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Protein

Thyroid hormone receptor beta

Gene

Thrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei282 – 2821Thyroid hormoneBy similarity
Binding sitei320 – 3201Thyroid hormoneBy similarity
Binding sitei331 – 3311Thyroid hormone; via amide nitrogenBy similarity
Binding sitei435 – 4351Thyroid hormoneBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi107 – 18175Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16925NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • female courtship behavior Source: MGI
  • intracellular receptor signaling pathway Source: MGI
  • negative regulation of female receptivity Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • organ morphogenesis Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of heart contraction Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • sensory perception of sound Source: MGI
  • Type I pneumocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
Gene namesi
Name:Thrb
Synonyms:Erba2, Nr1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98743. Thrb.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Thyroid hormone receptor betaPRO_0000053448Add
BLAST

Proteomic databases

PRIDEiP37242.

PTM databases

PhosphoSiteiP37242.

Expressioni

Gene expression databases

BgeeiP37242.
CleanExiMM_THRB.
GenevisibleiP37242. MM.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand (By similarity). Interacts with C1D. Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AipO089152EBI-6935043,EBI-6935014

Protein-protein interaction databases

BioGridi204184. 11 interactions.
DIPiDIP-43750N.
IntActiP37242. 2 interactions.
MINTiMINT-3374177.
STRINGi10090.ENSMUSP00000022304.

Structurei

3D structure databases

ProteinModelPortaliP37242.
SMRiP37242. Positions 105-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 106106ModulatingAdd
BLAST
Regioni244 – 461218Interaction with NR2F6By similarityAdd
BLAST
Regioni244 – 461218Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16925NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00780000121834.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP37242.
KOiK08362.
OMAiEKETITM.
OrthoDBiEOG7TBC2V.
PhylomeDBiP37242.
TreeFamiTF328382.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta-1 (identifier: P37242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPNSMTENG LPAWDKQKPR PDRGQDWKLV GMSEACLHRK SHVERRGALK
60 70 80 90 100
NEQTSPHLIQ ATWTSSIFHL DPDDVNDQSI SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKSLH PSYSCKYEGK
160 170 180 190 200
CIIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPDSETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,630
Last modified:October 1, 1994 - v1
Checksum:i99089194FC3E6B33
GO
Isoform Beta-2 (identifier: P37242-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENG...QTFQTEEKKC → MNYCMPEVHE...QVQSPPHSQK

Show »
Length:475
Mass (Da):53,916
Checksum:i0ED4FF2D92F889DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4451E → G in BAE34683 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9393MTPNS…EEKKC → MNYCMPEVHEVCPAASSNCY MQVTDYLAYLEDSPALSGRD VQAVPSSSIYMEQAWAVNQP YTCSYPGNLFKSKDSDLDMA LSQSSQPAHLPEEKPFPQVQ SPPHSQK in isoform Beta-2. 2 PublicationsVSP_031078Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62756 mRNA. Translation: AAB20226.1.
S62758 mRNA. Translation: AAB20227.1.
U15548
, U15542, U15543, U15544, U15545, U15546, U15547 Genomic DNA. Translation: AAA86957.1.
AK158826 mRNA. Translation: BAE34683.1.
BC089035 mRNA. Translation: AAH89035.1.
BC119552 mRNA. Translation: AAI19553.1.
BC119553 mRNA. Translation: AAI19554.1.
CCDSiCCDS26835.1. [P37242-2]
CCDS49404.1. [P37242-1]
PIRiA40377.
A57035.
RefSeqiNP_001106888.1. NM_001113417.1. [P37242-1]
NP_033406.1. NM_009380.3. [P37242-2]
XP_006518029.1. XM_006517966.2. [P37242-1]
XP_006518030.1. XM_006517967.2. [P37242-1]
XP_006518031.1. XM_006517968.2. [P37242-1]
XP_006518033.1. XM_006517970.2. [P37242-1]
XP_006518034.1. XM_006517971.2. [P37242-1]
XP_006518035.1. XM_006517972.2. [P37242-1]
UniGeneiMm.32563.
Mm.491616.

