ABZ1

Functionⁱ

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis.1 Publication

Miscellaneous

Present with 1550 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Pathwayⁱ: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobenzoate from chorismate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Aminodeoxychorismate synthase (ABZ1)
Aminodeoxychorismate lyase (ABZ2)

This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobenzoate from chorismate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	112	PROSITE-ProRule annotation	1
Active siteⁱ	207	PROSITE-ProRule annotation	1
Active siteⁱ	209	PROSITE-ProRule annotation	1

GO - Molecular functionⁱ

4-amino-4-deoxychorismate synthase activity
Source: SGD
Inferred from mutant phenotypeⁱ
- 8346682

Complete GO annotation...

GO - Biological processⁱ

folic acid biosynthetic process Source: UniProtKB-KW
glutamine metabolic process Source: UniProtKB-KW
para-aminobenzoic acid biosynthetic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 8346682
tetrahydrofolate biosynthetic process Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Transferase
Biological process	Folate biosynthesis

Enzyme and pathway databases

BioCycⁱ	YEAST:YNR033W-MONOMER.
UniPathwayⁱ	UPA00077; UER00149.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C26.958.

MEROPSⁱ

C26.958.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aminodeoxychorismate synthase (EC:2.6.1.85) Short name: ADC synthase Alternative name(s): P-aminobenzoic acid synthase Short name: PABA synthase Para-aminobenzoate synthase
Gene namesⁱ	Name:ABZ1 Ordered Locus Names:YNR033W ORF Names:N3286
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIV

Organism-specific databases

EuPathDBⁱ	FungiDB:YNR033W.
Saccharomyces Genome Database More...SGDⁱ	S000005316. ABZ1.

Subcellular locationⁱ

Cytoplasm
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Global analysis of protein localization in budding yeast."
  Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
  Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000154142	1 – 787	Aminodeoxychorismate synthaseAdd BLAST		787

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P37254.
PRIDEⁱ	P37254.

PTM databases

iPTMnetⁱ	P37254.

iPTMnetⁱ

P37254.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	35858. 74 interactors.
Database of interacting proteins More...DIPⁱ	DIP-6278N.
IntActⁱ	P37254. 9 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-604611.
STRINGⁱ	4932.YNR033W.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P37254.
SMRⁱ	P37254.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	16 – 233	Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST		218

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	304 – 787	PABB componentAdd BLAST		484

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	10 – 14	Poly-Gln		5

Domainⁱ

The PABA component provides the glutamine amidotransferase activity.

The PABB component catalyzes the formation of ADC by binding chorismate and ammonia.

Sequence similaritiesⁱ

In the C-terminal section; belongs to the anthranilate synthase component I family.Curated

Keywords - Domainⁱ

Glutamine amidotransferase

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00620000088738.
HOGENOMⁱ	HOG000025143.
InParanoidⁱ	P37254.
KEGG Orthology (KO) More...KOⁱ	K13950.
OMAⁱ	SMRPMKG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0U1F.

Family and domain databases

Gene3Dⁱ	3.40.50.880. 1 hit. 3.60.120.10. 1 hit.
InterProⁱ	View protein in InterPro IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR015890. Chorismate_C. IPR029062. Class_I_gatase-like. IPR017926. GATASE. IPR010117. PabB_fungal. IPR006221. TrpG/PapA_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. PF00117. GATase. 1 hit.
SUPFAMⁱ	SSF52317. SSF52317. 1 hit. SSF56322. SSF56322. 1 hit.
TIGRFAMsⁱ	TIGR01823. PabB-fungal. 1 hit. TIGR00566. trpG_papA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51273. GATASE_TYPE_1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P37254-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLSDTIDTKQ QQQQLHVLFI DSYDSFTYNV VRLIEQQTDI SPGVNAVHVT 
        60         70         80         90        100
TVHSDTFQSM DQLLPLLPLF DAIVVGPGPG NPNNGAQDMG IISELFENAN 
       110        120        130        140        150
GKLDEVPILG ICLGFQAMCL AQGADVSELN TIKHGQVYEM HLNDAARACG 
       160        170        180        190        200
LFSGYPDTFK STRYHSLHVN AEGIDTLLPL CTTEDENGIL LMSAQTKNKP 
       210        220        230        240        250
WFGVQYHPES CCSELGGLLV SNFLKLSFIN NVKTGRWEKK KLNGEFSDIL 
       260        270        280        290        300
SRLDRTIDRD PIYKVKEKYP KGEDTTYVKQ FEVSEDPKLT FEICNIIREE 
       310        320        330        340        350
KFVMSSSVIS ENTGEWSIIA LPNSASQVFT HYGAMKKTTV HYWQDSEISY 
       360        370        380        390        400
TLLKKCLDGQ DSDLPGSLEV IHEDKSQFWI TLGKFMENKI IDNHREIPFI 
       410        420        430        440        450
GGLVGILGYE IGQYIACGRC NDDENSLVPD AKLVFINNSI VINHKQGKLY 
       460        470        480        490        500
CISLDNTFPV ALEQSLRDSF VRKKNIKQSL SWPKYLPEEI DFIITMPDKL 
       510        520        530        540        550
DYAKAFKKCQ DYMHKGDSYE MCLTTQTKVV PSAVIEPWRI FQTLVQRNPA 
       560        570        580        590        600
PFSSFFEFKD IIPRQDETPP VLCFLSTSPE RFLKWDADTC ELRPIKGTVK 
       610        620        630        640        650
KGPQMNLAKA TRILKTPKEF GENLMILDLI RNDLYELVPD VRVEEFMSVQ 
       660        670        680        690        700
EYATVYQLVS VVKAHGLTSA SKKTRYSGID VLKHSLPPGS MTGAPKKITV 
       710        720        730        740        750
QLLQDKIESK LNKHVNGGAR GVYSGVTGYW SVNSNGDWSV NIRCMYSYNG 
       760        770        780 
GTSWQLGAGG AITVLSTLDG ELEEMYNKLE SNLQIFM

