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Protein

Squalene synthase

Gene

FDFT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Pathwayi: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Squalene synthase (FDFT1)
  2. Squalene monooxygenase (SQLE)
  3. Lanosterol synthase (LSS)
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

Magnesium, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS01329-MONOMER.
ZFISH:HS01329-MONOMER.
BRENDAi2.5.1.21. 2681.
ReactomeiR-HSA-191273. Cholesterol biosynthesis.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
SABIO-RKP37268.
UniPathwayiUPA00767; UER00751.

Chemistry databases

SwissLipidsiSLP:000000138.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene namesi
Name:FDFT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:3629. FDFT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: HPA
  • endoplasmic reticulum membrane Source: GO_Central
  • integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2222.
OpenTargetsiENSG00000079459.
PharmGKBiPA28073.

Chemistry databases

ChEMBLiCHEMBL3338.
GuidetoPHARMACOLOGYi645.

Polymorphism and mutation databases

BioMutaiFDFT1.
DMDMi585126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674431 – 417Squalene synthaseAdd BLAST417

Proteomic databases

EPDiP37268.
PaxDbiP37268.
PeptideAtlasiP37268.
PRIDEiP37268.

PTM databases

iPTMnetiP37268.
PhosphoSitePlusiP37268.
SwissPalmiP37268.

Expressioni

Gene expression databases

BgeeiENSG00000079459.
CleanExiHS_FDFT1.
ExpressionAtlasiP37268. baseline and differential.
GenevisibleiP37268. HS.

Organism-specific databases

HPAiHPA008874.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi108516. 29 interactors.
IntActiP37268. 9 interactors.
MINTiMINT-1401726.
STRINGi9606.ENSP00000220584.

Chemistry databases

BindingDBiP37268.

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 51Combined sources14
Helixi52 – 54Combined sources3
Helixi55 – 59Combined sources5
Helixi65 – 84Combined sources20
Helixi90 – 103Combined sources14
Turni117 – 119Combined sources3
Helixi120 – 123Combined sources4
Helixi125 – 134Combined sources10
Helixi137 – 156Combined sources20
Helixi157 – 159Combined sources3
Helixi165 – 175Combined sources11
Helixi177 – 189Combined sources13
Beta strandi191 – 193Combined sources3
Helixi195 – 199Combined sources5
Helixi201 – 218Combined sources18
Helixi220 – 225Combined sources6
Helixi233 – 236Combined sources4
Turni237 – 239Combined sources3
Helixi243 – 247Combined sources5
Helixi249 – 251Combined sources3
Helixi252 – 267Combined sources16
Helixi270 – 278Combined sources9
Helixi283 – 303Combined sources21
Helixi307 – 310Combined sources4
Helixi318 – 327Combined sources10
Beta strandi328 – 330Combined sources3
Helixi331 – 346Combined sources16
Helixi356 – 368Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZFX-ray2.15A/B/C31-370[»]
3ASXX-ray2.00A31-370[»]
3LEEX-ray3.20A/B/C/D/E/F31-370[»]
3Q2ZX-ray2.00A31-370[»]
3Q30X-ray2.00A31-370[»]
3V66X-ray1.80A31-370[»]
3VJ8X-ray1.52A31-370[»]
3VJ9X-ray1.52A31-370[»]
3VJAX-ray1.76A/B31-370[»]
3VJBX-ray2.05A/B/C/D/E/F31-370[»]
3VJCX-ray1.89A/B/C/D/E/F31-370[»]
3WC9X-ray2.82A/B/C/D/E/F31-370[»]
3WCDX-ray2.75A/B/C/D/E/F31-370[»]
3WCFX-ray2.22A/B/C/D/E/F31-370[»]
3WCHX-ray2.50A/B/C/D/E/F31-370[»]
3WCIX-ray2.30A/B/C/D/E/F31-370[»]
3WCJX-ray2.20A/B/C/D/E/F31-370[»]
3WCLX-ray2.24A/B/C/D/E/F31-370[»]
3WCMX-ray2.06A/B/C/D/E/F31-370[»]
3WEFX-ray2.35A/B/C/D/E/F31-370[»]
3WEGX-ray1.75A31-370[»]
3WEHX-ray1.87A31-370[»]
3WEIX-ray1.79A31-370[»]
3WEJX-ray2.00A31-370[»]
3WEKX-ray1.85A31-370[»]
3WSAX-ray2.90A/B/C/D/E/F31-370[»]
ProteinModelPortaliP37268.
SMRiP37268.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37268.

