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Protein

Hippocalcin-like protein 1

Gene

HPCAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Calcium-binding protein BDR-1
HLP2
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:HPCAL1
Synonyms:BDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5145. HPCAL1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29418.

Polymorphism and mutation databases

BioMutaiHPCAL1.
DMDMi20455519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 193192Hippocalcin-like protein 1PRO_0000073771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP37235.
PRIDEiP37235.

PTM databases

PhosphoSiteiP37235.

Expressioni

Gene expression databases

BgeeiP37235.
CleanExiHS_HPCAL1.
ExpressionAtlasiP37235. baseline and differential.
GenevisibleiP37235. HS.

Organism-specific databases

HPAiHPA043245.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C1QTNF2Q9BXJ55EBI-749311,EBI-2817707
HMG20AQ9NP664EBI-749311,EBI-740641
KRTAP10-5P603703EBI-749311,EBI-10172150
KRTAP10-7P604093EBI-749311,EBI-10172290
KRTAP10-8P604103EBI-749311,EBI-10171774
KRTAP10-9P604113EBI-749311,EBI-10172052
KRTAP4-2Q9BYR53EBI-749311,EBI-10172511
KRTAP5-9P263713EBI-749311,EBI-3958099
NOTCH2NLQ7Z3S93EBI-749311,EBI-945833
tirQ7DB773EBI-749311,EBI-6480811From a different organism.

Protein-protein interaction databases

BioGridi109481. 24 interactions.
IntActiP37235. 16 interactions.
MINTiMINT-1436151.
STRINGi9606.ENSP00000310749.

Structurei

3D structure databases

ProteinModelPortaliP37235.
SMRiP37235. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP37235.
OMAiLEIVQXK.
PhylomeDBiP37235.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,313
Last modified:January 23, 2007 - v3
Checksum:i87DCE938DCAD5E1F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191N → K in BAA03754 (PubMed:8038222).Curated
Sequence conflicti88 – 881A → G in BAA03754 (PubMed:8038222).Curated
Sequence conflicti93 – 942SR → RG in BAA03754 (PubMed:8038222).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16227 mRNA. Translation: BAA03754.1.
BC009846 mRNA. Translation: AAH09846.1.
BC017028 mRNA. Translation: AAH17028.1.
BC017482 mRNA. Translation: AAH17482.1.
CCDSiCCDS1671.1.
PIRiS47565.
RefSeqiNP_001245286.1. NM_001258357.1.
NP_001245287.1. NM_001258358.1.
NP_001245288.1. NM_001258359.1.
NP_002140.2. NM_002149.3.
NP_602293.1. NM_134421.2.
XP_005246217.1. XM_005246160.1.
XP_005246218.1. XM_005246161.1.
XP_005246219.1. XM_005246162.1.
XP_005246220.1. XM_005246163.1.
XP_011508647.1. XM_011510345.1.
XP_011508648.1. XM_011510346.1.
XP_011508649.1. XM_011510347.1.
XP_011508650.1. XM_011510348.1.
UniGeneiHs.580427.
Hs.741268.

Genome annotation databases

EnsembliENST00000307845; ENSP00000310749; ENSG00000115756.
ENST00000381765; ENSP00000371184; ENSG00000115756.
ENST00000613496; ENSP00000478231; ENSG00000115756.
ENST00000620771; ENSP00000483786; ENSG00000115756.
ENST00000622018; ENSP00000482993; ENSG00000115756.
GeneIDi3241.
KEGGihsa:3241.
UCSCiuc002raj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16227 mRNA. Translation: BAA03754.1.
BC009846 mRNA. Translation: AAH09846.1.
BC017028 mRNA. Translation: AAH17028.1.
BC017482 mRNA. Translation: AAH17482.1.
CCDSiCCDS1671.1.
PIRiS47565.
RefSeqiNP_001245286.1. NM_001258357.1.
NP_001245287.1. NM_001258358.1.
NP_001245288.1. NM_001258359.1.
NP_002140.2. NM_002149.3.
NP_602293.1. NM_134421.2.
XP_005246217.1. XM_005246160.1.
XP_005246218.1. XM_005246161.1.
XP_005246219.1. XM_005246162.1.
XP_005246220.1. XM_005246163.1.
XP_011508647.1. XM_011510345.1.
XP_011508648.1. XM_011510346.1.
XP_011508649.1. XM_011510347.1.
XP_011508650.1. XM_011510348.1.
UniGeneiHs.580427.
Hs.741268.

3D structure databases

ProteinModelPortaliP37235.
SMRiP37235. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109481. 24 interactions.
IntActiP37235. 16 interactions.
MINTiMINT-1436151.
STRINGi9606.ENSP00000310749.

PTM databases

PhosphoSiteiP37235.

Polymorphism and mutation databases

BioMutaiHPCAL1.
DMDMi20455519.

Proteomic databases

PaxDbiP37235.
PRIDEiP37235.

Protocols and materials databases

DNASUi3241.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307845; ENSP00000310749; ENSG00000115756.
ENST00000381765; ENSP00000371184; ENSG00000115756.
ENST00000613496; ENSP00000478231; ENSG00000115756.
ENST00000620771; ENSP00000483786; ENSG00000115756.
ENST00000622018; ENSP00000482993; ENSG00000115756.
GeneIDi3241.
KEGGihsa:3241.
UCSCiuc002raj.4. human.

Organism-specific databases

CTDi3241.
GeneCardsiGC02P010443.
HGNCiHGNC:5145. HPCAL1.
HPAiHPA043245.
MIMi600207. gene.
neXtProtiNX_P37235.
PharmGKBiPA29418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP37235.
OMAiLEIVQXK.
PhylomeDBiP37235.
TreeFamiTF300009.

Miscellaneous databases

ChiTaRSiHPCAL1. human.
GeneWikiiHPCAL1.
GenomeRNAii3241.
NextBioi12899.
PROiP37235.
SOURCEiSearch...

Gene expression databases

BgeeiP37235.
CleanExiHS_HPCAL1.
ExpressionAtlasiP37235. baseline and differential.
GenevisibleiP37235. HS.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene."
    Kobayashi M., Takamatsu K., Fujishiro M., Saitoh S., Noguchi T.
    Biochim. Biophys. Acta 1222:515-518(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Pancreas.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHPCL1_HUMAN
AccessioniPrimary (citable) accession number: P37235
Secondary accession number(s): Q969S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.