Probable cytochrome c peroxidase - Escherichia coli (strain K12)

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P37197 (YHJA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable cytochrome c peroxidase
EC=1.11.1.5

Gene names

Name:	yhjA
Ordered Locus Names:	b3518, JW3486

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	2 ferrocytochrome c + H₂O₂ = 2 ferricytochrome c + 2 H₂O.
Post-translational modification	Binds 3 heme groups per subunit Potential.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW response to hydrogen peroxide Inferred from mutant phenotype. Source: EcoCyc transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytochrome-c peroxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 465

465

Probable cytochrome c peroxidase

PRO_0000108444

Sites

Metal binding

Iron (heme 1 axial ligand) By similarity

Metal binding

195

Iron (heme 1 axial ligand) By similarity

Metal binding

211

Iron (heme 2 axial ligand) By similarity

Metal binding

355

Iron (heme 3 axial ligand) By similarity

Metal binding

415

Iron (heme 2 axial ligand) By similarity

Metal binding

429

Iron (heme 3 axial ligand) By similarity

Binding site

Heme 1 (covalent) By similarity

Binding site

Heme 1 (covalent) By similarity

Binding site

207

Heme 2 (covalent) By similarity

Binding site

210

Heme 2 (covalent) By similarity

Binding site

351

Heme 3 (covalent) By similarity

Binding site

354

Heme 3 (covalent) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P37197 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 9F494A698949E6DA
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FASTA

465

51,571

        10         20         30         40         50         60 
MKMVSRITAI GLAGVAICYL GLSGYVWYHD NKRSKQADVQ ASAVSENNKV LGFLREKGCD 

        70         80         90        100        110        120 
YCHTPSAELP AYYYIPGAKQ LMDYDIKLGY KSFNLEAVRA ALLADKPVSQ SDLNKIEWVM 

       130        140        150        160        170        180 
QYETMPPTRY TALHWAGKVS DEERAEILAW IAKQRAEYYA SNDTAPEHRN EPVQPIPQKL 

       190        200        210        220        230        240 
PTDAQKVALG FALYHDPRLS ADSTISCAHC HALNAGGVDG RKTSIGVGGA VGPINAPTVF 

       250        260        270        280        290        300 
NSVFNVEQFW DGRAATLQDQ AGGPPLNPIE MASKSWDEII AKLEKDPQLK TQFLEVYPQG 

       310        320        330        340        350        360 
FSGENITDAI AEFEKTLITP DSPFDKWLRG DENALTAQQK KGYQLFKDNK CATCHGGIIL 

       370        380        390        400        410        420 
GGRSFEPLGL KKDFNFGEIT AADIGRMNVT KEERDKLRQK VPGLRNVALT APYFHRGDVP 

       430        440        450        460 
TLDGAVKLML RYQVGKELPQ EDVDDIVAFL HSLNGVYTPY MQDKQ

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References

[1]	"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R. Nucleic Acids Res. 22:2576-2586(1994) [PubMed: 8041620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00039 Genomic DNA. Translation: AAB18494.1. U00096 Genomic DNA. Translation: AAC76543.1. AP009048 Genomic DNA. Translation: BAE77776.1.
PIR	S47738.
RefSeq	NP_417975.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P37197.
SMR	P37197. Positions 144-461.
ModBase	Search...
Protein-protein interaction databases
IntAct	P37197. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000002769; EBESCP00000002769; EBESCG00000002259. EBESCT00000015433; EBESCP00000014724; EBESCG00000014493.
GeneID	948038.
GenomeReviews	Gene locus JW3486 in contig AP009048_GR. Gene locus b3518 in contig U00096_GR.
KEGG	ecj:JW3486. eco:b3518.
PATRIC	32122498. VBIEscCol129921_3627.
Organism-specific databases
EchoBASE	EB2155.
EcoGene	EG12244. yhjA.
Phylogenomic databases
eggNOG	COG1858.
GeneTree	EBGT00050000011786.
HOGENOM	HBG624620.
OMA	LQFWDGR.
PhylomeDB	P37197.
ProtClustDB	CLSK880700.
Enzyme and pathway databases
BioCyc	EcoCyc:EG12244-MONOMER.
Gene expression databases
Genevestigator	P37197.
Family and domain databases
InterPro	IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. IPR004852. Di-haem_cyt_c_peroxidsae. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 2 hits.
KO	K00428.
Pfam	PF03150. CCP_MauG. 1 hit. PF00034. Cytochrom_C. 1 hit. [Graphical view]
SUPFAM	SSF46626. Cytochrome_c. 2 hits.
PROSITE	PS51007. CYTC. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YHJA_ECOLI

Accession

Primary (citable) accession number: P37197
Secondary accession number(s): Q2M7I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents