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P37227

- MDHM_SCHMA

UniProt

P37227 - MDHM_SCHMA

Protein

Malate dehydrogenase, mitochondrial

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei26 – 261NADBy similarity
    Binding sitei73 – 731SubstratePROSITE-ProRule annotation
    Binding sitei79 – 791SubstratePROSITE-ProRule annotation
    Binding sitei86 – 861NADBy similarity
    Binding sitei111 – 1111SubstratePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1 – 66NADBy similarity
    Nucleotide bindingi109 – 1113NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    SABIO-RKP37227.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
    OrganismiSchistosoma mansoni (Blood fluke)
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›142›142Malate dehydrogenase, mitochondrialPRO_0000113340Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in relatively high level in adults as compared to larval worms.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP37227.
    SMRiP37227. Positions 1-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR001236. Lactate/malate_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF00056. Ldh_1_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P37227-1 [UniParc]FASTAAdd to Basket

    « Hide

    ASGGIGEPLS LLLKQSPLIS QLALYDIAHV KGVAADLSHI ETQAHVTAHL    50
    GPGELAECLT GANVVIIPAG LPRKPGMTRD DLFNTNASIV AELIDSCAKN 100
    CPKAMICIIT NPVNSTVPIA AEILKRHNVY DPKRLFGVTT LD 142
    Length:142
    Mass (Da):14,956
    Last modified:October 1, 1994 - v1
    Checksum:iC06BC6726566AE72
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei142 – 1421

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10108 Genomic DNA. Translation: AAA29901.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10108 Genomic DNA. Translation: AAA29901.1 .

    3D structure databases

    ProteinModelPortali P37227.
    SMRi P37227. Positions 1-142.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P37227.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR001236. Lactate/malate_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of Schistosoma mansoni genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation."
      Skelly P.J., Stein L.D., Shoemaker C.B.
      Mol. Biochem. Parasitol. 60:93-104(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMDHM_SCHMA
    AccessioniPrimary (citable) accession number: P37227
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3