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P37270

- CRTB_THET2

UniProt

P37270 - CRTB_THET2

Protein

Phytoene synthase

Gene

crtB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene Probable.1 Publication

    Cofactori

    ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.By similarity
    Manganese or magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-2092-MONOMER.
    UniPathwayiUPA00799.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phytoene synthase (EC:2.5.1.-)
    Short name:
    PSase
    Gene namesi
    Name:crtB
    Ordered Locus Names:TT_P0057
    Encoded oniPlasmid pTT271 Publication
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Plasmid pTT27

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Phytoene synthasePRO_0000067439Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262724.TT_P0057.

    Structurei

    3D structure databases

    ProteinModelPortaliP37270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phytoene/squalene synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG1562.
    HOGENOMiHOG000220848.
    KOiK02291.
    OMAiKADHANI.
    OrthoDBiEOG63FW00.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37270-1 [UniParc]FASTAAdd to Basket

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    MKMPASMEPD WKALLRVLRA HSATFYLGSL LFPKEARKGA WAVYAACRLG    50
    DEAVDGEGGG PEALEAWWAG VERAYRGRPL AEWEKGLAWA LERWDIPFEA 100
    FLHMREGFLT DLGPVRLGTE AELLRYCYQV AGTVGRMMAP IAGGGKEAEA 150
    RAVKLGQAMQ LTNILRDVGE DLERDRVYLP LDLLRAHGVE VEDLRAGRVT 200
    PGYRALMAHL EGKARALYRE GLAGLGHLKV GRAAIALAAL QYRGILDKLR 250
    LSGYDNLGRR AHLKAWERAL LLPKAFLAAR FPPRPEGSP 289
    Length:289
    Mass (Da):31,964
    Last modified:October 1, 1994 - v1
    Checksum:i3E58C1141902D3C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001637 Genomic DNA. No translation available.
    AE017222 Genomic DNA. Translation: AAS82387.1.
    RefSeqiWP_011174502.1. NC_005838.1.
    YP_006040.1. NC_005838.1.

    Genome annotation databases

    EnsemblBacteriaiAAS82387; AAS82387; TT_P0057.
    GeneIDi2776542.
    KEGGitth:TT_P0057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001637 Genomic DNA. No translation available.
    AE017222 Genomic DNA. Translation: AAS82387.1 .
    RefSeqi WP_011174502.1. NC_005838.1.
    YP_006040.1. NC_005838.1.

    3D structure databases

    ProteinModelPortali P37270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TT_P0057.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS82387 ; AAS82387 ; TT_P0057 .
    GeneIDi 2776542.
    KEGGi tth:TT_P0057.

    Phylogenomic databases

    eggNOGi COG1562.
    HOGENOMi HOG000220848.
    KOi K02291.
    OMAi KADHANI.
    OrthoDBi EOG63FW00.

    Enzyme and pathway databases

    UniPathwayi UPA00799 .
    BioCyci TTHE262724:GCAT-2092-MONOMER.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequence analysis of the crtB gene of Thermus thermophilus HB27, an extreme thermophile producing carotenoid pigments."
      Hoshino T., Fujii R., Nakahara T.
      Appl. Environ. Microbiol. 59:3150-3153(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.
      Plasmid: pTT27

    Entry informationi

    Entry nameiCRTB_THET2
    AccessioniPrimary (citable) accession number: P37270
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3