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P37199

- NU155_RAT

UniProt

P37199 - NU155_RAT

Protein

Nuclear pore complex protein Nup155

Gene

Nup155

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. structural constituent of nuclear pore Source: InterPro

    GO - Biological processi

    1. mRNA transport Source: UniProtKB-KW
    2. nucleocytoplasmic transport Source: InterPro
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear pore complex protein Nup155
    Alternative name(s):
    155 kDa nucleoporin
    Nucleoporin Nup155
    P140
    Gene namesi
    Name:Nup155
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621199. Nup155.

    Subcellular locationi

    Nucleusnuclear pore complex 1 Publication. Nucleus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Nucleus membrane 1 Publication; Peripheral membrane protein 1 Publication; Nucleoplasmic side 1 Publication
    Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis.

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. nuclear envelope Source: RGD
    3. nuclear membrane Source: UniProtKB-SubCell
    4. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13901390Nuclear pore complex protein Nup155PRO_0000204846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi525 – 5251O-linked (GlcNAc)1 Publication

    Post-translational modificationi

    Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis.
    Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP37199.
    PRIDEiP37199.

    PTM databases

    PhosphoSiteiP37199.

    Expressioni

    Gene expression databases

    GenevestigatoriP37199.

    Interactioni

    Subunit structurei

    Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro By similarity. Forms a complex with NUP53, NUP93, NUP205 and lamin B.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi250622. 1 interaction.
    STRINGi10116.ENSRNOP00000019606.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi584 – 65471Pro-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5308.
    HOGENOMiHOG000043927.
    HOVERGENiHBG052680.
    KOiK14312.
    PhylomeDBiP37199.

    Family and domain databases

    InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
    IPR014908. Nucleoporin_Nup133/Nup155_N.
    IPR004870. Nucleoporin_Nup155.
    [Graphical view]
    PANTHERiPTHR10350. PTHR10350. 1 hit.
    PfamiPF03177. Nucleoporin_C. 1 hit.
    PF08801. Nucleoporin_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37199-1 [UniParc]FASTAAdd to Basket

