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P37230

- PPARA_RAT

UniProt

P37230 - PPARA_RAT

Protein

Peroxisome proliferator-activated receptor alpha

Gene

Ppara

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei433 – 4331Essential for heterodimerization with RXRABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi99 – 17375Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri102 – 12221NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16123NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. drug binding Source: UniProtKB
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RGD
    3. lipid binding Source: UniProtKB
    4. MDM2/MDM4 family protein binding Source: RGD
    5. NFAT protein binding Source: RGD
    6. phosphatase binding Source: RGD
    7. protein binding Source: UniProtKB
    8. protein complex binding Source: RGD
    9. protein domain specific binding Source: RGD
    10. sequence-specific DNA binding Source: Ensembl
    11. steroid hormone receptor activity Source: RGD
    12. zinc ion binding Source: InterPro

    GO - Biological processi

    1. behavioral response to nicotine Source: RGD
    2. circadian regulation of gene expression Source: UniProtKB
    3. enamel mineralization Source: Ensembl
    4. epidermis development Source: Ensembl
    5. fatty acid metabolic process Source: RGD
    6. heart development Source: RGD
    7. lipoprotein metabolic process Source: RGD
    8. negative regulation of appetite Source: UniProtKB
    9. negative regulation of blood pressure Source: RGD
    10. negative regulation of cholesterol storage Source: Ensembl
    11. negative regulation of neuron death Source: RGD
    12. negative regulation of protein binding Source: RGD
    13. negative regulation of receptor biosynthetic process Source: Ensembl
    14. negative regulation of sequestering of triglyceride Source: Ensembl
    15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. negative regulation of transcription regulatory region DNA binding Source: RGD
    17. positive regulation of fatty acid oxidation Source: Ensembl
    18. positive regulation of transcription, DNA-templated Source: UniProtKB
    19. regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    20. regulation of circadian rhythm Source: UniProtKB
    21. regulation of fatty acid metabolic process Source: RGD
    22. regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    23. regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. regulation of transcription, DNA-templated Source: RGD
    25. response to hypoxia Source: HGNC
    26. response to insulin Source: RGD
    27. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Activator, Receptor

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Lipid-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_196408. PPARA activates gene expression.
    REACT_196852. REV-ERBA represses gene expression.
    REACT_196856. RORA activates circadian gene expression.
    REACT_198613. Activation of gene expression by SREBF (SREBP).
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_216049. Transcriptional activation of mitochondrial biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome proliferator-activated receptor alpha
    Short name:
    PPAR-alpha
    Alternative name(s):
    Nuclear receptor subfamily 1 group C member 1
    Gene namesi
    Name:Ppara
    Synonyms:Nr1c1, Ppar
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi3369. Ppara.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Peroxisome proliferator-activated receptor alphaPRO_0000053484Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP37230.

    PTM databases

    PhosphoSiteiP37230.

    Expressioni

    Tissue specificityi

    Expressed predominantly in liver and kidney.

    Gene expression databases

    GenevestigatoriP37230.

    Interactioni

    Subunit structurei

    Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 AND ASXL2. Interacts with PER2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi247775. 5 interactions.
    DIPiDIP-29529N.
    STRINGi10116.ENSRNOP00000038651.

    Structurei

    3D structure databases

    ProteinModelPortaliP37230.
    SMRiP37230. Positions 100-179, 200-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni280 – 468189Ligand-bindingBy similarityAdd
    BLAST
    Regioni304 – 433130Required for heterodimerization with RXRABy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri102 – 12221NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri139 – 16123NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG266867.
    GeneTreeiENSGT00740000115076.
    HOGENOMiHOG000261626.
    HOVERGENiHBG106004.
    InParanoidiP37230.
    KOiK07294.
    OMAiTESPICP.
    OrthoDBiEOG7X9G7F.
    PhylomeDBiP37230.
    TreeFamiTF316304.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR003076. 1Cnucl_rcpt_A.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR01289. PROXISOMPAAR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37230-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS LGEESSGSFS    50
    FADYQYLGSC PGSEGSVITD TLSPASSPSS VSCPAVPTST DESPGNALNI 100
    ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLAYDKCD RSCKIQKKNR 150
    NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDLKDSET 200
    ADLKSLAKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV IHDMETLCMA 250
    EKTLVAKMVA NGVENKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL 300
    DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP 350
    FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL 400
    QEGIVHVLKL HLQSNHPDDT FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT 450
    ESDAALHPLL QEIYRDMY 468
    Length:468
    Mass (Da):52,377
    Last modified:October 1, 1994 - v1
    Checksum:i2A89E7D715C8DBA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88592 mRNA. Translation: AAA41918.1.
    PIRiA45288.
    RefSeqiNP_037328.1. NM_013196.1.
    XP_006242218.1. XM_006242156.1.
    UniGeneiRn.9753.

    Genome annotation databases

    EnsembliENSRNOT00000030082; ENSRNOP00000038651; ENSRNOG00000021463.
    GeneIDi25747.
    KEGGirno:25747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88592 mRNA. Translation: AAA41918.1 .
    PIRi A45288.
    RefSeqi NP_037328.1. NM_013196.1.
    XP_006242218.1. XM_006242156.1.
    UniGenei Rn.9753.

    3D structure databases

    ProteinModelPortali P37230.
    SMRi P37230. Positions 100-179, 200-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247775. 5 interactions.
    DIPi DIP-29529N.
    STRINGi 10116.ENSRNOP00000038651.

    Chemistry

    BindingDBi P37230.
    ChEMBLi CHEMBL2129.

    PTM databases

    PhosphoSitei P37230.

    Proteomic databases

    PRIDEi P37230.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000030082 ; ENSRNOP00000038651 ; ENSRNOG00000021463 .
    GeneIDi 25747.
    KEGGi rno:25747.

    Organism-specific databases

    CTDi 5465.
    RGDi 3369. Ppara.

    Phylogenomic databases

    eggNOGi NOG266867.
    GeneTreei ENSGT00740000115076.
    HOGENOMi HOG000261626.
    HOVERGENi HBG106004.
    InParanoidi P37230.
    KOi K07294.
    OMAi TESPICP.
    OrthoDBi EOG7X9G7F.
    PhylomeDBi P37230.
    TreeFami TF316304.

    Enzyme and pathway databases

    Reactomei REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_196408. PPARA activates gene expression.
    REACT_196852. REV-ERBA represses gene expression.
    REACT_196856. RORA activates circadian gene expression.
    REACT_198613. Activation of gene expression by SREBF (SREBP).
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_216049. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    NextBioi 607925.
    PROi P37230.

    Gene expression databases

    Genevestigatori P37230.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR003076. 1Cnucl_rcpt_A.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR01289. PROXISOMPAAR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor."
      Goettlicher M., Widmark E., Li Q., Gustafsson J.-A.
      Proc. Natl. Acad. Sci. U.S.A. 89:4653-4657(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin."
      Shalev A., Siegrist-Kaiser C.A., Yen P.M., Wahli W., Burger A.G., Chin W.W., Meier C.A.
      Endocrinology 137:4499-4502(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    3. "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator."
      Tien E.S., Davis J.W., Vanden Heuvel J.P.
      J. Biol. Chem. 279:24053-24063(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CITED2.

    Entry informationi

    Entry nameiPPARA_RAT
    AccessioniPrimary (citable) accession number: P37230
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3