UniProtKB - P37254 (PABS_YEAST)
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Protein
Aminodeoxychorismate synthase
Gene
ABZ1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis.1 Publication
Miscellaneous
Present with 1550 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
: tetrahydrofolate biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 4-aminobenzoate from chorismate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Aminodeoxychorismate synthase (ABZ1)
- Aminodeoxychorismate lyase (ABZ2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobenzoate from chorismate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 112 | PROSITE-ProRule annotation | 1 | |
Active sitei | 207 | PROSITE-ProRule annotation | 1 | |
Active sitei | 209 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 4-amino-4-deoxychorismate synthase activity Source: SGD
GO - Biological processi
- folic acid biosynthetic process Source: UniProtKB-KW
- glutamine metabolic process Source: UniProtKB-KW
- para-aminobenzoic acid biosynthetic process Source: SGD
- tetrahydrofolate biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Multifunctional enzyme, Transferase |
Biological process | Folate biosynthesis |
Enzyme and pathway databases
BioCyci | YEAST:YNR033W-MONOMER. |
UniPathwayi | UPA00077; UER00149. |
Protein family/group databases
MEROPSi | C26.958. |
Names & Taxonomyi
Protein namesi | Recommended name: Aminodeoxychorismate synthase (EC:2.6.1.85)Short name: ADC synthase Alternative name(s): P-aminobenzoic acid synthase Short name: PABA synthase Para-aminobenzoate synthase |
Gene namesi | Name:ABZ1 Ordered Locus Names:YNR033W ORF Names:N3286 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YNR033W. |
SGDi | S000005316. ABZ1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154142 | 1 – 787 | Aminodeoxychorismate synthaseAdd BLAST | 787 |
Proteomic databases
MaxQBi | P37254. |
PaxDbi | P37254. |
PRIDEi | P37254. |
PTM databases
iPTMneti | P37254. |
Interactioni
Protein-protein interaction databases
BioGridi | 35858. 76 interactors. |
DIPi | DIP-6278N. |
IntActi | P37254. 14 interactors. |
MINTi | P37254. |
STRINGi | 4932.YNR033W. |
Structurei
3D structure databases
ProteinModelPortali | P37254. |
SMRi | P37254. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 233 | Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST | 218 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 304 – 787 | PABB componentAdd BLAST | 484 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 14 | Poly-Gln | 5 |
Domaini
The PABA component provides the glutamine amidotransferase activity.
The PABB component catalyzes the formation of ADC by binding chorismate and ammonia.
Sequence similaritiesi
In the C-terminal section; belongs to the anthranilate synthase component I family.Curated
Keywords - Domaini
Glutamine amidotransferasePhylogenomic databases
GeneTreei | ENSGT00620000088738. |
HOGENOMi | HOG000025143. |
InParanoidi | P37254. |
KOi | K13950. |
OMAi | SMRPMKG. |
OrthoDBi | EOG092C0U1F. |
Family and domain databases
Gene3Di | 3.40.50.880. 1 hit. 3.60.120.10. 1 hit. |
InterProi | View protein in InterPro IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR015890. Chorismate_C. IPR029062. Class_I_gatase-like. IPR017926. GATASE. IPR010117. PabB_fungal. IPR006221. TrpG/PapA_dom. |
Pfami | View protein in Pfam PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. PF00117. GATase. 1 hit. |
SUPFAMi | SSF52317. SSF52317. 1 hit. SSF56322. SSF56322. 1 hit. |
TIGRFAMsi | TIGR01823. PabB-fungal. 1 hit. TIGR00566. trpG_papA. 1 hit. |
PROSITEi | View protein in PROSITE PS51273. GATASE_TYPE_1. 1 hit. |
i Sequence
Sequence statusi: Complete.
