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Protein

HTH-type transcriptional regulator DctR

Gene

dctR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a transcriptional regulator of dctA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi133 – 152H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of cellular carbohydrate catabolic process Source: EcoCyc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11889-MONOMER.
ECOL316407:JW3475-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator DctR
Gene namesi
Name:dctR
Synonyms:yhiF
Ordered Locus Names:b3507, JW3475
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11889. dctR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841451 – 176HTH-type transcriptional regulator DctRAdd BLAST176

Proteomic databases

PaxDbiP37195.
PRIDEiP37195.

Expressioni

Inductioni

By acidic conditions. Could be induced by EvgA via the induction of YdeO.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4261143. 13 interactors.
DIPiDIP-12362N.
IntActiP37195. 10 interactors.
STRINGi511145.b3507.

Structurei

3D structure databases

ProteinModelPortaliP37195.
SMRiP37195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 174HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2771. LUCA.
HOGENOMiHOG000125804.
OMAiAPEADIM.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLIITRDTM FFTAMKNILS KGNVVHIQNE EEIDVMLHQN AFVIIDTLMN
60 70 80 90 100
NVFHSNFLTQ IERLKPVHVI IFSPFNIKRC LGKVPVTFVP RTITIIDFVA
110 120 130 140 150
LINGSYCSVP EAAVSLSRKQ HQVLSCIANQ MTTEDILEKL KISLKTFYCH
160 170
KHNIMMILNL KRINELVRHQ HIDYLV
Length:176
Mass (Da):20,408
Last modified:October 1, 1994 - v1
Checksum:iF87354C3AB82BB83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163 – 176INELV…IDYLV → DQ in AAA60371 (PubMed:8022277).CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23635 Genomic DNA. Translation: AAA60371.1.
U00039 Genomic DNA. Translation: AAB18483.1.
U00096 Genomic DNA. Translation: AAC76532.1.
AP009048 Genomic DNA. Translation: BAE77787.1.
PIRiS47727.
RefSeqiNP_417964.1. NC_000913.3.
WP_000478619.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76532; AAC76532; b3507.
BAE77787; BAE77787; BAE77787.
GeneIDi948021.
KEGGiecj:JW3475.
eco:b3507.
PATRICi32122472. VBIEscCol129921_3614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23635 Genomic DNA. Translation: AAA60371.1.
U00039 Genomic DNA. Translation: AAB18483.1.
U00096 Genomic DNA. Translation: AAC76532.1.
AP009048 Genomic DNA. Translation: BAE77787.1.
PIRiS47727.
RefSeqiNP_417964.1. NC_000913.3.
WP_000478619.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37195.
SMRiP37195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261143. 13 interactors.
DIPiDIP-12362N.
IntActiP37195. 10 interactors.
STRINGi511145.b3507.

Proteomic databases

PaxDbiP37195.
PRIDEiP37195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76532; AAC76532; b3507.
BAE77787; BAE77787; BAE77787.
GeneIDi948021.
KEGGiecj:JW3475.
eco:b3507.
PATRICi32122472. VBIEscCol129921_3614.

Organism-specific databases

EchoBASEiEB1835.
EcoGeneiEG11889. dctR.

Phylogenomic databases

eggNOGiCOG2771. LUCA.
HOGENOMiHOG000125804.
OMAiAPEADIM.

Enzyme and pathway databases

BioCyciEcoCyc:EG11889-MONOMER.
ECOL316407:JW3475-MONOMER.

Miscellaneous databases

PROiP37195.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTR_ECOLI
AccessioniPrimary (citable) accession number: P37195
Secondary accession number(s): Q2M7G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression causes filamentous biofilm formation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.