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Protein

Early activation antigen CD69

Gene

Cd69

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: UniProtKB

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Early activation antigen CD69
Alternative name(s):
CD_antigen: CD69
Gene namesi
Name:Cd69
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:88343 Cd69

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini62 – 199ExtracellularSequence analysisAdd BLAST138

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465841 – 199Early activation antigen CD69Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68InterchainCurated
Disulfide bondi85 ↔ 96PROSITE-ProRule annotation
Disulfide bondi113 ↔ 194PROSITE-ProRule annotation
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 186PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP37217
PaxDbiP37217
PRIDEiP37217

PTM databases

iPTMnetiP37217
PhosphoSitePlusiP37217

Expressioni

Tissue specificityi

Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils and platelets.

Developmental stagei

Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Inductioni

By the activation of T-lymphocytes.

Gene expression databases

BgeeiENSMUSG00000030156
CleanExiMM_CD69
ExpressionAtlasiP37217 baseline and differential
GenevisibleiP37217 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60425N
IntActiP37217, 1 interactor
STRINGi10090.ENSMUSP00000032259

Structurei

3D structure databases

ProteinModelPortaliP37217
SMRiP37217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 195C-type lectinPROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00710000106527
HOGENOMiHOG000111491
HOVERGENiHBG005288
InParanoidiP37217
KOiK06502
OMAiVGQYNCP
OrthoDBiEOG091G0PON
PhylomeDBiP37217
TreeFamiTF351467

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P37217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSENCSITE NSSSHLERGQ KDHGTSIHFE KHHEGSIQVS IPWAVLIVVL
60 70 80 90 100
ITSLIIALIA LNVGKYNCPG LYEKLESSDH HVATCKNEWI SYKRTCYFFS
110 120 130 140 150
TTTKSWALAQ RSCSEDAATL AVIDSEKDMT FLKRYSGELE HWIGLKNEAN
160 170 180 190
QTWKWANGKE FNSWFNLTGS GRCVSVNHKN VTAVDCEANF HWVCSKPSR
Length:199
Mass (Da):22,517
Last modified:October 1, 1994 - v1
Checksum:i39F8E4941D36D4F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23638 Genomic DNA No translation available.
CCDSiCCDS20582.1
RefSeqiNP_001028294.1, NM_001033122.3
UniGeneiMm.74745

Genome annotation databases

EnsembliENSMUST00000032259; ENSMUSP00000032259; ENSMUSG00000030156
GeneIDi12515
KEGGimmu:12515
UCSCiuc009efi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCD69_MOUSE
AccessioniPrimary (citable) accession number: P37217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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