Reviewed, UniProtKB/Swiss-Prot P37217 (CD69_MOUSE)

Names and origin

Protein names

Recommended name:
    Early activation antigen CD69
Alternative name(s):
    CD_antigen=CD69

Gene names

Name:

Cd69

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils and platelets.
Developmental stage	Earliest inducible cell surface glycoprotein acquired during lymphoid activation.
Induction	By the activation of T-lymphocytes.
Post-translational modification	Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes By similarity.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Ligand	Lectin
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Cellular component	external side of plasma membrane Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Early activation antigen CD69		PRO_0000046584
Regions
	Topological domain	1 – 40	40	Cytoplasmic Potential
	Transmembrane	41 – 61	21	Signal-anchor for type II membrane protein Potential
	Topological domain	62 – 199	138	Extracellular Potential
	Domain	92 – 195	104	C-type lectin
Amino acid modifications
	Glycosylation	150	1	N-linked (GlcNAc...) Potential
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Disulfide bond	68		Interchain Probable
	Disulfide bond	85 ↔ 96		By similarity
	Disulfide bond	113 ↔ 194		By similarity
	Disulfide bond	173 ↔ 186		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37217-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 39F8E4941D36D4F6	FASTA	199	22,517
	10 20 30 40 50 60 MDSENCSITE NSSSHLERGQ KDHGTSIHFE KHHEGSIQVS IPWAVLIVVL ITSLIIALIA 70 80 90 100 110 120 LNVGKYNCPG LYEKLESSDH HVATCKNEWI SYKRTCYFFS TTTKSWALAQ RSCSEDAATL 130 140 150 160 170 180 AVIDSEKDMT FLKRYSGELE HWIGLKNEAN QTWKWANGKE FNSWFNLTGS GRCVSVNHKN 190 VTAVDCEANF HWVCSKPSR

References

[1]

"Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens." Ziegler S.F., Ramsdell F., Hjerrild K.A., Armitage R.J., Grabstein K.H., Hennen K.B., Farrah T., Fanslow W.C., Shevach E.M., Alderson M.R. Eur. J. Immunol. 23:1643-1648(1993) [PubMed: 8100776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

+

Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

CD69

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23638 Genomic DNA. No translation available.
IPI	IPI00125065.
RefSeq	NP_001028294.1.
UniGene	Mm.74745
3D structure databases
SMR	P37217. Positions 83-198.
ModBase	Search...
Protein-protein interaction databases
STRING	P37217.
Proteomic databases
PRIDE	P37217.
Genome annotation databases
Ensembl	ENSMUST00000032259; ENSMUSP00000032259; ENSMUSG00000030156; Mus musculus. [Genome view]
GeneID	12515.
KEGG	mmu:12515.
UCSC	uc009efi.1. mouse.
Organism-specific databases
CTD	12515.
MGI	MGI:88343. Cd69.
Phylogenomic databases
eggNOG	roNOG16956.
HOGENOM	HBG126630.
HOVERGEN	P37217.
InParanoid	P37217.
OMA	VGQYNCP.
OrthoDB	EOG9KSS3Z.
PhylomeDB	P37217.
Gene expression databases
ArrayExpress	P37217.
Bgee	P37217.
CleanEx	MM_CD69.
Genevestigator	P37217.
GermOnline	ENSMUSG00000030156. Mus musculus.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	281506.
SOURCE	Search...

Entry information

Entry name

CD69_MOUSE

Accession

Primary (citable) accession number: P37217

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	January 19, 2010
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)