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Protein

Probable cytochrome c peroxidase

Gene

yhjA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Heme 1 (covalent)PROSITE-ProRule annotation1
Binding sitei62Heme 1 (covalent)PROSITE-ProRule annotation1
Metal bindingi63Iron (heme 1 axial ligand)PROSITE-ProRule annotation1
Metal bindingi195Iron (heme 1 axial ligand)PROSITE-ProRule annotation1
Binding sitei207Heme 2 (covalent)PROSITE-ProRule annotation1
Binding sitei210Heme 2 (covalent)PROSITE-ProRule annotation1
Metal bindingi211Iron (heme 2 axial ligand)PROSITE-ProRule annotation1
Binding sitei351Heme 3 (covalent)PROSITE-ProRule annotation1
Binding sitei354Heme 3 (covalent)PROSITE-ProRule annotation1
Metal bindingi355Iron (heme 3 axial ligand)PROSITE-ProRule annotation1
Metal bindingi415Iron (heme 2 axial ligand)PROSITE-ProRule annotation1
Metal bindingi429Iron (heme 3 axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • response to hydrogen peroxide Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12244-MONOMER
MetaCyc:EG12244-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c peroxidase (EC:1.11.1.5)
Gene namesi
Name:yhjA
Ordered Locus Names:b3518, JW3486
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12244 yhjA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001084441 – 465Probable cytochrome c peroxidaseAdd BLAST465

Post-translational modificationi

Binds 3 heme groups per subunit.Curated

Proteomic databases

PaxDbiP37197
PRIDEiP37197

Interactioni

Protein-protein interaction databases

BioGridi4262525, 14 interactors
IntActiP37197, 2 interactors
STRINGi316385.ECDH10B_3695

Structurei

3D structure databases

ProteinModelPortaliP37197
SMRiP37197
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CA0 Bacteria
COG1858 LUCA
HOGENOMiHOG000173943
InParanoidiP37197
KOiK00428
OMAiEMGSHDW
PhylomeDBiP37197

Family and domain databases

Gene3Di1.10.760.10, 3 hits
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR004852 Di-haem_cyt_c_peroxidsae
IPR025992 Haem-bd
PfamiView protein in Pfam
PF03150 CCP_MauG, 1 hit
PF00034 Cytochrom_C, 1 hit
PF14376 Haem_bd, 1 hit
SMARTiView protein in SMART
SM01235 Haem_bd, 1 hit
SUPFAMiSSF46626 SSF46626, 2 hits
PROSITEiView protein in PROSITE
PS51007 CYTC, 3 hits

Sequencei

Sequence statusi: Complete.

P37197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMVSRITAI GLAGVAICYL GLSGYVWYHD NKRSKQADVQ ASAVSENNKV
60 70 80 90 100
LGFLREKGCD YCHTPSAELP AYYYIPGAKQ LMDYDIKLGY KSFNLEAVRA
110 120 130 140 150
ALLADKPVSQ SDLNKIEWVM QYETMPPTRY TALHWAGKVS DEERAEILAW
160 170 180 190 200
IAKQRAEYYA SNDTAPEHRN EPVQPIPQKL PTDAQKVALG FALYHDPRLS
210 220 230 240 250
ADSTISCAHC HALNAGGVDG RKTSIGVGGA VGPINAPTVF NSVFNVEQFW
260 270 280 290 300
DGRAATLQDQ AGGPPLNPIE MASKSWDEII AKLEKDPQLK TQFLEVYPQG
310 320 330 340 350
FSGENITDAI AEFEKTLITP DSPFDKWLRG DENALTAQQK KGYQLFKDNK
360 370 380 390 400
CATCHGGIIL GGRSFEPLGL KKDFNFGEIT AADIGRMNVT KEERDKLRQK
410 420 430 440 450
VPGLRNVALT APYFHRGDVP TLDGAVKLML RYQVGKELPQ EDVDDIVAFL
460
HSLNGVYTPY MQDKQ
Length:465
Mass (Da):51,571
Last modified:October 1, 1994 - v1
Checksum:i9F494A698949E6DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18494.1
U00096 Genomic DNA Translation: AAC76543.1
AP009048 Genomic DNA Translation: BAE77776.1
PIRiS47738
RefSeqiNP_417975.1, NC_000913.3
WP_000784827.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76543; AAC76543; b3518
BAE77776; BAE77776; BAE77776
GeneIDi948038
KEGGiecj:JW3486
eco:b3518
PATRICifig|1411691.4.peg.3200

Similar proteinsi

Entry informationi

Entry nameiYHJA_ECOLI
AccessioniPrimary (citable) accession number: P37197
Secondary accession number(s): Q2M7I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health