Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P37270 (CRTB_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phytoene synthase

Short name=PSase
EC=2.5.1.-
Gene names
Name:crtB
Ordered Locus Names:TT_P0057
Encoded onPlasmid pTT27 Ref.2
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene Probable. Ref.1

Cofactor

ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.

Manganese or magnesium By similarity.

Pathway

Carotenoid biosynthesis; phytoene biosynthesis.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Phytoene synthase
PRO_0000067439

Sequences

Sequence LengthMass (Da)Tools
P37270 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 3E58C1141902D3C5

FASTA28931,964
        10         20         30         40         50         60 
MKMPASMEPD WKALLRVLRA HSATFYLGSL LFPKEARKGA WAVYAACRLG DEAVDGEGGG 

        70         80         90        100        110        120 
PEALEAWWAG VERAYRGRPL AEWEKGLAWA LERWDIPFEA FLHMREGFLT DLGPVRLGTE 

       130        140        150        160        170        180 
AELLRYCYQV AGTVGRMMAP IAGGGKEAEA RAVKLGQAMQ LTNILRDVGE DLERDRVYLP 

       190        200        210        220        230        240 
LDLLRAHGVE VEDLRAGRVT PGYRALMAHL EGKARALYRE GLAGLGHLKV GRAAIALAAL 

       250        260        270        280 
QYRGILDKLR LSGYDNLGRR AHLKAWERAL LLPKAFLAAR FPPRPEGSP 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequence analysis of the crtB gene of Thermus thermophilus HB27, an extreme thermophile producing carotenoid pigments."
Hoshino T., Fujii R., Nakahara T.
Appl. Environ. Microbiol. 59:3150-3153(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The genome sequence of the extreme thermophile Thermus thermophilus."
Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.
Nat. Biotechnol. 22:547-553(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB27 / ATCC BAA-163 / DSM 7039.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB001637 Genomic DNA. No translation available.
AE017222 Genomic DNA. Translation: AAS82387.1.
RefSeqYP_006040.1. NC_005838.1.

3D structure databases

ProteinModelPortalP37270.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262724.TT_P0057.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS82387; AAS82387; TT_P0057.
GeneID2776542.
KEGGtth:TT_P0057.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000220848.
KOK02291.
OMAKADHANI.
OrthoDBEOG63FW00.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-2092-MONOMER.
UniPathwayUPA00799.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRTB_THET2
AccessionPrimary (citable) accession number: P37270
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways