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P37199 (NU155_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nuclear pore complex protein Nup155
Alternative name(s):
155 kDa nucleoporin
Nucleoporin Nup155
P140
Gene names
Name:Nup155
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1390 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

Subunit structure

Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro By similarity. Forms a complex with NUP53, NUP93, NUP205 and lamin B. Ref.3

Subcellular location

Nucleusnuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. Ref.3

Post-translational modification

Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis.

Disulfide-linked to NUP62. The the inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC By similarity.

Sequence similarities

Belongs to the non-repetitive/WGA-negative nucleoporin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13901390Nuclear pore complex protein Nup155
PRO_0000204846

Regions

Compositional bias584 – 65471Pro-rich

Amino acid modifications

Glycosylation5251O-linked (GlcNAc) Ref.2

Sequences

Sequence LengthMass (Da)Tools
P37199 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 1B51716043BF9CCF

FASTA1,390155,003
        10         20         30         40         50         60 
MPSMLGSMMV ASTSAPSLQE ALENAGRLID RQLQEDRMYP DLSELLMVSA PNSPTVSGMS 

        70         80         90        100        110        120 
DMDYPLQGPG LLSVPSLPEI STIRRVPLRL SWLNSLDTCS VTAMMGVFPP ISRAWLTIDS 

       130        140        150        160        170        180 
DIFMWNYEDG GDLAYFDGLS ETILAVGLVK PKAGIFQPHV RHLLVLATPV DIVILGLSYA 

       190        200        210        220        230        240 
NVQTGSGILN DSVCGGLQLL PDPLYSLPTD NTYLLTITST DNGRIFLAGK DGCLYEVAYQ 

       250        260        270        280        290        300 
AEAGWFSQRC RKINHSKSSL SFLVPSLLQF TFSEDDPIVQ IEIDNSRNIL YTRSEKGVIQ 

       310        320        330        340        350        360 
VYDLGHDGQG MSRVASVSQN AIVCAAGNIA RTIDRSVFKP IVQIAVIENS ESLDCQLLAV 

       370        380        390        400        410        420 
THAGVRLYFS TCPFRQPLAR PNTLTLVHVR LPPGFSASST VEKPSKVHKA LYSKGILLMT 

       430        440        450        460        470        480 
ASENEDNDIL WCVNHDTFPF QKPMMETQMT TRVDGHSWAL SAIDELKVDK IITPLNKDHI 

       490        500        510        520        530        540 
PITDSPVVVQ QHMLPPKKFV LLSAQGSLMF HKLRPVDQLR HLLVSNVGGD GEEIERFFKL 

       550        560        570        580        590        600 
HQEDQACATC LILACSTAAC DREVSAWATR AFFRYGGEAQ MRFPATLPTP SNVGPILGSP 

       610        620        630        640        650        660 
MYSSSPVPTG SPYPNPSSLG TPSHGAQPPT MSTPMSAVGN PAMQAASLSG LTGPEIVYSG 

       670        680        690        700        710        720 
KHNGICIYFS RIMGNIWDAS LVVERVFKSS NREITAIESS VPIQLLESVL QELKGLQEFL 

       730        740        750        760        770        780 
DRNSQFSGGP LGNPNTTAKV QQRLLGVMRP ENGNTQQMQQ ELQRKFHEAQ LSEKISLQAI 

       790        800        810        820        830        840 
QQLVRKSYQA LALWKLLCEH QFTVIVGELQ KEFQEQLKIT TFKDLVIREK EVTGALIASL 

       850        860        870        880        890        900 
INCYIRDNAA VDGISLHLQD TCPLLYSTDD AVCSKANELL QRSRQVQSKS ERERMLRESL 

       910        920        930        940        950        960 
KEYQKISNQV DLPSVCAQYR QVRFYEGVVE LSLTAAEKKD PQGLGLHFYK HGEPEEDVVG 

       970        980        990       1000       1010       1020 
LQTFQERLNS YKCITDTLQE LVNQSKAAPQ SPSVPKKPGP PVLSSDPNML SNEEAGHHFE 

      1030       1040       1050       1060       1070       1080 
QMLKLAQRSK DELFSIALYN WLIQADLADK LLQIASPFLE PHLVRMAKVD QNRVRYMDLL 

      1090       1100       1110       1120       1130       1140 
WRYYEKNRSF SSAARVLSKL ADMHSTEISL QQRLEYIARA ILSAKSSTAI SSIAADGEFL 

      1150       1160       1170       1180       1190       1200 
HELEEKMEVA RIQLQIQETL QRQYSHHSSV QDAISQLDSE LMDITKLYGE FADPFKLAEC 

      1210       1220       1230       1240       1250       1260 
KLAIIHCAGY SDPILVHTLW QDIIEKELSD SVTLSSSDRM HALSLKLVLL GKIYAGTPRF 

      1270       1280       1290       1300       1310       1320 
FPLDFIVQFL EQQVCTLNWD VGFVIQTMNE IGVPLPRLLE VYDQLFKSRD PFWNRVKSPL 

      1330       1340       1350       1360       1370       1380 
HLLDCIHVLL TRYVENPSLV LNCERRRFTN LCLDAVCGYL VELQSMSSSV AVQAITGNFK 

      1390 
SLQAKLERLH 

« Hide

References

[1]"Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA."
Radu A., Blobel G., Wozniak R.W.
J. Cell Biol. 121:1-9(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: Sprague-Dawley.
Tissue: Liver.
[2]"Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications."
Wells L., Vosseller K., Cole R.N., Cronshaw J.M., Matunis M.J., Hart G.W.
Mol. Cell. Proteomics 1:791-804(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT SER-525.
[3]"Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP53; NUP93 AND NUP155.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z21780 mRNA. Translation: CAA79848.1.
PIRA45455.
RefSeqNP_446404.1. NM_053952.1.
UniGeneRn.11328.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid250622. 1 interaction.
STRING10116.ENSRNOP00000019606.

PTM databases

PhosphoSiteP37199.

Proteomic databases

PaxDbP37199.
PRIDEP37199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID117021.
KEGGrno:117021.

Organism-specific databases

CTD9631.
RGD621199. Nup155.

Phylogenomic databases

eggNOGCOG5308.
HOGENOMHOG000043927.
HOVERGENHBG052680.
KOK14312.
PhylomeDBP37199.

Gene expression databases

GenevestigatorP37199.

Family and domain databases

InterProIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERPTHR10350. PTHR10350. 1 hit.
PfamPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619775.
PROP37199.

Entry information

Entry nameNU155_RAT
AccessionPrimary (citable) accession number: P37199
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families