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Protein

Hippocalcin-like protein 1

Gene

HPCAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Miscellaneous

Probably binds two or three calcium ions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1683PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Calcium-binding protein BDR-1
HLP2
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:HPCAL1
Synonyms:BDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115756.12
HGNCiHGNC:5145 HPCAL1
MIMi600207 gene
neXtProtiNX_P37235

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3241
OpenTargetsiENSG00000115756
PharmGKBiPA29418

Polymorphism and mutation databases

BioMutaiHPCAL1
DMDMi20455519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000737712 – 193Hippocalcin-like protein 1Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP37235
PaxDbiP37235
PeptideAtlasiP37235
PRIDEiP37235

PTM databases

iPTMnetiP37235
PhosphoSitePlusiP37235
SwissPalmiP37235

Expressioni

Gene expression databases

BgeeiENSG00000115756
CleanExiHS_HPCAL1
ExpressionAtlasiP37235 baseline and differential
GenevisibleiP37235 HS

Organism-specific databases

HPAiHPA043245

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109481, 33 interactors
IntActiP37235, 23 interactors
STRINGi9606.ENSP00000310749

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 14Combined sources5
Helixi25 – 35Combined sources11
Beta strandi37 – 40Combined sources4
Helixi46 – 54Combined sources9
Helixi61 – 71Combined sources11
Beta strandi75 – 77Combined sources3
Helixi82 – 89Combined sources8
Helixi97 – 105Combined sources9
Beta strandi110 – 114Combined sources5
Helixi118 – 132Combined sources15
Helixi146 – 156Combined sources11
Helixi167 – 174Combined sources8
Helixi176 – 182Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T7CNMR-A2-193[»]
ProteinModelPortaliP37235
SMRiP37235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP37235
OMAiLEIVQXK
OrthoDBiEOG091G11T4
PhylomeDBiP37235
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,313
Last modified:January 23, 2007 - v3
Checksum:i87DCE938DCAD5E1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19N → K in BAA03754 (PubMed:8038222).Curated1
Sequence conflicti88A → G in BAA03754 (PubMed:8038222).Curated1
Sequence conflicti93 – 94SR → RG in BAA03754 (PubMed:8038222).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16227 mRNA Translation: BAA03754.1
BC009846 mRNA Translation: AAH09846.1
BC017028 mRNA Translation: AAH17028.1
BC017482 mRNA Translation: AAH17482.1
CCDSiCCDS1671.1
PIRiS47565
RefSeqiNP_001245286.1, NM_001258357.1
NP_001245287.1, NM_001258358.1
NP_001245288.1, NM_001258359.1
NP_002140.2, NM_002149.3
NP_602293.1, NM_134421.2
XP_005246217.1, XM_005246160.1
XP_005246218.1, XM_005246161.1
XP_005246219.1, XM_005246162.1
XP_005246220.1, XM_005246163.1
XP_011508648.1, XM_011510346.2
XP_011508649.1, XM_011510347.1
XP_011508650.1, XM_011510348.1
XP_016859439.1, XM_017003950.1
XP_016859440.1, XM_017003951.1
XP_016859441.1, XM_017003952.1
XP_016859442.1, XM_017003953.1
UniGeneiHs.580427
Hs.741268

Genome annotation databases

EnsembliENST00000307845; ENSP00000310749; ENSG00000115756
ENST00000381765; ENSP00000371184; ENSG00000115756
ENST00000613496; ENSP00000478231; ENSG00000115756
ENST00000620771; ENSP00000483786; ENSG00000115756
ENST00000622018; ENSP00000482993; ENSG00000115756
GeneIDi3241
KEGGihsa:3241

Similar proteinsi

Entry informationi

Entry nameiHPCL1_HUMAN
AccessioniPrimary (citable) accession number: P37235
Secondary accession number(s): Q969S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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