ID   MDHM_SCHMA              Reviewed;         142 AA.
AC   P37227;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Malate dehydrogenase, mitochondrial;
DE            EC=1.1.1.37;
DE   Flags: Fragment;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93376025; PubMed=8396206; DOI=10.1016/0166-6851(93)90032-S;
RA   Skelly P.J., Stein L.D., Shoemaker C.B.;
RT   "Expression of Schistosoma mansoni genes involved in anaerobic and
RT   oxidative glucose metabolism during the cercaria to adult
RT   transformation.";
RL   Mol. Biochem. Parasitol. 60:93-104(1993).
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC   -!- DEVELOPMENTAL STAGE: Expressed in relatively high level in adults
CC       as compared to larval worms.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; L10108; AAA29901.1; -; Genomic_DNA.
DR   HSSP; P00346; 1MLD.
DR   SMR; P37227; 1-142.
DR   BRENDA; 1.1.1.37; 1460.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR001236; Lactate/malate_DH.
DR   InterPro; IPR001252; Malate_DH_AS.
DR   InterPro; IPR010097; Malate_DH_NAD-dep_euk_g_bac.
DR   PANTHER; PTHR11540:SF1; MDH_euk_g_bac; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PROSITE; PS00068; MDH; PARTIAL.
PE   2: Evidence at transcript level;
KW   Mitochondrion; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN        <1   >142       Malate dehydrogenase, mitochondrial.
FT                                /FTId=PRO_0000113340.
FT   NP_BIND       1      6       NAD (By similarity).
FT   NP_BIND     109    111       NAD (By similarity).
FT   BINDING      26     26       NAD (By similarity).
FT   BINDING      73     73       Substrate (By similarity).
FT   BINDING      79     79       Substrate (By similarity).
FT   BINDING      86     86       NAD (By similarity).
FT   BINDING     111    111       Substrate (By similarity).
FT   NON_TER       1      1
FT   NON_TER     142    142
SQ   SEQUENCE   142 AA;  14956 MW;  C06BC6726566AE72 CRC64;
     ASGGIGEPLS LLLKQSPLIS QLALYDIAHV KGVAADLSHI ETQAHVTAHL GPGELAECLT
     GANVVIIPAG LPRKPGMTRD DLFNTNASIV AELIDSCAKN CPKAMICIIT NPVNSTVPIA
     AEILKRHNVY DPKRLFGVTT LD
//