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P37228

- MDHG_SOYBN

UniProt

P37228 - MDHG_SOYBN

Protein

Malate dehydrogenase, glyoxysomal

Gene
N/A
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741NADBy similarity
    Binding sitei121 – 1211SubstratePROSITE-ProRule annotation
    Binding sitei127 – 1271SubstratePROSITE-ProRule annotation
    Binding sitei134 – 1341NADBy similarity
    Binding sitei159 – 1591SubstratePROSITE-ProRule annotation
    Binding sitei193 – 1931SubstratePROSITE-ProRule annotation
    Active sitei217 – 2171Proton acceptorBy similarity
    Binding sitei268 – 2681NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi48 – 547NADBy similarity
    Nucleotide bindingi157 – 1593NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase, glyoxysomal (EC:1.1.1.37)
    OrganismiGlycine max (Soybean) (Glycine hispida)
    Taxonomic identifieri3847 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
    ProteomesiUP000008827: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. glyoxysome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glyoxysome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333GlyoxysomeSequence AnalysisAdd
    BLAST
    Chaini34 – 353320Malate dehydrogenase, glyoxysomalPRO_0000018641Add
    BLAST

    Proteomic databases

    PRIDEiP37228.

    Expressioni

    Gene expression databases

    GenevestigatoriP37228.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP37228.
    SMRiP37228. Positions 41-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37228-1 [UniParc]FASTAAdd to Basket

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    MEANSGASDR ISRIAGHLRP QREDDVCLKR SDCRAKGGVS GFKVAILGAA    50
    GGIGQPLAML MKMNPLVSLL HLYDVVNTPG VTSDISHMDT GAVVRGFLGQ 100
    QQLEDALIGM DLVIIPAGVP RKPGMTRDDL FNINAGIVKT LCEAIAKCCP 150
    KAIVNVISNP VNSTVPIAAE VFKRAGTYDP KRLLGVTMLD VVRANTFVAE 200
    VLGVDPRDVD VPVVGGHAGI TILPLLSQIK PPCSFTPKEI EYLTGRIQNG 250
    GPEVVEAKAG AGSATLSMAY AAVKFADACL HALRGDAGII ECAYVASQVT 300
    ELPFFASKVR LGRVGVEEIL PLGPLNDYER ESLEKAKKEL AASIEKGISF 350
    IRK 353
    Length:353
    Mass (Da):37,395
    Last modified:February 1, 1996 - v2
    Checksum:iD2B0BF1AE6CC8925
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01628 mRNA. Translation: AAC37464.1.
    UniGeneiGma.1535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01628 mRNA. Translation: AAC37464.1 .
    UniGenei Gma.1535.

    3D structure databases

    ProteinModelPortali P37228.
    SMRi P37228. Positions 41-352.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P37228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    Genevestigatori P37228.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glyoxysomal malate dehydrogenase and malate synthase from soybean cotyledons (Glycine max L.): enzyme association, antibody production and cDNA cloning."
      Guex N., Henry H., Flach J., Richter H., Widmer F.
      Planta 197:369-375(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-353.
      Strain: cv. Maple Arrow.
      Tissue: Cotyledon.
    2. Richter H., Guex N.
      Submitted (JAN-1996) to UniProtKB
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-3.
      Strain: cv. Maple Arrow.
      Tissue: Cotyledon.
    3. "3D modeling of soybean glyoxysomal malate dehydrogenase (gMDH)."
      Guex N., Widmer F., Gaillard P., Carrupt P.-A.
      (In) Wermuth C.G. (eds.); Trends in QSAR and molecular modelling 92, pp.485-486, Escom Science Publishers, Leiden (1993)
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiMDHG_SOYBN
    AccessioniPrimary (citable) accession number: P37228
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3