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1459. Eukaryota.
COG1562. LUCA.
GeneTreeiENSGT00390000016034.
HOGENOMiHOG000186940.
HOVERGENiHBG002370.
InParanoidiP37268.
KOiK00801.
OMAiFHTYLYQ.
OrthoDBiEOG091G072P.
PhylomeDBiP37268.
TreeFamiTF105316.

Family and domain databases

CDDicd00683. Trans_IPPS_HH. 1 hit.
Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR033904. Trans_IPPS_HH.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR01559. squal_synth. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P37268-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFVKCLGHP EEFYNLVRFR IGGKRKVMPK MDQDSLSSSL KTCYKYLNQT
60 70 80 90 100
SRSFAAVIQA LDGEMRNAVC IFYLVLRALD TLEDDMTISV EKKVPLLHNF
110 120 130 140 150
HSFLYQPDWR FMESKEKDRQ VLEDFPTISL EFRNLAEKYQ TVIADICRRM
160 170 180 190 200
GIGMAEFLDK HVTSEQEWDK YCHYVAGLVG IGLSRLFSAS EFEDPLVGED
210 220 230 240 250
TERANSMGLF LQKTNIIRDY LEDQQGGREF WPQEVWSRYV KKLGDFAKPE
260 270 280 290 300
NIDLAVQCLN ELITNALHHI PDVITYLSRL RNQSVFNFCA IPQVMAIATL
310 320 330 340 350
AACYNNQQVF KGAVKIRKGQ AVTLMMDATN MPAVKAIIYQ YMEEIYHRIP
360 370 380 390 400
DSDPSSSKTR QIISTIRTQN LPNCQLISRS HYSPIYLSFV MLLAALSWQY
410
LTTLSQVTED YVQTGEH
Length:417
Mass (Da):48,115
Last modified:October 1, 1994 - v1
Checksum:iD36CBC8382F827EC
GO
Isoform 2 (identifier: P37268-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,770
Checksum:i45DC1E8B9F179D2B
GO
Isoform 3 (identifier: P37268-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):38,317
Checksum:iD58BAF0FA5DC6E5F
GO
Isoform 4 (identifier: P37268-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available.
Show »
Length:306
Mass (Da):35,101
Checksum:iC237E92AAE66264A
GO
Isoform 5 (identifier: P37268-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-170: Missing.

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):43,060
Checksum:iC9F61FDC11FAA49B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353D → N in AAB33404 (PubMed:7864626).Curated1
Sequence conflicti402T → A in CAA48896 (PubMed:8294001).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01178645K → R Influences plasma cholesterol levels; associated with increased total cholesterol and non-high-density lipoprotein cholesterol. 2 PublicationsCorresponds to variant rs11549147dbSNPEnsembl.1
Natural variantiVAR_011787392L → P.Corresponds to variant rs1804473dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565171 – 111Missing in isoform 4. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0562821 – 85Missing in isoform 3. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_0562831 – 64Missing in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_056518128 – 170Missing in isoform 5. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06070 mRNA. Translation: AAA60582.1.
L06105 mRNA. Translation: AAA36645.1.
X69141 mRNA. Translation: CAA48896.1.
S76822 mRNA. Translation: AAB33404.1.
AK057726 mRNA. Translation: BAG51957.1.
AK293545 mRNA. Translation: BAH11529.1.
AK296043 mRNA. Translation: BAG58807.1.
AK300059 mRNA. Translation: BAG61868.1.
AK315993 mRNA. Translation: BAH14364.1.
AK316351 mRNA. Translation: BAH14722.1.
AK316531 mRNA. Translation: BAH14902.1.
AK316534 mRNA. Translation: BAH14905.1.
AC069185 Genomic DNA. No translation available.
BC003573 mRNA. Translation: AAH03573.1.
BC009251 mRNA. Translation: AAH09251.1.
BC029641 mRNA. Translation: AAH29641.1.
CCDSiCCDS5985.1. [P37268-1]
CCDS75696.1. [P37268-2]
CCDS75697.1. [P37268-3]
PIRiA45998.
I38245.
I52090.
RefSeqiNP_001274671.1. NM_001287742.1. [P37268-1]
NP_001274672.1. NM_001287743.1. [P37268-1]
NP_001274673.1. NM_001287744.1. [P37268-2]
NP_001274674.1. NM_001287745.1. [P37268-2]
NP_001274676.1. NM_001287747.1. [P37268-2]
NP_001274677.1. NM_001287748.1. [P37268-2]
NP_001274678.1. NM_001287749.1. [P37268-2]
NP_001274679.1. NM_001287750.1.
NP_001274680.1. NM_001287751.1. [P37268-3]
NP_001274685.1. NM_001287756.1.
NP_004453.3. NM_004462.4. [P37268-1]
XP_016868706.1. XM_017013217.1. [P37268-2]
UniGeneiHs.593928.

