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P37242

- THB_MOUSE

UniProt

P37242 - THB_MOUSE

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Protein

Thyroid hormone receptor beta

Gene
Thrb, Erba2, Nr1a2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei282 – 2821Thyroid hormone By similarity
Binding sitei320 – 3201Thyroid hormone By similarity
Binding sitei331 – 3311Thyroid hormone; via amide nitrogen By similarity
Binding sitei435 – 4351Thyroid hormone By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi107 – 18175Nuclear receptorAdd
BLAST
Zinc fingeri107 – 12721NR C4-typeAdd
BLAST
Zinc fingeri145 – 16925NR C4-typeAdd
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: MGI
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: MGI
  5. steroid hormone receptor activity Source: InterPro
  6. thyroid hormone binding Source: UniProtKB
  7. thyroid hormone receptor activity Source: UniProtKB
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. female courtship behavior Source: MGI
  2. intracellular receptor signaling pathway Source: GOC
  3. negative regulation of female receptivity Source: MGI
  4. negative regulation of transcription, DNA-templated Source: MGI
  5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  6. organ morphogenesis Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  8. regulation of heart contraction Source: MGI
  9. regulation of transcription, DNA-templated Source: MGI
  10. regulation of transcription from RNA polymerase II promoter Source: MGI
  11. sensory perception of sound Source: MGI
  12. Type I pneumocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
Gene namesi
Name:Thrb
Synonyms:Erba2, Nr1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:98743. Thrb.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Thyroid hormone receptor betaPRO_0000053448Add
BLAST

Proteomic databases

PRIDEiP37242.

PTM databases

PhosphoSiteiP37242.

Expressioni

Gene expression databases

BgeeiP37242.
CleanExiMM_THRB.
GenevestigatoriP37242.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand By similarity. Interacts with C1D. Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AipO089152EBI-6935043,EBI-6935014

Protein-protein interaction databases

BioGridi204184. 9 interactions.
IntActiP37242. 2 interactions.
MINTiMINT-3374177.

Structurei

3D structure databases

ProteinModelPortaliP37242.
SMRiP37242. Positions 105-461.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 106106ModulatingAdd
BLAST
Regioni244 – 461218Interaction with NR2F6 By similarityAdd
BLAST
Regioni244 – 461218Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 12721NR C4-typeAdd
BLAST
Zinc fingeri145 – 16925NR C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00740000114969.
HOGENOMiHOG000010313.
HOVERGENiHBG005606.
KOiK08362.
OMAiCSNILES.
OrthoDBiEOG7TBC2V.
PhylomeDBiP37242.
TreeFamiTF328382.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Beta-1 (identifier: P37242-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTPNSMTENG LPAWDKQKPR PDRGQDWKLV GMSEACLHRK SHVERRGALK    50
NEQTSPHLIQ ATWTSSIFHL DPDDVNDQSI SSAQTFQTEE KKCKGYIPSY 100
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKSLH PSYSCKYEGK 150
CIIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR 200
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI 250
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED 300
QIILLKGCCM EIMSLRAAVR YDPDSETLTL NGEMAVTRGQ LKNGGLGVVS 350
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL 400
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL 450
FPPLFLEVFE D 461
Length:461
Mass (Da):52,630
Last modified:October 1, 1994 - v1
Checksum:i99089194FC3E6B33
GO
Isoform Beta-2 (identifier: P37242-2) [UniParc] [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENG...QTFQTEEKKC → MNYCMPEVHE...QVQSPPHSQK

Show »
Length:475
Mass (Da):53,916
Checksum:i0ED4FF2D92F889DE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9393MTPNS…EEKKC → MNYCMPEVHEVCPAASSNCY MQVTDYLAYLEDSPALSGRD VQAVPSSSIYMEQAWAVNQP YTCSYPGNLFKSKDSDLDMA LSQSSQPAHLPEEKPFPQVQ SPPHSQK in isoform Beta-2. VSP_031078Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti445 – 4451E → G in BAE34683. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62756 mRNA. Translation: AAB20226.1.
S62758 mRNA. Translation: AAB20227.1.
U15548
, U15542, U15543, U15544, U15545, U15546, U15547 Genomic DNA. Translation: AAA86957.1.
AK158826 mRNA. Translation: BAE34683.1.
BC089035 mRNA. Translation: AAH89035.1.
BC119552 mRNA. Translation: AAI19553.1.
BC119553 mRNA. Translation: AAI19554.1.
CCDSiCCDS26835.1. [P37242-2]
CCDS49404.1. [P37242-1]
PIRiA40377.
A57035.
RefSeqiNP_001106888.1. NM_001113417.1. [P37242-1]
NP_033406.1. NM_009380.3. [P37242-2]
XP_006518029.1. XM_006517966.1. [P37242-1]
XP_006518030.1. XM_006517967.1. [P37242-1]
XP_006518031.1. XM_006517968.1. [P37242-1]
XP_006518032.1. XM_006517969.1. [P37242-1]
XP_006518033.1. XM_006517970.1. [P37242-1]
XP_006518034.1. XM_006517971.1. [P37242-1]
XP_006518035.1. XM_006517972.1. [P37242-1]
UniGeneiMm.32563.
Mm.491616.