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    MPSMLGSMMV ASTSAPSLQE ALENAGRLID RQLQEDRMYP DLSELLMVSA     50
    PNSPTVSGMS DMDYPLQGPG LLSVPSLPEI STIRRVPLRL SWLNSLDTCS 100
    VTAMMGVFPP ISRAWLTIDS DIFMWNYEDG GDLAYFDGLS ETILAVGLVK 150
    PKAGIFQPHV RHLLVLATPV DIVILGLSYA NVQTGSGILN DSVCGGLQLL 200
    PDPLYSLPTD NTYLLTITST DNGRIFLAGK DGCLYEVAYQ AEAGWFSQRC 250
    RKINHSKSSL SFLVPSLLQF TFSEDDPIVQ IEIDNSRNIL YTRSEKGVIQ 300
    VYDLGHDGQG MSRVASVSQN AIVCAAGNIA RTIDRSVFKP IVQIAVIENS 350
    ESLDCQLLAV THAGVRLYFS TCPFRQPLAR PNTLTLVHVR LPPGFSASST 400
    VEKPSKVHKA LYSKGILLMT ASENEDNDIL WCVNHDTFPF QKPMMETQMT 450
    TRVDGHSWAL SAIDELKVDK IITPLNKDHI PITDSPVVVQ QHMLPPKKFV 500
    LLSAQGSLMF HKLRPVDQLR HLLVSNVGGD GEEIERFFKL HQEDQACATC 550
    LILACSTAAC DREVSAWATR AFFRYGGEAQ MRFPATLPTP SNVGPILGSP 600
    MYSSSPVPTG SPYPNPSSLG TPSHGAQPPT MSTPMSAVGN PAMQAASLSG 650
    LTGPEIVYSG KHNGICIYFS RIMGNIWDAS LVVERVFKSS NREITAIESS 700
    VPIQLLESVL QELKGLQEFL DRNSQFSGGP LGNPNTTAKV QQRLLGVMRP 750
    ENGNTQQMQQ ELQRKFHEAQ LSEKISLQAI QQLVRKSYQA LALWKLLCEH 800
    QFTVIVGELQ KEFQEQLKIT TFKDLVIREK EVTGALIASL INCYIRDNAA 850
    VDGISLHLQD TCPLLYSTDD AVCSKANELL QRSRQVQSKS ERERMLRESL 900
    KEYQKISNQV DLPSVCAQYR QVRFYEGVVE LSLTAAEKKD PQGLGLHFYK 950
    HGEPEEDVVG LQTFQERLNS YKCITDTLQE LVNQSKAAPQ SPSVPKKPGP 1000
    PVLSSDPNML SNEEAGHHFE QMLKLAQRSK DELFSIALYN WLIQADLADK 1050
    LLQIASPFLE PHLVRMAKVD QNRVRYMDLL WRYYEKNRSF SSAARVLSKL 1100
    ADMHSTEISL QQRLEYIARA ILSAKSSTAI SSIAADGEFL HELEEKMEVA 1150
    RIQLQIQETL QRQYSHHSSV QDAISQLDSE LMDITKLYGE FADPFKLAEC 1200
    KLAIIHCAGY SDPILVHTLW QDIIEKELSD SVTLSSSDRM HALSLKLVLL 1250
    GKIYAGTPRF FPLDFIVQFL EQQVCTLNWD VGFVIQTMNE IGVPLPRLLE 1300
    VYDQLFKSRD PFWNRVKSPL HLLDCIHVLL TRYVENPSLV LNCERRRFTN 1350
    LCLDAVCGYL VELQSMSSSV AVQAITGNFK SLQAKLERLH 1390
    Length:1,390
    Mass (Da):155,003
    Last modified:October 1, 1994 - v1
    Checksum:i1B51716043BF9CCF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21780 mRNA. Translation: CAA79848.1.
    PIRiA45455.
    RefSeqiNP_446404.1. NM_053952.1.
    UniGeneiRn.11328.

    Genome annotation databases

    GeneIDi117021.
    KEGGirno:117021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21780 mRNA. Translation: CAA79848.1 .
    PIRi A45455.
    RefSeqi NP_446404.1. NM_053952.1.
    UniGenei Rn.11328.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250622. 1 interaction.
    STRINGi 10116.ENSRNOP00000019606.

    PTM databases

    PhosphoSitei P37199.

    Proteomic databases

    PaxDbi P37199.
    PRIDEi P37199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 117021.
    KEGGi rno:117021.

    Organism-specific databases

    CTDi 9631.
    RGDi 621199. Nup155.

    Phylogenomic databases

    eggNOGi COG5308.
    HOGENOMi HOG000043927.
    HOVERGENi HBG052680.
    KOi K14312.
    PhylomeDBi P37199.

    Miscellaneous databases

    NextBioi 619775.
    PROi P37199.

    Gene expression databases

    Genevestigatori P37199.

    Family and domain databases

    InterProi IPR007187. Nucleoporin_Nup133/Nup155_C.
    IPR014908. Nucleoporin_Nup133/Nup155_N.
    IPR004870. Nucleoporin_Nup155.
    [Graphical view ]
    PANTHERi PTHR10350. PTHR10350. 1 hit.
    Pfami PF03177. Nucleoporin_C. 1 hit.
    PF08801. Nucleoporin_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA."
      Radu A., Blobel G., Wozniak R.W.
      J. Cell Biol. 121:1-9(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications."
      Wells L., Vosseller K., Cole R.N., Cronshaw J.M., Matunis M.J., Hart G.W.
      Mol. Cell. Proteomics 1:791-804(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-525.
    3. "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
      Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
      Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP155.

    Entry informationi

    Entry nameiNU155_RAT
    AccessioniPrimary (citable) accession number: P37199
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3