Genome annotation databases

EnsembliENSMUST00000022303; ENSMUSP00000022303; ENSMUSG00000021779. [P37242-1]
ENSMUST00000022304; ENSMUSP00000022304; ENSMUSG00000021779. [P37242-2]
ENSMUST00000091471; ENSMUSP00000089053; ENSMUSG00000021779. [P37242-1]
GeneIDi21834.
KEGGimmu:21834.
UCSCiuc007shk.2. mouse. [P37242-1]
uc007sho.2. mouse. [P37242-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62756 mRNA. Translation: AAB20226.1.
S62758 mRNA. Translation: AAB20227.1.
U15548
, U15542, U15543, U15544, U15545, U15546, U15547 Genomic DNA. Translation: AAA86957.1.
AK158826 mRNA. Translation: BAE34683.1.
BC089035 mRNA. Translation: AAH89035.1.
BC119552 mRNA. Translation: AAI19553.1.
BC119553 mRNA. Translation: AAI19554.1.
CCDSiCCDS26835.1. [P37242-2]
CCDS49404.1. [P37242-1]
PIRiA40377.
A57035.
RefSeqiNP_001106888.1. NM_001113417.1. [P37242-1]
NP_033406.1. NM_009380.3. [P37242-2]
XP_006518029.1. XM_006517966.2. [P37242-1]
XP_006518030.1. XM_006517967.2. [P37242-1]
XP_006518031.1. XM_006517968.2. [P37242-1]
XP_006518033.1. XM_006517970.2. [P37242-1]
XP_006518034.1. XM_006517971.2. [P37242-1]
XP_006518035.1. XM_006517972.2. [P37242-1]
UniGeneiMm.32563.
Mm.491616.

3D structure databases

ProteinModelPortaliP37242.
SMRiP37242. Positions 105-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204184. 11 interactions.
DIPiDIP-43750N.
IntActiP37242. 2 interactions.
MINTiMINT-3374177.
STRINGi10090.ENSMUSP00000022304.

Chemistry

GuidetoPHARMACOLOGYi589.

PTM databases

PhosphoSiteiP37242.

Proteomic databases

PRIDEiP37242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022303; ENSMUSP00000022303; ENSMUSG00000021779. [P37242-1]
ENSMUST00000022304; ENSMUSP00000022304; ENSMUSG00000021779. [P37242-2]
ENSMUST00000091471; ENSMUSP00000089053; ENSMUSG00000021779. [P37242-1]
GeneIDi21834.
KEGGimmu:21834.
UCSCiuc007shk.2. mouse. [P37242-1]
uc007sho.2. mouse. [P37242-2]

Organism-specific databases

CTDi7068.
MGIiMGI:98743. Thrb.

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00780000121834.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
InParanoidiP37242.
KOiK08362.
OMAiEKETITM.
OrthoDBiEOG7TBC2V.
PhylomeDBiP37242.
TreeFamiTF328382.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi301286.
PROiP37242.
SOURCEiSearch...

Gene expression databases

BgeeiP37242.
CleanExiMM_THRB.
GenevisibleiP37242. MM.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of mouse complementary DNAs encoding alpha and beta thyroid hormone receptors from thyrotrope cells: the mouse pituitary-specific beta 2 isoform differs at the amino terminus from the corresponding species from rat pituitary tumor cells."
    Wood W.M., Ocran K.W., Gordon D.F., Ridgway E.C.
    Mol. Endocrinol. 5:1049-1061(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA-1 AND BETA-2).
    Tissue: Thyroid.
  2. "Structural and functional characterization of the genomic locus encoding the murine beta 2 thyroid hormone receptor."
    Wood W.M., Dowding J.M., Haugen B.R., Bright T.M., Gordon D.F., Ridgway E.C.
    Mol. Endocrinol. 8:1605-1617(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-1).
    Strain: C57BL/6J.
    Tissue: Visual cortex.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-2).
    Strain: C57BL/6.
    Tissue: Eye.
  5. "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
    Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
    Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH C1D.

Entry informationi

Entry nameiTHB_MOUSE
AccessioniPrimary (citable) accession number: P37242
Secondary accession number(s): P37244, Q0VDR8, Q3TY80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 24, 2015
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.