Genome annotation databases

EnsembliENSMUST00000022303; ENSMUSP00000022303; ENSMUSG00000021779. [P37242-1]
ENSMUST00000022304; ENSMUSP00000022304; ENSMUSG00000021779. [P37242-2]
ENSMUST00000091471; ENSMUSP00000089053; ENSMUSG00000021779. [P37242-1]
GeneIDi21834.
KEGGimmu:21834.
UCSCiuc007shk.2. mouse. [P37242-1]
uc007sho.2. mouse. [P37242-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S62756 mRNA. Translation: AAB20226.1 .
S62758 mRNA. Translation: AAB20227.1 .
U15548
, U15542 , U15543 , U15544 , U15545 , U15546 , U15547 Genomic DNA. Translation: AAA86957.1 .
AK158826 mRNA. Translation: BAE34683.1 .
BC089035 mRNA. Translation: AAH89035.1 .
BC119552 mRNA. Translation: AAI19553.1 .
BC119553 mRNA. Translation: AAI19554.1 .
CCDSi CCDS26835.1. [P37242-2 ]
CCDS49404.1. [P37242-1 ]
PIRi A40377.
A57035.
RefSeqi NP_001106888.1. NM_001113417.1. [P37242-1 ]
NP_033406.1. NM_009380.3. [P37242-2 ]
XP_006518029.1. XM_006517966.1. [P37242-1 ]
XP_006518030.1. XM_006517967.1. [P37242-1 ]
XP_006518031.1. XM_006517968.1. [P37242-1 ]
XP_006518032.1. XM_006517969.1. [P37242-1 ]
XP_006518033.1. XM_006517970.1. [P37242-1 ]
XP_006518034.1. XM_006517971.1. [P37242-1 ]
XP_006518035.1. XM_006517972.1. [P37242-1 ]
UniGenei Mm.32563.
Mm.491616.

3D structure databases

ProteinModelPortali P37242.
SMRi P37242. Positions 105-461.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204184. 9 interactions.
IntActi P37242. 2 interactions.
MINTi MINT-3374177.

Chemistry

GuidetoPHARMACOLOGYi 589.

PTM databases

PhosphoSitei P37242.

Proteomic databases

PRIDEi P37242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022303 ; ENSMUSP00000022303 ; ENSMUSG00000021779 . [P37242-1 ]
ENSMUST00000022304 ; ENSMUSP00000022304 ; ENSMUSG00000021779 . [P37242-2 ]
ENSMUST00000091471 ; ENSMUSP00000089053 ; ENSMUSG00000021779 . [P37242-1 ]
GeneIDi 21834.
KEGGi mmu:21834.
UCSCi uc007shk.2. mouse. [P37242-1 ]
uc007sho.2. mouse. [P37242-2 ]

Organism-specific databases

CTDi 7068.
MGIi MGI:98743. Thrb.

Phylogenomic databases

eggNOGi NOG272726.
GeneTreei ENSGT00740000114969.
HOGENOMi HOG000010313.
HOVERGENi HBG005606.
KOi K08362.
OMAi CSNILES.
OrthoDBi EOG7TBC2V.
PhylomeDBi P37242.
TreeFami TF328382.

Miscellaneous databases

NextBioi 301286.
PROi P37242.
SOURCEi Search...

Gene expression databases

Bgeei P37242.
CleanExi MM_THRB.
Genevestigatori P37242.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of mouse complementary DNAs encoding alpha and beta thyroid hormone receptors from thyrotrope cells: the mouse pituitary-specific beta 2 isoform differs at the amino terminus from the corresponding species from rat pituitary tumor cells."
    Wood W.M., Ocran K.W., Gordon D.F., Ridgway E.C.
    Mol. Endocrinol. 5:1049-1061(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA-1 AND BETA-2).
    Tissue: Thyroid.
  2. "Structural and functional characterization of the genomic locus encoding the murine beta 2 thyroid hormone receptor."
    Wood W.M., Dowding J.M., Haugen B.R., Bright T.M., Gordon D.F., Ridgway E.C.
    Mol. Endocrinol. 8:1605-1617(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-1).
    Strain: C57BL/6J.
    Tissue: Visual cortex.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-2).
    Strain: C57BL/6.
    Tissue: Eye.
  5. "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
    Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
    Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH C1D.

Entry informationi

Entry nameiTHB_MOUSE
AccessioniPrimary (citable) accession number: P37242
Secondary accession number(s): P37244, Q0VDR8, Q3TY80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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