P37199 (NU155_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup155

Alternative name(s):
155 kDa nucleoporin
Nucleoporin Nup155
P140

Gene names

Name:

Nup155

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1390 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.
Subunit structure	Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro By similarity. Forms a complex with NUP53, NUP93, NUP205 and lamin B. Ref.3
Subcellular location	Nucleus › nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. Ref.3
Post-translational modification	Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis.
Sequence similarities	Belongs to the non-repetitive/WGA-negative nucleoporin family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Membrane Nuclear pore complex Nucleus
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW nucleocytoplasmic transport Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural constituent of nuclear pore Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1390	1390	Nuclear pore complex protein Nup155		PRO_0000204846
Regions
	Compositional bias	584 – 654	71	Pro-rich
Amino acid modifications
	Glycosylation	525	1	O-linked (GlcNAc) Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P37199 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 1B51716043BF9CCF	FASTA	1,390	155,003
	10 20 30 40 50 60 MPSMLGSMMV ASTSAPSLQE ALENAGRLID RQLQEDRMYP DLSELLMVSA PNSPTVSGMS 70 80 90 100 110 120 DMDYPLQGPG LLSVPSLPEI STIRRVPLRL SWLNSLDTCS VTAMMGVFPP ISRAWLTIDS 130 140 150 160 170 180 DIFMWNYEDG GDLAYFDGLS ETILAVGLVK PKAGIFQPHV RHLLVLATPV DIVILGLSYA 190 200 210 220 230 240 NVQTGSGILN DSVCGGLQLL PDPLYSLPTD NTYLLTITST DNGRIFLAGK DGCLYEVAYQ 250 260 270 280 290 300 AEAGWFSQRC RKINHSKSSL SFLVPSLLQF TFSEDDPIVQ IEIDNSRNIL YTRSEKGVIQ 310 320 330 340 350 360 VYDLGHDGQG MSRVASVSQN AIVCAAGNIA RTIDRSVFKP IVQIAVIENS ESLDCQLLAV 370 380 390 400 410 420 THAGVRLYFS TCPFRQPLAR PNTLTLVHVR LPPGFSASST VEKPSKVHKA LYSKGILLMT 430 440 450 460 470 480 ASENEDNDIL WCVNHDTFPF QKPMMETQMT TRVDGHSWAL SAIDELKVDK IITPLNKDHI 490 500 510 520 530 540 PITDSPVVVQ QHMLPPKKFV LLSAQGSLMF HKLRPVDQLR HLLVSNVGGD GEEIERFFKL 550 560 570 580 590 600 HQEDQACATC LILACSTAAC DREVSAWATR AFFRYGGEAQ MRFPATLPTP SNVGPILGSP 610 620 630 640 650 660 MYSSSPVPTG SPYPNPSSLG TPSHGAQPPT MSTPMSAVGN PAMQAASLSG LTGPEIVYSG 670 680 690 700 710 720 KHNGICIYFS RIMGNIWDAS LVVERVFKSS NREITAIESS VPIQLLESVL QELKGLQEFL 730 740 750 760 770 780 DRNSQFSGGP LGNPNTTAKV QQRLLGVMRP ENGNTQQMQQ ELQRKFHEAQ LSEKISLQAI 790 800 810 820 830 840 QQLVRKSYQA LALWKLLCEH QFTVIVGELQ KEFQEQLKIT TFKDLVIREK EVTGALIASL 850 860 870 880 890 900 INCYIRDNAA VDGISLHLQD TCPLLYSTDD AVCSKANELL QRSRQVQSKS ERERMLRESL 910 920 930 940 950 960 KEYQKISNQV DLPSVCAQYR QVRFYEGVVE LSLTAAEKKD PQGLGLHFYK HGEPEEDVVG 970 980 990 1000 1010 1020 LQTFQERLNS YKCITDTLQE LVNQSKAAPQ SPSVPKKPGP PVLSSDPNML SNEEAGHHFE 1030 1040 1050 1060 1070 1080 QMLKLAQRSK DELFSIALYN WLIQADLADK LLQIASPFLE PHLVRMAKVD QNRVRYMDLL 1090 1100 1110 1120 1130 1140 WRYYEKNRSF SSAARVLSKL ADMHSTEISL QQRLEYIARA ILSAKSSTAI SSIAADGEFL 1150 1160 1170 1180 1190 1200 HELEEKMEVA RIQLQIQETL QRQYSHHSSV QDAISQLDSE LMDITKLYGE FADPFKLAEC 1210 1220 1230 1240 1250 1260 KLAIIHCAGY SDPILVHTLW QDIIEKELSD SVTLSSSDRM HALSLKLVLL GKIYAGTPRF 1270 1280 1290 1300 1310 1320 FPLDFIVQFL EQQVCTLNWD VGFVIQTMNE IGVPLPRLLE VYDQLFKSRD PFWNRVKSPL 1330 1340 1350 1360 1370 1380 HLLDCIHVLL TRYVENPSLV LNCERRRFTN LCLDAVCGYL VELQSMSSSV AVQAITGNFK 1390 SLQAKLERLH

References

[1]	"Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA." Radu A., Blobel G., Wozniak R.W. J. Cell Biol. 121:1-9(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Strain: Sprague-Dawley. Tissue: Liver.
[2]	"Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications." Wells L., Vosseller K., Cole R.N., Cronshaw J.M., Matunis M.J., Hart G.W. Mol. Cell. Proteomics 1:791-804(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT SER-525.
[3]	"Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex." Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W. Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP155.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z21780 mRNA. Translation: CAA79848.1.
IPI	IPI00203525.
PIR	A45455.
RefSeq	NP_446404.1. NM_053952.1.
UniGene	Rn.11328.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000019606.
PTM databases
PhosphoSite	P37199.
Proteomic databases
PaxDb	P37199.
PRIDE	P37199.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	117021.
KEGG	rno:117021.
Organism-specific databases
CTD	9631.
RGD	621199. Nup155.
Phylogenomic databases
eggNOG	COG5308.
HOGENOM	HOG000043927.
HOVERGEN	HBG052680.
KO	K14312.
Gene expression databases
ArrayExpress	P37199.
Genevestigator	P37199.
GermOnline	ENSRNOG00000013411. Rattus norvegicus.
Family and domain databases
InterPro	IPR007187. Nucleoporin_Nup133/Nup155_C. IPR014908. Nucleoporin_Nup133/Nup155_N. IPR004870. Nucleoporin_Nup155. [Graphical view]
PANTHER	PTHR10350. PTHR10350. 1 hit.
Pfam	PF03177. Nucleoporin_C. 1 hit. PF08801. Nucleoporin_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	619775.

Entry information

Entry name

NU155_RAT

Accession

Primary (citable) accession number: P37199

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program