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Protein

Malate dehydrogenase

Gene

mdh

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei81SubstrateUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei94NADUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei227NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 13NADUniRule annotation7
Nucleotide bindingi117 – 119NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:PBPRA0391
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133201 – 312Malate dehydrogenaseAdd BLAST312

Proteomic databases

PRIDEiP37226

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA0391

Structurei

3D structure databases

ProteinModelPortaliP37226
SMRiP37226
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213792
KOiK00024
OMAiQCTPKVE
OrthoDBiPOG091H036H

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01516 Malate_dehydrog_1, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11540:SF22 PTHR11540:SF22, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

P37226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAVIGAAG GIGQALALLL KNGLPAGSDL ALYDIAPVTP GVAADLSHIP
60 70 80 90 100
TPVSIKGYGG VDPTPALEGA DVVLISAGVA RKPGMDRSDL FNVNAGIIKS
110 120 130 140 150
LAEKIAVVCP KACVGIITNP VNTTVAIAAD VLKKAGVYDK RRLFGITTLD
160 170 180 190 200
IIRSETFVAE LKGKTPSDIQ VPVIGGHSGV TILPLLSQVE GVEFSDEEIK
210 220 230 240 250
ALTPRIQNAG TEVVEAKAGG GSATLSMGQA AYRFGLSLVR ALQGEQGIVE
260 270 280 290 300
CAYVEGDGKH ARFFAQPVLL GKDGVEEVID YGKLSTFEQE ALNNMLDTLT
310
SDITLGEEFA AK
Length:312
Mass (Da):32,293
Last modified:July 5, 2004 - v2
Checksum:i6927C7F1B4639F1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168 – 169DI → EL in AAA25624 (PubMed:9003456).Curated2
Sequence conflicti218A → R in AAA25624 (PubMed:9003456).Curated1
Sequence conflicti245E → Q in AAA25624 (PubMed:9003456).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13319 Genomic DNA Translation: AAA25624.1
CR378664 Genomic DNA Translation: CAG18823.1
RefSeqiWP_011217182.1, NC_006370.1

Genome annotation databases

EnsemblBacteriaiCAG18823; CAG18823; PBPRA0391
KEGGippr:PBPRA0391

Similar proteinsi

Entry informationi

Entry nameiMDH_PHOPR
AccessioniPrimary (citable) accession number: P37226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health