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Protein

Phytoene synthase

Gene

crtB

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (Probable).1 Publication

Cofactori

Protein has several cofactor binding sites:
  • ATPBy similarityNote: ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction.By similarity
  • Mn2+By similarity, Mg2+By similarity

Pathwayi: phytoene biosynthesis

This protein is involved in the pathway phytoene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCarotenoid biosynthesis
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00799

Names & Taxonomyi

Protein namesi
Recommended name:
Phytoene synthase (EC:2.5.1.-)
Short name:
PSase
Gene namesi
Name:crtB
Ordered Locus Names:TT_P0057
Encoded oniPlasmid pTT271 Publication
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000592 Componenti: Plasmid pTT27

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674391 – 289Phytoene synthaseAdd BLAST289

Proteomic databases

PRIDEiP37270

Interactioni

Protein-protein interaction databases

STRINGi262724.TT_P0057

Structurei

3D structure databases

ProteinModelPortaliP37270
SMRiP37270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105FE1 Bacteria
COG1562 LUCA
HOGENOMiHOG000220848
KOiK02291
OMAiMIAGQRM

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P37270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMPASMEPD WKALLRVLRA HSATFYLGSL LFPKEARKGA WAVYAACRLG
60 70 80 90 100
DEAVDGEGGG PEALEAWWAG VERAYRGRPL AEWEKGLAWA LERWDIPFEA
110 120 130 140 150
FLHMREGFLT DLGPVRLGTE AELLRYCYQV AGTVGRMMAP IAGGGKEAEA
160 170 180 190 200
RAVKLGQAMQ LTNILRDVGE DLERDRVYLP LDLLRAHGVE VEDLRAGRVT
210 220 230 240 250
PGYRALMAHL EGKARALYRE GLAGLGHLKV GRAAIALAAL QYRGILDKLR
260 270 280
LSGYDNLGRR AHLKAWERAL LLPKAFLAAR FPPRPEGSP
Length:289
Mass (Da):31,964
Last modified:October 1, 1994 - v1
Checksum:i3E58C1141902D3C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001637 Genomic DNA No translation available.
AE017222 Genomic DNA Translation: AAS82387.1

Genome annotation databases

EnsemblBacteriaiAAS82387; AAS82387; TT_P0057
KEGGitth:TT_P0057

Similar proteinsi

Entry informationi

Entry nameiCRTB_THET2
AccessioniPrimary (citable) accession number: P37270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

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