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P37242

- THB_MOUSE

UniProt

P37242 - THB_MOUSE

Protein

Thyroid hormone receptor beta

Gene

Thrb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei282 – 2821Thyroid hormoneBy similarity
    Binding sitei320 – 3201Thyroid hormoneBy similarity
    Binding sitei331 – 3311Thyroid hormone; via amide nitrogenBy similarity
    Binding sitei435 – 4351Thyroid hormoneBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi107 – 18175Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri145 – 16925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin DNA binding Source: MGI
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: MGI
    5. steroid hormone receptor activity Source: InterPro
    6. thyroid hormone binding Source: UniProtKB
    7. thyroid hormone receptor activity Source: UniProtKB
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. female courtship behavior Source: MGI
    2. intracellular receptor signaling pathway Source: GOC
    3. negative regulation of female receptivity Source: MGI
    4. negative regulation of transcription, DNA-templated Source: MGI
    5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    6. organ morphogenesis Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    8. regulation of heart contraction Source: MGI
    9. regulation of transcription, DNA-templated Source: MGI
    10. regulation of transcription from RNA polymerase II promoter Source: MGI
    11. sensory perception of sound Source: MGI
    12. Type I pneumocyte differentiation Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyroid hormone receptor beta
    Alternative name(s):
    Nuclear receptor subfamily 1 group A member 2
    c-erbA-2
    c-erbA-beta
    Gene namesi
    Name:Thrb
    Synonyms:Erba2, Nr1a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:98743. Thrb.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Thyroid hormone receptor betaPRO_0000053448Add
    BLAST

    Proteomic databases

    PRIDEiP37242.

    PTM databases

    PhosphoSiteiP37242.

    Expressioni

    Gene expression databases

    BgeeiP37242.
    CleanExiMM_THRB.
    GenevestigatoriP37242.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand By similarity. Interacts with C1D. Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AipO089152EBI-6935043,EBI-6935014

    Protein-protein interaction databases

    BioGridi204184. 9 interactions.
    IntActiP37242. 2 interactions.
    MINTiMINT-3374177.

    Structurei

    3D structure databases

    ProteinModelPortaliP37242.
    SMRiP37242. Positions 105-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 106106ModulatingAdd
    BLAST
    Regioni244 – 461218Interaction with NR2F6By similarityAdd
    BLAST
    Regioni244 – 461218Ligand-bindingAdd
    BLAST

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri145 – 16925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG272726.
    GeneTreeiENSGT00740000114969.
    HOGENOMiHOG000010313.
    HOVERGENiHBG005606.
    KOiK08362.
    OMAiCSNILES.
    OrthoDBiEOG7TBC2V.
    PhylomeDBiP37242.
    TreeFamiTF328382.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001728. ThyrH_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00546. THYROIDHORMR.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Beta-1 (identifier: P37242-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPNSMTENG LPAWDKQKPR PDRGQDWKLV GMSEACLHRK SHVERRGALK    50
    NEQTSPHLIQ ATWTSSIFHL DPDDVNDQSI SSAQTFQTEE KKCKGYIPSY 100
    LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKSLH PSYSCKYEGK 150
    CIIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR 200
    REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI 250
    GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED 300
    QIILLKGCCM EIMSLRAAVR YDPDSETLTL NGEMAVTRGQ LKNGGLGVVS 350
    DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL 400
    LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL 450
    FPPLFLEVFE D 461
    Length:461
    Mass (Da):52,630
    Last modified:October 1, 1994 - v1
    Checksum:i99089194FC3E6B33
    GO
    Isoform Beta-2 (identifier: P37242-2) [UniParc] [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-93: MTPNSMTENG...QTFQTEEKKC → MNYCMPEVHE...QVQSPPHSQK

    Show »
    Length:475
    Mass (Da):53,916
    Checksum:i0ED4FF2D92F889DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti445 – 4451E → G in BAE34683. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9393MTPNS…EEKKC → MNYCMPEVHEVCPAASSNCY MQVTDYLAYLEDSPALSGRD VQAVPSSSIYMEQAWAVNQP YTCSYPGNLFKSKDSDLDMA LSQSSQPAHLPEEKPFPQVQ SPPHSQK in isoform Beta-2. 2 PublicationsVSP_031078Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62756 mRNA. Translation: AAB20226.1.
    S62758 mRNA. Translation: AAB20227.1.
    U15548
    , U15542, U15543, U15544, U15545, U15546, U15547 Genomic DNA. Translation: AAA86957.1.
    AK158826 mRNA. Translation: BAE34683.1.
    BC089035 mRNA. Translation: AAH89035.1.
    BC119552 mRNA. Translation: AAI19553.1.
    BC119553 mRNA. Translation: AAI19554.1.
    CCDSiCCDS26835.1. [P37242-2]
    CCDS49404.1. [P37242-1]
    PIRiA40377.
    A57035.
    RefSeqiNP_001106888.1. NM_001113417.1. [P37242-1]
    NP_033406.1. NM_009380.3. [P37242-2]
    XP_006518029.1. XM_006517966.1. [P37242-1]
    XP_006518030.1. XM_006517967.1. [P37242-1]
    XP_006518031.1. XM_006517968.1. [P37242-1]
    XP_006518032.1. XM_006517969.1. [P37242-1]
    XP_006518033.1. XM_006517970.1. [P37242-1]
    XP_006518034.1. XM_006517971.1. [P37242-1]
    XP_006518035.1. XM_006517972.1. [P37242-1]
    UniGeneiMm.32563.
    Mm.491616.

