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Protein

Thyroid hormone receptor beta

Gene

Thrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei282Thyroid hormoneBy similarity1
Binding sitei320Thyroid hormoneBy similarity1
Binding sitei331Thyroid hormone; via amide nitrogenBy similarity1
Binding sitei435Thyroid hormoneBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 181Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • chromatin DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • enzyme binding Source: MGI
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • thyroid hormone binding Source: UniProtKB
  • thyroid hormone receptor activity Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • female courtship behavior Source: MGI
  • negative regulation of female receptivity Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of heart contraction Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • sensory perception of sound Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • Type I pneumocyte differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
Gene namesi
Name:Thrb
Synonyms:Erba2, Nr1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98743 Thrb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534481 – 461Thyroid hormone receptor betaAdd BLAST461

Proteomic databases

MaxQBiP37242
PaxDbiP37242
PRIDEiP37242

PTM databases

PhosphoSitePlusiP37242

Expressioni

Gene expression databases

BgeeiENSMUSG00000021779
CleanExiMM_THRB
GenevisibleiP37242 MM

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand (By similarity). Interacts with C1D. Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AipO089152EBI-6935043,EBI-6935014

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204184, 10 interactors
DIPiDIP-43750N
IntActiP37242, 3 interactors
MINTiP37242
STRINGi10090.ENSMUSP00000022304

Structurei

3D structure databases

ProteinModelPortaliP37242
SMRiP37242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 461NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 106ModulatingAdd BLAST106
Regioni244 – 461Interaction with NR2F6By similarityAdd BLAST218

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000010313
HOVERGENiHBG005606
InParanoidiP37242
KOiK08362
OMAiQEWELIK
OrthoDBiEOG091G0GC1
PhylomeDBiP37242
TreeFamiTF328382

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta-1 (identifier: P37242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPNSMTENG LPAWDKQKPR PDRGQDWKLV GMSEACLHRK SHVERRGALK
60 70 80 90 100
NEQTSPHLIQ ATWTSSIFHL DPDDVNDQSI SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKSLH PSYSCKYEGK
160 170 180 190 200
CIIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPDSETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,630
Last modified:October 1, 1994 - v1
Checksum:i99089194FC3E6B33
GO
Isoform Beta-2 (identifier: P37242-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENG...QTFQTEEKKC → MNYCMPEVHE...QVQSPPHSQK

Show »
Length:475
Mass (Da):53,916
Checksum:i0ED4FF2D92F889DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445E → G in BAE34683 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310781 – 93MTPNS…EEKKC → MNYCMPEVHEVCPAASSNCY MQVTDYLAYLEDSPALSGRD VQAVPSSSIYMEQAWAVNQP YTCSYPGNLFKSKDSDLDMA LSQSSQPAHLPEEKPFPQVQ SPPHSQK in isoform Beta-2. 2 PublicationsAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62756 mRNA Translation: AAB20226.1
S62758 mRNA Translation: AAB20227.1
U15548
, U15542, U15543, U15544, U15545, U15546, U15547 Genomic DNA Translation: AAA86957.1
AK158826 mRNA Translation: BAE34683.1
BC089035 mRNA Translation: AAH89035.1
BC119552 mRNA Translation: AAI19553.1
BC119553 mRNA Translation: AAI19554.1
CCDSiCCDS26835.1 [P37242-2]
CCDS49404.1 [P37242-1]
PIRiA40377
A57035
RefSeqiNP_001106888.1, NM_001113417.1 [P37242-1]
NP_033406.1, NM_009380.3 [P37242-2]
XP_006518029.1, XM_006517966.2 [P37242-1]
XP_006518030.1, XM_006517967.3 [P37242-1]
XP_006518031.1, XM_006517968.3 [P37242-1]
XP_006518033.1, XM_006517970.3 [P37242-1]
XP_006518034.1, XM_006517971.3 [P37242-1]
XP_006518035.1, XM_006517972.3 [P37242-1]
XP_011243039.1, XM_011244737.1 [P37242-1]
XP_011243040.1, XM_011244738.2 [P37242-1]
XP_011243041.1, XM_011244739.2 [P37242-1]
XP_011243042.1, XM_011244740.2 [P37242-1]
XP_011243043.1, XM_011244741.2 [P37242-1]
XP_011243044.1, XM_011244742.1 [P37242-1]
XP_011243045.1, XM_011244743.2 [P37242-1]
XP_017171435.1, XM_017315946.1 [P37242-1]
XP_017171436.1, XM_017315947.1 [P37242-1]
UniGeneiMm.32563
Mm.491616

Genome annotation databases

EnsembliENSMUST00000022303; ENSMUSP00000022303; ENSMUSG00000021779 [P37242-1]
ENSMUST00000022304; ENSMUSP00000022304; ENSMUSG00000021779 [P37242-2]
ENSMUST00000091471; ENSMUSP00000089053; ENSMUSG00000021779 [P37242-1]
GeneIDi21834
KEGGimmu:21834
UCSCiuc007shk.2 mouse [P37242-1]
uc007sho.2 mouse [P37242-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTHB_MOUSE
AccessioniPrimary (citable) accession number: P37242
Secondary accession number(s): P37244, Q0VDR8, Q3TY80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health