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P37235

- HPCL1_HUMAN

UniProt

P37235 - HPCL1_HUMAN

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Protein

Hippocalcin-like protein 1

Gene

HPCAL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: ProtInc

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Calcium-binding protein BDR-1
HLP2
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:HPCAL1
Synonyms:BDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5145. HPCAL1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 193192Hippocalcin-like protein 1PRO_0000073771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP37235.
PRIDEiP37235.

PTM databases

PhosphoSiteiP37235.

Expressioni

Gene expression databases

BgeeiP37235.
CleanExiHS_HPCAL1.
ExpressionAtlasiP37235. baseline and differential.
GenevestigatoriP37235.

Organism-specific databases

HPAiHPA043245.

Interactioni

Protein-protein interaction databases

BioGridi109481. 13 interactions.
IntActiP37235. 6 interactions.
MINTiMINT-1436151.
STRINGi9606.ENSP00000310749.

Structurei

3D structure databases

ProteinModelPortaliP37235.
SMRiP37235. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP37235.
OMAiLEIVQXK.
PhylomeDBiP37235.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37235-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,313
Last modified:January 23, 2007 - v3
Checksum:i87DCE938DCAD5E1F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191N → K in BAA03754. (PubMed:8038222)Curated
Sequence conflicti88 – 881A → G in BAA03754. (PubMed:8038222)Curated
Sequence conflicti93 – 942SR → RG in BAA03754. (PubMed:8038222)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16227 mRNA. Translation: BAA03754.1.
BC009846 mRNA. Translation: AAH09846.1.
BC017028 mRNA. Translation: AAH17028.1.
BC017482 mRNA. Translation: AAH17482.1.
CCDSiCCDS1671.1.
PIRiS47565.
RefSeqiNP_001245286.1. NM_001258357.1.
NP_001245287.1. NM_001258358.1.
NP_001245288.1. NM_001258359.1.
NP_002140.2. NM_002149.3.
NP_602293.1. NM_134421.2.
XP_005246217.1. XM_005246160.1.
XP_005246218.1. XM_005246161.1.
XP_005246219.1. XM_005246162.1.
XP_005246220.1. XM_005246163.1.
UniGeneiHs.580427.
Hs.741268.

Genome annotation databases

EnsembliENST00000307845; ENSP00000310749; ENSG00000115756.
ENST00000381765; ENSP00000371184; ENSG00000115756.
ENST00000613496; ENSP00000478231; ENSG00000115756.
ENST00000620771; ENSP00000483786; ENSG00000115756.
ENST00000622018; ENSP00000482993; ENSG00000115756.
GeneIDi3241.
KEGGihsa:3241.
UCSCiuc002raj.4. human.

Polymorphism databases

DMDMi20455519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16227 mRNA. Translation: BAA03754.1 .
BC009846 mRNA. Translation: AAH09846.1 .
BC017028 mRNA. Translation: AAH17028.1 .
BC017482 mRNA. Translation: AAH17482.1 .
CCDSi CCDS1671.1.
PIRi S47565.
RefSeqi NP_001245286.1. NM_001258357.1.
NP_001245287.1. NM_001258358.1.
NP_001245288.1. NM_001258359.1.
NP_002140.2. NM_002149.3.
NP_602293.1. NM_134421.2.
XP_005246217.1. XM_005246160.1.
XP_005246218.1. XM_005246161.1.
XP_005246219.1. XM_005246162.1.
XP_005246220.1. XM_005246163.1.
UniGenei Hs.580427.
Hs.741268.

3D structure databases

ProteinModelPortali P37235.
SMRi P37235. Positions 5-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109481. 13 interactions.
IntActi P37235. 6 interactions.
MINTi MINT-1436151.
STRINGi 9606.ENSP00000310749.

PTM databases

PhosphoSitei P37235.

Polymorphism databases

DMDMi 20455519.

Proteomic databases

PaxDbi P37235.
PRIDEi P37235.

Protocols and materials databases

DNASUi 3241.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307845 ; ENSP00000310749 ; ENSG00000115756 .
ENST00000381765 ; ENSP00000371184 ; ENSG00000115756 .
ENST00000613496 ; ENSP00000478231 ; ENSG00000115756 .
ENST00000620771 ; ENSP00000483786 ; ENSG00000115756 .
ENST00000622018 ; ENSP00000482993 ; ENSG00000115756 .
GeneIDi 3241.
KEGGi hsa:3241.
UCSCi uc002raj.4. human.

Organism-specific databases

CTDi 3241.
GeneCardsi GC02P010443.
HGNCi HGNC:5145. HPCAL1.
HPAi HPA043245.
MIMi 600207. gene.
neXtProti NX_P37235.
PharmGKBi PA29418.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000233019.
HOVERGENi HBG108179.
InParanoidi P37235.
OMAi LEIVQXK.
PhylomeDBi P37235.
TreeFami TF300009.

Miscellaneous databases

ChiTaRSi HPCAL1. human.
GeneWikii HPCAL1.
GenomeRNAii 3241.
NextBioi 12899.
PROi P37235.
SOURCEi Search...

Gene expression databases

Bgeei P37235.
CleanExi HS_HPCAL1.
ExpressionAtlasi P37235. baseline and differential.
Genevestigatori P37235.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
Pfami PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene."
    Kobayashi M., Takamatsu K., Fujishiro M., Saitoh S., Noguchi T.
    Biochim. Biophys. Acta 1222:515-518(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Pancreas.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHPCL1_HUMAN
AccessioniPrimary (citable) accession number: P37235
Secondary accession number(s): Q969S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3