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Protein

TGF-beta receptor type-2

Gene

TGFBR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.1 Publication

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei277ATPPROSITE-ProRule annotation1
Active sitei379Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi250 – 258ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glycosaminoglycan binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • receptor signaling protein serine/threonine kinase activity Source: InterPro
  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta-activated receptor activity Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor activity, type II Source: Ensembl
  • transmembrane receptor protein serine/threonine kinase activity Source: BHF-UCL
  • type III transforming growth factor beta receptor binding Source: BHF-UCL
  • type I transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Differentiation, Growth regulation

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08865-MONOMER.
BRENDAi2.7.10.2. 2681.
ReactomeiR-HSA-2173788. Downregulation of TGF-beta receptor signaling.
R-HSA-2173789. TGF-beta receptor signaling activates SMADs.
R-HSA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-HSA-3304356. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
R-HSA-3315487. SMAD2/3 MH2 Domain Mutants in Cancer.
R-HSA-3642279. TGFBR2 MSI Frameshift Mutants in Cancer.
R-HSA-3645790. TGFBR2 Kinase Domain Mutants in Cancer.
R-HSA-3656532. TGFBR1 KD Mutants in Cancer.
R-HSA-3656535. TGFBR1 LBD Mutants in Cancer.
R-HSA-5689603. UCH proteinases.
SignaLinkiP37173.
SIGNORiP37173.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta receptor type-2 (EC:2.7.11.30)
Short name:
TGFR-2
Alternative name(s):
TGF-beta type II receptor
Transforming growth factor-beta receptor type II
Short name:
TGF-beta receptor type II
Short name:
TbetaR-II
Gene namesi
Name:TGFBR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11773. TGFBR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 166ExtracellularSequence analysisAdd BLAST144
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 567CytoplasmicSequence analysisAdd BLAST380

GO - Cellular componenti

  • caveola Source: BHF-UCL
  • cytosol Source: Reactome
  • external side of plasma membrane Source: BHF-UCL
  • integral component of membrane Source: BHF-UCL
  • membrane raft Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • receptor complex Source: BHF-UCL
  • transforming growth factor beta receptor homodimeric complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hereditary non-polyposis colorectal cancer 6 (HNPCC6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
See also OMIM:614331
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_008156315T → M in HNPCC6. 2 PublicationsCorresponds to variant rs34833812dbSNPEnsembl.1
Esophageal cancer (ESCR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
See also OMIM:133239
Loeys-Dietz syndrome 2 (LDS2)10 Publications
The disease is caused by mutations affecting the gene represented in this entry. TGFBR2 mutations Cys-460 and His-460 have been reported to be associated with thoracic aortic aneurysms and dissection (TAAD). This phenotype, also known as thoracic aortic aneurysms type 3 (AAT3), is distinguised from LDS2 by having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit descending aortic disease and aneurysms of other arteries (PubMed:16027248), they have been considered as LDS2 by the OMIM resource.1 Publication
Disease descriptionAn aortic aneurysm syndrome with widespread systemic involvement, characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. Some patients have craniosynostosis, exotropy, micrognathia and retrognathia, structural brain abnormalities, and intellectual deficit.
See also OMIM:610168
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076167190R → H in LDS2. 1 PublicationCorresponds to variant rs780542125dbSNPEnsembl.1
Natural variantiVAR_076168247D → V in LDS2. 1 PublicationCorresponds to variant rs761231369dbSNPEnsembl.1
Natural variantiVAR_066723306Q → HE in LDS2. 1 Publication1
Natural variantiVAR_022351308L → P in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant rs28934568dbSNPEnsembl.1
Natural variantiVAR_076169325T → P in LDS2. 1 Publication1
Natural variantiVAR_022352336Y → N in LDS2. 1 PublicationCorresponds to variant rs104893812dbSNPEnsembl.1
Natural variantiVAR_022353355A → P in LDS2. 1 PublicationCorresponds to variant rs104893813dbSNPEnsembl.1
Natural variantiVAR_076170357G → R in LDS2. 1 Publication1
Natural variantiVAR_022354357G → W in LDS2. 1 PublicationCorresponds to variant rs104893814dbSNPEnsembl.1
Natural variantiVAR_066724377H → R in LDS2. 1 Publication1
Natural variantiVAR_066725446D → N in LDS2. 1 Publication1
Natural variantiVAR_022358449S → F in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant rs104893807dbSNPEnsembl.1
Natural variantiVAR_066726457M → K in LDS2. 1 Publication1
Natural variantiVAR_029760460R → C in LDS2. 1 PublicationCorresponds to variant rs104893811dbSNPEnsembl.1
Natural variantiVAR_029761460R → H in LDS2. 1 PublicationCorresponds to variant rs104893816dbSNPEnsembl.1
Natural variantiVAR_066727509G → V in LDS2. 1 Publication1
Natural variantiVAR_066728510I → F in LDS2. 1 Publication1
Natural variantiVAR_066729510I → S in LDS2. 1 Publication1
Natural variantiVAR_066730514C → R in LDS2. 1 PublicationCorresponds to variant rs193922664dbSNPEnsembl.1
Natural variantiVAR_066731521W → R in LDS2. 1 Publication1
Natural variantiVAR_022360528R → C in LDS2. 1 PublicationCorresponds to variant rs104893810dbSNPEnsembl.1
Natural variantiVAR_022361528R → H in LDS2. 2 PublicationsCorresponds to variant rs104893815dbSNPEnsembl.1
Natural variantiVAR_076171530T → I in LDS2. 1 Publication1
Natural variantiVAR_022362537R → C in LDS2; has a negative effect on TGF-beta signaling. 1 PublicationCorresponds to variant rs28934869dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi277K → R: Abolishes kinase activity, TGF-beta signaling and interaction with DAXX. 1 Publication1

