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P37254

- PABS_YEAST

UniProt

P37254 - PABS_YEAST

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Protein
Aminodeoxychorismate synthase
Gene
ABZ1, YNR033W, N3286
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis.1 Publication

Catalytic activityi

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121 By similarity
Active sitei207 – 2071 By similarity
Active sitei209 – 2091 By similarity

GO - Molecular functioni

  1. 4-amino-4-deoxychorismate synthase activity Source: SGD
  2. oxo-acid-lyase activity Source: InterPro

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. glutamine metabolic process Source: UniProtKB-KW
  3. para-aminobenzoic acid biosynthetic process Source: SGD
  4. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Folate biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YNR033W-MONOMER.
UniPathwayiUPA00077; UER00149.

Protein family/group databases

MEROPSiC26.958.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate synthase (EC:2.6.1.85)
Short name:
ADC synthase
Alternative name(s):
P-aminobenzoic acid synthase
Short name:
PABA synthase
Para-aminobenzoate synthase
Gene namesi
Name:ABZ1
Ordered Locus Names:YNR033W
ORF Names:N3286
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNR033w.
SGDiS000005316. ABZ1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 787787Aminodeoxychorismate synthase
PRO_0000154142Add
BLAST

Proteomic databases

MaxQBiP37254.
PaxDbiP37254.
PeptideAtlasiP37254.

Expressioni

Gene expression databases

GenevestigatoriP37254.

Interactioni

Protein-protein interaction databases

BioGridi35858. 47 interactions.
DIPiDIP-6278N.
IntActiP37254. 9 interactions.
MINTiMINT-604611.

Structurei

3D structure databases

ProteinModelPortaliP37254.
SMRiP37254. Positions 17-224, 492-786.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 233218Glutamine amidotransferase type-1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni304 – 787484PABB component
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 145Poly-Gln

Domaini

The PABA component provides the glutamine amidotransferase activity.
The PABB component catalyzes the formation of ADC by binding chorismate and ammonia.

Sequence similaritiesi

In the C-terminal section; belongs to the anthranilate synthase component I family.

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0147.
GeneTreeiENSGT00620000088738.
HOGENOMiHOG000025143.
KOiK13950.
OMAiYEANDAT.
OrthoDBiEOG7PZS5V.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
3.60.120.10. 1 hit.
InterProiIPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate-bd_C.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010117. PabB_fungal.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF56322. SSF56322. 1 hit.
TIGRFAMsiTIGR01823. PabB-fungal. 1 hit.
TIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37254-1 [UniParc]FASTAAdd to Basket

« Hide

MLSDTIDTKQ QQQQLHVLFI DSYDSFTYNV VRLIEQQTDI SPGVNAVHVT    50
TVHSDTFQSM DQLLPLLPLF DAIVVGPGPG NPNNGAQDMG IISELFENAN 100
GKLDEVPILG ICLGFQAMCL AQGADVSELN TIKHGQVYEM HLNDAARACG 150
LFSGYPDTFK STRYHSLHVN AEGIDTLLPL CTTEDENGIL LMSAQTKNKP 200
WFGVQYHPES CCSELGGLLV SNFLKLSFIN NVKTGRWEKK KLNGEFSDIL 250
SRLDRTIDRD PIYKVKEKYP KGEDTTYVKQ FEVSEDPKLT FEICNIIREE 300
KFVMSSSVIS ENTGEWSIIA LPNSASQVFT HYGAMKKTTV HYWQDSEISY 350
TLLKKCLDGQ DSDLPGSLEV IHEDKSQFWI TLGKFMENKI IDNHREIPFI 400
GGLVGILGYE IGQYIACGRC NDDENSLVPD AKLVFINNSI VINHKQGKLY 450
CISLDNTFPV ALEQSLRDSF VRKKNIKQSL SWPKYLPEEI DFIITMPDKL 500
DYAKAFKKCQ DYMHKGDSYE MCLTTQTKVV PSAVIEPWRI FQTLVQRNPA 550
PFSSFFEFKD IIPRQDETPP VLCFLSTSPE RFLKWDADTC ELRPIKGTVK 600
KGPQMNLAKA TRILKTPKEF GENLMILDLI RNDLYELVPD VRVEEFMSVQ 650
EYATVYQLVS VVKAHGLTSA SKKTRYSGID VLKHSLPPGS MTGAPKKITV 700
QLLQDKIESK LNKHVNGGAR GVYSGVTGYW SVNSNGDWSV NIRCMYSYNG 750
GTSWQLGAGG AITVLSTLDG ELEEMYNKLE SNLQIFM 787
Length:787
Mass (Da):88,544
Last modified:February 21, 2006 - v4
Checksum:i13117891486B5B0E
GO