Genome annotation databases

EnsembliENST00000220584; ENSP00000220584; ENSG00000079459. [P37268-1]
ENST00000443614; ENSP00000390367; ENSG00000079459. [P37268-5]
ENST00000525777; ENSP00000436069; ENSG00000079459. [P37268-3]
ENST00000528643; ENSP00000431649; ENSG00000079459. [P37268-3]
ENST00000528812; ENSP00000431749; ENSG00000079459. [P37268-2]
ENST00000530664; ENSP00000432331; ENSG00000079459. [P37268-2]
ENST00000538689; ENSP00000444248; ENSG00000079459. [P37268-2]
ENST00000615631; ENSP00000481481; ENSG00000079459. [P37268-1]
ENST00000618539; ENSP00000480828; ENSG00000079459. [P37268-1]
ENST00000622850; ENSP00000484122; ENSG00000079459. [P37268-2]
ENST00000623368; ENSP00000485229; ENSG00000079459. [P37268-2]
GeneIDi2222.
KEGGihsa:2222.
UCSCiuc003wuh.4. human. [P37268-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06070 mRNA. Translation: AAA60582.1.
L06105 mRNA. Translation: AAA36645.1.
X69141 mRNA. Translation: CAA48896.1.
S76822 mRNA. Translation: AAB33404.1.
AK057726 mRNA. Translation: BAG51957.1.
AK293545 mRNA. Translation: BAH11529.1.
AK296043 mRNA. Translation: BAG58807.1.
AK300059 mRNA. Translation: BAG61868.1.
AK315993 mRNA. Translation: BAH14364.1.
AK316351 mRNA. Translation: BAH14722.1.
AK316531 mRNA. Translation: BAH14902.1.
AK316534 mRNA. Translation: BAH14905.1.
AC069185 Genomic DNA. No translation available.
BC003573 mRNA. Translation: AAH03573.1.
BC009251 mRNA. Translation: AAH09251.1.
BC029641 mRNA. Translation: AAH29641.1.
CCDSiCCDS5985.1. [P37268-1]
CCDS75696.1. [P37268-2]
CCDS75697.1. [P37268-3]
PIRiA45998.
I38245.
I52090.
RefSeqiNP_001274671.1. NM_001287742.1. [P37268-1]
NP_001274672.1. NM_001287743.1. [P37268-1]
NP_001274673.1. NM_001287744.1. [P37268-2]
NP_001274674.1. NM_001287745.1. [P37268-2]
NP_001274676.1. NM_001287747.1. [P37268-2]
NP_001274677.1. NM_001287748.1. [P37268-2]
NP_001274678.1. NM_001287749.1. [P37268-2]
NP_001274679.1. NM_001287750.1.
NP_001274680.1. NM_001287751.1. [P37268-3]
NP_001274685.1. NM_001287756.1.
NP_004453.3. NM_004462.4. [P37268-1]
XP_016868706.1. XM_017013217.1. [P37268-2]
UniGeneiHs.593928.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZFX-ray2.15A/B/C31-370[»]
3ASXX-ray2.00A31-370[»]
3LEEX-ray3.20A/B/C/D/E/F31-370[»]
3Q2ZX-ray2.00A31-370[»]
3Q30X-ray2.00A31-370[»]
3V66X-ray1.80A31-370[»]
3VJ8X-ray1.52A31-370[»]
3VJ9X-ray1.52A31-370[»]
3VJAX-ray1.76A/B31-370[»]
3VJBX-ray2.05A/B/C/D/E/F31-370[»]
3VJCX-ray1.89A/B/C/D/E/F31-370[»]
3WC9X-ray2.82A/B/C/D/E/F31-370[»]
3WCDX-ray2.75A/B/C/D/E/F31-370[»]
3WCFX-ray2.22A/B/C/D/E/F31-370[»]
3WCHX-ray2.50A/B/C/D/E/F31-370[»]
3WCIX-ray2.30A/B/C/D/E/F31-370[»]
3WCJX-ray2.20A/B/C/D/E/F31-370[»]
3WCLX-ray2.24A/B/C/D/E/F31-370[»]
3WCMX-ray2.06A/B/C/D/E/F31-370[»]
3WEFX-ray2.35A/B/C/D/E/F31-370[»]
3WEGX-ray1.75A31-370[»]
3WEHX-ray1.87A31-370[»]
3WEIX-ray1.79A31-370[»]
3WEJX-ray2.00A31-370[»]
3WEKX-ray1.85A31-370[»]
3WSAX-ray2.90A/B/C/D/E/F31-370[»]
ProteinModelPortaliP37268.
SMRiP37268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108516. 29 interactors.
IntActiP37268. 9 interactors.
MINTiMINT-1401726.
STRINGi9606.ENSP00000220584.

