P37269 (CRTB_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phytoene synthase
EC=2.5.1.32

Gene names

Name:	crtB
Synonyms:	pys
Ordered Locus Names:	Synpcc7942_1984

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reaction from prephytoene diphosphate to phytoene.
Catalytic activity	2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.
Pathway	Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.
Sequence similarities	Belongs to the phytoene/squalene synthase family.

Ontologies

Keywords
Biological process	Carotenoid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	geranylgeranyl-diphosphate geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Phytoene synthase		PRO_0000067437
Experimental info
	Sequence conflict	249	1	G → C Ref.1
	Sequence conflict	251 – 252	2	RQ → E Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P37269 [UniParc]. Last modified April 18, 2006. Version 2. Checksum: 9399E7308C4FFC18	FASTA	308	35,891
	10 20 30 40 50 60 MLQMIPARPS RALASLSEAY EECRQITARY AKTFYLGTLL MPEAKRQAIW AIYVWCRRTD 70 80 90 100 110 120 ELVDGPQAAQ TNFATLDAWE RRLERLFAGE PEDDCDVALV DTLARYPLDI QPFRDMIEGQ 130 140 150 160 170 180 RMDLLQNRYS TFEDLYTYCY RVAGTVGLMS QPVMGIESTN SRAPWDPTTP PDPTQEALAL 190 200 210 220 230 240 GIANQLTNIL RDVGEDARRG RIYLPQEELA QFNYSEQDLF NGVIDDRWRA FMQFQLDRAR 250 260 270 280 290 300 DYFEQAERGI RQLSHDARWP VWASLMLYRE ILDVIEQNNY DVFRKRAYVP TWRKLCSLPV AMLRATVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme." Chamovitz D., Misawa D., Sandmann N., Hirshberg J. FEBS Lett. 296:305-310(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7942.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63873 Genomic DNA. Translation: CAA45350.1. CP000100 Genomic DNA. Translation: ABB58014.1.
PIR	S20383.
RefSeq	YP_401001.1. NC_007604.1.
3D structure databases
ProteinModelPortal	P37269.
ModBase	Search...
Protein-protein interaction databases
STRING	1140.Synpcc7942_1984.
Protocols and materials databases
DNASU	3774171.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB58014; ABB58014; Synpcc7942_1984.
GeneID	3774171.
KEGG	syf:Synpcc7942_1984.
PATRIC	23789427. VBISynElo51371_2236.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1562.
HOGENOM	HOG000220848.
KO	K02291.
ProtClustDB	CLSK893015.
Enzyme and pathway databases
BioCyc	SELO1140:GJWQ-2014-MONOMER.
UniPathway	UPA00799; UER00773.
Family and domain databases
Gene3D	1.10.600.10. 1 hit.
InterPro	IPR002060. Squ/phyt_synthse. IPR019845. Squalene/phytoene_synthase_CS. IPR008949. Terpenoid_synth. [Graphical view]
Pfam	PF00494. SQS_PSY. 1 hit. [Graphical view]
SUPFAM	SSF48576. Terpenoid_synth. 1 hit.
PROSITE	PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRTB_SYNE7

Accession

Primary (citable) accession number: P37269
Secondary accession number(s): Q31LQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	April 18, 2006
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program