Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P37270

- CRTB_THET2

UniProt

P37270 - CRTB_THET2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phytoene synthase

Gene

crtB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (Probable).1 Publication

Cofactori

ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction (By similarity).By similarity
Manganese or magnesium.By similarity

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-2092-MONOMER.
UniPathwayiUPA00799.

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase (EC:2.5.1.-)
Short name:
PSase
Gene namesi
Name:crtB
Ordered Locus Names:TT_P0057
Encoded oniPlasmid pTT271 Publication
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Plasmid pTT27

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Phytoene synthasePRO_0000067439Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TT_P0057.

Structurei

3D structure databases

ProteinModelPortaliP37270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Phylogenomic databases

eggNOGiCOG1562.
HOGENOMiHOG000220848.
KOiK02291.
OMAiKADHANI.
OrthoDBiEOG63FW00.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37270-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMPASMEPD WKALLRVLRA HSATFYLGSL LFPKEARKGA WAVYAACRLG
60 70 80 90 100
DEAVDGEGGG PEALEAWWAG VERAYRGRPL AEWEKGLAWA LERWDIPFEA
110 120 130 140 150
FLHMREGFLT DLGPVRLGTE AELLRYCYQV AGTVGRMMAP IAGGGKEAEA
160 170 180 190 200
RAVKLGQAMQ LTNILRDVGE DLERDRVYLP LDLLRAHGVE VEDLRAGRVT
210 220 230 240 250
PGYRALMAHL EGKARALYRE GLAGLGHLKV GRAAIALAAL QYRGILDKLR
260 270 280
LSGYDNLGRR AHLKAWERAL LLPKAFLAAR FPPRPEGSP
Length:289
Mass (Da):31,964
Last modified:October 1, 1994 - v1
Checksum:i3E58C1141902D3C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001637 Genomic DNA. No translation available.
AE017222 Genomic DNA. Translation: AAS82387.1.
RefSeqiWP_011174502.1. NC_005838.1.
YP_006040.1. NC_005838.1.

Genome annotation databases

EnsemblBacteriaiAAS82387; AAS82387; TT_P0057.
GeneIDi2776542.
KEGGitth:TT_P0057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001637 Genomic DNA. No translation available.
AE017222 Genomic DNA. Translation: AAS82387.1 .
RefSeqi WP_011174502.1. NC_005838.1.
YP_006040.1. NC_005838.1.

3D structure databases

ProteinModelPortali P37270.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TT_P0057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82387 ; AAS82387 ; TT_P0057 .
GeneIDi 2776542.
KEGGi tth:TT_P0057.

Phylogenomic databases

eggNOGi COG1562.
HOGENOMi HOG000220848.
KOi K02291.
OMAi KADHANI.
OrthoDBi EOG63FW00.

Enzyme and pathway databases

UniPathwayi UPA00799 .
BioCyci TTHE262724:GCAT-2092-MONOMER.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequence analysis of the crtB gene of Thermus thermophilus HB27, an extreme thermophile producing carotenoid pigments."
    Hoshino T., Fujii R., Nakahara T.
    Appl. Environ. Microbiol. 59:3150-3153(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.
    Plasmid: pTT27

Entry informationi

Entry nameiCRTB_THET2
AccessioniPrimary (citable) accession number: P37270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3