Reviewed, UniProtKB/Swiss-Prot P37227 (MDHM_SCHMA)

Names and origin

Protein names	Recommended name:     Malate dehydrogenase, mitochondrial     EC=1.1.1.37
Organism	Schistosoma mansoni (Blood fluke)
Taxonomic identifier	6183 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	142 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion matrix.
Developmental stage	Expressed in relatively high level in adults as compared to larval worms.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	malate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›142	›142	Malate dehydrogenase, mitochondrial		PRO_0000113340
Regions
	Nucleotide binding	1 – 6	6	NAD By similarity
	Nucleotide binding	109 – 111	3	NAD By similarity
Sites
	Binding site	26	1	NAD By similarity
	Binding site	73	1	Substrate By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	86	1	NAD By similarity
	Binding site	111	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	142	1

Sequences

	Sequence		Length	Mass (Da)
	P37227-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: C06BC6726566AE72	FASTA	142	14,956
	10 20 30 40 50 60 ASGGIGEPLS LLLKQSPLIS QLALYDIAHV KGVAADLSHI ETQAHVTAHL GPGELAECLT 70 80 90 100 110 120 GANVVIIPAG LPRKPGMTRD DLFNTNASIV AELIDSCAKN CPKAMICIIT NPVNSTVPIA 130 140 AEILKRHNVY DPKRLFGVTT LD

References

[1]	"Expression of Schistosoma mansoni genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation." Skelly P.J., Stein L.D., Shoemaker C.B. Mol. Biochem. Parasitol. 60:93-104(1993) [PubMed: 8396206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L10108 Genomic DNA. Translation: AAA29901.1.
3D structure databases
HSSP	HSSP built from PDB template 1MLD based on UniProtKB P00346.
SMR	P37227. Positions 1-142.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.37. 1460.
Family and domain databases
InterPro	IPR001236. Lactate/malate_DH. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_NAD-dep_euk_g_bac. [Graphical view]
PANTHER	PTHR11540:SF1. MDH_euk_g_bac. 1 hit.
Pfam	PF00056. Ldh_1_N. 1 hit. [Graphical view]
PROSITE	PS00068. MDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDHM_SCHMA

Accession

Primary (citable) accession number: P37227

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)