190 200 210 220 230 240 RFTSLKEHIK YRHEKNEDNF SCSLCSYTFA YRTQLERHMT SHKSGRDQRH VTQSGCNRKF 250 260 270 280 290 300 KCTECGKAFK YKHHLKEHLR IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCISLIPVNG 310 320 330 340 350 360 RPRTGLKTSQ CSSPSLSASP GSPTRPQIRQ KIENKPLQEQ LSVNQIKTEP VDYEFKPIVV 370 380 390 400 410 420 ASGINCSTPL QNGVFTGGGP LQATSSPQGM VQAVVLPTVG LVSPISINLS DIQNVLKVAV 430 440 450 460 470 480 DGNVIRQVLE NNQANLASKE QETINASPIQ QGGHSVISAI SLPLVDQDGT TKIIINYSLE 490 500 510 520 530 540 QPSQLQVVPQ NLKKENPVAT NSCKSEKLPE DLTVKSEKDK SFEGGVNDST CLLCDDCPGD 550 560 570 580 590 600 INALPELKHY DLKQPTQPPP LPAAEAEKPE SSVSSATGDG NLSPSQPPLK NLLSLLKAYY 610 620 630 640 650 660 ALNAQPSAEE LSKIADSVNL PLDVVKKWFE KMQAGQISVQ SSEPSSPEPG KVNIPAKNND 670 680 690 700 710 720 QPQSANANEP QDSTVNLQSP LKMTNSPVLP VGSTTNGSRS STPSPSPLNL SSSRNTQGYL 730 740 750 760 770 780 YTAEGAQEEP QVEPLDLSLP KQQGELLERS TITSVYQNSV YSVQEEPLNL SCAKKEPQKD 790 800 810 820 830 840 SCVTDSEPVV NVIPPSANPI NIAIPTVTAQ LPTIVAIADQ NSVPCLRALA ANKQTILIPQ 850 860 870 880 890 900 VAYTYSTTVS PAVQEPPLKV IQPNGNQDER QDTSSEGVSN VEDQNDSDST PPKKKMRKTE 910 920 930 940 950 960 NGMYACDLCD KIFQKSSSLL RHKYEHTGKR PHECGICKKA FKHKHHLIEH MRLHSGEKPY 970 980 990 1000 1010 1020 QCDKCGKRFS HSGSYSQHMN HRYSYCKREA EERDSTEQEE AGPEILSNEH VGARASPSQG 1030 1040 1050 1060 1070 1080 DSDERESLTR EEDEDSEKEE EEEDKEMEEL QEEKECEKPQ GDEEEEEEEE EVEEEEVEEA 1090 1100 1110 1120 ENEGEEAKTE GLMKDDRAES QASSLGQKVG ESSEQVSEEK TNEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene." Watanabe Y., Kawakami K., Hirayama Y., Nagano K. J. Biochem. 114:849-855(1993) [PubMed: 8138542] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A human zinc finger homeodomain protein homologous to the chicken delta-crystallin enhancer binding protein, delta EF1." Bachman N.J., Scarpulla R.C. Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Identification of a zinc finger protein that inhibits IL-2 gene expression." Williams T.M., Moolten D., Burlein J., Romano J., Bhaerman R., Godillot A., Mellon M., Rauscher F.J. III, Kant J.A. Science 254:1791-1794(1991) [PubMed: 1840704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 390-1124.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-679, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells." Krafchak C.M., Pawar H., Moroi S.E., Sugar A., Lichter P.R., Mackey D.A., Mian S., Nairus T., Elner V., Schteingart M.T., Downs C.A., Kijek T.G., Johnson J.M., Trager E.H., Rozsa F.W., Mandal M.N.A., Epstein M.P., Vollrath D. , Ayyagari R., Boehnke M., Richards J.E. Am. J. Hum. Genet. 77:694-708(2005) [PubMed: 16252232] [Abstract] Cited for: INVOLVEMENT IN PPCD3.
[8]	"Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin." Long J., Zuo D., Park M. J. Biol. Chem. 280:35477-35489(2005) [PubMed: 16061479] [Abstract] Cited for: SUMOYLATION AT LYS-347 AND LYS-774.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31 AND SER-33, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322 AND SER-646, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583; SER-646; THR-702 AND SER-704, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[12]	"The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs." Wellner U., Schubert J., Burk U.C., Schmalhofer O., Zhu F., Sonntag A., Waldvogel B., Vannier C., Darling D., zur Hausen A., Brunton V.G., Morton J., Sansom O., Schuler J., Stemmler M.P., Herzberger C., Hopt U., Keck T., Brabletz S., Brabletz T. Nat. Cell Biol. 11:1487-1495(2009) [PubMed: 19935649] [Abstract] Cited for: FUNCTION.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642; SER-679 AND THR-702, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus." Papadopoulou V., Postigo A., Sanchez-Tillo E., Porter A.C., Wagner S.D. Biochem. J. 427:541-550(2010) [PubMed: 20175752] [Abstract] Cited for: FUNCTION.
[15]	"ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1." Sanchez-Tillo E., Lazaro A., Torrent R., Cuatrecasas M., Vaquero E.C., Castells A., Engel P., Postigo A. Oncogene 29:3490-3500(2010) [PubMed: 20418909] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMARCA4, TISSUE SPECIFICITY.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8." RIKEN structural genomics initiative (RSGI) Submitted (APR-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 583-642.
[18]	"Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p." Riazuddin S.A., Zaghloul N.A., Al-Saif A., Davey L., Diplas B.H., Meadows D.N., Eghrari A.O., Minear M.A., Li Y.J., Klintworth G.K., Afshari N., Gregory S.G., Gottsch J.D., Katsanis N. Am. J. Hum. Genet. 86:45-53(2010) [PubMed: 20036349] [Abstract] Cited for: VARIANTS FECD6 THR-78; ALA-649; PRO-810; PRO-840 AND THR-905.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D15050 mRNA. Translation: BAA03646.1.
U12170 mRNA. Translation: AAA20602.1.
AL158080 , AL117340, AL161935, AL355148 Genomic DNA. Translation: CAI17320.1.
AL161935 , AL117340, AL158080, AL355148 Genomic DNA. Translation: CAH74132.1.
AL117340 , AL158080, AL161935, AL355148 Genomic DNA. Translation: CAI12550.1.
AL355148 , AL117340, AL158080, AL161935 Genomic DNA. Translation: CAI15108.1.
CH471072 Genomic DNA. Translation: EAW85989.1.
M81699 mRNA. No translation available.

