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Protein

Early activation antigen CD69

Gene

Cd69

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Early activation antigen CD69
Alternative name(s):
CD_antigen: CD69
Gene namesi
Name:Cd69
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88343. Cd69.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini62 – 199138ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Early activation antigen CD69PRO_0000046584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 – 68InterchainCurated
Disulfide bondi85 ↔ 96PROSITE-ProRule annotation
Disulfide bondi113 ↔ 194PROSITE-ProRule annotation
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi173 ↔ 186PROSITE-ProRule annotation
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP37217.
PaxDbiP37217.
PRIDEiP37217.

PTM databases

PhosphoSiteiP37217.

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils and platelets.

Developmental stagei

Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Inductioni

By the activation of T-lymphocytes.

Gene expression databases

BgeeiP37217.
CleanExiMM_CD69.
ExpressionAtlasiP37217. baseline and differential.
GenevisibleiP37217. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

DIPiDIP-60425N.
STRINGi10090.ENSMUSP00000032259.

Structurei

3D structure databases

ProteinModelPortaliP37217.
SMRiP37217. Positions 84-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 195104C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000111491.
HOVERGENiHBG005288.
InParanoidiP37217.
KOiK06502.
OMAiVGQYNCP.
OrthoDBiEOG793B96.
PhylomeDBiP37217.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSENCSITE NSSSHLERGQ KDHGTSIHFE KHHEGSIQVS IPWAVLIVVL
60 70 80 90 100
ITSLIIALIA LNVGKYNCPG LYEKLESSDH HVATCKNEWI SYKRTCYFFS
110 120 130 140 150
TTTKSWALAQ RSCSEDAATL AVIDSEKDMT FLKRYSGELE HWIGLKNEAN
160 170 180 190
QTWKWANGKE FNSWFNLTGS GRCVSVNHKN VTAVDCEANF HWVCSKPSR
Length:199
Mass (Da):22,517
Last modified:October 1, 1994 - v1
Checksum:i39F8E4941D36D4F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23638 Genomic DNA. No translation available.
CCDSiCCDS20582.1.
RefSeqiNP_001028294.1. NM_001033122.3.
UniGeneiMm.74745.

Genome annotation databases

EnsembliENSMUST00000032259; ENSMUSP00000032259; ENSMUSG00000030156.
GeneIDi12515.
KEGGimmu:12515.
UCSCiuc009efi.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23638 Genomic DNA. No translation available.
CCDSiCCDS20582.1.
RefSeqiNP_001028294.1. NM_001033122.3.
UniGeneiMm.74745.

3D structure databases

ProteinModelPortaliP37217.
SMRiP37217. Positions 84-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60425N.
STRINGi10090.ENSMUSP00000032259.

PTM databases

PhosphoSiteiP37217.

Proteomic databases

EPDiP37217.
PaxDbiP37217.
PRIDEiP37217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032259; ENSMUSP00000032259; ENSMUSG00000030156.
GeneIDi12515.
KEGGimmu:12515.
UCSCiuc009efi.1. mouse.

Organism-specific databases

CTDi969.
MGIiMGI:88343. Cd69.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000111491.
HOVERGENiHBG005288.
InParanoidiP37217.
KOiK06502.
OMAiVGQYNCP.
OrthoDBiEOG793B96.
PhylomeDBiP37217.
TreeFamiTF351467.

Miscellaneous databases

NextBioi281506.
PROiP37217.
SOURCEiSearch...

Gene expression databases

BgeeiP37217.
CleanExiMM_CD69.
ExpressionAtlasiP37217. baseline and differential.
GenevisibleiP37217. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens."
    Ziegler S.F., Ramsdell F., Hjerrild K.A., Armitage R.J., Grabstein K.H., Hennen K.B., Farrah T., Fanslow W.C., Shevach E.M., Alderson M.R.
    Eur. J. Immunol. 23:1643-1648(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCD69_MOUSE
AccessioniPrimary (citable) accession number: P37217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 16, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.