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P37227

- MDHM_SCHMA

UniProt

P37227 - MDHM_SCHMA

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Protein

Malate dehydrogenase, mitochondrial

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261NADBy similarity
Binding sitei73 – 731SubstratePROSITE-ProRule annotation
Binding sitei79 – 791SubstratePROSITE-ProRule annotation
Binding sitei86 – 861NADBy similarity
Binding sitei111 – 1111SubstratePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1 – 66NADBy similarity
Nucleotide bindingi109 – 1113NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKP37227.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›142›142Malate dehydrogenase, mitochondrialPRO_0000113340Add
BLAST

Expressioni

Developmental stagei

Expressed in relatively high level in adults as compared to larval worms.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP37227.
SMRiP37227. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR001236. Lactate/malate_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF00056. Ldh_1_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P37227-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ASGGIGEPLS LLLKQSPLIS QLALYDIAHV KGVAADLSHI ETQAHVTAHL
60 70 80 90 100
GPGELAECLT GANVVIIPAG LPRKPGMTRD DLFNTNASIV AELIDSCAKN
110 120 130 140
CPKAMICIIT NPVNSTVPIA AEILKRHNVY DPKRLFGVTT LD
Length:142
Mass (Da):14,956
Last modified:October 1, 1994 - v1
Checksum:iC06BC6726566AE72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei142 – 1421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10108 Genomic DNA. Translation: AAA29901.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10108 Genomic DNA. Translation: AAA29901.1 .

3D structure databases

ProteinModelPortali P37227.
SMRi P37227. Positions 1-142.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P37227.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR001236. Lactate/malate_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of Schistosoma mansoni genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation."
    Skelly P.J., Stein L.D., Shoemaker C.B.
    Mol. Biochem. Parasitol. 60:93-104(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMDHM_SCHMA
AccessioniPrimary (citable) accession number: P37227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3