Chemistry databases

BindingDBiP37268.
ChEMBLiCHEMBL3338.
GuidetoPHARMACOLOGYi645.
SwissLipidsiSLP:000000138.

PTM databases

iPTMnetiP37268.
PhosphoSitePlusiP37268.
SwissPalmiP37268.

Polymorphism and mutation databases

BioMutaiFDFT1.
DMDMi585126.

Proteomic databases

EPDiP37268.
PaxDbiP37268.
PeptideAtlasiP37268.
PRIDEiP37268.

Protocols and materials databases

DNASUi2222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220584; ENSP00000220584; ENSG00000079459. [P37268-1]
ENST00000443614; ENSP00000390367; ENSG00000079459. [P37268-5]
ENST00000525777; ENSP00000436069; ENSG00000079459. [P37268-3]
ENST00000528643; ENSP00000431649; ENSG00000079459. [P37268-3]
ENST00000528812; ENSP00000431749; ENSG00000079459. [P37268-2]
ENST00000530664; ENSP00000432331; ENSG00000079459. [P37268-2]
ENST00000538689; ENSP00000444248; ENSG00000079459. [P37268-2]
ENST00000615631; ENSP00000481481; ENSG00000079459. [P37268-1]
ENST00000618539; ENSP00000480828; ENSG00000079459. [P37268-1]
ENST00000622850; ENSP00000484122; ENSG00000079459. [P37268-2]
ENST00000623368; ENSP00000485229; ENSG00000079459. [P37268-2]
GeneIDi2222.
KEGGihsa:2222.
UCSCiuc003wuh.4. human. [P37268-1]

Organism-specific databases

CTDi2222.
DisGeNETi2222.
GeneCardsiFDFT1.
H-InvDBHIX0168873.
HGNCiHGNC:3629. FDFT1.
HPAiHPA008874.
MIMi184420. gene.
neXtProtiNX_P37268.
OpenTargetsiENSG00000079459.
PharmGKBiPA28073.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1459. Eukaryota.
COG1562. LUCA.
GeneTreeiENSGT00390000016034.
HOGENOMiHOG000186940.
HOVERGENiHBG002370.
InParanoidiP37268.
KOiK00801.
OMAiFHTYLYQ.
OrthoDBiEOG091G072P.
PhylomeDBiP37268.
TreeFamiTF105316.

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751.
BioCyciMetaCyc:HS01329-MONOMER.
ZFISH:HS01329-MONOMER.
BRENDAi2.5.1.21. 2681.
ReactomeiR-HSA-191273. Cholesterol biosynthesis.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2426168. Activation of gene expression by SREBF (SREBP).
SABIO-RKP37268.

Miscellaneous databases

ChiTaRSiFDFT1. human.
EvolutionaryTraceiP37268.
GenomeRNAii2222.
PROiP37268.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079459.
CleanExiHS_FDFT1.
ExpressionAtlasiP37268. baseline and differential.
GenevisibleiP37268. HS.

Family and domain databases

CDDicd00683. Trans_IPPS_HH. 1 hit.
Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR033904. Trans_IPPS_HH.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR01559. squal_synth. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDFT_HUMAN
AccessioniPrimary (citable) accession number: P37268
Secondary accession number(s): B3KQ95
, B4DJE5, B4DT56, B7Z1J3, Q96GT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.