P37235 (HPCL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hippocalcin-like protein 1

Alternative name(s):
Calcium-binding protein BDR-1
HLP2
Visinin-like protein 3
Short name=VILIP-3

Gene names

Name:	HPCAL1
Synonyms:	BDR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
Miscellaneous	Probably binds two or three calcium ions By similarity.
Sequence similarities	Belongs to the recoverin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	calcium ion binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Hippocalcin-like protein 1		PRO_0000073771
Regions
	Domain	23 – 58	36	EF-hand 1
	Domain	60 – 95	36	EF-hand 2
	Domain	96 – 131	36	EF-hand 3
	Domain	144 – 179	36	EF-hand 4
	Calcium binding	73 – 84	12	1 Potential
	Calcium binding	109 – 120	12	2 Potential
	Calcium binding	157 – 168	12	3 Potential
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity
Experimental info
	Sequence conflict	19	1	N → K in BAA03754. Ref.1
	Sequence conflict	88	1	A → G in BAA03754. Ref.1
	Sequence conflict	93 – 94	2	SR → RG in BAA03754. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P37235 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 87DCE938DCAD5E1F	FASTA	193	22,313
	10 20 30 40 50 60 MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 70 80 90 100 110 120 ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 130 140 150 160 170 180 MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 190 RLLQCDPSSA SQF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene." Kobayashi M., Takamatsu K., Fujishiro M., Saitoh S., Noguchi T. Biochim. Biophys. Acta 1222:515-518(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Pancreas.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16227 mRNA. Translation: BAA03754.1. BC009846 mRNA. Translation: AAH09846.1. BC017028 mRNA. Translation: AAH17028.1. BC017482 mRNA. Translation: AAH17482.1.
IPI	IPI00219344.
PIR	S47565.
RefSeq	NP_001245286.1. NM_001258357.1. NP_001245287.1. NM_001258358.1. NP_001245288.1. NM_001258359.1. NP_002140.2. NM_002149.3. NP_602293.1. NM_134421.2.
UniGene	Hs.580427. Hs.741268.
3D structure databases
ProteinModelPortal	P37235.
ModBase	Search...
Protein-protein interaction databases
IntAct	P37235. 6 interactions.
MINT	MINT-1436151.
STRING	9606.ENSP00000310749.
PTM databases
PhosphoSite	P37235.
Polymorphism databases
DMDM	20455519.
Proteomic databases
PaxDb	P37235.
PRIDE	P37235.
Protocols and materials databases
DNASU	3241.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307845; ENSP00000310749; ENSG00000115756. ENST00000381765; ENSP00000371184; ENSG00000115756.
GeneID	3241.
KEGG	hsa:3241.
UCSC	uc002raj.3. human.
Organism-specific databases
CTD	3241.
GeneCards	GC02P010443.
HGNC	HGNC:5145. HPCAL1.
HPA	HPA043245.
MIM	600207. gene.
neXtProt	NX_P37235.
PharmGKB	PA29418.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5126.
HOGENOM	HOG000233019.
HOVERGEN	HBG108179.
InParanoid	P37235.
OMA	LEIVQXK.
PhylomeDB	P37235.
Gene expression databases
ArrayExpress	P37235.
Bgee	P37235.
CleanEx	HS_HPCAL1.
Genevestigator	P37235.
GermOnline	ENSG00000115756. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 3 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001125. Recoverin. [Graphical view]
Pfam	PF13499. EF_hand_5. 2 hits. [Graphical view]
PRINTS	PR00450. RECOVERIN.
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HPCAL1. human.
GenomeRNAi	3241.
NextBio	12899.
SOURCE	Search...

Entry information

Entry name

HPCL1_HUMAN

Accession

Primary (citable) accession number: P37235
Secondary accession number(s): Q969S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 117 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.