Length:787

Mass (Da):88,544

Last modified:February 21, 2006 - v4

Checksum:ⁱ13117891486B5B0E

GO

Sequence cautionⁱ

The sequence AAA34840 differs from that shown. Reason: Frameshift at positions 581, 586, 591, 716, 729 and 734.Curated

The sequence AAB49319 differs from that shown. Reason: Frameshift at positions 581, 586 and 591.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	85	G → D in AAT93048 (PubMed:17322287).Curated	1
Sequence conflictⁱ	171	A → P in AAA34840 (PubMed:8346682).Curated	1
Sequence conflictⁱ	171	A → P in AAB49319 (PubMed:8725220).Curated	1
Sequence conflictⁱ	533	A → T in AAA34840 (PubMed:8346682).Curated	1
Sequence conflictⁱ	586	D → Y in AAB49319 (PubMed:8725220).Curated	1
Sequence conflictⁱ	590 – 591	CE → FV in AAA34840 (PubMed:8346682).Curated	2
Sequence conflictⁱ	721	G → GL in AAB49319 (PubMed:8725220).Curated	1
Sequence conflictⁱ	722	V → G in AAA34840 (PubMed:8346682).Curated	1
Sequence conflictⁱ	735 – 737	NGD → FGF in AAA34840 (PubMed:8346682).Curated	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L15299 Genomic DNA. Translation: AAA34840.1. Frameshift. U43608 Genomic DNA. Translation: AAB49319.1. Frameshift. Z71648 Genomic DNA. Translation: CAA96313.1. AY693029 Genomic DNA. Translation: AAT93048.1. BK006947 Genomic DNA. Translation: DAA10574.1.
PIRⁱ	S63364.
NCBI Reference Sequences More...RefSeqⁱ	NP_014431.1. NM_001183210.1.

Genome annotation databases

EnsemblFungiⁱ	YNR033W; YNR033W; YNR033W.
GeneIDⁱ	855768.
KEGGⁱ	sce:YNR033W.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L15299 Genomic DNA. Translation: AAA34840.1. Frameshift. U43608 Genomic DNA. Translation: AAB49319.1. Frameshift. Z71648 Genomic DNA. Translation: CAA96313.1. AY693029 Genomic DNA. Translation: AAT93048.1. BK006947 Genomic DNA. Translation: DAA10574.1.
PIRⁱ	S63364.
NCBI Reference Sequences More...RefSeqⁱ	NP_014431.1. NM_001183210.1.

3D structure databases

ProteinModelPortalⁱ	P37254.
SMRⁱ	P37254.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35858. 74 interactors.
Database of interacting proteins More...DIPⁱ	DIP-6278N.
IntActⁱ	P37254. 9 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-604611.
STRINGⁱ	4932.YNR033W.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C26.958.

MEROPSⁱ

C26.958.

PTM databases

iPTMnetⁱ	P37254.

iPTMnetⁱ

P37254.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P37254.
PRIDEⁱ	P37254.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YNR033W; YNR033W; YNR033W.
GeneIDⁱ	855768.
KEGGⁱ	sce:YNR033W.

Organism-specific databases

EuPathDBⁱ	FungiDB:YNR033W.
Saccharomyces Genome Database More...SGDⁱ	S000005316. ABZ1.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00620000088738.
HOGENOMⁱ	HOG000025143.
InParanoidⁱ	P37254.
KEGG Orthology (KO) More...KOⁱ	K13950.
OMAⁱ	SMRPMKG.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0U1F.

Enzyme and pathway databases

UniPathwayⁱ	UPA00077; UER00149.
BioCycⁱ	YEAST:YNR033W-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P37254.

PROⁱ

PR:P37254.

Family and domain databases

Gene3Dⁱ	3.40.50.880. 1 hit. 3.60.120.10. 1 hit.
InterProⁱ	View protein in InterPro IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR015890. Chorismate_C. IPR029062. Class_I_gatase-like. IPR017926. GATASE. IPR010117. PabB_fungal. IPR006221. TrpG/PapA_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. PF00117. GATase. 1 hit.
SUPFAMⁱ	SSF52317. SSF52317. 1 hit. SSF56322. SSF56322. 1 hit.
TIGRFAMsⁱ	TIGR01823. PabB-fungal. 1 hit. TIGR00566. trpG_papA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51273. GATASE_TYPE_1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PABS_YEAST
Accessionⁱ	P37254Primary (citable) accession number: P37254 Secondary accession number(s): D6W1K8, Q02982, Q6B1Q1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	February 21, 2006
	Last modified:	July 5, 2017
	This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P37254 (PABS_YEAST)

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Aminodeoxychorismate synthase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: tetrahydrofolate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