IPI

IPI00375505.

PIR

JX0293.

RefSeq

NP_001121600.1. NM_001128128.2.
NP_001167565.1. NM_001174094.1.
NP_001167566.1. NM_001174095.1.
NP_110378.3. NM_030751.5.

UniGene

Hs.124503.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E19	NMR	-	A	586-642	[»]

ProteinModelPortal

P37275.

SMR

P37275. Positions 134-332, 521-558, 583-642, 822-1002.

ModBase

Search...

Protein-protein interaction databases

IntAct

P37275. 1 interaction.

MINT

MINT-94525.

STRING

P37275.

PTM databases

PhosphoSite

P37275.

Polymorphism databases

DMDM

6166575.

Proteomic databases

PRIDE

P37275.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000320985; ENSP00000319248; ENSG00000148516.

GeneID

6935.

KEGG

hsa:6935.

UCSC

uc001ivs.2. human.

Organism-specific databases

CTD

6935.

GeneCards

GC10P031648.

HGNC

HGNC:11642. ZEB1.

HPA

HPA027524.

MIM

189909. gene.
609141. phenotype.
613270. phenotype.

neXtProt

NX_P37275.

Orphanet

98974. Fuchs endothelial corneal dystrophy.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG004697.

OMA

ERDSTEQ.

OrthoDB

EOG49CQ6Z.

PhylomeDB

P37275.

Gene expression databases

ArrayExpress

P37275.

Bgee

P37275.

CleanEx

HS_ZEB1.

Genevestigator

P37275.

GermOnline

ENSG00000148516. Homo sapiens.

Family and domain databases

InterPro

IPR001356. Homeobox.
IPR012287. Homeodomain-rel.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Gene3D

G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 7 hits.

KO

K09299.

Pfam

PF00046. Homeobox. 1 hit.
PF00096. zf-C2H2. 7 hits.
[Graphical view]

SMART

SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]

PROSITE

PS00027. HOMEOBOX_1. False negative.
PS50071. HOMEOBOX_2. False negative.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

27137.

SOURCE

Search...

Entry information

Entry name

ZEB1_HUMAN

Accession

Primary (citable) accession number: P37275
Secondary accession number(s): Q12924, Q13800, Q5T968

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	July 15, 1999
Last modified:	January 25, 2012
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.