P37254-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSDTIDTKQ QQQQLHVLFI DSYDSFTYNV VRLIEQQTDI SPGVNAVHVT
60 70 80 90 100
TVHSDTFQSM DQLLPLLPLF DAIVVGPGPG NPNNGAQDMG IISELFENAN
110 120 130 140 150
GKLDEVPILG ICLGFQAMCL AQGADVSELN TIKHGQVYEM HLNDAARACG
160 170 180 190 200
LFSGYPDTFK STRYHSLHVN AEGIDTLLPL CTTEDENGIL LMSAQTKNKP
210 220 230 240 250
WFGVQYHPES CCSELGGLLV SNFLKLSFIN NVKTGRWEKK KLNGEFSDIL
260 270 280 290 300
SRLDRTIDRD PIYKVKEKYP KGEDTTYVKQ FEVSEDPKLT FEICNIIREE
310 320 330 340 350
KFVMSSSVIS ENTGEWSIIA LPNSASQVFT HYGAMKKTTV HYWQDSEISY
360 370 380 390 400
TLLKKCLDGQ DSDLPGSLEV IHEDKSQFWI TLGKFMENKI IDNHREIPFI
410 420 430 440 450
GGLVGILGYE IGQYIACGRC NDDENSLVPD AKLVFINNSI VINHKQGKLY
460 470 480 490 500
CISLDNTFPV ALEQSLRDSF VRKKNIKQSL SWPKYLPEEI DFIITMPDKL
510 520 530 540 550
DYAKAFKKCQ DYMHKGDSYE MCLTTQTKVV PSAVIEPWRI FQTLVQRNPA
560 570 580 590 600
PFSSFFEFKD IIPRQDETPP VLCFLSTSPE RFLKWDADTC ELRPIKGTVK
610 620 630 640 650
KGPQMNLAKA TRILKTPKEF GENLMILDLI RNDLYELVPD VRVEEFMSVQ
660 670 680 690 700
EYATVYQLVS VVKAHGLTSA SKKTRYSGID VLKHSLPPGS MTGAPKKITV
710 720 730 740 750
QLLQDKIESK LNKHVNGGAR GVYSGVTGYW SVNSNGDWSV NIRCMYSYNG
760 770 780
GTSWQLGAGG AITVLSTLDG ELEEMYNKLE SNLQIFM
Sequence cautioni
The sequence AAA34840 differs from that shown. Reason: Frameshift at positions 581, 586, 591, 716, 729 and 734.Curated
The sequence AAB49319 differs from that shown. Reason: Frameshift at positions 581, 586 and 591.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 85 | G → D in AAT93048 (PubMed:17322287).Curated | 1 | |
Sequence conflicti | 171 | A → P in AAA34840 (PubMed:8346682).Curated | 1 | |
Sequence conflicti | 171 | A → P in AAB49319 (PubMed:8725220).Curated | 1 | |
Sequence conflicti | 533 | A → T in AAA34840 (PubMed:8346682).Curated | 1 | |
Sequence conflicti | 586 | D → Y in AAB49319 (PubMed:8725220).Curated | 1 | |
Sequence conflicti | 590 – 591 | CE → FV in AAA34840 (PubMed:8346682).Curated | 2 | |
Sequence conflicti | 721 | G → GL in AAB49319 (PubMed:8725220).Curated | 1 | |
Sequence conflicti | 722 | V → G in AAA34840 (PubMed:8346682).Curated | 1 | |
Sequence conflicti | 735 – 737 | NGD → FGF in AAA34840 (PubMed:8346682).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L15299 Genomic DNA. Translation: AAA34840.1. Frameshift. U43608 Genomic DNA. Translation: AAB49319.1. Frameshift. Z71648 Genomic DNA. Translation: CAA96313.1. AY693029 Genomic DNA. Translation: AAT93048.1. BK006947 Genomic DNA. Translation: DAA10574.1. |
PIRi | S63364. |
RefSeqi | NP_014431.1. NM_001183210.1. |
Genome annotation databases
EnsemblFungii | YNR033W; YNR033W; YNR033W. |
GeneIDi | 855768. |
KEGGi | sce:YNR033W. |
Similar proteinsi
Entry informationi
Entry namei | PABS_YEAST | |
Accessioni | P37254Primary (citable) accession number: P37254 Secondary accession number(s): D6W1K8, Q02982, Q6B1Q1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | February 21, 2006 | |
Last modified: | March 28, 2018 | |
This is version 171 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |