P37217 (CD69_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Early activation antigen CD69

Alternative name(s):
CD_antigen=CD69

Gene names

Name:

Cd69

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils and platelets.
Developmental stage	Earliest inducible cell surface glycoprotein acquired during lymphoid activation.
Induction	By the activation of T-lymphocytes.
Post-translational modification	Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes By similarity.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Lectin
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to drug Inferred from expression pattern. Source: UniProtKB
Cellular component	external side of plasma membrane Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Early activation antigen CD69		PRO_0000046584
Regions
	Topological domain	1 – 40	40	Cytoplasmic Potential
	Transmembrane	41 – 61	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	62 – 199	138	Extracellular Potential
	Domain	92 – 195	104	C-type lectin
Amino acid modifications
	Glycosylation	150	1	N-linked (GlcNAc...) Potential
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Disulfide bond	68		Interchain Probable
	Disulfide bond	85 ↔ 96		By similarity
	Disulfide bond	113 ↔ 194		By similarity
	Disulfide bond	173 ↔ 186		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37217 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 39F8E4941D36D4F6	FASTA	199	22,517
	10 20 30 40 50 60 MDSENCSITE NSSSHLERGQ KDHGTSIHFE KHHEGSIQVS IPWAVLIVVL ITSLIIALIA 70 80 90 100 110 120 LNVGKYNCPG LYEKLESSDH HVATCKNEWI SYKRTCYFFS TTTKSWALAQ RSCSEDAATL 130 140 150 160 170 180 AVIDSEKDMT FLKRYSGELE HWIGLKNEAN QTWKWANGKE FNSWFNLTGS GRCVSVNHKN 190 VTAVDCEANF HWVCSKPSR

References

[1]

"Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens." Ziegler S.F., Ramsdell F., Hjerrild K.A., Armitage R.J., Grabstein K.H., Hennen K.B., Farrah T., Fanslow W.C., Shevach E.M., Alderson M.R. Eur. J. Immunol. 23:1643-1648(1993) [PubMed: 8100776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

+

Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

CD69

Cross-references

Sequence databases
EMBL GenBank DDBJ	L23638 Genomic DNA. No translation available.
IPI	IPI00125065.
RefSeq	NP_001028294.1. NM_001033122.3.
UniGene	Mm.74745.
3D structure databases
ProteinModelPortal	P37217.
SMR	P37217. Positions 79-199.
ModBase	Search...
Protein-protein interaction databases
STRING	P37217.
Proteomic databases
PRIDE	P37217.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000032259; ENSMUSP00000032259; ENSMUSG00000030156.
GeneID	12515.
KEGG	mmu:12515.
Organism-specific databases
CTD	969.
MGI	MGI:88343. Cd69.
Phylogenomic databases
eggNOG	roNOG16956.
HOGENOM	HBG126630.
HOVERGEN	HBG005288.
InParanoid	P37217.
OMA	VPIPCAV.
OrthoDB	EOG495ZT7.
PhylomeDB	P37217.
Gene expression databases
ArrayExpress	P37217.
Bgee	P37217.
CleanEx	MM_CD69.
Genevestigator	P37217.
GermOnline	ENSMUSG00000030156. Mus musculus.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
KO	K06502.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281506.
SOURCE	Search...

Entry information

Entry name

CD69_MOUSE

Accession

Primary (citable) accession number: P37217

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 16, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program