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Protein

Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit

Gene

hybB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable b-type cytochrome.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11800-MONOMER.
ECOL316407:JW5494-MONOMER.
MetaCyc:EG11800-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit
Gene namesi
Name:hybB
Ordered Locus Names:b2995, JW5494
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11800. hybB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111PeriplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 342CytoplasmicSequence analysis
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 583PeriplasmicSequence analysis
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Topological domaini80 – 9011CytoplasmicSequence analysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Topological domaini112 – 13322PeriplasmicSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 16814CytoplasmicSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Topological domaini190 – 20718PeriplasmicSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Topological domaini229 – 24921CytoplasmicSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Topological domaini271 – 28111PeriplasmicSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Topological domaini303 – 33331CytoplasmicSequence analysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence analysisAdd
BLAST
Topological domaini355 – 3551PeriplasmicSequence analysis
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Topological domaini377 – 39216CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunitPRO_0000159326Add
BLAST

Proteomic databases

PaxDbiP37180.

Interactioni

Protein-protein interaction databases

BioGridi4262376. 6 interactions.
STRINGi511145.b2995.

Structurei

3D structure databases

ProteinModelPortaliP37180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NrfD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJ5. Bacteria.
COG5557. LUCA.
HOGENOMiHOG000278811.
InParanoidiP37180.
OMAiAIEVCAY.
PhylomeDBiP37180.

Family and domain databases

InterProiIPR005614. NrfD_fam.
[Graphical view]
PfamiPF03916. NrfD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHDPQPLGG KIISKPVMIF GPLIVICMLL IVKRLVFGLG SVSDLNGGFP
60 70 80 90 100
WGVWIAFDLL IGTGFACGGW ALAWAVYVFN RGQYHPLVRP ALLASLFGYS
110 120 130 140 150
LGGLSITIDV GRYWNLPYFY IPGHFNVNSV LFETAVCMTI YIGVMALEFA
160 170 180 190 200
PALFERLGWK VSLQRLNKVM FFIIALGALL PTMHQSSMGS LMISAGYKVH
210 220 230 240 250
PLWQSYEMLP LFSLLTAFIM GFSIVIFEGS LVQAGLRGNG PDEKSLFVKL
260 270 280 290 300
TNTISVLLAI FIVLRFGELI YRDKLSLAFA GDFYSVMFWI EVLLMLFPLV
310 320 330 340 350
VLRVAKLRND SRMLFLSALS ALLGCATWRL TYSLVAFNPG GGYAYFPTWE
360 370 380 390
ELLISIGFVA IEICAYIVLI RLLPILPPLK QNDHNRHEAS KA
Length:392
Mass (Da):43,602
Last modified:August 29, 2003 - v2
Checksum:i8A25CDCB3EDB67FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti306 – 3072KL → NV in AAA21590 (PubMed:8021226).Curated
Sequence conflicti306 – 3072KL → NV in AAA69162 (PubMed:8021226).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09177 Genomic DNA. Translation: AAA21590.1.
U28377 Genomic DNA. Translation: AAA69162.1. Sequence problems.
U00096 Genomic DNA. Translation: AAC76031.1.
AP009048 Genomic DNA. Translation: BAE77056.1.
PIRiA65086.
RefSeqiNP_417469.1. NC_000913.3.
WP_000017703.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76031; AAC76031; b2995.
BAE77056; BAE77056; BAE77056.
GeneIDi948615.
KEGGiecj:JW5494.
eco:b2995.
PATRICi32121406. VBIEscCol129921_3090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09177 Genomic DNA. Translation: AAA21590.1.
U28377 Genomic DNA. Translation: AAA69162.1. Sequence problems.
U00096 Genomic DNA. Translation: AAC76031.1.
AP009048 Genomic DNA. Translation: BAE77056.1.
PIRiA65086.
RefSeqiNP_417469.1. NC_000913.3.
WP_000017703.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP37180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262376. 6 interactions.
STRINGi511145.b2995.

Proteomic databases

PaxDbiP37180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76031; AAC76031; b2995.
BAE77056; BAE77056; BAE77056.
GeneIDi948615.
KEGGiecj:JW5494.
eco:b2995.
PATRICi32121406. VBIEscCol129921_3090.

Organism-specific databases

EchoBASEiEB1748.
EcoGeneiEG11800. hybB.

Phylogenomic databases

eggNOGiENOG4105CJ5. Bacteria.
COG5557. LUCA.
HOGENOMiHOG000278811.
InParanoidiP37180.
OMAiAIEVCAY.
PhylomeDBiP37180.

Enzyme and pathway databases

BioCyciEcoCyc:EG11800-MONOMER.
ECOL316407:JW5494-MONOMER.
MetaCyc:EG11800-MONOMER.

Miscellaneous databases

PROiP37180.

Family and domain databases

InterProiIPR005614. NrfD_fam.
[Graphical view]
PfamiPF03916. NrfD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYBB_ECOLI
AccessioniPrimary (citable) accession number: P37180
Secondary accession number(s): Q2M9K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 29, 2003
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.