P37198B3KWU5Q503A4Q6GTM2Q96C43Q9NSL1NUP62_HUMANNuclear pore glycoprotein p6262 kDa nucleoporinNucleoporin Nup62NUP62Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoHuman nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization.NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONSUBCELLULAR LOCATIONVARIANT THR-283The full-ORF clone resource of the German cDNA consortium.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]VARIANT THR-283Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The DNA sequence and biology of human chromosome 19.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]VARIANT THR-283Proteomic characterization of the human centrosome by protein correlation profiling.IDENTIFICATION BY MASS SPECTROMETRYSUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.INTERACTION WITH CAPGLys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Initial characterization of the human central proteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.INTERACTION WITH OSBPL8Hikeshi, a nuclear import carrier for hsp70s, protects cells from heat shock-induced nuclear damage.INTERACTION WITH HIKESHIEpstein-Barr virus protein kinase BGLF4 targets the nucleus through interaction with nucleoporins.INTERACTION WITH EPSTEIN-BARR VIRUS BGLF4Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Nucleoporin Nup62 maintains centrosome homeostasis.FUNCTIONINTERACTION WITH SAS6 AND TUBG1SUBCELLULAR LOCATIONToward a comprehensive characterization of a human cancer cell phosphoproteome.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408 AND SER-418IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.INTERACTION WITH MCM3APAn enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Mutated nup62 causes autosomal recessive infantile bilateral striatal necrosis.INVOLVEMENT IN SNDIVARIANT SNDI PRO-391Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.INTERACTION WITH NUP88Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630).Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58 (By similarity). Interacts with NUP88 (PubMed:30543681). Interacts with NUTF2 (By similarity). Interacts with HIKESHI (PubMed:22541429). Interacts with OSBPL8 (PubMed:21698267). Interacts with CAPG (PubMed:18266911). Interacts with SAS6 and TUBG1 at the centrosome (PubMed:24107630). Interacts with MCM3AP isoform GANP (PubMed:23652018).(Microbial infection) Interacts with Epstein-barr virus BGLF4; this interaction allows BGLF4 nuclear entry.P37198Q9NYB9false6P37198Q13444false3P37198Q8TD06false6P37198P53365false3P37198O15265false2P37198Q12934false3P37198Q12934-2false3P37198Q9UL45false6P37198Q9NWQ9false5P37198Q8TAB5false6P37198Q969G5false3P37198Q6ZUS5false4P37198Q8IYE0false5P37198Q8IYE0-2false3P37198Q8NCX0false3P37198Q494R4false3P37198Q8TD31-3false6P37198Q71F23false3P37198Q8IYX8-2false3P37198Q9UGL9false6P37198Q6W0C5false3P37198O60941false5P37198O60941-5false3P37198P05413false7P37198Q96CS2false3P37198A0A024R8L2false3P37198A0A0S2Z4Q4false3P37198O14964false3P37198Q03933false5P37198Q03933-2false3P37198Q9ULV5-2false3P37198Q8IY31false3P37198Q70UQ0false3P37198Q9H1K1false6P37198Q7Z3B3false4P37198Q9BVG8false3P37198Q5THT1false3P37198P52292false3P37198P04264false7P37198P35900false7P37198P12035false3P37198P02538false3P37198P04259false3P37198O95678false5P37198P25791false3P37198Q8TBB1false3P37198Q9BW11false3P37198Q7Z3B4false12P37198Q9BVL2false7P37198Q99567false6P37198P61970false7P37198Q9UBU9false11P37198O43482false6P37198Q7L8S5false3P37198Q9HAT8false3P37198Q96BD5false7P37198Q13526false6P37198Q969G3false3P37198O75971false3P37198A1L4H1false6P37198P51687false6P37198Q9NVV9false12P37198Q04727-2false3P37198Q8N7C3false3P37198P40222false8P37198P10599false3P37198Q8N6Y0false3P37198Q9Y3C0false8P37198Q96QU8false3P37198Q96QU8-2false3P37198Q9H614false3P37198E5LBS6true2P37198P10238true3NucleusNuclear pore complexCytoplasmCytoskeletonSpindle poleNucleus envelopeCytoplasmCytoskeletonMicrotubule organizing centerCentrosomeCentral region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630).Contains FG repeats.O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.Infantile striatonigral degeneration
SNDI
Neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and intellectual disability.The disease is caused by variants affecting the gene represented in this entry.Belongs to the nucleoporin NSP1/NUP62 family.3D-structureAcetylationCoiled coilCytoplasmCytoskeletonDisease variantDisulfide bondGlycoproteinHost-virus interactionmRNA transportNuclear pore complexNucleusPhosphoproteinProtein transportReference proteomeRepeatTranslocationTransportGSASSTQPSGRAEQEVMSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNFGAPFQPATSTPSTGLFSLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNTAATPAMANPSGFGLGSSNLTNAISSTVTSSQGTAPTGFVFGPSTTSVAPATTSGGFSFTGGSTAQPSGFNIGSAGNSAQPTAPATLPFTPATPAATTAGATQPAAPTPTATITSTGPSLFASIATAPTSSATTGLSLCTPVTTAGAPTAGTQGFSLKAPGAASGTSTTTSTAATATATTTSSSSTTGFALNLKPLAPAGIPSNTAAAVTAPPGPGAAAGAAASSAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNTSGAPADTSDPLQQICKILNAHMDSLQWIDQNSALLQRKVEEVTKVCEGRRKEQERSFRITFD
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