P37216 (AROG_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic EC=2.5.1.54 Alternative name(s): 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2 DAHP synthase 2 Phospho-2-keto-3-deoxyheptonate aldolase 2
Organism	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifier	4081 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Lycopersicon

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in maintaining the supply of chorismate for the biosynthesis of the aromatic amino acids and other chorismate-derived metabolites.
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Subcellular location	Plastid › chloroplast.
Tissue specificity	Highest levels seen in the roots and lower levels seen in the stems and flowers. Is undetectable in the leaves and cotyledons.
Sequence similarities	Belongs to the class-II DAHP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Transferase
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 74	74	Chloroplast Potential
	Chain	75 – 541	467	Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic		PRO_0000002301

Sequences

	Sequence		Length	Mass (Da)
	P37216 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 233EBB9F2108FD85	FASTA	541	59,937
	10 20 30 40 50 60 MALSTNTTTN SLLSNKSLLQ NQPLLSSPSK NAFFSNKSTK TVRFVQPIAA VHSSDSNKNP 70 80 90 100 110 120 IVSDKPTKSS PPAATATTAP APAVTKTEWA VDSWKSKKAL QLPEYPDQEE LRSVLKTIDE 130 140 150 160 170 180 FPPIVFAGEA RSLEERLGEA AMGRAFLLQG GDCAESFKEF NANNIRDTFR ILLQMGAVLM 190 200 210 220 230 240 FGGQMPVIKV GRMAGQFAKP RSDSFEEKDG VKLPSYRGDN VNGDAFDVKS RTPDPQRLIR 250 260 270 280 290 300 AYCQSAATLN LLRAFATGGY AAMQRINQWN LDFTEHSEQG DRYRELASRV DEALGFMTAA 310 320 330 340 350 360 GLTMDHPIMK TTEFWTSHEC LLLPYEQSLT RRDSTSGLHY DCSAHFLWVG ERTRQLDGAH 370 380 390 400 410 420 VEFLRGIANP LGIKVSDKMD PSALVKLIEI LNPQNKAGRI TIITRMGAEN MRVKLPHLIR 430 440 450 460 470 480 AVRRAGQIVT WVSDPMHGNT IKAPCGLKTR PFDSIRAEVR AFFDVHDQEG SHPGGVHLEM 490 500 510 520 530 540 TGQNVTECIG GSRTVTFDDL SSRYHTHCDP RLNASQSLEL SFIIAERLRK RRLGSQSTLG Q

References

[1]

"Differential expression of tomato (Lycopersicon esculentum L.) genes encoding shikimate pathway isoenzymes. I. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase." Goerlach J., Beck A., Henstrand J.M., Handa A.K., Herrmann K.M., Schmid J., Amrhein N. Plant Mol. Biol. 23:697-706(1993) [PubMed: 7902741] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. UC82B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z21793 mRNA. Translation: CAA79856.1.
PIR	S40412.
RefSeq	NP_001234418.1. NM_001247489.1.
UniGene	Les.3039.
3D structure databases
ProteinModelPortal	P37216.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	544153.
Family and domain databases
InterPro	IPR002480. DAHP_synth_2. [Graphical view]
PANTHER	PTHR21337. DAHP_synth_2. 1 hit.
Pfam	PF01474. DAHP_synth_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01358. DAHP_synth_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROG_SOLLC

Accession

Primary (citable) accession number: P37216

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program