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Protein

Frequenin-1

Gene

Frq1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ca2+-dependent modulation of synaptic efficacy.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi156 – 167123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • calcium sensitive guanylate cyclase activator activity Source: FlyBase

GO - Biological processi

  • neuromuscular junction development Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • regulation of neurotransmitter secretion Source: FlyBase
  • synaptic transmission Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Frequenin-1
Alternative name(s):
d-FRQ
Gene namesi
Name:Frq1
Synonyms:Frq
ORF Names:CG5744
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030897. Frq1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 187186Frequenin-1PRO_0000073800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP37236.

Expressioni

Tissue specificityi

Enriched in synapses, such as the motor nerve endings at neuromuscular junctions.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Gene expression databases

BgeeiP37236.
ExpressionAtlasiP37236. differential.
GenevisibleiP37236. DM.

Interactioni

Protein-protein interaction databases

BioGridi59117. 3 interactions.
DIPiDIP-23066N.
IntActiP37236. 3 interactions.
MINTiMINT-967367.
STRINGi7227.FBpp0074319.

Structurei

3D structure databases

ProteinModelPortaliP37236.
SMRiP37236. Positions 5-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini143 – 17836EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
InParanoidiP37236.
KOiK19932.
OMAiSEMTRIV.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP37236.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKSSKLKQ DTIDRLTTDT YFTEKEIRQW HKGFLKDCPN GLLTEQGFIK
60 70 80 90 100
IYKQFFPQGD PSKFASLVFR VFDENNDGSI EFEEFIRALS VTSKGNLDEK
110 120 130 140 150
LQWAFRLYDV DNDGYITREE MYNIVDAIYQ MVGQQPQSED ENTPQKRVDK
160 170 180
IFDQMDKNHD GKLTLEEFRE GSKADPRIVQ ALSLGGG
Length:187
Mass (Da):21,668
Last modified:January 23, 2007 - v2
Checksum:iEE4C4022C1DDC77E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08064 Genomic DNA. Translation: AAA28539.1.
AE014298 Genomic DNA. Translation: AAG22356.1.
AE014298 Genomic DNA. Translation: ABC67191.1.
RefSeqiNP_001033853.1. NM_001038764.2.
NP_001259673.1. NM_001272744.1.
NP_001259674.1. NM_001272745.1.
NP_573271.1. NM_133043.3.
UniGeneiDm.35315.

Genome annotation databases

EnsemblMetazoaiFBtr0074545; FBpp0074319; FBgn0030897.
FBtr0100239; FBpp0099625; FBgn0030897.
FBtr0335119; FBpp0307120; FBgn0030897.
FBtr0335120; FBpp0307121; FBgn0030897.
GeneIDi32797.
KEGGidme:Dmel_CG5744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08064 Genomic DNA. Translation: AAA28539.1.
AE014298 Genomic DNA. Translation: AAG22356.1.
AE014298 Genomic DNA. Translation: ABC67191.1.
RefSeqiNP_001033853.1. NM_001038764.2.
NP_001259673.1. NM_001272744.1.
NP_001259674.1. NM_001272745.1.
NP_573271.1. NM_133043.3.
UniGeneiDm.35315.

3D structure databases

ProteinModelPortaliP37236.
SMRiP37236. Positions 5-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59117. 3 interactions.
DIPiDIP-23066N.
IntActiP37236. 3 interactions.
MINTiMINT-967367.
STRINGi7227.FBpp0074319.

Proteomic databases

PaxDbiP37236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074545; FBpp0074319; FBgn0030897.
FBtr0100239; FBpp0099625; FBgn0030897.
FBtr0335119; FBpp0307120; FBgn0030897.
FBtr0335120; FBpp0307121; FBgn0030897.
GeneIDi32797.
KEGGidme:Dmel_CG5744.

Organism-specific databases

CTDi32797.
FlyBaseiFBgn0030897. Frq1.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
InParanoidiP37236.
KOiK19932.
OMAiSEMTRIV.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP37236.

Miscellaneous databases

ChiTaRSiFrq1. fly.
GenomeRNAii32797.
PROiP37236.

Gene expression databases

BgeeiP37236.
ExpressionAtlasiP37236. differential.
GenevisibleiP37236. DM.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Frequenin -- a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system."
    Pongs O., Lindemeier J., Zhu X.R., Theil T., Engelkamp D., Krah-Jentgens I., Lambrecht H.-G., Koch K.W., Schwemer G., Rivosecchi R., Mallart A., Calceran J., Canal I., Barbas J.A., Ferrus A.
    Neuron 11:15-28(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Canton-S and Oregon-R.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiFREQ_DROME
AccessioniPrimary (citable) accession number: P37236
Secondary accession number(s): A4V4Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

May bind 3 calcium ions via the second, third and fourth EF-hand.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.