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P37230

- PPARA_RAT

UniProt

P37230 - PPARA_RAT

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Protein

Peroxisome proliferator-activated receptor alpha

Gene

Ppara

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei433 – 4331Essential for heterodimerization with RXRABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi99 – 17375Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri102 – 12221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16123NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. drug binding Source: UniProtKB
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RGD
  3. lipid binding Source: UniProtKB
  4. MDM2/MDM4 family protein binding Source: RGD
  5. NFAT protein binding Source: RGD
  6. phosphatase binding Source: RGD
  7. protein complex binding Source: RGD
  8. protein domain specific binding Source: RGD
  9. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  10. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  11. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  12. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  13. steroid hormone receptor activity Source: RGD
  14. zinc ion binding Source: InterPro

GO - Biological processi

  1. behavioral response to nicotine Source: RGD
  2. circadian regulation of gene expression Source: UniProtKB
  3. enamel mineralization Source: Ensembl
  4. epidermis development Source: Ensembl
  5. fatty acid metabolic process Source: RGD
  6. heart development Source: RGD
  7. intracellular receptor signaling pathway Source: GOC
  8. lipoprotein metabolic process Source: RGD
  9. negative regulation of appetite Source: UniProtKB
  10. negative regulation of blood pressure Source: RGD
  11. negative regulation of cholesterol storage Source: Ensembl
  12. negative regulation of neuron death Source: RGD
  13. negative regulation of protein binding Source: RGD
  14. negative regulation of receptor biosynthetic process Source: Ensembl
  15. negative regulation of sequestering of triglyceride Source: Ensembl
  16. negative regulation of transcription regulatory region DNA binding Source: RGD
  17. positive regulation of fatty acid oxidation Source: Ensembl
  18. positive regulation of gluconeogenesis Source: Ensembl
  19. positive regulation of transcription, DNA-templated Source: UniProtKB
  20. regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  21. regulation of circadian rhythm Source: UniProtKB
  22. regulation of fatty acid metabolic process Source: RGD
  23. regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. regulation of transcription, DNA-templated Source: RGD
  26. response to hypoxia Source: HGNC
  27. response to insulin Source: RGD
  28. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_196408. PPARA activates gene expression.
REACT_196852. REV-ERBA represses gene expression.
REACT_196856. RORA activates circadian gene expression.
REACT_198613. Activation of gene expression by SREBF (SREBP).
REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_216049. Transcriptional activation of mitochondrial biogenesis.
REACT_242509. Nuclear Receptor transcription pathway.
REACT_245846. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_257889. Circadian Clock.
REACT_260360. Transcriptional regulation of white adipocyte differentiation.
REACT_270861. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor alpha
Short name:
PPAR-alpha
Alternative name(s):
Nuclear receptor subfamily 1 group C member 1
Gene namesi
Name:Ppara
Synonyms:Nr1c1, Ppar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi3369. Ppara.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Peroxisome proliferator-activated receptor alphaPRO_0000053484Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP37230.

PTM databases

PhosphoSiteiP37230.

Expressioni

Tissue specificityi

Expressed predominantly in liver and kidney.

Gene expression databases

GenevestigatoriP37230.

Interactioni

Subunit structurei

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 AND ASXL2. Interacts with PER2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247775. 5 interactions.
DIPiDIP-29529N.
STRINGi10116.ENSRNOP00000038651.

Structurei

3D structure databases

ProteinModelPortaliP37230.
SMRiP37230. Positions 100-179, 200-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 468189Ligand-bindingBy similarityAdd
BLAST
Regioni304 – 433130Required for heterodimerization with RXRABy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri102 – 12221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 16123NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG266867.
GeneTreeiENSGT00760000119049.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiP37230.
KOiK07294.
OMAiTESPICP.
OrthoDBiEOG7X9G7F.
PhylomeDBiP37230.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37230-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS LGEESSGSFS
60 70 80 90 100
FADYQYLGSC PGSEGSVITD TLSPASSPSS VSCPAVPTST DESPGNALNI
110 120 130 140 150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLAYDKCD RSCKIQKKNR
160 170 180 190 200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDLKDSET
210 220 230 240 250
ADLKSLAKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV IHDMETLCMA
260 270 280 290 300
EKTLVAKMVA NGVENKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL
310 320 330 340 350
DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP
360 370 380 390 400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL
410 420 430 440 450
QEGIVHVLKL HLQSNHPDDT FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT
460
ESDAALHPLL QEIYRDMY
Length:468
Mass (Da):52,377
Last modified:October 1, 1994 - v1
Checksum:i2A89E7D715C8DBA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88592 mRNA. Translation: AAA41918.1.
PIRiA45288.
RefSeqiNP_037328.1. NM_013196.1.
XP_006242218.1. XM_006242156.2.
UniGeneiRn.9753.

Genome annotation databases

EnsembliENSRNOT00000030082; ENSRNOP00000038651; ENSRNOG00000021463.
GeneIDi25747.
KEGGirno:25747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88592 mRNA. Translation: AAA41918.1 .
PIRi A45288.
RefSeqi NP_037328.1. NM_013196.1.
XP_006242218.1. XM_006242156.2.
UniGenei Rn.9753.

3D structure databases

ProteinModelPortali P37230.
SMRi P37230. Positions 100-179, 200-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247775. 5 interactions.
DIPi DIP-29529N.
STRINGi 10116.ENSRNOP00000038651.

Chemistry

BindingDBi P37230.
ChEMBLi CHEMBL2129.

PTM databases

PhosphoSitei P37230.

Proteomic databases

PRIDEi P37230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000030082 ; ENSRNOP00000038651 ; ENSRNOG00000021463 .
GeneIDi 25747.
KEGGi rno:25747.

Organism-specific databases

CTDi 5465.
RGDi 3369. Ppara.

Phylogenomic databases

eggNOGi NOG266867.
GeneTreei ENSGT00760000119049.
HOGENOMi HOG000261626.
HOVERGENi HBG106004.
InParanoidi P37230.
KOi K07294.
OMAi TESPICP.
OrthoDBi EOG7X9G7F.
PhylomeDBi P37230.
TreeFami TF316304.

Enzyme and pathway databases

Reactomei REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_196408. PPARA activates gene expression.
REACT_196852. REV-ERBA represses gene expression.
REACT_196856. RORA activates circadian gene expression.
REACT_198613. Activation of gene expression by SREBF (SREBP).
REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_216049. Transcriptional activation of mitochondrial biogenesis.
REACT_242509. Nuclear Receptor transcription pathway.
REACT_245846. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_257889. Circadian Clock.
REACT_260360. Transcriptional regulation of white adipocyte differentiation.
REACT_270861. Orphan transporters.

Miscellaneous databases

NextBioi 607925.
PROi P37230.

Gene expression databases

Genevestigatori P37230.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor."
    Goettlicher M., Widmark E., Li Q., Gustafsson J.-A.
    Proc. Natl. Acad. Sci. U.S.A. 89:4653-4657(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin."
    Shalev A., Siegrist-Kaiser C.A., Yen P.M., Wahli W., Burger A.G., Chin W.W., Meier C.A.
    Endocrinology 137:4499-4502(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  3. "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator."
    Tien E.S., Davis J.W., Vanden Heuvel J.P.
    J. Biol. Chem. 279:24053-24063(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CITED2.

Entry informationi

Entry nameiPPARA_RAT
AccessioniPrimary (citable) accession number: P37230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3