P37227 (MDHM_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Malate dehydrogenase, mitochondrial EC=1.1.1.37
Organism	Schistosoma mansoni (Blood fluke)
Taxonomic identifier	6183 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	142 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion matrix.
Developmental stage	Expressed in relatively high level in adults as compared to larval worms.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›142	›142	Malate dehydrogenase, mitochondrial		PRO_0000113340
Regions
	Nucleotide binding	1 – 6	6	NAD By similarity
	Nucleotide binding	109 – 111	3	NAD By similarity
Sites
	Binding site	26	1	NAD By similarity
	Binding site	73	1	Substrate By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	86	1	NAD By similarity
	Binding site	111	1	Substrate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	142	1

Sequences

	Sequence		Length	Mass (Da)
	P37227 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: C06BC6726566AE72	FASTA	142	14,956
	10 20 30 40 50 60 ASGGIGEPLS LLLKQSPLIS QLALYDIAHV KGVAADLSHI ETQAHVTAHL GPGELAECLT 70 80 90 100 110 120 GANVVIIPAG LPRKPGMTRD DLFNTNASIV AELIDSCAKN CPKAMICIIT NPVNSTVPIA 130 140 AEILKRHNVY DPKRLFGVTT LD

References

[1]

"Expression of Schistosoma mansoni genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation." Skelly P.J., Stein L.D., Shoemaker C.B. Mol. Biochem. Parasitol. 60:93-104(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L10108 Genomic DNA. Translation: AAA29901.1.
3D structure databases
ProteinModelPortal	P37227.
SMR	P37227. Positions 1-142.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
SABIO-RK	P37227.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR001557. L-lactate/malate_DH. IPR001236. Lactate/malate_DH_N. IPR010097. Malate_DH_type1. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11540. PTHR11540. 1 hit. PTHR11540:SF1. PTHR11540:SF1. 1 hit.
Pfam	PF00056. Ldh_1_N. 1 hit. [Graphical view]
PROSITE	PS00068. MDH. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDHM_SCHMA

Accession

Primary (citable) accession number: P37227

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)