Keywords - Diseasei

Aortic aneurysm, Disease mutation, Hereditary nonpolyposis colorectal cancer

Organism-specific databases

DisGeNETi7048.
MalaCardsiTGFBR2.
MIMi133239. phenotype.
610168. phenotype.
614331. phenotype.
OpenTargetsiENSG00000163513.
Orphaneti91387. Familial thoracic aortic aneurysm and aortic dissection.
144. Hereditary nonpolyposis colon cancer.
60030. Loeys-Dietz syndrome.
284973. Marfan syndrome type 2.
PharmGKBiPA36486.

Chemistry databases

ChEMBLiCHEMBL4267.
GuidetoPHARMACOLOGYi1795.

Polymorphism and mutation databases

BioMutaiTGFBR2.
DMDMi116242818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002442623 – 567TGF-beta receptor type-2Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 845 Publications
Disulfide bondi54 ↔ 715 Publications
Disulfide bondi61 ↔ 675 Publications
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi77 ↔ 1015 Publications
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 1365 Publications
Disulfide bondi138 ↔ 1435 Publications
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Modified residuei409PhosphoserineBy similarity1
Modified residuei548PhosphoserineCombined sources1
Modified residuei553PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP37173.
PaxDbiP37173.
PeptideAtlasiP37173.
PRIDEiP37173.

PTM databases

iPTMnetiP37173.
PhosphoSitePlusiP37173.

Expressioni

Gene expression databases

BgeeiENSG00000163513.
CleanExiHS_TGFBR2.
ExpressionAtlasiP37173. baseline and differential.
GenevisibleiP37173. HS.

Organism-specific databases

HPAiCAB073537.

Interactioni

Subunit structurei

Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with TCTEX1D4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DAXXQ9UER72EBI-296151,EBI-77321
MED12Q930743EBI-296151,EBI-394357
Med12A2AGH63EBI-296151,EBI-5744969From a different organism.
SCUBE3Q8IX306EBI-296151,EBI-4479975
TGFB1P011376EBI-296151,EBI-779636
TGFB1P072002EBI-296151,EBI-907660From a different organism.
TGFB3P106008EBI-296151,EBI-1033020

GO - Molecular functioni

  • SMAD binding Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • type III transforming growth factor beta receptor binding Source: BHF-UCL
  • type I transforming growth factor beta receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112906. 85 interactors.
DIPiDIP-5939N.
IntActiP37173. 26 interactors.
MINTiMINT-206666.
STRINGi9606.ENSP00000351905.

Chemistry databases

BindingDBiP37173.

Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 45Combined sources6
Beta strandi50 – 52Combined sources3
Beta strandi55 – 58Combined sources4
Beta strandi65 – 68Combined sources4
Beta strandi74 – 76Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi83 – 90Combined sources8
Beta strandi95 – 102Combined sources8
Beta strandi106 – 110Combined sources5
Turni114 – 117Combined sources4
Beta strandi119 – 122Combined sources4
Beta strandi124 – 126Combined sources3
Beta strandi131 – 138Combined sources8
Beta strandi140 – 142Combined sources3
Helixi143 – 145Combined sources3
Beta strandi146 – 148Combined sources3
Beta strandi149 – 154Combined sources6
Beta strandi244 – 252Combined sources9
Beta strandi257 – 263Combined sources7
Beta strandi273 – 280Combined sources8
Helixi281 – 283Combined sources3
Helixi284 – 294Combined sources11
Helixi297 – 299Combined sources3
Beta strandi307 – 314Combined sources8
Beta strandi316 – 326Combined sources11
Helixi333 – 339Combined sources7
Helixi344 – 362Combined sources19
Helixi382 – 384Combined sources3
Beta strandi385 – 387Combined sources3
Beta strandi393 – 395Combined sources3
Turni410 – 414Combined sources5
Helixi422 – 424Combined sources3
Helixi427 – 430Combined sources4
Helixi439 – 459Combined sources21
Helixi462 – 464Combined sources3
Turni473 – 477Combined sources5
Helixi484 – 491Combined sources8
Turni492 – 494Combined sources3
Helixi502 – 506Combined sources5
Helixi508 – 520Combined sources13
Helixi525 – 527Combined sources3
Helixi531 – 540Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KTZX-ray2.15B38-159[»]
1M9ZX-ray1.05A49-159[»]
1PLONMR-A38-159[»]
2PJYX-ray3.00B42-149[»]
3KFDX-ray3.00E/F/G/H38-153[»]
4P7UX-ray1.50A49-159[»]
4XJJX-ray1.40A50-159[»]
5E8VX-ray1.69A237-549[»]
5E8YX-ray2.05A237-549[»]
5E91X-ray2.42A237-549[»]
5E92X-ray2.08A237-549[»]
ProteinModelPortaliP37173.
SMRiP37173.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37173.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini244 – 544Protein kinasePROSITE-ProRule annotationAdd BLAST301

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG104975.
InParanoidiP37173.
KOiK04388.
OMAiTRHIISW.
PhylomeDBiP37173.
TreeFamiTF314724.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
IPR017194. Transform_growth_fac-b_typ-2.
IPR015013. Transforming_GF_b_rcpt_2_ecto.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF08917. ecTbetaR2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF037393. TGFRII. 1 hit.
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P37173-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMIVTD NNGAVKFPQL
60 70 80 90 100
CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV
110 120 130 140 150
CHDPKLPYHD FILEDAASPK CIMKEKKKPG ETFFMCSCSS DECNDNIIFS
160 170 180 190 200
EEYNTSNPDL LLVIFQVTGI SLLPPLGVAI SVIIIFYCYR VNRQQKLSST
210 220 230 240 250
WETGKTRKLM EFSEHCAIIL EDDRSDISST CANNINHNTE LLPIELDTLV
260 270 280 290 300
GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK
310 320 330 340 350
HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL
360 370 380 390 400
GSSLARGIAH LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL
410 420 430 440 450
SLRLDPTLSV DDLANSGQVG TARYMAPEVL ESRMNLENVE SFKQTDVYSM
460 470 480 490 500
ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE HPCVESMKDN VLRDRGRPEI
510 520 530 540 550
PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE LEHLDRLSGR
560
SCSEEKIPED GSLNTTK
Length:567
Mass (Da):64,568
Last modified:October 17, 2006 - v2
Checksum:iC541DA751FFBDBEB
GO
Isoform 2 (identifier: P37173-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-32: SV → SDVEMEAQKDEIICPSCNRTAHPLRHI

