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P37269

- CRTB_SYNE7

UniProt

P37269 - CRTB_SYNE7

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Protein

All-trans-phytoene synthase

Gene
crtB, pys, Synpcc7942_1984
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield all-trans phytoene.1 Publication

Catalytic activityi

2 geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate.1 Publication

Cofactori

ATP. ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction By similarity.
Manganese or magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_1984-MONOMER.
UniPathwayiUPA00799; UER00773.

Names & Taxonomyi

Protein namesi
Recommended name:
All-trans-phytoene synthase (EC:2.5.1.99)
Short name:
PSase
Gene namesi
Name:crtB
Synonyms:pys
Ordered Locus Names:Synpcc7942_1984
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308All-trans-phytoene synthasePRO_0000067437Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_1984.

Structurei

3D structure databases

ProteinModelPortaliP37269.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1562.
HOGENOMiHOG000220848.
KOiK02291.
OrthoDBiEOG63FW00.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37269-1 [UniParc]FASTAAdd to Basket

« Hide

MLQMIPARPS RALASLSEAY EECRQITARY AKTFYLGTLL MPEAKRQAIW    50
AIYVWCRRTD ELVDGPQAAQ TNFATLDAWE RRLERLFAGE PEDDCDVALV 100
DTLARYPLDI QPFRDMIEGQ RMDLLQNRYS TFEDLYTYCY RVAGTVGLMS 150
QPVMGIESTN SRAPWDPTTP PDPTQEALAL GIANQLTNIL RDVGEDARRG 200
RIYLPQEELA QFNYSEQDLF NGVIDDRWRA FMQFQLDRAR DYFEQAERGI 250
RQLSHDARWP VWASLMLYRE ILDVIEQNNY DVFRKRAYVP TWRKLCSLPV 300
AMLRATVL 308
Length:308
Mass (Da):35,891
Last modified:April 18, 2006 - v2
Checksum:i9399E7308C4FFC18
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491G → C1 Publication
Sequence conflicti251 – 2522RQ → E1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63873 Genomic DNA. Translation: CAA45350.1.
CP000100 Genomic DNA. Translation: ABB58014.1.
PIRiS20383.
RefSeqiYP_401001.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB58014; ABB58014; Synpcc7942_1984.
GeneIDi3774171.
KEGGisyf:Synpcc7942_1984.
PATRICi23789427. VBISynElo51371_2236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63873 Genomic DNA. Translation: CAA45350.1 .
CP000100 Genomic DNA. Translation: ABB58014.1 .
PIRi S20383.
RefSeqi YP_401001.1. NC_007604.1.

3D structure databases

ProteinModelPortali P37269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_1984.

Protocols and materials databases

DNASUi 3774171.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB58014 ; ABB58014 ; Synpcc7942_1984 .
GeneIDi 3774171.
KEGGi syf:Synpcc7942_1984.
PATRICi 23789427. VBISynElo51371_2236.

Phylogenomic databases

eggNOGi COG1562.
HOGENOMi HOG000220848.
KOi K02291.
OrthoDBi EOG63FW00.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
BioCyci SYNEL:SYNPCC7942_1984-MONOMER.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme."
    Chamovitz D., Misawa D., Sandmann N., Hirshberg J.
    FEBS Lett. 296:305-310(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiCRTB_SYNE7
AccessioniPrimary (citable) accession number: P37269
Secondary accession number(s): Q31LQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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