    Genome annotation databases

    EnsembliENSMUST00000022303; ENSMUSP00000022303; ENSMUSG00000021779. [P37242-1]
    ENSMUST00000022304; ENSMUSP00000022304; ENSMUSG00000021779. [P37242-2]
    ENSMUST00000091471; ENSMUSP00000089053; ENSMUSG00000021779. [P37242-1]
    GeneIDi21834.
    KEGGimmu:21834.
    UCSCiuc007shk.2. mouse. [P37242-1]
    uc007sho.2. mouse. [P37242-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S62756 mRNA. Translation: AAB20226.1 .
    S62758 mRNA. Translation: AAB20227.1 .
    U15548
    , U15542 , U15543 , U15544 , U15545 , U15546 , U15547 Genomic DNA. Translation: AAA86957.1 .
    AK158826 mRNA. Translation: BAE34683.1 .
    BC089035 mRNA. Translation: AAH89035.1 .
    BC119552 mRNA. Translation: AAI19553.1 .
    BC119553 mRNA. Translation: AAI19554.1 .
    CCDSi CCDS26835.1. [P37242-2 ]
    CCDS49404.1. [P37242-1 ]
    PIRi A40377.
    A57035.
    RefSeqi NP_001106888.1. NM_001113417.1. [P37242-1 ]
    NP_033406.1. NM_009380.3. [P37242-2 ]
    XP_006518029.1. XM_006517966.1. [P37242-1 ]
    XP_006518030.1. XM_006517967.1. [P37242-1 ]
    XP_006518031.1. XM_006517968.1. [P37242-1 ]
    XP_006518032.1. XM_006517969.1. [P37242-1 ]
    XP_006518033.1. XM_006517970.1. [P37242-1 ]
    XP_006518034.1. XM_006517971.1. [P37242-1 ]
    XP_006518035.1. XM_006517972.1. [P37242-1 ]
    UniGenei Mm.32563.
    Mm.491616.

    3D structure databases

    ProteinModelPortali P37242.
    SMRi P37242. Positions 105-461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204184. 9 interactions.
    IntActi P37242. 2 interactions.
    MINTi MINT-3374177.

    Chemistry

    GuidetoPHARMACOLOGYi 589.

    PTM databases

    PhosphoSitei P37242.

    Proteomic databases

    PRIDEi P37242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022303 ; ENSMUSP00000022303 ; ENSMUSG00000021779 . [P37242-1 ]
    ENSMUST00000022304 ; ENSMUSP00000022304 ; ENSMUSG00000021779 . [P37242-2 ]
    ENSMUST00000091471 ; ENSMUSP00000089053 ; ENSMUSG00000021779 . [P37242-1 ]
    GeneIDi 21834.
    KEGGi mmu:21834.
    UCSCi uc007shk.2. mouse. [P37242-1 ]
    uc007sho.2. mouse. [P37242-2 ]

    Organism-specific databases

    CTDi 7068.
    MGIi MGI:98743. Thrb.

    Phylogenomic databases

    eggNOGi NOG272726.
    GeneTreei ENSGT00740000114969.
    HOGENOMi HOG000010313.
    HOVERGENi HBG005606.
    KOi K08362.
    OMAi CSNILES.
    OrthoDBi EOG7TBC2V.
    PhylomeDBi P37242.
    TreeFami TF328382.

    Miscellaneous databases

    NextBioi 301286.
    PROi P37242.
    SOURCEi Search...

    Gene expression databases

    Bgeei P37242.
    CleanExi MM_THRB.
    Genevestigatori P37242.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001728. ThyrH_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00546. THYROIDHORMR.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of mouse complementary DNAs encoding alpha and beta thyroid hormone receptors from thyrotrope cells: the mouse pituitary-specific beta 2 isoform differs at the amino terminus from the corresponding species from rat pituitary tumor cells."
      Wood W.M., Ocran K.W., Gordon D.F., Ridgway E.C.
      Mol. Endocrinol. 5:1049-1061(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA-1 AND BETA-2).
      Tissue: Thyroid.
    2. "Structural and functional characterization of the genomic locus encoding the murine beta 2 thyroid hormone receptor."
      Wood W.M., Dowding J.M., Haugen B.R., Bright T.M., Gordon D.F., Ridgway E.C.
      Mol. Endocrinol. 8:1605-1617(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2J.
      Tissue: Liver.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-1).
      Strain: C57BL/6J.
      Tissue: Visual cortex.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-2).
      Strain: C57BL/6.
      Tissue: Eye.
    5. "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
      Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
      Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH C1D.

    Entry informationi

    Entry nameiTHB_MOUSE
    AccessioniPrimary (citable) accession number: P37242
    Secondary accession number(s): P37244, Q0VDR8, Q3TY80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3