Show »
Length:592
Mass (Da):67,457
Checksum:i8ADCBA70F95E1CBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti381K → N in BAA09332 (PubMed:8973329).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02051036M → V.1 PublicationCorresponds to variant rs17025864dbSNPEnsembl.1
Natural variantiVAR_04141461C → R in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_03607073I → V in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_076167190R → H in LDS2. 1 PublicationCorresponds to variant rs780542125dbSNPEnsembl.1
Natural variantiVAR_017606191V → I.2 PublicationsCorresponds to variant rs56105708dbSNPEnsembl.1
Natural variantiVAR_076168247D → V in LDS2. 1 PublicationCorresponds to variant rs761231369dbSNPEnsembl.1
Natural variantiVAR_066723306Q → HE in LDS2. 1 Publication1
Natural variantiVAR_022351308L → P in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant rs28934568dbSNPEnsembl.1
Natural variantiVAR_008156315T → M in HNPCC6. 2 PublicationsCorresponds to variant rs34833812dbSNPEnsembl.1
Natural variantiVAR_076169325T → P in LDS2. 1 Publication1
Natural variantiVAR_041415328H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_022352336Y → N in LDS2. 1 PublicationCorresponds to variant rs104893812dbSNPEnsembl.1
Natural variantiVAR_022353355A → P in LDS2. 1 PublicationCorresponds to variant rs104893813dbSNPEnsembl.1
Natural variantiVAR_076170357G → R in LDS2. 1 Publication1
Natural variantiVAR_022354357G → W in LDS2. 1 PublicationCorresponds to variant rs104893814dbSNPEnsembl.1
Natural variantiVAR_041416373M → I.1 PublicationCorresponds to variant rs35719192dbSNPEnsembl.1
Natural variantiVAR_066724377H → R in LDS2. 1 Publication1
Natural variantiVAR_022355387V → M in a breast tumor. 2 PublicationsCorresponds to variant rs35766612dbSNPEnsembl.1
Natural variantiVAR_022356435N → S in a breast tumor; signaling of TGF-beta significantly inhibited. 1 Publication1
Natural variantiVAR_028063439V → A.4 PublicationsCorresponds to variant rs1050833dbSNPEnsembl.1
Natural variantiVAR_066725446D → N in LDS2. 1 Publication1
Natural variantiVAR_022357447V → A in a breast tumor; signaling of TGF-beta significantly inhibited. 1 Publication1
Natural variantiVAR_022358449S → F in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant rs104893807dbSNPEnsembl.1
Natural variantiVAR_022359452L → M in a breast tumor; signaling of TGF-beta significantly inhibited. 1 Publication1
Natural variantiVAR_066726457M → K in LDS2. 1 Publication1
Natural variantiVAR_029760460R → C in LDS2. 1 PublicationCorresponds to variant rs104893811dbSNPEnsembl.1
Natural variantiVAR_029761460R → H in LDS2. 1 PublicationCorresponds to variant rs104893816dbSNPEnsembl.1
Natural variantiVAR_041417490N → S in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066727509G → V in LDS2. 1 Publication1
Natural variantiVAR_066728510I → F in LDS2. 1 Publication1
Natural variantiVAR_066729510I → S in LDS2. 1 Publication1
Natural variantiVAR_066730514C → R in LDS2. 1 PublicationCorresponds to variant rs193922664dbSNPEnsembl.1
Natural variantiVAR_066731521W → R in LDS2. 1 Publication1
Natural variantiVAR_015816526E → Q in esophageal cancer. 1 PublicationCorresponds to variant rs121918714dbSNPEnsembl.1
Natural variantiVAR_022360528R → C in LDS2. 1 PublicationCorresponds to variant rs104893810dbSNPEnsembl.1
Natural variantiVAR_022361528R → H in LDS2. 2 PublicationsCorresponds to variant rs104893815dbSNPEnsembl.1
Natural variantiVAR_076171530T → I in LDS2. 1 Publication1
Natural variantiVAR_022362537R → C in LDS2; has a negative effect on TGF-beta signaling. 1 PublicationCorresponds to variant rs28934869dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01215731 – 32SV → SDVEMEAQKDEIICPSCNRT AHPLRHI in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85079 mRNA. Translation: AAA61164.1.
D28131 mRNA. Translation: BAA05673.1.
U52246
, U52240, U52241, U52242, U52244, U52245 Genomic DNA. Translation: AAB17553.1.
U69152
, U69146, U69147, U69148, U69149, U69150, U69151 Genomic DNA. Translation: AAB40916.1.
D50683 mRNA. Translation: BAA09332.1.
AY675319 Genomic DNA. Translation: AAT70724.1.
AK300383 mRNA. Translation: BAG62117.1.
CH471055 Genomic DNA. Translation: EAW64412.1.
CCDSiCCDS2648.1. [P37173-1]
CCDS33727.1. [P37173-2]
PIRiA42100.
RefSeqiNP_001020018.1. NM_001024847.2. [P37173-2]
NP_003233.4. NM_003242.5. [P37173-1]
UniGeneiHs.604277.
Hs.82028.

Genome annotation databases

EnsembliENST00000295754; ENSP00000295754; ENSG00000163513. [P37173-1]
ENST00000359013; ENSP00000351905; ENSG00000163513. [P37173-2]
GeneIDi7048.
KEGGihsa:7048.
UCSCiuc003cen.4. human. [P37173-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85079 mRNA. Translation: AAA61164.1.
D28131 mRNA. Translation: BAA05673.1.
U52246
, U52240, U52241, U52242, U52244, U52245 Genomic DNA. Translation: AAB17553.1.
U69152
, U69146, U69147, U69148, U69149, U69150, U69151 Genomic DNA. Translation: AAB40916.1.
D50683 mRNA. Translation: BAA09332.1.
AY675319 Genomic DNA. Translation: AAT70724.1.
AK300383 mRNA. Translation: BAG62117.1.
CH471055 Genomic DNA. Translation: EAW64412.1.
CCDSiCCDS2648.1. [P37173-1]
CCDS33727.1. [P37173-2]
PIRiA42100.
RefSeqiNP_001020018.1. NM_001024847.2. [P37173-2]
NP_003233.4. NM_003242.5. [P37173-1]
UniGeneiHs.604277.
Hs.82028.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KTZX-ray2.15B38-159[»]
1M9ZX-ray1.05A49-159[»]
1PLONMR-A38-159[»]
2PJYX-ray3.00B42-149[»]
3KFDX-ray3.00E/F/G/H38-153[»]
4P7UX-ray1.50A49-159[»]
4XJJX-ray1.40A50-159[»]
5E8VX-ray1.69A237-549[»]
5E8YX-ray2.05A237-549[»]
5E91X-ray2.42A237-549[»]
5E92X-ray2.08A237-549[»]
ProteinModelPortaliP37173.
SMRiP37173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112906. 85 interactors.
DIPiDIP-5939N.
IntActiP37173. 26 interactors.
MINTiMINT-206666.
STRINGi9606.ENSP00000351905.

Chemistry databases

BindingDBiP37173.
ChEMBLiCHEMBL4267.
GuidetoPHARMACOLOGYi1795.

PTM databases

iPTMnetiP37173.
PhosphoSitePlusiP37173.

Polymorphism and mutation databases

BioMutaiTGFBR2.
DMDMi116242818.

Proteomic databases

MaxQBiP37173.
PaxDbiP37173.
PeptideAtlasiP37173.
PRIDEiP37173.

Protocols and materials databases

DNASUi7048.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295754; ENSP00000295754; ENSG00000163513. [P37173-1]
ENST00000359013; ENSP00000351905; ENSG00000163513. [P37173-2]
GeneIDi7048.
KEGGihsa:7048.
UCSCiuc003cen.4. human. [P37173-1]

Organism-specific databases

CTDi7048.
DisGeNETi7048.
GeneCardsiTGFBR2.
GeneReviewsiTGFBR2.
H-InvDBHIX0024332.
HGNCiHGNC:11773. TGFBR2.
HPAiCAB073537.
MalaCardsiTGFBR2.
MIMi133239. phenotype.
190182. gene.
610168. phenotype.
614331. phenotype.
neXtProtiNX_P37173.
OpenTargetsiENSG00000163513.
Orphaneti91387. Familial thoracic aortic aneurysm and aortic dissection.
144. Hereditary nonpolyposis colon cancer.
60030. Loeys-Dietz syndrome.
284973. Marfan syndrome type 2.
PharmGKBiPA36486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG104975.
InParanoidiP37173.
KOiK04388.
OMAiTRHIISW.
PhylomeDBiP37173.
TreeFamiTF314724.

Enzyme and pathway databases

BioCyciZFISH:HS08865-MONOMER.
BRENDAi2.7.10.2. 2681.
ReactomeiR-HSA-2173788. Downregulation of TGF-beta receptor signaling.
R-HSA-2173789. TGF-beta receptor signaling activates SMADs.
R-HSA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-HSA-3304356. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
R-HSA-3315487. SMAD2/3 MH2 Domain Mutants in Cancer.
R-HSA-3642279. TGFBR2 MSI Frameshift Mutants in Cancer.
R-HSA-3645790. TGFBR2 Kinase Domain Mutants in Cancer.
R-HSA-3656532. TGFBR1 KD Mutants in Cancer.
R-HSA-3656535. TGFBR1 LBD Mutants in Cancer.
R-HSA-5689603. UCH proteinases.
SignaLinkiP37173.
SIGNORiP37173.

Miscellaneous databases

ChiTaRSiTGFBR2. human.
EvolutionaryTraceiP37173.
GeneWikiiTGF_beta_receptor_2.
GenomeRNAii7048.
PROiP37173.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163513.
CleanExiHS_TGFBR2.
ExpressionAtlasiP37173. baseline and differential.
GenevisibleiP37173. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
IPR017194. Transform_growth_fac-b_typ-2.
IPR015013. Transforming_GF_b_rcpt_2_ecto.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF08917. ecTbetaR2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF037393. TGFRII. 1 hit.
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGFR2_HUMAN
AccessioniPrimary (citable) accession number: P37173
Secondary accession number(s): B4DTV5
, Q15580, Q6DKT6, Q99474
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 200 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.