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P37235 (HPCL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hippocalcin-like protein 1
Alternative name(s):
Calcium-binding protein BDR-1
HLP2
Visinin-like protein 3
Short name=VILIP-3
Gene names
Name:HPCAL1
Synonyms:BDR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Miscellaneous

Probably binds two or three calcium ions By similarity.

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Metal-binding
   PTMLipoprotein
Myristate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 193192Hippocalcin-like protein 1
PRO_0000073771

Regions

Domain23 – 5836EF-hand 1
Domain60 – 9536EF-hand 2
Domain96 – 13136EF-hand 3
Domain144 – 17936EF-hand 4
Calcium binding73 – 84121 Potential
Calcium binding109 – 120122 Potential
Calcium binding157 – 168123 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Experimental info

Sequence conflict191N → K in BAA03754. Ref.1
Sequence conflict881A → G in BAA03754. Ref.1
Sequence conflict93 – 942SR → RG in BAA03754. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P37235 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 87DCE938DCAD5E1F

FASTA19322,313
        10         20         30         40         50         60 
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 

        70         80         90        100        110        120 
ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 

       130        140        150        160        170        180 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 

       190 
RLLQCDPSSA SQF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene."
Kobayashi M., Takamatsu K., Fujishiro M., Saitoh S., Noguchi T.
Biochim. Biophys. Acta 1222:515-518(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Pancreas.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16227 mRNA. Translation: BAA03754.1.
BC009846 mRNA. Translation: AAH09846.1.
BC017028 mRNA. Translation: AAH17028.1.
BC017482 mRNA. Translation: AAH17482.1.
PIRS47565.
RefSeqNP_001245286.1. NM_001258357.1.
NP_001245287.1. NM_001258358.1.
NP_001245288.1. NM_001258359.1.
NP_002140.2. NM_002149.3.
NP_602293.1. NM_134421.2.
XP_005246217.1. XM_005246160.1.
XP_005246218.1. XM_005246161.1.
XP_005246219.1. XM_005246162.1.
XP_005246220.1. XM_005246163.1.
UniGeneHs.580427.
Hs.741268.

3D structure databases

ProteinModelPortalP37235.
SMRP37235. Positions 5-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109481. 6 interactions.
IntActP37235. 6 interactions.
MINTMINT-1436151.
STRING9606.ENSP00000310749.

PTM databases

PhosphoSiteP37235.

Polymorphism databases

DMDM20455519.

Proteomic databases

PaxDbP37235.
PRIDEP37235.

Protocols and materials databases

DNASU3241.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307845; ENSP00000310749; ENSG00000115756.
ENST00000381765; ENSP00000371184; ENSG00000115756.
GeneID3241.
KEGGhsa:3241.
UCSCuc002raj.4. human.

Organism-specific databases

CTD3241.
GeneCardsGC02P010443.
HGNCHGNC:5145. HPCAL1.
HPAHPA043245.
MIM600207. gene.
neXtProtNX_P37235.
PharmGKBPA29418.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233019.
HOVERGENHBG108179.
InParanoidP37235.
OMALEIVQXK.
PhylomeDBP37235.
TreeFamTF300009.

Gene expression databases

ArrayExpressP37235.
BgeeP37235.
CleanExHS_HPCAL1.
GenevestigatorP37235.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin_like.
[Graphical view]
PfamPF13499. EF-hand_7. 2 hits.
[Graphical view]
PRINTSPR00450. RECOVERIN.
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHPCAL1. human.
GeneWikiHPCAL1.
GenomeRNAi3241.
NextBio12899.
PROP37235.
SOURCESearch...

Entry information

Entry nameHPCL1_HUMAN
AccessionPrimary (citable) accession number: P37235
Secondary accession number(s): Q969S5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM