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Protein

Aminodeoxychorismate synthase

Gene

ABZ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis.1 Publication

Miscellaneous

Present with 1550 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobenzoate from chorismate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Aminodeoxychorismate synthase (ABZ1)
  2. Aminodeoxychorismate lyase (ABZ2)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobenzoate from chorismate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei112PROSITE-ProRule annotation1
Active sitei207PROSITE-ProRule annotation1
Active sitei209PROSITE-ProRule annotation1

GO - Molecular functioni

  • 4-amino-4-deoxychorismate synthase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processFolate biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YNR033W-MONOMER
UniPathwayiUPA00077; UER00149

Protein family/group databases

MEROPSiC26.958

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate synthase (EC:2.6.1.85)
Short name:
ADC synthase
Alternative name(s):
P-aminobenzoic acid synthase
Short name:
PABA synthase
Para-aminobenzoate synthase
Gene namesi
Name:ABZ1
Ordered Locus Names:YNR033W
ORF Names:N3286
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR033W
SGDiS000005316 ABZ1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001541421 – 787Aminodeoxychorismate synthaseAdd BLAST787

Proteomic databases

MaxQBiP37254
PaxDbiP37254
PRIDEiP37254

PTM databases

iPTMnetiP37254

Interactioni

Protein-protein interaction databases

BioGridi35858, 77 interactors
DIPiDIP-6278N
IntActiP37254, 9 interactors
MINTiP37254
STRINGi4932.YNR033W

Structurei

3D structure databases

ProteinModelPortaliP37254
SMRiP37254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 233Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni304 – 787PABB componentAdd BLAST484

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 14Poly-Gln5

Domaini

The PABA component provides the glutamine amidotransferase activity.
The PABB component catalyzes the formation of ADC by binding chorismate and ammonia.

Sequence similaritiesi

In the C-terminal section; belongs to the anthranilate synthase component I family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

GeneTreeiENSGT00620000088738
HOGENOMiHOG000025143
InParanoidiP37254
KOiK13950
OMAiSMRPMKG
OrthoDBiEOG092C0U1F

Family and domain databases

Gene3Di3.40.50.880, 1 hit
3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801 ADC_synthase
IPR006805 Anth_synth_I_N
IPR015890 Chorismate_C
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010117 PabB_fungal
IPR006221 TrpG/PapA_dom
PfamiView protein in Pfam
PF04715 Anth_synt_I_N, 1 hit
PF00425 Chorismate_bind, 1 hit
PF00117 GATase, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
SSF56322 SSF56322, 1 hit
TIGRFAMsiTIGR01823 PabB-fungal, 1 hit
TIGR00566 trpG_papA, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P37254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDTIDTKQ QQQQLHVLFI DSYDSFTYNV VRLIEQQTDI SPGVNAVHVT
60 70 80 90 100
TVHSDTFQSM DQLLPLLPLF DAIVVGPGPG NPNNGAQDMG IISELFENAN
110 120 130 140 150
GKLDEVPILG ICLGFQAMCL AQGADVSELN TIKHGQVYEM HLNDAARACG
160 170 180 190 200
LFSGYPDTFK STRYHSLHVN AEGIDTLLPL CTTEDENGIL LMSAQTKNKP
210 220 230 240 250
WFGVQYHPES CCSELGGLLV SNFLKLSFIN NVKTGRWEKK KLNGEFSDIL
260 270 280 290 300
SRLDRTIDRD PIYKVKEKYP KGEDTTYVKQ FEVSEDPKLT FEICNIIREE
310 320 330 340 350
KFVMSSSVIS ENTGEWSIIA LPNSASQVFT HYGAMKKTTV HYWQDSEISY
360 370 380 390 400
TLLKKCLDGQ DSDLPGSLEV IHEDKSQFWI TLGKFMENKI IDNHREIPFI
410 420 430 440 450
GGLVGILGYE IGQYIACGRC NDDENSLVPD AKLVFINNSI VINHKQGKLY
460 470 480 490 500
CISLDNTFPV ALEQSLRDSF VRKKNIKQSL SWPKYLPEEI DFIITMPDKL
510 520 530 540 550
DYAKAFKKCQ DYMHKGDSYE MCLTTQTKVV PSAVIEPWRI FQTLVQRNPA
560 570 580 590 600
PFSSFFEFKD IIPRQDETPP VLCFLSTSPE RFLKWDADTC ELRPIKGTVK
610 620 630 640 650
KGPQMNLAKA TRILKTPKEF GENLMILDLI RNDLYELVPD VRVEEFMSVQ
660 670 680 690 700
EYATVYQLVS VVKAHGLTSA SKKTRYSGID VLKHSLPPGS MTGAPKKITV
710 720 730 740 750
QLLQDKIESK LNKHVNGGAR GVYSGVTGYW SVNSNGDWSV NIRCMYSYNG
760 770 780
GTSWQLGAGG AITVLSTLDG ELEEMYNKLE SNLQIFM
Length:787
Mass (Da):88,544
Last modified:February 21, 2006 - v4
Checksum:i13117891486B5B0E
GO

Sequence cautioni

The sequence AAA34840 differs from that shown. Reason: Frameshift at positions 581, 586, 591, 716, 729 and 734.Curated
The sequence AAB49319 differs from that shown. Reason: Frameshift at positions 581, 586 and 591.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85G → D in AAT93048 (PubMed:17322287).Curated1
Sequence conflicti171A → P in AAA34840 (PubMed:8346682).Curated1
Sequence conflicti171A → P in AAB49319 (PubMed:8725220).Curated1
Sequence conflicti533A → T in AAA34840 (PubMed:8346682).Curated1
Sequence conflicti586D → Y in AAB49319 (PubMed:8725220).Curated1
Sequence conflicti590 – 591CE → FV in AAA34840 (PubMed:8346682).Curated2
Sequence conflicti721G → GL in AAB49319 (PubMed:8725220).Curated1
Sequence conflicti722V → G in AAA34840 (PubMed:8346682).Curated1
Sequence conflicti735 – 737NGD → FGF in AAA34840 (PubMed:8346682).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15299 Genomic DNA Translation: AAA34840.1 Frameshift.
U43608 Genomic DNA Translation: AAB49319.1 Frameshift.
Z71648 Genomic DNA Translation: CAA96313.1
AY693029 Genomic DNA Translation: AAT93048.1
BK006947 Genomic DNA Translation: DAA10574.1
PIRiS63364
RefSeqiNP_014431.1, NM_001183210.1

Genome annotation databases

EnsemblFungiiYNR033W; YNR033W; YNR033W
GeneIDi855768
KEGGisce:YNR033W

Similar proteinsi

Entry informationi

Entry nameiPABS_YEAST
AccessioniPrimary (citable) accession number: P37254
Secondary accession number(s): D6W1K8, Q02982, Q6B1Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 21, 2006
Last modified: June 20, 2018
This is version 173 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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