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Protein

Phosphate-repressible acid phosphatase

Gene

PHOA

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei215 – 2151Proton donorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate-repressible acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:PHOA
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 412393Phosphate-repressible acid phosphatasePRO_0000023979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002558290.1.

Structurei

3D structure databases

ProteinModelPortaliP37274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

PhylomeDBiP37274.

Family and domain databases

InterProiIPR007312. Phosphoesterase.
[Graphical view]
PfamiPF04185. Phosphoesterase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKQTLLAF VGALALATGT TTTEETPTQA EIDAARATAL PYSPVSNVKG
60 70 80 90 100
LAFDRFVNIW LENTDFEPAA LDENLSKLAK EGILLTNYFA ISHPSQPNYC
110 120 130 140 150
ASAGGDTFGM DNDDFLQIPS NVSTIADLFD TKHISWGEYQ EDMPYAGYQG
160 170 180 190 200
KRYPLSGPNQ YVRKHNPLVL FNSVTDDAVR PRQIKNFTTF YDDLKHHSLP
210 220 230 240 250
QHMFITPNMT NDAHDTNITV AGNWVDRFLS PLLKNEYFTK DSLVLLTFDE
260 270 280 290 300
GDTYSYPNRV FSFLVGGAIP EHLKGTTDDT FYTHYSIVAS LSANWGLPSL
310 320 330 340 350
GRWDCGANLL KMVADKTGYV NWEVDTSNVY LNETYPGPMS TDNYSSKWAV
360 370 380 390 400
PATKGKCSAG HGIAEVVKNT YHGLQPTYDY ASPVPYDVTS GNNVGIKYHR
410
TLVCILSCSS LS
Length:412
Mass (Da):45,628
Last modified:October 1, 1994 - v1
Checksum:i5659A7F07B1DDFD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80366 Genomic DNA. Translation: AAA33693.1.
PIRiJN0319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80366 Genomic DNA. Translation: AAA33693.1.
PIRiJN0319.

3D structure databases

ProteinModelPortaliP37274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002558290.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

PhylomeDBiP37274.

Family and domain databases

InterProiIPR007312. Phosphoesterase.
[Graphical view]
PfamiPF04185. Phosphoesterase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and analysis of the Penicillium chrysogenum phoA gene encoding a secreted phosphate-repressible acid phosphatase."
    Haas H., Redl B., Friedlin E., Stoeffler G.
    Gene 113:129-133(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiPHOA_PENCH
AccessioniPrimary (citable) accession number: P37274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.