Reviewed,
UniProtKB/Swiss-Prot P37227 (MDHM_SCHMA)
Last modified
June 16, 2009.
Version 58.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Malate dehydrogenase, mitochondrial EC=1.1.1.37 |
| Organism | Schistosoma mansoni (Blood fluke) |
| Taxonomic identifier | 6183 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma |
Protein attributes
| Sequence length | 142 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | (S)-malate + NAD+ = oxaloacetate + NADH. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Developmental stage | Expressed in relatively high level in adults as compared to larval worms. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Mitochondrion |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | malate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – ›142 | ›142 | Malate dehydrogenase, mitochondrial | PRO_0000113340 | |||||
Regions | |||||||||
| Nucleotide binding | 1 – 6 | 6 | NAD By similarity | ||||||
| Nucleotide binding | 109 – 111 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Binding site | 26 | 1 | NAD By similarity | ||||||
| Binding site | 73 | 1 | Substrate By similarity | ||||||
| Binding site | 79 | 1 | Substrate By similarity | ||||||
| Binding site | 86 | 1 | NAD By similarity | ||||||
| Binding site | 111 | 1 | Substrate By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 1 | 1 | |||||||
| Non-terminal residue | 142 | 1 | |||||||
Sequences
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References
| [1] | "Expression of Schistosoma mansoni genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation." Skelly P.J., Stein L.D., Shoemaker C.B. Mol. Biochem. Parasitol. 60:93-104(1993) [PubMed: 8396206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| L10108 Genomic DNA. Translation: AAA29901.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MLD based on UniProtKB P00346. |
| SMR | P37227. Positions 1-142. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.37. 1460. |
Family and domain databases | |
| InterPro | IPR001236. Lactate/malate_DH. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_NAD-dep_euk_g_bac. [Graphical view] |
| PANTHER | PTHR11540:SF1. MDH_euk_g_bac. 1 hit. |
| Pfam | PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PROSITE | PS00068. MDH. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDHM_SCHMA | ||||||||
| Accession | Primary (citable) accession number: P37227 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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