Sequence cautioni

The sequence AAA34840.1 differs from that shown. Reason: Frameshift at positions 581, 586, 591, 716, 729 and 734.
The sequence AAB49319.1 differs from that shown. Reason: Frameshift at positions 581, 586 and 591.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851G → D in AAT93048. 1 Publication
Sequence conflicti171 – 1711A → P in AAA34840. 1 Publication
Sequence conflicti171 – 1711A → P in AAB49319. 1 Publication
Sequence conflicti533 – 5331A → T in AAA34840. 1 Publication
Sequence conflicti586 – 5861D → Y in AAB49319. 1 Publication
Sequence conflicti590 – 5912CE → FV in AAA34840. 1 Publication
Sequence conflicti721 – 7211G → GL in AAB49319. 1 Publication
Sequence conflicti722 – 7221V → G in AAA34840. 1 Publication
Sequence conflicti735 – 7373NGD → FGF in AAA34840. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15299 Genomic DNA. Translation: AAA34840.1. Frameshift.
U43608 Genomic DNA. Translation: AAB49319.1. Frameshift.
Z71648 Genomic DNA. Translation: CAA96313.1.
AY693029 Genomic DNA. Translation: AAT93048.1.
BK006947 Genomic DNA. Translation: DAA10574.1.
PIRiS63364.
RefSeqiNP_014431.1. NM_001183210.1.

Genome annotation databases

EnsemblFungiiYNR033W; YNR033W; YNR033W.
GeneIDi855768.
KEGGisce:YNR033W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15299 Genomic DNA. Translation: AAA34840.1 . Frameshift.
U43608 Genomic DNA. Translation: AAB49319.1 . Frameshift.
Z71648 Genomic DNA. Translation: CAA96313.1 .
AY693029 Genomic DNA. Translation: AAT93048.1 .
BK006947 Genomic DNA. Translation: DAA10574.1 .
PIRi S63364.
RefSeqi NP_014431.1. NM_001183210.1.

3D structure databases

ProteinModelPortali P37254.
SMRi P37254. Positions 17-224, 492-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35858. 47 interactions.
DIPi DIP-6278N.
IntActi P37254. 9 interactions.
MINTi MINT-604611.

Chemistry

DrugBanki DB00259. Sulfanilamide.

Protein family/group databases

MEROPSi C26.958.

Proteomic databases

MaxQBi P37254.
PaxDbi P37254.
PeptideAtlasi P37254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNR033W ; YNR033W ; YNR033W .
GeneIDi 855768.
KEGGi sce:YNR033W.

Organism-specific databases

CYGDi YNR033w.
SGDi S000005316. ABZ1.

Phylogenomic databases

eggNOGi COG0147.
GeneTreei ENSGT00620000088738.
HOGENOMi HOG000025143.
KOi K13950.
OMAi YEANDAT.
OrthoDBi EOG7PZS5V.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00149 .
BioCyci YEAST:YNR033W-MONOMER.

Miscellaneous databases

NextBioi 980214.

Gene expression databases

Genevestigatori P37254.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
3.60.120.10. 1 hit.
InterProi IPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate-bd_C.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010117. PabB_fungal.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF56322. SSF56322. 1 hit.
TIGRFAMsi TIGR01823. PabB-fungal. 1 hit.
TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Para-aminobenzoate synthase gene of Saccharomyces cerevisiae encodes a bifunctional enzyme."
    Edman J.C., Goldstein A.L., Erbe J.G.
    Yeast 9:669-675(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family."
    Shen W.-C., Stanford D.R., Hopper A.K.
    Genetics 143:699-712(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPABS_YEAST
AccessioniPrimary (citable) accession number: P37254
Secondary accession number(s): D6W1K8, Q02982, Q6B1Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 21, 2006
Last modified: July 9, 2014
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1550 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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