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P37269

- CRTB_SYNE7

UniProt

P37269 - CRTB_SYNE7

Protein

All-trans-phytoene synthase

Gene

crtB

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield all-trans phytoene.1 Publication

    Catalytic activityi

    2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate.1 Publication

    Cofactori

    ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.By similarity
    Manganese or magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSYNEL:SYNPCC7942_1984-MONOMER.
    UniPathwayiUPA00799; UER00773.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    All-trans-phytoene synthase (EC:2.5.1.99)
    Short name:
    PSase
    Gene namesi
    Name:crtB
    Synonyms:pys
    Ordered Locus Names:Synpcc7942_1984
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308All-trans-phytoene synthasePRO_0000067437Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_1984.

    Structurei

    3D structure databases

    ProteinModelPortaliP37269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phytoene/squalene synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG1562.
    HOGENOMiHOG000220848.
    KOiK02291.
    OrthoDBiEOG63FW00.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37269-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQMIPARPS RALASLSEAY EECRQITARY AKTFYLGTLL MPEAKRQAIW    50
    AIYVWCRRTD ELVDGPQAAQ TNFATLDAWE RRLERLFAGE PEDDCDVALV 100
    DTLARYPLDI QPFRDMIEGQ RMDLLQNRYS TFEDLYTYCY RVAGTVGLMS 150
    QPVMGIESTN SRAPWDPTTP PDPTQEALAL GIANQLTNIL RDVGEDARRG 200
    RIYLPQEELA QFNYSEQDLF NGVIDDRWRA FMQFQLDRAR DYFEQAERGI 250
    RQLSHDARWP VWASLMLYRE ILDVIEQNNY DVFRKRAYVP TWRKLCSLPV 300
    AMLRATVL 308
    Length:308
    Mass (Da):35,891
    Last modified:April 18, 2006 - v2
    Checksum:i9399E7308C4FFC18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti249 – 2491G → C(PubMed:1537409)Curated
    Sequence conflicti251 – 2522RQ → E(PubMed:1537409)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63873 Genomic DNA. Translation: CAA45350.1.
    CP000100 Genomic DNA. Translation: ABB58014.1.
    PIRiS20383.
    RefSeqiYP_401001.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB58014; ABB58014; Synpcc7942_1984.
    GeneIDi3774171.
    KEGGisyf:Synpcc7942_1984.
    PATRICi23789427. VBISynElo51371_2236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63873 Genomic DNA. Translation: CAA45350.1 .
    CP000100 Genomic DNA. Translation: ABB58014.1 .
    PIRi S20383.
    RefSeqi YP_401001.1. NC_007604.1.

    3D structure databases

    ProteinModelPortali P37269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_1984.

    Protocols and materials databases

    DNASUi 3774171.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB58014 ; ABB58014 ; Synpcc7942_1984 .
    GeneIDi 3774171.
    KEGGi syf:Synpcc7942_1984.
    PATRICi 23789427. VBISynElo51371_2236.

    Phylogenomic databases

    eggNOGi COG1562.
    HOGENOMi HOG000220848.
    KOi K02291.
    OrthoDBi EOG63FW00.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    BioCyci SYNEL:SYNPCC7942_1984-MONOMER.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme."
      Chamovitz D., Misawa D., Sandmann N., Hirshberg J.
      FEBS Lett. 296:305-310(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
    2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiCRTB_SYNE7
    AccessioniPrimary (citable) accession number: P37269
    Secondary accession number(s): Q31LQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3