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Protein

Phytoene synthase, chloroplastic

Gene

PSY1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reaction from prephytoene diphosphate to phytoene.1 Publication

Catalytic activityi

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.1 Publication

Pathwayi: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.Curated
Proteins known to be involved in this subpathway in this organism are:
  1. Phytoene synthase, chloroplastic (PSY1)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • carotenoid biosynthetic process Source: UniProtKB
  • ergosterol biosynthetic process Source: InterPro

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processCarotenoid biosynthesis, Isoprene biosynthesis

Enzyme and pathway databases

BioCyciARA:AT5G17230-MONOMER
MetaCyc:AT5G17230-MONOMER
BRENDAi2.5.1.32 399
UniPathwayiUPA00799; UER00773

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase, chloroplastic (EC:2.5.1.321 Publication)
Gene namesi
Name:PSY1
Synonyms:PSY
Ordered Locus Names:At5g17230
ORF Names:MKP11.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G17230

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 70ChloroplastSequence analysisAdd BLAST70
ChainiPRO_000002985271 – 422Phytoene synthase, chloroplasticAdd BLAST352

Proteomic databases

PaxDbiP37271
PRIDEiP37271

Expressioni

Gene expression databases

ExpressionAtlasiP37271 baseline and differential
GenevisibleiP37271 AT

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with OR (PubMed:26224804, PubMed:25675505). Interacts with ORLIKE (PubMed:25675505).By similarity2 Publications

Protein-protein interaction databases

BioGridi16863, 3 interactors
STRINGi3702.AT5G17230.3

Structurei

3D structure databases

ProteinModelPortaliP37271
SMRiP37271
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1459 Eukaryota
COG1562 LUCA
HOGENOMiHOG000220848
InParanoidiP37271
KOiK02291
PhylomeDBiP37271

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P37271-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSVAVLWV ATSSLNPDPM NNCGLVRVLE SSRLFSPCQN QRLNKGKKKQ
60 70 80 90 100
IPTWSSSFVR NRSRRIGVVS SSLVASPSGE IALSSEEKVY NVVLKQAALV
110 120 130 140 150
NKQLRSSSYD LDVKKPQDVV LPGSLSLLGE AYDRCGEVCA EYAKTFYLGT
160 170 180 190 200
LLMTPERRKA IWAIYVWCRR TDELVDGPNA SHITPMALDR WEARLEDLFR
210 220 230 240 250
GRPFDMLDAA LADTVARYPV DIQPFRDMIE GMRMDLKKSR YQNFDDLYLY
260 270 280 290 300
CYYVAGTVGL MSVPVMGIDP KSKATTESVY NAALALGIAN QLTNILRDVG
310 320 330 340 350
EDARRGRVYL PQDELAQAGL SDEDIFAGKV TDKWRNFMKM QLKRARMFFD
360 370 380 390 400
EAEKGVTELS AASRWPVWAS LLLYRRILDE IEANDYNNFT KRAYVGKVKK
410 420
IAALPLAYAK SVLKTSSSRL SI
Length:422
Mass (Da):47,487
Last modified:January 10, 2003 - v2
Checksum:iC44F0A512F2DD31E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60R → M in AAM62787 (Ref. 6) Curated1
Sequence conflicti128L → LV in AAA32836 (PubMed:8016277).Curated1
Sequence conflicti143A → P in AAA32836 (PubMed:8016277).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25812 mRNA Translation: AAA32836.1
AF009954 Genomic DNA Translation: AAB65697.1
AB005238 Genomic DNA Translation: BAB10510.1
CP002688 Genomic DNA Translation: AED92399.1
CP002688 Genomic DNA Translation: AED92400.1
CP002688 Genomic DNA Translation: ANM69856.1
BT000450 mRNA Translation: AAN17427.1
BT002084 mRNA Translation: AAN72095.1
AY085565 mRNA Translation: AAM62787.1
RefSeqiNP_001031895.1, NM_001036818.2 [P37271-1]
NP_001331504.1, NM_001343484.1 [P37271-1]
NP_197225.1, NM_121729.3 [P37271-1]
UniGeneiAt.23726

Genome annotation databases

EnsemblPlantsiAT5G17230.1; AT5G17230.1; AT5G17230 [P37271-1]
AT5G17230.2; AT5G17230.2; AT5G17230 [P37271-1]
AT5G17230.4; AT5G17230.4; AT5G17230 [P37271-1]
GeneIDi831587
GrameneiAT5G17230.1; AT5G17230.1; AT5G17230 [P37271-1]
AT5G17230.2; AT5G17230.2; AT5G17230 [P37271-1]
AT5G17230.4; AT5G17230.4; AT5G17230 [P37271-1]
KEGGiath:AT5G17230

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPSY_ARATH
AccessioniPrimary (citable) accession number: P37271
Secondary accession number(s): O22375, Q8LE86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 10, 2003
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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