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P37235

- HPCL1_HUMAN

UniProt

P37235 - HPCL1_HUMAN

Protein

Hippocalcin-like protein 1

Gene

HPCAL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: ProtInc

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hippocalcin-like protein 1
    Alternative name(s):
    Calcium-binding protein BDR-1
    HLP2
    Visinin-like protein 3
    Short name:
    VILIP-3
    Gene namesi
    Name:HPCAL1
    Synonyms:BDR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5145. HPCAL1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29418.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 193192Hippocalcin-like protein 1PRO_0000073771Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP37235.
    PaxDbiP37235.
    PRIDEiP37235.

    PTM databases

    PhosphoSiteiP37235.

    Expressioni

    Gene expression databases

    ArrayExpressiP37235.
    BgeeiP37235.
    CleanExiHS_HPCAL1.
    GenevestigatoriP37235.

    Organism-specific databases

    HPAiHPA043245.

    Interactioni

    Protein-protein interaction databases

    BioGridi109481. 6 interactions.
    IntActiP37235. 6 interactions.
    MINTiMINT-1436151.
    STRINGi9606.ENSP00000310749.

    Structurei

    3D structure databases

    ProteinModelPortaliP37235.
    SMRiP37235. Positions 5-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233019.
    HOVERGENiHBG108179.
    InParanoidiP37235.
    OMAiLEIVQXK.
    PhylomeDBiP37235.
    TreeFamiTF300009.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029535. VILIP-3.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF79. PTHR23055:SF79. 1 hit.
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37235-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK    50
    IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK 100
    LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD 150
    KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF 193
    Length:193
    Mass (Da):22,313
    Last modified:January 23, 2007 - v3
    Checksum:i87DCE938DCAD5E1F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191N → K in BAA03754. (PubMed:8038222)Curated
    Sequence conflicti88 – 881A → G in BAA03754. (PubMed:8038222)Curated
    Sequence conflicti93 – 942SR → RG in BAA03754. (PubMed:8038222)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16227 mRNA. Translation: BAA03754.1.
    BC009846 mRNA. Translation: AAH09846.1.
    BC017028 mRNA. Translation: AAH17028.1.
    BC017482 mRNA. Translation: AAH17482.1.
    CCDSiCCDS1671.1.
    PIRiS47565.
    RefSeqiNP_001245286.1. NM_001258357.1.
    NP_001245287.1. NM_001258358.1.
    NP_001245288.1. NM_001258359.1.
    NP_002140.2. NM_002149.3.
    NP_602293.1. NM_134421.2.
    XP_005246217.1. XM_005246160.1.
    XP_005246218.1. XM_005246161.1.
    XP_005246219.1. XM_005246162.1.
    XP_005246220.1. XM_005246163.1.
    UniGeneiHs.580427.
    Hs.741268.

    Genome annotation databases

    EnsembliENST00000307845; ENSP00000310749; ENSG00000115756.
    ENST00000381765; ENSP00000371184; ENSG00000115756.
    GeneIDi3241.
    KEGGihsa:3241.
    UCSCiuc002raj.4. human.

    Polymorphism databases

    DMDMi20455519.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16227 mRNA. Translation: BAA03754.1 .
    BC009846 mRNA. Translation: AAH09846.1 .
    BC017028 mRNA. Translation: AAH17028.1 .
    BC017482 mRNA. Translation: AAH17482.1 .
    CCDSi CCDS1671.1.
    PIRi S47565.
    RefSeqi NP_001245286.1. NM_001258357.1.
    NP_001245287.1. NM_001258358.1.
    NP_001245288.1. NM_001258359.1.
    NP_002140.2. NM_002149.3.
    NP_602293.1. NM_134421.2.
    XP_005246217.1. XM_005246160.1.
    XP_005246218.1. XM_005246161.1.
    XP_005246219.1. XM_005246162.1.
    XP_005246220.1. XM_005246163.1.
    UniGenei Hs.580427.
    Hs.741268.

    3D structure databases

    ProteinModelPortali P37235.
    SMRi P37235. Positions 5-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109481. 6 interactions.
    IntActi P37235. 6 interactions.
    MINTi MINT-1436151.
    STRINGi 9606.ENSP00000310749.

    PTM databases

    PhosphoSitei P37235.

    Polymorphism databases

    DMDMi 20455519.

    Proteomic databases

    MaxQBi P37235.
    PaxDbi P37235.
    PRIDEi P37235.

    Protocols and materials databases

    DNASUi 3241.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307845 ; ENSP00000310749 ; ENSG00000115756 .
    ENST00000381765 ; ENSP00000371184 ; ENSG00000115756 .
    GeneIDi 3241.
    KEGGi hsa:3241.
    UCSCi uc002raj.4. human.

    Organism-specific databases

    CTDi 3241.
    GeneCardsi GC02P010443.
    HGNCi HGNC:5145. HPCAL1.
    HPAi HPA043245.
    MIMi 600207. gene.
    neXtProti NX_P37235.
    PharmGKBi PA29418.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233019.
    HOVERGENi HBG108179.
    InParanoidi P37235.
    OMAi LEIVQXK.
    PhylomeDBi P37235.
    TreeFami TF300009.

    Miscellaneous databases

    ChiTaRSi HPCAL1. human.
    GeneWikii HPCAL1.
    GenomeRNAii 3241.
    NextBioi 12899.
    PROi P37235.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P37235.
    Bgeei P37235.
    CleanExi HS_HPCAL1.
    Genevestigatori P37235.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029535. VILIP-3.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF79. PTHR23055:SF79. 1 hit.
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene."
      Kobayashi M., Takamatsu K., Fujishiro M., Saitoh S., Noguchi T.
      Biochim. Biophys. Acta 1222:515-518(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Pancreas.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHPCL1_HUMAN
    AccessioniPrimary (citable) accession number: P37235
    Secondary accession number(s): Q969S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Probably binds two or three calcium ions.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3